Details of the Drug

General Information of Drug (ID: DMRKE63)

Drug Name
Chlorambucil
Synonyms
Ambochlorin; Amboclorin; Chlocambucil; Chloorambucol; Chlorambucilum; Chloraminophen; Chloraminophene; Chlorbutin; Chlorbutine; Chlorbutinum; Chloroambucil; Chlorobutin; Chlorobutine; Clorambucile; Clorambucilo; Ecloril; Elcoril; Elcorin; Leukeran; Leukersan; Leukoran; Linfolizin; Linfolysin; Lympholysin; Clorambucile [DCIT]; Glaxo Wellcome Brand of Chlorambucil; GlaxoSmithKline Brand of Chlorambucil; Leuk ersan; Leukeran tablets; Phenylbutyric acid nitrogen mustard; Wellcome Brand of Chlorambucil; C0253; CB 1348; CB1348; Cb l348; CB-1348; Chlorambucil [INN:BAN]; Chlorambucilum [INN-Latin]; Clorambucilo [INN-Spanish]; LEUKERAN (TN); Leukeran (TN); Phenylbuttersaeure-lost; Phenylbuttersaeure-lost[German]; Chlorambucil (USP/INN)
Indication
Disease Entry ICD 11 Status REF
Chronic lymphocytic leukaemia 2A82.0 Approved [1]
Small lymphocytic lymphoma 2A82.0 Approved [2]
Classic Hodgkin lymphoma N.A. Investigative [2]
Follicular lymphoma 2A80 Investigative [2]
Therapeutic Class
Anticancer Agents
Affected Organisms
Humans and other mammals
ATC Code
L01AA02: Chlorambucil
L01AA: Nitrogen mustard analogues
L01A: ALKYLATING AGENTS
L01: ANTINEOPLASTIC AGENTS
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 304.2
Logarithm of the Partition Coefficient (xlogp) 1.7
Rotatable Bond Count (rotbonds) 9
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 3
ADMET Property
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 1: high solubility and high permeability [3]
Bioavailability
82% of drug becomes completely available to its intended biological destination(s) [4]
Clearance
The drug present in the plasma can be removed from the body at the rate of 2.8 mL/min/kg [5]
Elimination
0.5% of drug is excreted from urine in the unchanged form [3]
Half-life
The concentration or amount of drug in body reduced by one-half in 1.5 hours [5]
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 0.65742 micromolar/kg/day [6]
Unbound Fraction
The unbound fraction of drug in plasma is 0.01% [5]
Vd
Fluid volume that would be required to contain the amount of drug present in the body at the same concentration as in the plasma 0.26 L/kg [5]
Water Solubility
The ability of drug to dissolve in water is measured as 12 mg/mL [3]
Chemical Identifiers
Formula
C14H19Cl2NO2
IUPAC Name
4-[4-[bis(2-chloroethyl)amino]phenyl]butanoic acid
Canonical SMILES
C1=CC(=CC=C1CCCC(=O)O)N(CCCl)CCCl
InChI
InChI=1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)
InChIKey
JCKYGMPEJWAADB-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
2708
ChEBI ID
CHEBI:28830
CAS Number
305-03-3
UNII
18D0SL7309
DrugBank ID
DB00291
TTD ID
D0V8QT
VARIDT ID
DR00895
INTEDE ID
DR0297
ACDINA ID
D00119
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
DNA replication (DNA repli) TTABD5E NOUNIPROTAC Intercalator [7]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic anion transporting polypeptide 1A2 (SLCO1A2) DTE2B1D SO1A2_HUMAN Substrate [8]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [9]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Glutathione S-transferase pi (GSTP1)
Main DME 		DEK6079 GSTP1_HUMAN Substrate [10]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Gene/Protein Processing [11]
Aldo-keto reductase family 1 member B10 (AKR1B10) OTOA4HTH AK1BA_HUMAN Gene/Protein Processing [12]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Gene/Protein Processing [12]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [13]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [14]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Regulation of Drug Effects [15]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [16]
Baculoviral IAP repeat-containing protein 2 (BIRC2) OTFXFREP BIRC2_HUMAN Drug Response [17]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [18]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Gene/Protein Processing [18]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 140 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JK1 CTRP2 2.1797 7.6077 1.7629 40.2912
MEC1 CTRP2 4.7961 7.0027 4.7224 22.0852
JM1 CTRP2 3.9395 4.6749 3.9395 27.5368
HuT 78 CTRP2 0.03 14.1288 -2.8672 51.8722
KMS-28BM CTRP2 1.1888 7.8647 0.6165 46.495
EoL-1 CTRP2 1.2485 4.2696 1.2295 45.4873
NU-DUL-1 CTRP2 1.5189 4.3628 1.4427 35.1154
EB1 CTRP2 1.7978 8.0495 1.2317 42.9125
MHH-CALL-4 CTRP2 1.9026 4.6425 1.8851 41.1451
RCH-ACV CTRP2 1.9357 4.7686 1.9139 40.9376
NALM-6 CTRP2 2.013 4.0472 2.0103 40.3675
GA-10 CTRP2 2.1778 7.36 1.8196 40.175
TALL-1 [Human adult T-ALL] CTRP2 2.2143 6.2807 2.0647 39.4405
RS4;11 CTRP2 2.2796 4.6391 2.2699 38.6157
MV4-11 CTRP2 2.2805 4.3809 2.2761 38.5927
MOLM-13 CTRP2 2.3013 6.0102 2.1945 38.7545
MOLT-16 CTRP2 2.3199 4.4933 2.314 38.3357
KMS-34 CTRP2 2.671 3.8884 2.671 35.9797
KE-37 CTRP2 2.7053 3.7896 2.7053 35.7513
L-540 CTRP2 2.8133 4.3058 2.8127 35.0347
OCI-Ly19 CTRP2 2.9717 5.1679 2.9597 34.0179
SEM CTRP2 2.9741 4.5467 2.973 33.9657
BV-173 CTRP2 2.9818 4.9854 2.9749 33.9339
