Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZQVDI)

Drug Name
T0901317 Drug Info
Synonyms
T0901317; 293754-55-9; T 0901317; TO-901317; TO901317; UNII-A07663A39I; T-0901317; CHEMBL62136; N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide; A07663A39I; N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE; N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzenesulfonamide; T-1317
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
447912
ChEBI ID
CHEMBL62136
CAS Number
CAS 293754-55-9
TTD Drug ID
DMZQVDI

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Oxysterols receptor LXR (NR1H)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ALX-101 DMCAFXM Atopic dermatitis EA80 Phase 2 [12]
RGX-104 DM5AIKR Non-small-cell lung cancer 2C25.Y Phase 1/2 [13]
BMS-779788 DMKR8S1 Arteriosclerosis BD40 Phase 1 [14]
CS-8080 DMRH740 Arteriosclerosis BD40 Phase 1 [14]
BMS-852927 DMZS1D2 Arteriosclerosis BD40 Phase 1 [14]
XL-041 DMYSQHT Arteriosclerosis BD40 Phase 1 [15]
XL652/XL014 DM89NML Cardiovascular disease BA00-BE2Z Phase 1 [16]
LXR 623 DM3OP41 Arteriosclerosis BD40 Phase 1 [14]
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Drug(s) Affected By Tumor necrosis factor ligand superfamily member 15 (TNFSF15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [17]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [19]
Testosterone DM7HUNW Hot flushes GA30 Approved [20]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [20]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Clozapine DMFC71L Schizophrenia 6A20 Approved [22]
Menthol DMG2KW7 Back pain ME84.Z Approved [23]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [24]
Arsenic DMTL2Y1 N. A. N. A. Approved [25]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [26]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [27]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [28]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [29]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [30]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [31]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [32]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [33]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [34]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [32]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [35]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [35]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [36]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [37]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [38]
Etidronic acid DM1XHYJ Bone Paget disease Approved [35]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [35]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [35]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [39]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [40]
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Drug(s) Affected By Stearoyl-CoA desaturase (SCD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clavulanate DM2FGRT Bacteremia 1A73 Approved [41]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [42]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [42]
Methotrexate DM2TEOL Anterior urethra cancer Approved [43]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [45]
Fluoxetine DM3PD2C Bipolar depression Approved [42]
Fructose DM43AN2 Vomiting MD90 Approved [46]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [47]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [42]
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Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [48]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [49]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Fluoxetine DM3PD2C Bipolar depression Approved [50]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [51]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [52]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [55]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [56]
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Drug(s) Affected By Alpha-synuclein (SNCA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [57]
Testosterone enanthate DMB6871 N. A. N. A. Approved [58]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [59]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [60]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [61]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [62]
Bortezomib DMNO38U Leukemia Approved [63]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [64]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [65]
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Drug(s) Affected By Nuclear receptor-interacting protein 1 (NRIP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [66]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [67]
Panobinostat DM58WKG Chronic graft versus host disease Approved [68]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [69]
Leflunomide DMR8ONJ Arthritis FA20 Approved [70]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [71]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [72]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [73]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [74]
Teniposide DMLW57T Acute lymphoblastic leukaemia 2A85 Approved [75]
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Drug(s) Affected By Microsomal triglyceride transfer protein large subunit (MTTP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [76]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [76]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [76]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [76]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [77]
Tolcapone DM8MNVO Parkinson disease 8A00.0 Approved [78]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [79]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [80]
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Drug(s) Affected By Acetyl-CoA carboxylase 1 (ACACA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [81]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [76]
Quercetin DM3NC4M Obesity 5B81 Approved [83]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [85]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [86]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [87]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [88]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [39]
