Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTABD5E)

• DTT Name: DNA replication (DNA repli)
• Gene Name: DNA repli
• DTT Type: Successful target; [1]
• UniProt ID: NOUNIPROTAC
• TTD ID: T21112

Molecular Interaction Atlas (MIA) of This DTT

4 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[2]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[3]
Elliptinium acetate	DMZC6GT	Solid tumour/cancer	2A00-2F9Z	Approved	[4]
Ozenoxacin	DM6KZMG	Impetigo	1B72	Approved	[1]

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DFP-10917	DM1WNGJ	Acute myeloid leukaemia	2A60	Phase 3	[5]

References

• [1] 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
• [2] Roles of DNA repair and reductase activity in the cytotoxicity of the hypoxia-activated dinitrobenzamide mustard PR-104A. Mol Cancer Ther. 2009 Jun;8(6):1714-23.
• [3] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [4] Stationary potential of the brain: Part II. Clinical studies. Neurol Med Chir (Tokyo). 1979 Jul;19(7):655-64.
• [5] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)