MOLM-6 CTRP2 2.989 7.2184 2.733 34.67
DEL CTRP2 3.0727 4.3413 3.0725 33.3066
SUP-T11 CTRP2 3.1657 6.2217 3.0866 32.9477
P12-Ichikawa CTRP2 3.17 4.3321 3.1699 32.6584
SU-DHL-8 CTRP2 3.2386 7.2752 2.9921 33.002
Daudi CTRP2 3.3117 5.28 3.303 31.7443
OCI-AML-3 CTRP2 3.344 4.6818 3.3435 31.5022
MHH-CALL-3 CTRP2 3.5275 13.592 0.9884 36.9357
L-363 CTRP2 3.5752 7.6243 3.2799 30.943
KMS-26 CTRP2 3.6323 7.018 3.469 30.1285
SET-2 CTRP2 3.644 4.7905 3.6437 29.5046
OCI-Ly3 CTRP2 3.6882 4.3291 3.6882 29.2092
SUP-B15 CTRP2 3.7484 4.6041 3.7484 28.8084
Mino CTRP2 3.7948 4.3481 3.7948 28.4997
WSU-DLCL2 CTRP2 3.8363 5.6377 3.827 28.2548
MOLP-8 CTRP2 3.8649 4.9402 3.8647 28.0342
SU-DHL-1 CTRP2 3.8652 4.6795 3.8652 28.0311
SR CTRP2 3.8722 5.4201 3.8686 27.9965
KMS-12-BM CTRP2 3.8801 6.3586 3.8268 28.1112
Granta-519 CTRP2 3.9148 5.6403 3.907 27.7275
KYO-1 CTRP2 4.0229 5.6802 4.0159 27.0049
DoHH2 CTRP2 4.0374 6.362 3.9919 27.0378
SUP-HD1 CTRP2 4.0509 5.3218 4.0498 26.7993
HEL 92.1.7 CTRP2 4.0525 4.8551 4.0525 26.7848
THP-1 CTRP2 4.0859 5.4019 4.0843 26.5678
KMS-21-BM CTRP2 4.1162 5.5375 4.1134 26.3701
SIG-M5 CTRP2 4.1367 4.8429 4.1367 26.2241
CML-T1 CTRP2 4.1446 5.1398 4.1444 26.1725
EM-2 CTRP2 4.1516 5.3435 4.1509 26.1275
RPMI-8402 CTRP2 4.1893 5.3038 4.1888 25.8758
Mono-Mac-1 CTRP2 4.2068 7.0534 4.0823 26.1802
KE-97 CTRP2 4.2153 6.2354 4.1881 25.7923
Hs 611.T CTRP2 4.2955 6.3443 4.2638 25.2738
HuNS1 CTRP2 4.3252 6.0985 4.3099 25.0207
U-937 CTRP2 4.4236 5.3494 4.4235 24.3152
JURL-MK1 CTRP2 4.4478 5.3928 4.4476 24.1546
OCI-AML-2 CTRP2 4.4611 5.0061 4.4611 24.065
Reh CTRP2 4.5067 5.4846 4.5064 23.7628
CMK CTRP2 4.5177 5.0248 4.5177 23.6884
MOLP-2 CTRP2 4.5304 7.1175 4.4199 23.9799
SU-DHL-4 CTRP2 4.5343 7.3255 4.387 24.0815
JVM-2 CTRP2 4.5348 8.248 4.1632 24.8665
ST486 CTRP2 4.553 6.3542 4.5311 23.5269
Pfeiffer CTRP2 4.5666 14.0288 1.8362 31.954
RPMI-6666 CTRP2 4.5902 6.3006 4.5728 23.2642
Ri-1 CTRP2 4.6073 6.973 4.5247 23.3719
P31/FUJ CTRP2 4.6136 6.3318 4.5952 23.1116
L-428 CTRP2 4.629 8.5745 4.1673 24.5637
A4/Fukuda CTRP2 4.644 5.428 4.644 22.8478
KO52 CTRP2 4.6498 6.327 4.6329 22.8657
KMS-27 CTRP2 4.6551 5.7776 4.6538 22.7782
HL-60 CTRP2 4.6639 5.2254 4.6639 22.7156
SUP-T1 CTRP2 4.6652 6.4153 4.6435 22.7796
MOTN-1 CTRP2 4.7087 6.1092 4.7023 22.4384
HEL CTRP2 4.718 5.3347 4.718 22.3553
PF-382 CTRP2 4.7427 6.6345 4.7076 22.3092
OCI-M1 CTRP2 4.7533 5.4076 4.7533 22.1203
AML-193 CTRP2 4.7704 6.5772 4.7414 22.104
SK-MM-2 CTRP2 4.7824 8.011 4.4993 22.9108
NB4 CTRP2 4.8075 5.3301 4.8075 21.7596
SKM-1 CTRP2 4.8086 5.5718 4.8086 21.7523
KMS-20 CTRP2 4.8167 6.5075 4.7948 21.772
SU-DHL-6 CTRP2 4.8509 6.9251 4.7909 21.6736
OCI-AML-5 CTRP2 4.8979 7.7625 4.6881 21.8831
Ci-1 CTRP2 4.9354 6.6863 4.905 21.0106
SU-DHL-10 CTRP2 5.0337 9.2075 4.3905 22.5517
Ku812 CTRP2 5.036 7.5631 4.8831 20.7641
KMS-11 CTRP2 5.1545 8.8423 4.65 21.2468
MOLT-13 CTRP2 5.226 6.7033 5.2069 19.038
M-07e CTRP2 5.2461 7.204 5.1747 19.0825
MJ CTRP2 5.2654 9.2442 4.6261 21.0122
NCO2 CTRP2 5.3045 8.0009 5.0716 19.2631
NCI-H929 CTRP2 5.3094 7.2674 5.2329 18.6791
KMS-18 CTRP2 5.3398 8.5557 4.9465 19.6112
EHEB CTRP2 5.353 8.3946 5.0117 19.3332
KM-H2 CTRP2 5.3843 7.2514 5.3157 18.1537
Ki-JK CTRP2 5.4586 6.657 5.4497 17.456
JeKo-1 CTRP2 5.5374 7.516 5.436 17.2488
Jurkat CTRP2 5.5538 6.8316 5.5388 16.8428
GDM-1 CTRP2 5.6005 8.0363 5.3853 17.2322
OPM-2 CTRP2 5.6844 14.7495 2.5844 26.8777
DB CTRP2 5.7183 8.0134 5.5199 16.3891
Peer CTRP2 5.9825 7.9092 5.8347 14.4515
NOMO-1 CTRP2 6.034 8.2606 5.7946 14.4399
PL21 CTRP2 6.0391 8.3364 5.777 14.4894
HPB-ALL CTRP2 6.0906 9.1513 5.544 15.2151
JJN-3 CTRP2 6.1229 9.8481 5.2928 16.0967
RL CTRP2 6.1738 8.6722 5.8116 13.9667
MM1.S CTRP2 6.2609 7.7743 6.1687 12.4033
HD-MY-Z CTRP2 6.329 8.5958 6.0061 12.7914
Karpas-299 CTRP2 6.3398 7.9445 6.2155 11.9924
JVM-3 CTRP2 6.3891 7.6466 6.332 11.4278
RPMI-8226 CTRP2 6.4232 8.3093 6.2037 11.7832
TF-1 CTRP2 6.4354 8.4104 6.1845 11.818
Raji CTRP2 6.4387 8.6445 6.1072 12.0967
LAMA-84 CTRP2 6.4432 8.3565 6.2105 11.699
MOLM-16 CTRP2 6.4452 8.7264 6.0845 12.1637
HT CTRP2 6.4866 8.3451 6.2613 11.3835
KCL-22 CTRP2 6.5207 8.8459 6.1205 11.814
AMO1 CTRP2 6.5704 8.5303 6.2899 11.0327
HDLM-2 CTRP2 6.6489 9.7357 5.8839 12.3912
Karpas-422 CTRP2 6.6557 8.4148 6.422 10.2929
DND-41 CTRP2 6.8924 8.5565 6.6275 8.8416
F-36P CTRP2 6.9372 10.2669 5.9307 11.4795
ME1 CTRP2 7.0759 8.8322 6.7144 7.9998
P3HR-1 CTRP2 7.1804 11.994 5.3288 13.3702
Kasumi-1 CTRP2 7.2519 8.8893 6.8737 6.9068
EJM CTRP2 7.3523 8.3643 7.1925 5.3996
KHM-1B CTRP2 7.3783 8.8472 7.0222 5.9903
LP-1 CTRP2 7.471 8.7169 7.1745 5.1465
OCI-Ly10 CTRP2 7.5879 8.7978 7.2573 4.5169
K-562 CTRP2 7.7224 8.3439 7.5946 2.8319
U266B1 CTRP2 7.8867 14.9316 4.4897 15.2262
Karpas-620 CTRP2 8.4565 12.831 6.0083 7.9757
REC-1 CTRP2 8.6066 12.6317 6.2244 6.8126
KMM-1 CTRP2 9.8444 12.394 7.1524 1.5231
MC116 CTRP2 11.0551 17.6043 5.5071 6.1718
⏷ Show the Full List of 140 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE8 CTRP2 5.489 11.4431 3.9423 22.9132
TE15 CTRP2 5.6844 7.467 5.6036 16.1988
TE-5 CTRP2 6.0074 8.0318 5.8305 14.3904
