Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZQVDI)

• Drug Name: T0901317 Drug Info
• Synonyms: T0901317; 293754-55-9; T 0901317; TO-901317; TO901317; UNII-A07663A39I; T-0901317; CHEMBL62136; N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide; A07663A39I; N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE; N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzenesulfonamide; T-1317

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 447912
  CAS Number: CAS 293754-55-9
  TTD Drug ID: DMZQVDI

Molecule-Related Drug Atlas

Drug(s) Targeting Oxysterols receptor LXR (NR1H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ALX-101	DMCAFXM	Atopic dermatitis	EA80	Phase 2	[12]
RGX-104	DM5AIKR	Non-small-cell lung cancer	2C25.Y	Phase 1/2	[13]
BMS-779788	DMKR8S1	Arteriosclerosis	BD40	Phase 1	[14]
CS-8080	DMRH740	Arteriosclerosis	BD40	Phase 1	[14]
BMS-852927	DMZS1D2	Arteriosclerosis	BD40	Phase 1	[14]
XL-041	DMYSQHT	Arteriosclerosis	BD40	Phase 1	[15]
XL652/XL014	DM89NML	Cardiovascular disease	BA00-BE2Z	Phase 1	[16]
LXR 623	DM3OP41	Arteriosclerosis	BD40	Phase 1	[14]

Drug(s) Affected By Oxysterols receptor LXR-beta (NR1H2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[18]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Gemfibrozil	DMD8Q3J	Hyperlipidaemia	5C80	Approved	[21]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[21]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[22]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[23]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[21]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[24]

Drug(s) Affected By Apolipoprotein E (APOE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[25]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[26]
Selenium	DM25CGV	N. A.	N. A.	Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[29]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]

Drug(s) Affected By Phospholipid transfer protein (PLTP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[35]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[36]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[41]

Drug(s) Affected By Oxysterols receptor LXR-alpha (NR1H3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Gemfibrozil	DMD8Q3J	Hyperlipidaemia	5C80	Approved	[21]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[44]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[21]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[45]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[22]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[23]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[46]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 15 (TNFSF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[48]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[50]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[51]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[52]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[53]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[54]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[54]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[55]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[56]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[57]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[60]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[61]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[62]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[63]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[64]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[65]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[66]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[67]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[69]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[71]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[69]

Drug(s) Affected By E-selectin (SELE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[72]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[74]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[75]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[78]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[79]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[80]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[81]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[82]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[82]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[83]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[85]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[82]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[82]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[82]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[86]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[87]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[88]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[89]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[90]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[91]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[93]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[94]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[95]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[96]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[97]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[98]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[99]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[100]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[101]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[102]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[102]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[103]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[104]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[105]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[106]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[107]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[108]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[108]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[110]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[108]
Fructose	DM43AN2	Vomiting	MD90	Approved	[111]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[108]

Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[114]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[115]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[29]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[116]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[120]

Drug(s) Affected By Low-density lipoprotein receptor (LDLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[121]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[121]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[123]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[29]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[37]

Drug(s) Affected By Apolipoprotein A-I (APOA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[127]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[29]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[129]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[130]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[131]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[133]

Drug(s) Affected By Apolipoprotein B-100 (APOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[134]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[29]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[137]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[134]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[138]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[139]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[140]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[141]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[66]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[142]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[143]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[144]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[145]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]

Drug(s) Affected By Lipoprotein lipase (LPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[55]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[146]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[147]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[36]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[149]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[149]

Drug(s) Affected By Cholesteryl ester transfer protein (CETP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[18]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[24]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[10]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[24]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[152]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[153]

Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[30]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[55]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[154]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[107]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[120]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[157]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[159]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[36]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[161]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[162]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[164]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[165]

Drug(s) Affected By Alpha-synuclein (SNCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[166]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[168]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[169]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[170]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[23]
Bortezomib	DMNO38U	Leukemia		Approved	[171]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[172]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]

Drug(s) Affected By ATP-binding cassette sub-family G member 1 (ABCG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[114]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[36]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[174]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[175]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[176]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[176]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[177]

Drug(s) Affected By Nuclear receptor-interacting protein 1 (NRIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[146]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[178]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[180]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[183]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[184]
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[24]

Drug(s) Affected By Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[185]
Selenium	DM25CGV	N. A.	N. A.	Approved	[27]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[186]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[134]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[187]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[188]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[29]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[190]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[191]

Drug(s) Affected By ATP-citrate synthase (ACLY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[134]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[192]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[125]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[9]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[169]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[193]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[194]
OPC-34712	DMHG57U	Major depressive disorder	6A70.3	Approved	[195]

Drug(s) Affected By Microsomal triglyceride transfer protein large subunit (MTTP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[134]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[134]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[134]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[196]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[124]

Drug(s) Affected By Sulfotransferase 2A1 (SULT2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[198]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[190]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[190]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[200]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[201]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]

Drug(s) Affected By Peroxisome proliferator-activated receptor alpha (PPARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[109]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[202]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[203]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[164]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[204]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[205]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[206]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]

Drug(s) Affected By Acetyl-CoA carboxylase 1 (ACACA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[207]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[134]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[192]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[191]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[209]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[37]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[210]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[86]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[211]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[189]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[212]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[213]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[200]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[214]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[215]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[216]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]

Drug(s) Affected By Scavenger receptor class B member 1 (SCARB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[217]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[218]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[219]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[119]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[220]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]

Drug(s) Affected By E3 ubiquitin-protein ligase MYLIP (MYLIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[36]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[179]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[221]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[180]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[23]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[222]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[223]

Drug(s) Affected By Diacylglycerol O-acyltransferase 2 (DGAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[224]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[180]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[225]

Drug(s) Affected By Very long chain fatty acid elongase 6 (ELOVL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[29]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[52]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[226]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[227]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[228]

Drug(s) Affected By 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (PNPLA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[115]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[229]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[222]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[41]

Drug(s) Affected By Endothelial lipase (LIPG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[221]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[180]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[230]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[125]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[52]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[170]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Oxysterols receptor LXR (NR1H)	TTM1EQF	NOUNIPROTAC	Binder	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (PNPLA3)	OTR4990X	PLPL3_HUMAN	Gene/Protein Processing	[3]
Acetyl-CoA carboxylase 1 (ACACA)	OT5CQPZY	ACACA_HUMAN	Gene/Protein Processing	[4]
Alpha-synuclein (SNCA)	OTPWC1MR	SYUA_HUMAN	Gene/Protein Processing	[5]
Apolipoprotein A-I (APOA1)	OT5THARI	APOA1_HUMAN	Gene/Protein Processing	[6]
Apolipoprotein B-100 (APOB)	OTH0UOCZ	APOB_HUMAN	Gene/Protein Processing	[4]
Apolipoprotein E (APOE)	OTFOWL2H	APOE_HUMAN	Gene/Protein Processing	[7]
ATP-binding cassette sub-family G member 1 (ABCG1)	OT5BG6MK	ABCG1_HUMAN	Gene/Protein Processing	[8]
ATP-citrate synthase (ACLY)	OTRL9ZRP	ACLY_HUMAN	Gene/Protein Processing	[9]
Cholesteryl ester transfer protein (CETP)	OTAGPPOE	CETP_HUMAN	Gene/Protein Processing	[10]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Gene/Protein Processing	[11]

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