Quercetin DM3NC4M Obesity 5B81 Approved [89]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [90]
Artemether DM48QOT Malaria 1F40-1F45 Approved [91]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [92]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [93]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [94]
Estrone DM5T6US Acne vulgaris ED80 Approved [95]
Leflunomide DMR8ONJ Arthritis FA20 Approved [96]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [79]
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Drug(s) Affected By E3 ubiquitin-protein ligase MYLIP (MYLIP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [18]
Panobinostat DM58WKG Chronic graft versus host disease Approved [68]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [97]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [69]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [71]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [62]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [98]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [99]
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Drug(s) Affected By Very long chain fatty acid elongase 6 (ELOVL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [44]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [51]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [101]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [79]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [21]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [24]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [102]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [103]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [104]
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Drug(s) Affected By 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (PNPLA3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [105]
Methotrexate DM2TEOL Anterior urethra cancer Approved [43]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Fluoxetine DM3PD2C Bipolar depression Approved [50]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [87]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [79]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [73]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [106]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [98]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [107]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Oxysterols receptor LXR (NR1H) TTM1EQF NOUNIPROTAC Binder [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (PNPLA3) OTR4990X PLPL3_HUMAN Gene/Protein Processing [3]
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Gene/Protein Processing [4]
Alpha-synuclein (SNCA) OTPWC1MR SYUA_HUMAN Gene/Protein Processing [5]
E3 ubiquitin-protein ligase MYLIP (MYLIP) OTL0PFGV MYLIP_HUMAN Gene/Protein Processing [6]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [7]
Microsomal triglyceride transfer protein large subunit (MTTP) OTNUVSDT MTP_HUMAN Gene/Protein Processing [3]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Gene/Protein Processing [8]
Nuclear receptor subfamily 1 group I member 3 (NR1I3) OTS3SGH7 NR1I3_HUMAN Gene/Protein Processing [9]
Nuclear receptor-interacting protein 1 (NRIP1) OTIZOJQV NRIP1_HUMAN Gene/Protein Processing [10]
Phospholipid-transporting ATPase ABCA1 (ABCA1) OT94G6BQ ABCA1_HUMAN Gene/Protein Processing [11]

References

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2 The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse. J Lipid Res. 2003 Nov;44(11):2039-48.
3 Isosilybin regulates lipogenesis and fatty acid oxidation via the AMPK/SREBP-1c/PPAR pathway. Chem Biol Interact. 2022 Dec 1;368:110250. doi: 10.1016/j.cbi.2022.110250. Epub 2022 Nov 5.
4 Editor's Highlight: Mechanistic Toxicity Tests Based on an Adverse Outcome Pathway Network for Hepatic Steatosis. Toxicol Sci. 2017 Sep 1;159(1):159-169. doi: 10.1093/toxsci/kfx121.
5 Regulation of alpha-synuclein expression by liver X receptor ligands in vitro. Neuroreport. 2008 Nov 19;19(17):1685-9. doi: 10.1097/WNR.0b013e32831578b2.
6 The liver X receptors and sterol regulatory element binding proteins alter progesterone secretion and are regulated by human chorionic gonadotropin in human luteinized granulosa cells. Mol Cell Endocrinol. 2018 Sep 15;473:124-135. doi: 10.1016/j.mce.2018.01.011. Epub 2018 Jan 31.
7 LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms. Atherosclerosis. 2009 Nov;207(1):38-44.
8 Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptor. Toxicol Sci. 2011 Apr;120(2):381-91.
9 TO901317, a potent LXR agonist, is an inverse agonist of CAR. J Toxicol Sci. 2013;38(3):309-15. doi: 10.2131/jts.38.309.
10 Combinations of LXR and RXR agonists induce triglyceride accumulation in human HepaRG cells in a synergistic manner. Arch Toxicol. 2020 Apr;94(4):1303-1320. doi: 10.1007/s00204-020-02685-7. Epub 2020 Mar 2.
11 Adipocytic differentiation and liver x receptor pathways regulate the accumulation of triacylglycerols in human vascular smooth muscle cells. J Biol Chem. 2005 Feb 4;280(5):3911-9. doi: 10.1074/jbc.M410075200. Epub 2004 Nov 16.
12 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
13 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
14 Liver X receptors in lipid metabolism: opportunities for drug discovery. Nat Rev Drug Discov. 2014 Jun;13(6):433-44.
15 Emerging small molecule drugs. Handb Exp Pharmacol. 2015;224:617-30.
16 Clinical pipeline report, company report or official report of Exelixis (2011).
17 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
18 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
19 Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
20 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
21 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
22 Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T-cell responses. Immunology. 2007 Jun;121(2):266-75. doi: 10.1111/j.1365-2567.2007.02574.x. Epub 2007 Mar 7.
23 Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
24 Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
25 Prenatal arsenic exposure and shifts in the newborn proteome: interindividual differences in tumor necrosis factor (TNF)-responsive signaling. Toxicol Sci. 2014 Jun;139(2):328-37. doi: 10.1093/toxsci/kfu053. Epub 2014 Mar 27.
26 Monomeric and oligomeric flavanols maintain the endogenous glucocorticoid response in human macrophages in pro-oxidant conditions in vitro. Chem Biol Interact. 2018 Aug 1;291:237-244.