TE-4 CTRP2 6.1691 11.8244 4.4461 19.2688
EC-GI-10 CTRP2 6.5583 8.8647 6.1534 11.5832
COLO 680N CTRP2 7.1275 9.756 6.3568 9.2891
TE-6 CTRP2 7.2474 15.4481 3.6791 19.5837
TE-11 CTRP2 7.3272 8.932 6.9325 6.4782
KYSE-150 CTRP2 7.5255 8.0784 7.4747 3.847
KYSE-30 CTRP2 7.5259 8.8267 7.1816 4.9767
KYSE-140 CTRP2 7.7821 10.493 6.6151 6.731
KYSE-410 CTRP2 7.8351 9.3424 7.2328 4.0399
KYSE-510 CTRP2 7.9202 13.8205 5.0735 12.8469
TE-14 CTRP2 7.9286 15.9819 4.0001 16.9898
OE21 CTRP2 8.0888 10.1262 7.0621 4.2379
TE-9 CTRP2 8.4239 10.6399 7.0718 3.5967
KYSE-70 CTRP2 8.5553 11.2314 6.8784 4.1819
TE-10 CTRP2 8.8337 11.4519 6.9708 3.372
KYSE-180 CTRP2 8.9926 13.0382 6.3117 5.8198
TE-1 CTRP2 9.319 12.4839 6.8026 3.376
KYSE-520 CTRP2 9.7318 11.5585 7.4456 0.7085
KYSE-450 CTRP2 9.7544 10.9599 7.6838 0.1677
OE19 CTRP2 9.9649 11.0329 7.7349 0.0658
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 36 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 10.0845 13.7454 6.6893 2.9064
KP-4 CTRP2 4.4814 6.8763 4.4038 24.1928
L3.3 CTRP2 6.5013 7.3572 6.4879 10.5313
SU.86.86 CTRP2 6.6185 8.4502 6.3697 10.5957
BxPC-3 CTRP2 6.773 9.4852 6.1213 11.1294
Panc 08.13 CTRP2 6.9771 8.0367 6.8874 7.6318
SW1990 CTRP2 7.1608 10.3948 6.0876 10.3046
HuP-T4 CTRP2 7.2006 10.919 5.8727 11.0937
Panc 03.27 CTRP2 7.4202 10.8853 6.0938 9.6853
HuP-T3 CTRP2 7.5438 8.3444 7.4052 4.0525
Panc 04.03 CTRP2 7.6377 13.3202 5.0808 13.3931
SUIT-2 CTRP2 7.6396 11.0746 6.1996 8.7677
PSN1 CTRP2 7.7202 9.8264 6.8896 5.7186
DAN-G CTRP2 7.7892 18.0612 2.8429 21.2369
YAPC CTRP2 7.8357 9.7966 7.0086 4.9737
MIA PaCa-2 CTRP2 7.9905 11.6314 6.2271 7.9343
Panc 10.05 CTRP2 8.048 10.6605 6.7609 5.5817
SNU-410 CTRP2 8.0688 16.2841 3.9665 16.8313
AsPC-1 CTRP2 8.08 9.2495 7.4931 2.445
Capan-2 CTRP2 8.1391 9.2919 7.5203 2.2195
CFPAC-1 CTRP2 8.2485 10.3342 7.0878 3.834
Panc 02.03 CTRP2 8.2509 9.3579 7.575 1.7945
KP-3 CTRP2 8.3743 11.414 6.6492 5.4454
TCC-Pan2 CTRP2 8.4031 10.4072 7.1711 3.2187
Panc 05.04 CTRP2 8.7104 11.6359 6.7937 4.2827
QGP-1 CTRP2 8.8758 11.5324 6.961 3.3506
Hs 766T CTRP2 9.1909 11.9146 6.988 2.8175
HPAC CTRP2 9.1983 11.3182 7.2679 1.7473
HPAF-II CTRP2 9.2962 11.7874 7.1124 2.2148
SNU-213 CTRP2 9.3584 16.7689 4.7471 11.5197
KP-2 CTRP2 9.5274 10.8872 7.6189 0.3773
PaTu 8988t CTRP2 9.793 10.8362 7.7414 0.084
PK-59 CTRP2 9.815 18.1614 4.3995 12.0916
PaTu 8988s CTRP2 9.8701 11.3703 7.5793 0.3173
PaTu 8902 CTRP2 10.1513 16.5754 5.4074 7.7282
PK-45H CTRP2 10.1738 11.8428 7.5267 0.31
⏷ Show the Full List of 36 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 48 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 9.7632 15.0236 5.8885 6.3864
Hs 944.T CTRP2 5.2648 7.5694 5.1301 19.1785
RPMI-7951 CTRP2 5.2999 8.4957 4.9223 19.8182
WM266-4 CTRP2 6.204 8.4631 5.9157 13.4914
CJM [Human melanoma] CTRP2 6.248 7.787 6.152 12.5026
WT2-iPS CTRP2 6.2557 8.7174 5.8839 13.4603
WM115 CTRP2 6.8201 9.3024 6.2493 10.5014
IGR-37 CTRP2 6.837 9.6114 6.131 10.9255
SK-MEL-31 CTRP2 6.9723 8.9122 6.5727 8.8302
MeWo CTRP2 7.055 10.4343 5.9667 11.0492
G-361 CTRP2 7.0653 9.0429 6.6145 8.4186
SK-MEL-1 CTRP2 7.0864 8.9189 6.6892 8.0696
Malme-3M CTRP2 7.2771 9.1772 6.772 7.2456
WM88 CTRP2 7.3641 8.5921 7.116 5.6601
HMCB CTRP2 7.4157 7.9863 7.3779 4.5306
UACC-62 CTRP2 7.4275 8.9896 7.0087 5.9179
SK-MEL-5 CTRP2 7.4871 8.613 7.2359 4.8624
Mel Ho CTRP2 7.494 10.0103 6.5898 7.467
COLO 800 CTRP2 7.4994 9.5324 6.8255 6.4851
RVH-421 CTRP2 7.5134 8.1258 7.4479 3.9805
Hs 294T CTRP2 7.5145 10.0007 6.6137 7.3218
LOX-IMVI CTRP2 7.562 10.9592 6.1869 8.9872
Hs 852.T CTRP2 7.6125 10.9845 6.2199 8.7409
HT-144 CTRP2 7.6683 8.1739 7.6011 2.959
SK-MEL-28 CTRP2 7.6828 8.1162 7.6354 2.7895
COLO 829 CTRP2 7.6906 14.3802 4.5977 15.2072
WM1799 CTRP2 7.7005 9.7506 6.9088 5.6822
A-375 CTRP2 7.7216 9.8979 6.8556 5.8572
WM983B CTRP2 7.8129 9.1556 7.3043 3.7916
SK-MEL-3 CTRP2 7.8332 8.3778 7.6947 2.1462
IPC-298 CTRP2 7.8466 10.1296 6.8527 5.6021
WM793 CTRP2 7.955 10.8573 6.5838 6.5086
COLO 792 CTRP2 8.0393 9.9804 7.0935 4.2021
IGR-39 CTRP2 8.2527 9.2482 7.6305 1.5612
K029AX CTRP2 8.2995 10.1037 7.2424 3.0974
Hs 688(A).T CTRP2 8.3844 10.0081 7.354 2.4912
IGR-1 CTRP2 8.4474 12.198 6.3164 6.7069
Hs 895.T CTRP2 8.5758 9.7066 7.6307 1.1015
UACC-257 CTRP2 8.6747 10.3932 7.371 1.9899
Hs 940.T CTRP2 8.7028 12.0009 6.6089 5.0569
Mel JuSo CTRP2 8.8153 12.4006 6.4952 5.3455
Hs 839.T CTRP2 9.1794 10.2533 7.7131 0.3241
SK-MEL-30 CTRP2 9.2534 12.6354 6.6878 3.9157
A101D CTRP2 9.4384 13.923 6.1958 5.6228
Hs 934.T CTRP2 9.5105 10.6394 7.7051 0.2038
Hs 936.T CTRP2 9.5643 13.5258 6.4699 4.3595
A2058 CTRP2 9.5979 10.6886 7.7213 0.1508
MDA-MB-435S CTRP2 9.9582 15.6836 5.704 6.8405
⏷ Show the Full List of 48 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 CTRP2 7.419 9.7637 6.6377 7.444
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
IMR-32 CTRP2 -0.4697 1.2988 -0.4697 56.8814
MHH-NB-11 CTRP2 2.9429 4.9833 2.9356 34.194
CHP-126 CTRP2 2.9894 4.9866 2.9827 33.8827
NH-6 CTRP2 4.4285 5.2814 4.4284 24.2825
SK-N-BE(2) CTRP2 4.5896 8.1725 4.2446 24.4096
Kelly CTRP2 4.6778 5.7125 4.6771 22.6253
