Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUK75B)

Drug Name

Urea Drug Info

Synonyms

carbamide; 57-13-6; Isourea; Carbonyldiamide; Ureophil; Carbonyldiamine; Carbamimidic acid; Pseudourea; Ureaphil; Urevert; Carbaderm; Alphadrate; Keratinamin; Calmurid; Aquadrate; Carbonyl diamide; Pastaron; Urepearl; Carbamide resin; Ultra Mide; Varioform ii; Aqua Care; Prespersion, 75 urea; carmol; basodexan; Harnstoff; Nutraplus; Mocovina; Urea solution; Supercel 3000; Aqua Care HP; Ureacin-20; Ureacin-40 Creme; Ureacin-10 lotion; Polyurea; Panafil; Onychomal; Hyanit; Caswell No. 902; Carbonyl Diamine; Mocovina [Czech]; Harnstoff [Ge

Indication

Disease Entry	ICD 11	Status	REF
Dermatological disease	DA24.Y	Approved	[1]
Exanthem		Approved	[2]
Impacted cerumen	AA42	Approved	[2]
Pityriasis simplex		Approved	[2]
Skin disease	EA00-EM0Z	Approved	[2]
Tinea versicolor	1F2D.0	Approved	[2]

Cross-matching ID

PubChem CID: 1176
ChEBI ID: CHEMBL16199
CAS Number: CAS 57-13-6
TTD Drug ID: DMUK75B
VARIDT Drug ID: DR00048

Molecule-Related Drug Atlas

Molecule Type:

DTP

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Transported By Organic anion transporting polypeptide 1A2 (SLCO1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[10]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[11]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[12]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[13]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[14]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[15]
Saquinavir	DMG814N	Human immunodeficiency virus infection	1C62	Approved	[16]
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[17]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[18]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[19]
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Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[20]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[8]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[21]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[22]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[23]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[24]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[25]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
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Drug(s) Affected By Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[29]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[32]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[36]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[37]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[38]
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Drug(s) Affected By Aquaporin-10 (AQP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[41]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[40]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[43]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[44]
1,6-hexamethylene diisocyanate	DMLB3RT	Discovery agent	N.A.	Investigative	[45]
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Drug(s) Affected By Arginase-2, mitochondrial (ARG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[46]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[47]
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[50]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[54]
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Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[58]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[59]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[61]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[32]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
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Drug(s) Affected By Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[64]
Paricalcitol	DMYBV3G	Hyperparathyroidism	5A51	Approved	[8]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[69]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[70]
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[8]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[8]
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Drug(s) Affected By Hemoglobin subunit alpha (HBA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[73]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[41]
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[75]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[76]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[77]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[78]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[79]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Organic anion transporting polypeptide 1A2 (SLCO1A2)	DTE2B1D	SO1A2_HUMAN	Substrate	[3]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Protein Interaction/Cellular Processes	[4]
Aquaporin-10 (AQP10)	OT8Q5UWS	AQP10_HUMAN	Regulation of Drug Effects	[5]
Arginase-2, mitochondrial (ARG2)	OTCPI0E8	ARGI2_HUMAN	Biotransformations	[6]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)	OTI862QH	CPT1A_HUMAN	Gene/Protein Processing	[7]
Hemoglobin subunit alpha (HBA1)	OTW2BQF4	HBA_HUMAN	Drug Response	[8]
Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R)	OTQF5ZAK	PTH1R_HUMAN	Drug Response	[8]
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Regulation of Drug Effects	[9]

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References

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2	Urea FDA Label
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