27 Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1 or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling. Arch Oral Biol. 2012 May;57(5):483-90. doi: 10.1016/j.archoralbio.2011.10.007. Epub 2011 Nov 25.
28 Ca(2+) Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2. Int J Mol Sci. 2018 Sep 19;19(9):2829. doi: 10.3390/ijms19092829.
29 Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
30 Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
31 ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
32 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
33 Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
34 Nitric oxide synthase inhibitors attenuate ozone-induced airway inflammation in guinea pigs. Possible role of interleukin-8. Am J Respir Crit Care Med. 2000 Jan;161(1):249-56. doi: 10.1164/ajrccm.161.1.9804096.
35 Screening of a chemical library reveals novel PXR-activating pharmacologic compounds. Toxicol Lett. 2015 Jan 5;232(1):193-202. doi: 10.1016/j.toxlet.2014.10.009. Epub 2014 Oct 16.
36 Induction of PXR-mediated metabolism by beta-carotene. Biochim Biophys Acta. 2005 May 30;1740(2):162-9. doi: 10.1016/j.bbadis.2004.11.013. Epub 2004 Dec 8.
37 Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR). Toxicol Appl Pharmacol. 2005 Dec 1;209(2):123-33. doi: 10.1016/j.taap.2005.03.015.
38 Identification and validation of novel human pregnane X receptor activators among prescribed drugs via ligand-based virtual screening. Drug Metab Dispos. 2011 Feb;39(2):337-44. doi: 10.1124/dmd.110.035808. Epub 2010 Nov 10.
39 Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor. Drug Metab Dispos. 2005 Jul;33(7):924-9.
40 Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor. Toxicol Lett. 2017 Jan 4;265:86-96.
41 Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food Chem Toxicol. 2021 Dec;158:112664. doi: 10.1016/j.fct.2021.112664. Epub 2021 Nov 9.
42 Antidepressant drugs activate SREBP and up-regulate cholesterol and fatty acid biosynthesis in human glial cells. Neurosci Lett. 2006 Mar 13;395(3):185-90. doi: 10.1016/j.neulet.2005.10.096. Epub 2005 Dec 1.
43 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
44 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
45 Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
46 Effects of four-week high-fructose diet on gene expression in skeletal muscle of healthy men. Diabetes Metab. 2008 Feb;34(1):82-5. doi: 10.1016/j.diabet.2007.08.004. Epub 2007 Dec 11.
47 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
48 Atheroprotective effects of methotrexate on reverse cholesterol transport proteins and foam cell transformation in human THP-1 monocyte/macrophages. Arthritis Rheum. 2008 Dec;58(12):3675-83.
49 Combining simvastatin with the farnesyltransferase inhibitor tipifarnib results in an enhanced cytotoxic effect in a subset of primary CD34+ acute myeloid leukemia samples. Clin Cancer Res. 2009 May 1;15(9):3076-83. doi: 10.1158/1078-0432.CCR-08-3004. Epub 2009 Apr 21.
50 Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
51 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
52 Differential effects of peroxisome proliferator-activated receptor activators on the mRNA levels of genes involved in lipid metabolism in primary human monocyte-derived macrophages. Metabolism. 2003 May;52(5):652-7. doi: 10.1053/meta.2003.50100.
53 Proton pump inhibitor lansoprazole is a nuclear liver X receptor agonist. Biochem Pharmacol. 2010 May 1;79(9):1310-6. doi: 10.1016/j.bcp.2009.12.018. Epub 2010 Jan 8.
54 Repression of hepatocyte nuclear factor 4 alpha by AP-1 underlies dyslipidemia associated with retinoic acid. J Lipid Res. 2019 Apr;60(4):794-804. doi: 10.1194/jlr.M088880. Epub 2019 Feb 1.
55 Pregnane X receptor-agonists down-regulate hepatic ATP-binding cassette transporter A1 and scavenger receptor class B type I. Biochem Biophys Res Commun. 2005 Jun 17;331(4):1533-41. doi: 10.1016/j.bbrc.2005.04.071.
56 Inhibition of liver x receptor/retinoid X receptor-mediated transcription contributes to the proatherogenic effects of arsenic in macrophages in vitro. Arterioscler Thromb Vasc Biol. 2010 Jun;30(6):1228-36. doi: 10.1161/ATVBAHA.110.205500. Epub 2010 Mar 25.
57 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
58 Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
59 The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
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