SK-N-SH CTRP2 5.2607 8.1169 4.9925 19.6811
NB1 CTRP2 5.5437 7.2782 5.4823 17.0681
KP-N-SI9s CTRP2 6.5665 9.7938 5.774 13.0402
KP-N-YN CTRP2 7.7519 9.9197 6.8723 5.7215
SK-N-DZ CTRP2 7.7893 10.0208 6.8559 5.7095
SK-N-FI CTRP2 7.8358 11.4452 6.1878 8.4087
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-478 CTRP2 6.8966 10.6928 5.6903 12.5527
HuH-28 CTRP2 7.0222 10.884 5.7202 12.1329
SNU-1079 CTRP2 7.0995 8.855 6.7297 7.8763
HuCC-T1 CTRP2 7.2676 8.3681 7.0999 5.9904
SNU-1196 CTRP2 7.449 10.4471 6.335 8.6223
SNU-869 CTRP2 7.8223 9.4461 7.17 4.329
SNU-308 CTRP2 8.9282 11.2488 7.1318 2.5955
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-ES-1 CTRP2 2.5073 4.6595 2.5007 37.0909
SK-N-MC CTRP2 3.8327 4.4352 3.8327 28.2475
A-673 CTRP2 4.3352 5.5612 4.3338 24.9077
MHH-ES-1 CTRP2 4.4901 7.4311 4.318 24.4614
TC71 CTRP2 5.7552 7.9477 5.5772 16.0708
SJSA-1 CTRP2 6.2379 9.5823 5.5248 14.886
SaOS-2 CTRP2 6.2841 8.8518 5.8651 13.4505
CAL-78 CTRP2 6.7984 10.558 5.658 12.9213
HOS CTRP2 7.5045 8.8615 7.1443 5.1802
G-292 clone A141B1 CTRP2 7.5517 13.4441 4.9439 14.1249
U2OS CTRP2 7.6224 9.2166 7.0948 5.0925
Hs 822.T CTRP2 8.2228 9.8021 7.3326 2.855
MG-63 CTRP2 8.508 11.6386 6.6412 5.2463
SW1353 CTRP2 10.8318 18.384 4.9987 8.3494
Hs 888.T CTRP2 12.4087 40.0462 -4.4569 28.5706
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 67 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MDA-MB-157 CTRP2 3.357 6.6762 3.2297 31.8355
DU4475 CTRP2 3.53 7.5354 3.2514 31.1859
MDA-MB-468 CTRP2 5.5466 9.0689 4.9928 18.8372
CAL-148 CTRP2 6.5749 8.9284 6.1463 11.5643
HCC2218 CTRP2 6.8322 10.2898 5.8165 12.1983
CAL-51 CTRP2 7.294 10.7243 6.055 10.1296
HCC1500 CTRP2 7.3809 8.433 7.1973 5.301
HCC38 CTRP2 7.4527 8.758 7.1377 5.3398
T-47D CTRP2 7.6289 11.1864 6.1346 9.0614
BT-20 CTRP2 7.7321 8.3934 7.5839 2.8478
KPL-1 CTRP2 7.7681 10.2676 5.9714 3.6623
BT-549 CTRP2 7.8261 9.0412 7.3725 3.4793
CAL-85-1 CTRP2 7.8266 9.4578 7.1682 4.3272
MDA-MB-361 CTRP2 7.8471 8.6348 7.5892 2.5384
MDA-MB-453 CTRP2 7.9653 10.0035 7.0191 4.6617
CAL-120 CTRP2 8.0213 9.0293 7.5536 2.3067
HCC1419 CTRP2 8.0216 8.9886 7.5742 2.2197
HCC1428 CTRP2 8.0651 8.8527 7.679 1.6931
JIMT-1 CTRP2 8.0788 9.7297 7.252 3.4597
HMC-1-8 CTRP2 8.154 11.4374 6.4604 6.6399
EFM-192A CTRP2 8.2652 10.7039 6.9168 4.5199
HCC1806 CTRP2 8.3682 10.2803 7.2075 3.1258
MDA-MB-231 CTRP2 8.4248 10.4523 7.1651 3.2078
ZR-75-1 CTRP2 8.4495 9.962 7.4239 2.1012
HCC1395 CTRP2 8.502 12.4718 6.2228 7.0012
ZR-75-30 CTRP2 8.6668 10.8053 7.1675 2.8196
MCF-7 CTRP2 8.7055 11.6665 6.7751 4.3667
HCC1954 CTRP2 8.7565 11.3351 6.9735 3.475
BT-474 CTRP2 8.9658 12.225 6.6888 4.3211
CAMA-1 CTRP2 9.1866 13.1604 6.3899 5.2068
HDQ-P1 CTRP2 9.5815 16.7409 4.9259 10.4622
HCC1143 CTRP2 9.6706 17.4972 4.6199 11.4953
Hs 578T CTRP2 10.3838 12.4338 7.3916 0.5029
HCC202 CTRP2 10.5034 12.4543 7.433 0.3723
HCC1937 CTRP2 10.6908 13.4587 7.127 0.9916
BT 286 CTRP2 3.7687 7.9626 3.406 29.8918
BT 145 CTRP2 4.4245 6.9841 4.3274 24.6383
BT 239 CTRP2 4.5786 6.2594 4.5629 23.3358
BT164 CTRP2 4.9074 6.6968 4.8748 21.2043
BT 112 CTRP2 5.3594 8.2797 5.0534 19.1626
BT 504 CTRP2 6.0565 9.5555 5.3459 16.07
BT 248 CTRP2 6.2727 13.3197 3.8333 21.2903
BT 416 CTRP2 6.4785 8.0609 6.3369 11.1322
BT 330 CTRP2 6.7256 9.0325 6.2639 10.6973
BT 428 CTRP2 6.7441 8.9492 6.3173 10.4403
BT 228 CTRP2 7.0188 9.1062 6.5392 8.8373
BT 340 CTRP2 7.085 11.541 5.4618 13.0429
BT 159 CTRP2 7.4087 8.0532 7.354 4.6372
BT 482 CTRP2 7.446 8.9338 7.0526 5.6953
BT 231 CTRP2 7.4569 8.7334 7.1527 5.2695
BT 232 CTRP2 7.6169 10.5151 6.4559 7.7485
BT 179 CTRP2 7.7465 8.2063 7.6742 2.46
BT 216 CTRP2 8.0028 9.0312 7.5366 2.4154
BT 498 CTRP2 8.1004 11.7771 6.2463 7.6404
BT 440 CTRP2 8.1035 10.4682 6.9033 4.8766
BT 172 CTRP2 8.1268 9.6789 7.317 3.0954
BT 245 CTRP2 8.132 10.2668 7.0274 4.3014
BT 187 CTRP2 8.1998 14.7279 4.8532 13.1815
BT 422 CTRP2 8.2134 9.783 7.3347 2.8628
BT 139 CTRP2 8.2173 11.4695 6.4961 6.3716
BT 333 CTRP2 8.2289 10.6277 6.9258 4.548
BT147 CTRP2 8.5077 10.6386 7.1349 3.1983
BT 328 CTRP2 8.9542 10.4645 7.5106 1.1259
BT 224 CTRP2 8.9657 10.9549 7.2939 1.9171
BT 320 CTRP2 9.131 10.211 7.7081 0.3623
BT 359 CTRP2 9.4157 10.7633 7.6181 0.4359
BT 444 CTRP2 9.6485 10.7875 7.7051 0.1625
⏷ Show the Full List of 67 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 8.6147 10.467 7.2949 2.3799
Cancer Drug Sensitivity Data Curated from 43 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D283 Med CTRP2 3.9579 5.1784 3.9572 27.4167
Daoy CTRP2 4.2704 7.414 4.0832 25.9741
SF539 CTRP2 4.612 7.7806 4.3722 23.8887
GB-1 CTRP2 5.0002 8.7899 4.5005 22.2488
SF268 CTRP2 5.1759 12.1155 3.3226 25.9198
KNS-60 CTRP2 5.1909 9.2113 4.5582 21.4782
AM-38 CTRP2 6.26 11.5004 4.6872 18.1115
SNU-466 CTRP2 6.5401 8.2092 6.3618 10.856
SNU-738 CTRP2 6.5895 8.0776 6.4535 10.3743
8-MG-BA CTRP2 6.591 8.517 6.3169 10.8724
SF295 CTRP2 6.6918 10.3276 5.6596 13.1774
U-251MG CTRP2 6.8159 10.2639 5.8124 12.2555
SNU-626 CTRP2 7.0232 9.2343 6.488 9.0275
SF126 CTRP2 7.2271 10.9516 5.8817 10.9962
YH-13 CTRP2 7.3767 9.0869 6.9133 6.4281
42-MG-BA CTRP2 7.528 8.8437 7.1761 4.9937
TM-31 CTRP2 7.6869 8.3916 7.5376 3.1496
KG-1-C CTRP2 7.8282 8.9098 7.4385 3.2016
KNS-81 CTRP2 7.881 20.9164 1.4931 24.9105
GMS-10 CTRP2 7.8855 8.4129 7.7312 1.868
ONS-76 CTRP2 7.9268 11.6696 6.1539 8.3671
Hs 683 CTRP2 8.0055 11.3803 6.3653 7.3253
T98G CTRP2 8.0471 9.4727 7.3539 3.0934
DK-MG CTRP2 8.1102 9.0098 7.6378 1.78
CAS-1 CTRP2 8.1448 11.6115 5.5824 4.8503
Becker CTRP2 8.1526 12.691 5.8326 9.2699
SNB-75 CTRP2 8.1725 10.1586 7.1146 3.8599
SNU-201 CTRP2 8.2486 10.66 6.9254 4.5138
NMC-G1 CTRP2 8.433 10.2668 7.2626 2.7907
U-118MG CTRP2 8.4394 13.5354 5.6435 9.5201
M059K CTRP2 8.5641 10.4 7.292 2.4662
U-87MG ATCC CTRP2 8.6584 10.8318 7.1487 2.9085
LN-18 CTRP2 8.7061 9.988 7.5808 1.1366
SW1088 CTRP2 8.8685 13.6635 5.9127 7.6604
KALS-1 CTRP2 8.8841 17.4786 4.0306 15.0465
GOS-3 CTRP2 9.0016 11.7792 6.928 3.3052
LN-229 CTRP2 9.0659 11.4287 7.136 2.4011
GaMG CTRP2 9.0686 12.517 6.619 4.4526
SNU-489 CTRP2 9.2145 12.1088 6.9118 3.0841
CCF-STTG1 CTRP2 9.3395 10.4485 7.7067 0.2645
SNU-1105 CTRP2 9.3932 13.0278 6.5937 4.0994
A-172 CTRP2 9.5208 13.6708 6.3724 4.8031
DBTRG-05MG CTRP2 10.0581 29.2637 -0.9142 26.3336
⏷ Show the Full List of 43 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHUEM-2 CTRP2 3.9091 6.6065 3.8294 28.0077
KLE CTRP2 5.4719 8.3696 5.1489 18.4774
ESS-1 CTRP2 5.5717 7.5461 5.4674 17.0307
MFE-296 CTRP2 6.3564 9.4831 5.6902 13.9239
JHUEM-1 CTRP2 6.5614 9.5108 5.8918 12.5893
HEC-151 CTRP2 6.6102 9.4891 5.9517 12.2251
JHUEM-7 CTRP2 7.2433 9.6697 6.5114 8.3796
HEC-59 CTRP2 7.262 8.4696 7.0562 6.1718
AN3-CA CTRP2 7.556 8.1561 7.485 3.7181
EFE-184 CTRP2 7.5993 9.8091 6.7864 6.4157
HEC-6 CTRP2 7.6565 9.9877 6.7519 6.4311
JHUEM-3 CTRP2 7.6978 9.31 7.1216 4.8074
HEC-251 CTRP2 8.0861 10.213 7.0165 4.4347
HEC-1-A CTRP2 8.1819 9.5492 7.4262 2.536
HEC-50B CTRP2 8.3239 9.6094 7.5054 1.963
HEC-265 CTRP2 8.5718 10.1131 7.4358 1.8736
MFE-319 CTRP2 8.9327 10.671 7.4046 1.5371
HEC-1-B CTRP2 9.1288 11.9223 6.9442 3.0691
RL95-2 CTRP2 9.1737 13.9102 6.016 6.7461
HEC-108 CTRP2 9.3783 17.9813 4.163 13.6908
EN CTRP2 10.0922 11.2413 7.7088 0.073
Ishikawa (Heraklio) 02 ER- CTRP2 8.5775 9.5796 7.6903 0.8738
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 18 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TUHR14TKB CTRP2 5.226 8.3473 4.8877 20.165
786-O CTRP2 7.2 8.9501 6.7938 7.3579
TUHR4TKB CTRP2 7.4977 9.8468 6.6726 7.1176
TUHR10TKB CTRP2 7.541 8.364 7.3945 4.1011
RCC10RGB CTRP2 7.5506 8.2093 7.4616 3.8207
BFTC-909 CTRP2 7.5621 9.5334 6.885 6.0945
KMRC-20 CTRP2 7.5917 9.1729 7.086 5.2016
ACHN CTRP2 7.606 11.3293 6.0433 9.4905
VMRC-RCZ CTRP2 7.9363 9.6837 7.1534 4.1573
KMRC-2 CTRP2 7.9698 8.6186 7.7123 1.7507
KMRC-3 CTRP2 8.2106 11.1121 6.6692 5.658
OS-RC-2 CTRP2 8.2756 11.5636 6.4961 6.2639
VMRC-RCW CTRP2 8.306 9.6859 7.4543 2.204
KMRC-1 CTRP2 8.3292 10.9169 6.8612 4.6382
769-P CTRP2 9.4177 13.4577 6.4051 4.8149
Caki-2 CTRP2 9.4582 10.8433 7.6056 0.4446
Caki-1 CTRP2 10.2952 12.6537 7.2669 0.8517
SNU-1272 CTRP2 11.2379 21.1744 3.9383 11.6108
⏷ Show the Full List of 18 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-CO-1 CTRP2 3.8649 6.006 3.8394 28.1186
SW48 CTRP2 4.828 7.0324 4.7522 21.8801
SW1463 CTRP2 5.2589 9.9219 4.3562 22.0313
LoVo CTRP2 6.1225 8.959 5.6517 14.7159
LS513 CTRP2 6.3673 8.9475 5.9177 13.0167
CL-11 CTRP2 6.3819 12.7877 4.1936 19.6991
SW620 CTRP2 6.5391 9.1064 6.0373 12.0822
LS123 CTRP2 6.5451 7.88 6.4546 10.507
CCK-81 CTRP2 6.6161 9.8221 5.8121 12.7606
LS1034 CTRP2 6.8119 9.4101 6.1941 10.7405
HT-55 CTRP2 6.832 9.4523 6.1962 10.6795
SNU-407 CTRP2 6.9676 11.5046 5.3691 13.6909
CW-2 CTRP2 6.9712 9.9918 6.0926 10.7417
LS180 CTRP2 6.9785 11.5132 5.3751 13.641
RKO CTRP2 7.3173 11.3965 5.7481 11.3434
SNU-C5 CTRP2 7.3635 10.1039 6.4212 8.4621
DLD-1 CTRP2 7.3843 9.0305 6.9466 6.2755
NCI-H508 CTRP2 7.4155 9.9654 6.5374 7.8638
GP2d CTRP2 7.4511 9.0932 6.985 5.954
HCC-56 CTRP2 7.5024 8.2675 7.3892 4.2303
SNU-1033 CTRP2 7.5665 14.685 4.3384 16.4682
HCT 15 CTRP2 7.5909 8.1815 7.5146 3.506
T84 CTRP2 7.6013 10.0239 6.6832 6.8385
NCI-H747 CTRP2 7.6839 10.2624 6.6415 6.8304
SNU-61 CTRP2 7.7219 10.6848 6.4664 7.4795
SNU-C1 CTRP2 7.7422 8.4674 7.5622 2.9069
SNU-C4 CTRP2 7.7476 8.2995 7.6393 2.5901
SNU-C2A CTRP2 7.9224 10.0795 6.9441 5.063
SW1417 CTRP2 7.9591 8.8568 7.5849 2.3046
RCM-1 [Human ESC] CTRP2 8.0016 8.8143 7.6437 1.9693
SNU-503 CTRP2 8.0823 8.9729 7.6333 1.8519
COLO 678 CTRP2 8.2026 9.3573 7.5382 2.0308
HT115 CTRP2 8.2384 10.6703 6.9121 4.5881
MDST8 CTRP2 8.277 10.2222 7.166 3.4557
KM12 CTRP2 8.3731 10.8365 6.9354 4.2514
COLO201 CTRP2 8.93 10.8891 7.3021 1.9291
C2BBe1 CTRP2 9.1056 11.4635 7.1448 2.318
SW948 CTRP2 9.1157 10.6475 7.5192 0.9429
LS411N CTRP2 9.3108 10.5723 7.6463 0.4214
HT-29 CTRP2 9.731 10.8706 7.7067 0.1394
OUMS-23 CTRP2 9.7422 10.8795 7.7078 0.1353
COLO205 CTRP2 10.1864 15.3627 6.0061 5.3588
HCT 116 CTRP2 10.2487 11.3761 7.7175 0.0492
HCT 8 CTRP2 10.2997 11.4051 7.7251 0.0401
NCI-H716 CTRP2 10.6646 12.3342 7.5376 0.1651
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHH-5 CTRP2 5.8011 11.1967 4.369 20.5069
SNU-761 CTRP2 6.4222 13.3645 3.953 20.4925
Li-7 CTRP2 6.5268 10.5543 5.3907 14.6662
JHH-2 CTRP2 6.6812 8.4732 6.4296 10.1905
SNU-886 CTRP2 6.7604 7.9976 6.661 10.4908
JHH-4 CTRP2 6.981 9.1172 6.4954 9.1092
SNU-182 CTRP2 7.3314 8.4728 7.129 5.6999
HLF CTRP2 7.5569 9.7654 6.7679 6.5887
SK-HEP-1 CTRP2 7.7867 8.3826 7.645 2.4632
SNU-387 CTRP2 7.8519 8.716 7.5547 2.6683
PLC/PRF/5 CTRP2 7.9468 8.7474 7.6278 2.1524
JHH-1 CTRP2 7.9557 8.9242 7.5484 2.464
SNU-398 CTRP2 8.044 10.3586 6.9085 4.9699
Hep 3B2.1-7 CTRP2 8.1808 9.2457 7.5766 1.9084
SNU-449 CTRP2 8.3078 9.6263 7.4851 2.0733
SNU-423 CTRP2 8.393 11.1424 6.7989 4.7865
Hep-G2 CTRP2 8.6773 11.6872 6.7444 4.5383
HuH-1 CTRP2 9.1989 12.6648 6.6372 4.193
JHH-6 CTRP2 9.2787 10.0959 7.8117 0.0959
HuH-6 CTRP2 9.8454 12.5776 7.0733 1.788
SNU-475 CTRP2 10.1691 11.3856 7.6868 0.0832
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 131 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SBC-5 CTRP2 3.0283 4.6867 3.0265 33.6075
NCI-H1155 CTRP2 3.2792 5.2426 3.2709 31.9592
NCI-H1694 CTRP2 3.6715 5.9221 3.6441 29.4123
Lu-99 CTRP2 4.2915 9.0038 3.66 27.3743
COLO 668 CTRP2 4.39 6.7525 4.3224 24.7667
NCI-H1581 CTRP2 4.3995 7.504 4.2043 25.1441
NCI-H526 CTRP2 4.5709 5.3114 4.5709 23.3343
NCI-H1184 CTRP2 4.5835 9.2724 3.8821 25.7119
DV-90 CTRP2 4.6022 8.6745 4.1062 24.8625
NCI-H211 CTRP2 4.7443 8.1548 4.4183 23.3167
SW1271 CTRP2 5.1433 9.9046 4.2409 22.7837
HCC78 CTRP2 5.2265 7.2702 5.1434 19.2536
NCI-H1734 CTRP2 5.2496 8.2572 4.9403 19.9035
Calu-3 CTRP2 5.3009 10.9317 3.9759 23.3062
NCI-H2228 CTRP2 5.3602 14.755 2.2711 28.6223
NCI-H2081 CTRP2 5.3969 8.4463 5.0435 19.0864
RERF-LC-A1 CTRP2 5.399 8.0045 5.1738 18.6074
NCI-H1341 CTRP2 5.494 7.0298 5.4601 17.3045
PC-14 CTRP2 5.5383 14.3484 2.6369 27.1011
NCI-H446 CTRP2 5.5719 10.2066 4.5674 20.372
NCI-H226 CTRP2 5.625 15.8683 1.9875 28.7033
Sq-1 CTRP2 5.7007 10.8298 4.431 20.539
NCI-H1650 CTRP2 5.7593 8.0088 5.5659 16.0988
NCI-H2087 CTRP2 5.7852 10.0681 4.8482 18.723
NCI-H2286 CTRP2 5.9721 8.4689 5.662 15.1104
HCC1588 CTRP2 5.9896 10.3117 4.9549 17.7647
COR-L95 CTRP2 6.1416 8.8157 5.7254 14.383
SK-LU-1 CTRP2 6.1551 9.4803 5.4804 15.2824
HARA [Human squamous cell lung carcinoma] CTRP2 6.2017 9.8105 5.3906 15.5058
NCI-H1105 CTRP2 6.2229 10.724 5.0085 16.949
NCI-H23 CTRP2 6.3211 9.5775 5.6137 14.3167
HCC44 CTRP2 6.4028 10.8894 5.1127 16.0824
NCI-H1568 CTRP2 6.4274 8.698 6.0757 12.2475
NCI-H2405 CTRP2 6.4493 10.0889 5.5235 14.3349
NCI-H2106 CTRP2 6.6337 8.0095 6.5197 10.0015
NCI-H2444 CTRP2 6.6935 20.5749 0.6406 29.4082
DMS 273 CTRP2 6.6972 9.0103 6.243 10.8556
NCI-H889 CTRP2 6.7322 9.3701 6.1291 11.2055
HCC366 CTRP2 6.7924 9.5074 6.1315 11.0387
HOP-62 CTRP2 6.7985 9.4715 6.1534 10.9362
NCI-H1793 CTRP2 6.882 11.357 5.3589 13.932
NCI-H1563 CTRP2 6.8907 8.9272 6.4808 9.4083
NCI-H460 CTRP2 7.1008 11.4502 5.5208 12.7659
HCC4006 CTRP2 7.1278 8.109 7.0321 6.6519
NCI-H292 CTRP2 7.1437 10.349 6.093 10.3227
NCI-H2085 CTRP2 7.2548 9.3137 6.6876 7.6402
NCI-H1339 CTRP2 7.2665 9.226 6.7392 7.4038
NCI-H810 CTRP2 7.3823 9.0604 6.931 6.3429
NCI-H2196 CTRP2 7.3859 9.2233 6.8601 6.619
NCI-H2170 CTRP2 7.4013 9.7103 6.6461 7.4514
NCI-H522 CTRP2 7.4164 8.3652 7.2609 4.9595
RERF-LC-MS CTRP2 7.4221 11.0533 6.013 10.0157
EBC-1 CTRP2 7.4224 9.8125 6.6175 7.5188
NCI-H1092 CTRP2 7.4856 9.5343 6.8113 6.5761
NCI-H358 CTRP2 7.5484 12.4819 5.4198 12.1968
HCC1195 CTRP2 7.5585 12.9436 5.199 13.079
NCI-H1703 CTRP2 7.5702 8.8507 7.2153 4.7302
NCI-H2023 CTRP2 7.5773 9.5653 6.8841 6.063
NCI-H2110 CTRP2 7.5994 9.2849 7.04 5.371
SHP-77 CTRP2 7.6398 8.9863 7.2211 4.5355
NCI-H1944 CTRP2 7.6445 10.3332 6.5708 7.2101
NCI-H69 CTRP2 7.6611 11.3167 6.0986 9.1435
HCC1438 CTRP2 7.6639 8.7913 7.3361 4.0106
NCI-H1651 CTRP2 7.7018 13.0138 5.2892 12.4122
NCI-H1838 CTRP2 7.7165 9.4131 7.0889 4.8999
NCI-H1395 CTRP2 7.7398 9.8957 6.8732 5.7442
HCC15 CTRP2 7.7496 13.0218 5.3266 12.1611
NCI-H1666 CTRP2 7.7928 15.9632 3.8945 17.6526
LCLC-97TM1 CTRP2 7.7961 12.3436 5.7052 10.5029
LUDLU-1 CTRP2 7.7996 10.4215 6.6662 6.4809
NCI-H520 CTRP2 7.8013 9.7574 6.9972 5.0945
KNS-62 CTRP2 7.8082 8.3533 7.6799 2.2691
NCI-H2009 CTRP2 7.8399 11.7688 6.0298 9.0609
NCI-H1755 CTRP2 7.8798 8.8499 7.5159 2.7651
DMS 454 CTRP2 7.8979 11.842 6.0431 8.8887
LC-1/sq-SF CTRP2 7.9129 8.5848 7.676 2.0284
Lu-65 CTRP2 7.9516 8.8201 7.5963 2.2733
T3M-10 CTRP2 7.956 8.9412 7.5402 2.4976
COR-L105 CTRP2 7.962 9.3916 7.3214 3.4008
NCI-H1623 CTRP2 8.0125 9.7891 7.1665 3.9485
HCC1833 CTRP2 8.0136 12.965 5.5798 10.5885
RERF-LC-Ad2 CTRP2 8.0268 8.7391 7.7031 1.6685
SK-MES-1 CTRP2 8.0639 9.5975 7.3056 3.2634
NCI-H838 CTRP2 8.065 8.923 7.6438 1.841
MOR/CPR CTRP2 8.0876 8.9408 7.6538 1.7559
Calu-6 CTRP2 8.1158 10.0715 7.1118 3.9777
Calu-1 CTRP2 8.123 9.7153 7.2957 3.1921
NCI-H2029 CTRP2 8.2422 9.562 7.4671 2.2588
VMRC-LCD CTRP2 8.2579 9.4244 7.5474 1.8976
NCI-H1869 CTRP2 8.3082 9.6055 7.4957 2.0287
HOP-92 CTRP2 8.3337 9.8946 7.3721 2.4994
NCI-H650 CTRP2 8.3344 10.5928 7.0265 3.9381
NCI-H2291 CTRP2 8.4291 10.9904 6.9021 4.294
LXF 289 CTRP2 8.4882 11.2318 6.8277 4.5036
ChaGo-K-1 CTRP2 8.5837 10.1512 7.4256 1.898
HCC2279 CTRP2 8.6285 15.7767 4.6764 13.0708
HCC2935 CTRP2 8.6293 10.5283 7.2753 2.4379
LCLC-103H CTRP2 8.6356 10.026 7.5193 1.4575
NCI-H1915 CTRP2 8.6734 10.3032 7.4129 1.8258
NCI-H441 CTRP2 8.7103 13.4405 5.9029 7.968
COLO 699 CTRP2 8.7477 11.2222 7.0221 3.2905
NCI-H196 CTRP2 8.7748 12.5925 6.3709 5.9237
NCI-H322 CTRP2 8.8468 11.092 7.1525 2.6236
NCI-H1435 CTRP2 8.8636 11.6019 6.9191 3.5377
LOU-NH91 CTRP2 8.8686 12.7151 6.3799 5.7356
NCI-H727 CTRP2 8.8891 11.7684 6.8563 3.7548
A-549 CTRP2 8.8913 12.1762 6.6599 4.5511
NCI-H1299 CTRP2 8.912 13.165 6.1908 6.4444
HCC95 CTRP2 8.9291 11.2567 7.1287 2.6067
NCI-H2126 CTRP2 8.9722 11.7083 6.9422 3.2894
RERF-LC-Ad1 CTRP2 9.0543 9.9109 7.791 0.2033
LK2 CTRP2 9.0878 9.7951 7.8468 0.0907
NCI-H1373 CTRP2 9.1252 13.4097 6.2255 5.9672
HCC2108 CTRP2 9.1338 11.7424 7.0322 2.7179
HCC827 CTRP2 9.232 13.5775 6.2196 5.8297
BEN CTRP2 9.2605 10.494 7.6546 0.4281
NCI-H647 CTRP2 9.3963 11.697 7.2121 1.7401
NCI-H661 CTRP2 9.406 20.8216 2.7754 18.3734
NCI-H841 CTRP2 9.435 20.5146 2.9504 17.7689
NCI-H1792 CTRP2 9.4451 14.206 6.064 6.1424
NCI-H1355 CTRP2 9.4581 13.3077 6.5036 4.3683
NCI-H1573 CTRP2 9.534 11.1213 7.5296 0.6005
NCI-H2030 CTRP2 9.6599 13.0738 6.742 3.1871
CAL-12T CTRP2 9.8368 19.383 3.8151 14.1747
NCI-H2342 CTRP2 9.8939 11.6277 7.4914 0.5004
DMS 114 CTRP2 10.1938 20.5582 3.5005 14.6818
NCI-H2172 CTRP2 10.332 11.5271 7.6955 0.0568
HCC1171 CTRP2 10.4458 18.6082 4.6308 10.2626
EKVX CTRP2 10.9397 13.1994 7.3327 0.4105
NCI-H2122 CTRP2 11.1972 19.6083 4.6582 9.1145
Hs 888.Lu CTRP2 8.8277 10.9644 7.2007 2.4583
⏷ Show the Full List of 131 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
P-STS CTRP2 5.5163 7.7775 5.3581 17.5888
SYO-1 CTRP2 6.378 8.9682 5.9211 12.9736
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 7.78 9.868 6.9232 5.4486
A2780 CTRP2 2.5524 7.36 2.2274 37.7022
OC 314 CTRP2 4.1253 5.2633 4.1248 26.302
TOV-112D CTRP2 4.1528 6.5479 4.0948 26.3122
TYK-nu CTRP2 4.227 7.0567 4.1035 26.0429
Caov-3 CTRP2 5.6498 8.2929 5.3662 17.1525
OVK18 CTRP2 6.0769 8.9703 5.5986 15.0458
HEY A8 CTRP2 6.0945 8.8708 5.6544 14.7848
SNU-119 CTRP2 6.6097 8.0247 6.4896 10.1832
IGROV-1 CTRP2 6.7027 11.8115 4.9692 15.9223
OV56 CTRP2 6.8914 8.5791 6.6181 8.8795
OVTOKO CTRP2 7.006 9.9605 6.1415 10.4581
OAW42 CTRP2 7.1954 15.9404 3.3883 20.7093
TOV-21G CTRP2 7.2613 10.0431 6.3523 8.9845
COV434 CTRP2 7.2762 9.1956 6.7628 7.2846
OVCAR-8 CTRP2 7.3302 9.5901 6.634 7.6709
MCAS CTRP2 7.3563 9.4034 6.7471 7.1485
ONCO-DG-1 CTRP2 7.4069 8.144 7.3263 4.7429
RMG-I CTRP2 7.5533 8.6176 7.3024 4.4261
OVCAR-5 CTRP2 7.5665 10.1981 6.5657 7.4035
JHOC-5 CTRP2 7.5986 9.8244 6.7783 6.4511
EFO-27 CTRP2 7.6019 8.2358 7.5078 3.4994
EFO-21 CTRP2 7.6444 9.8422 6.8121 6.2079
OV7 CTRP2 7.6743 10.2212 6.6532 6.8025
OAW28 CTRP2 7.7122 8.7776 7.3901 3.6736
JHOM-1 CTRP2 7.8272 8.5537 7.608 2.5095
JHOS-2 CTRP2 7.859 8.7054 7.5666 2.6029
ES2 CTRP2 7.8784 9.2105 7.3372 3.5111
FU-OV-1 CTRP2 7.9161 9.3486 7.3024 3.5757
SK-OV-3 CTRP2 7.9181 10.5074 6.7269 5.9823
OVSAHO CTRP2 7.9243 10.4786 6.7465 5.8874
SNU-8 CTRP2 7.9642 9.1504 7.4435 2.8848
SNU-840 CTRP2 7.9852 9.0051 7.5343 2.4611
OVCAR-4 CTRP2 8.0384 9.3997 7.3831 2.9883
COV362 CTRP2 8.1822 9.5368 7.4327 2.5082
DOV13 CTRP2 8.3067 11.1643 6.7202 5.2688
COV644 CTRP2 8.4153 9.8898 7.4346 2.1098
Kuramochi CTRP2 8.5678 10.4217 7.2841 2.493
OVISE CTRP2 9.5667 10.5903 7.7445 0.1241
OV-90 CTRP2 9.6111 11.3426 7.4763 0.6996
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 8.1336 9.8867 7.2187 3.4956
Aska-SS CTRP2 8.3745 11.181 6.7653 4.9597
A-204 CTRP2 4.9129 10.0529 3.9377 24.5418
GCT CTRP2 5.1566 8.3154 4.8217 20.613
TE 617.T CTRP2 5.5861 9.8499 4.7305 19.7157
Rh41 CTRP2 5.6333 7.4592 5.5498 16.5481
G-401 CTRP2 6.1228 8.7613 5.7248 14.439
G-402 CTRP2 6.3559 8.8369 5.9476 12.9349
HT-1080 CTRP2 6.8825 10.2963 5.8632 11.8864
TTC-709 CTRP2 7.0925 9.3369 6.5133 8.7486
Hs 729.T CTRP2 7.4343 9.2189 6.9101 6.2974
RKN CTRP2 7.4835 8.3559 7.3363 4.4837
Rh18 CTRP2 7.5068 14.4897 4.3838 16.4206
MES-SA CTRP2 7.7537 16.7643 3.461 19.2687
SK-UT-1 CTRP2 7.8095 9.788 6.9894 5.1095
SK-LMS-1 CTRP2 8.0377 9.9547 7.1051 4.1563
TE 441.T CTRP2 8.0979 9.2892 7.4881 2.4321
SW982 CTRP2 8.3719 10.261 7.2199 3.0682
Tm87-16 CTRP2 8.4941 10.3049 7.2885 2.5874
RD CTRP2 8.8177 11.7736 6.8036 4.0759
BT-16 CTRP2 9.8719 11.0174 7.7072 0.1092
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 8.1651 9.5234 7.4257 2.5686
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H2452 CTRP2 4.7905 10.3434 3.6913 25.7648
MSTO-211H CTRP2 5.3485 8.6568 4.9229 19.6723
NCI-H28 CTRP2 5.6997 8.2104 5.445 16.716
NCI-H2052 CTRP2 6.7533 11.2074 5.307 14.4475
ACC-MESO-1 CTRP2 9.0635 10.8333 7.4081 1.3809
IST-Mes1 CTRP2 9.4545 12.097 7.0657 2.2105
JL-1 CTRP2 9.9452 12.2348 7.2712 1.068
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC CTRP2 6.6032 8.7209 6.2561 11.0665
DU145 CTRP2 6.9777 9.4909 6.3278 9.7814
22Rv1 CTRP2 7.3724 8.8696 7.0063 6.0683
PaCa-3 CTRP2 8.0716 8.9315 7.6451 1.8231
VCaP CTRP2 8.4255 9.9591 7.4081 2.2031
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-15 CTRP2 6.2908 7.145 6.283 11.9135
A-253 CTRP2 7.552 9.9006 6.6976 6.89
Cancer Drug Sensitivity Data Curated from 33 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ECC10 CTRP2 4.8393 6.8302 4.7898 21.7146
HGC-27 CTRP2 4.8691 13.7012 2.2881 29.9158
NCI-N87 CTRP2 6.0402 8.9866 5.5531 15.3219
SNU-601 CTRP2 6.1263 9.6928 5.362 15.8187
SNU-5 CTRP2 6.4225 8.0737 6.2723 11.5356
GSS CTRP2 6.4985 9.57 5.8013 13.1109
SNU-1 CTRP2 6.5699 8.5847 6.2702 11.108
NUGC-3 CTRP2 6.7425 7.9954 6.6421 9.2296
SNU-16 CTRP2 6.7633 8.6413 6.4575 9.8503
LMSU CTRP2 6.8765 7.9551 6.798 8.2606
ECC12 CTRP2 7.0752 8.4397 6.8669 7.4173
23132/87 CTRP2 7.4085 10.1753 6.4292 8.3251
SNU-620 CTRP2 7.4656 11.179 5.991 10.0114
MKN7 CTRP2 7.573 8.4878 7.3783 4.0765
NUGC-4 CTRP2 7.5846 12.1777 5.603 11.3648
MKN1 CTRP2 7.6197 9.6439 6.1699 2.9832
SH-10-TC CTRP2 7.9583 8.6203 7.7009 1.8231
MKN74 CTRP2 7.9978 10.2529 6.9222 5.0031
KE-39 CTRP2 8.1252 12.2267 6.0421 8.4477
AGS CTRP2 8.1338 11.2757 6.5246 6.4088
SNU-216 CTRP2 8.1518 9.3965 7.4784 2.3719
GSU CTRP2 8.4286 9.196 7.7761 0.7239
OCUM-1 CTRP2 8.4423 10.284 7.261 2.7822
SNU-719 CTRP2 8.7441 12.7823 6.2544 6.4561
SNU-668 CTRP2 8.9077 12.8444 6.345 5.8166
MKN45 CTRP2 8.9159 10.0032 7.6904 0.5548
IM95 CTRP2 9.0294 14.1817 5.7773 7.9504
Fu97 CTRP2 9.1196 12.2943 6.761 3.8085
HuG1-N CTRP2 9.5516 11.1728 7.517 0.6242
Hs 746.T CTRP2 9.9428 11.5873 7.5277 0.3956
SNU-1077 CTRP2 7.7579 8.7545 7.4457 3.3368
SNU-685 CTRP2 7.7894 8.522 7.5853 2.6945
SNG-M CTRP2 7.8276 14.4923 4.6591 14.6859
⏷ Show the Full List of 33 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ML-1 [Human leukemia] CTRP2 3.4584 10.2631 2.3074 34.2194
8505C CTRP2 4.6038 7.7766 4.3642 23.9426
FTC-133 CTRP2 5.6403 8.0205 5.433 16.9396
CAL-62 CTRP2 5.8015 7.9398 5.6297 15.7409
CGTH-W-1 CTRP2 6.2664 8.6105 5.9333 13.2442
B-CPAP CTRP2 6.7528 8.8052 6.3836 10.1615
FTC-238 CTRP2 7.1544 8.7805 6.8182 7.3842
SW579 CTRP2 7.6641 10.482 6.5151 7.4
BHT-101 CTRP2 8.0285 9.7516 7.1988 3.7813
8305C CTRP2 8.0426 11.1946 6.4893 6.7323
TT2609-C02 CTRP2 8.1936 12.2734 6.075 8.1802
TT CTRP2 9.3983 14.6915 5.7956 7.2936
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HSC-4 CTRP2 4.447 6.6861 4.3907 24.3487
HSC-2 CTRP2 6.1824 7.7385 6.0909 12.9231
FaDu CTRP2 6.6142 8.697 6.2768 10.9568
SNU-1076 CTRP2 6.6242 8.9753 6.18 11.2984
PE/CA-PJ15 CTRP2 6.9701 10.0413 6.0685 10.8418
PE/CA-PJ34 (clone C12) CTRP2 7.0238 9.1517 6.5247 8.8811
PE/CA-PJ49 CTRP2 7.2901 8.9161 6.9014 6.6977
YD-8 CTRP2 7.3606 12.5481 5.2194 13.419
HSC-3 CTRP2 7.4173 8.8573 7.0576 5.7487
BICR 22 CTRP2 7.4344 10.8921 6.1035 9.6137
SCC-4 CTRP2 7.5608 8.1529 7.4912 3.6809
SCC-25 CTRP2 7.6421 16.0601 3.7174 18.6029
BHY CTRP2 7.6778 10.6752 6.4318 7.7179
PE/CA-PJ41 (clone D2) CTRP2 7.6837 9.4531 7.0387 5.1817
YD-10B CTRP2 7.7654 9.6934 6.9963 5.1761
SCC-9 CTRP2 7.838 8.5525 7.6193 2.4376
BICR 56 CTRP2 8.0206 8.6991 7.7177 1.62
CAL-33 CTRP2 8.133 15.6571 4.3334 15.3349
SNU-46 CTRP2 8.356 11.1869 6.7479 5.0647
BICR 6 CTRP2 8.429 11.9176 6.4414 6.2173
Detroit 562 CTRP2 8.5561 10.7191 7.1307 3.1389
BICR 18 CTRP2 8.8659 11.0092 7.2046 2.3915
CAL-27 CTRP2 8.9162 12.0873 6.7207 4.2652
SNU-899 CTRP2 9.0092 11.1177 7.2453 2.0501
BICR 16 CTRP2 9.2788 12.9611 6.5492 4.4332
SNU-1041 CTRP2 9.4247 13.3973 6.4387 4.6713
BICR 31 CTRP2 9.7593 11.5741 7.4521 0.6739
SNU-1066 CTRP2 9.8094 11.3328 7.5683 0.3644
SNU-1214 CTRP2 10.2592 17.0909 5.2333 8.2491
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UM-UC-3 CTRP2 5.164 7.8401 4.9593 20.0963
5637 CTRP2 5.4887 9.182 4.8888 19.3923
J82 CTRP2 5.8121 9.5467 5.0918 17.7162
639V CTRP2 6.1337 7.1316 6.1213 12.9743
JMSU-1 CTRP2 6.3431 8.1713 6.1582 12.1887
UM-UC-1 CTRP2 6.415 9.4285 5.7743 13.4392
647V CTRP2 6.4174 7.6632 6.3597 11.2418
SW1710 CTRP2 6.8873 8.8727 6.4994 9.3455
TCCSUP CTRP2 7.0277 9.7061 6.2806 9.8438
HT-1197 CTRP2 7.0554 10.1086 6.121 10.4205
KMBC-2 CTRP2 7.0862 11.4032 5.53 12.7617
T24 CTRP2 7.2155 10.3481 6.1624 9.8698
U-BLC1 CTRP2 7.3448 11.1116 5.9132 10.6002
HT-1376 CTRP2 7.4412 8.3478 7.294 4.7635
SCaBER CTRP2 7.5583 8.0248 7.5243 3.5688
253J CTRP2 7.6534 11.1565 6.1713 8.8562
VM-CUB-1 CTRP2 7.7275 11.2013 6.2147 8.5191
CAL-29 CTRP2 7.738 9.513 7.06 4.9715
RT-4 CTRP2 8.1466 10.6969 6.8245 5.1259
KU-19-19 CTRP2 8.1748 11.1029 6.6447 5.8277
BFTC-905 CTRP2 8.3174 9.6021 7.5043 1.9783
RT-112 CTRP2 8.593 12.4432 6.3075 6.4905
253J-BV CTRP2 9.005 11.9263 6.8598 3.5735
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 9.5701 10.392 7.8141 0.0455

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Chlorambucil (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Roflumilast DMPGHY8 Moderate Additive immunosuppressive effects by the combination of Chlorambucil and Roflumilast. Asthma [CA23] [19]
Ofloxacin DM0VQN3 Minor Decreased absorption of Chlorambucil due to intestinal mucosa variation caused by Ofloxacin. Bacterial infection [1A00-1C4Z] [20]
Ciprofloxacin XR DM2NLS9 Minor Decreased absorption of Chlorambucil due to intestinal mucosa variation caused by Ciprofloxacin XR. Bacterial infection [1A00-1C4Z] [20]
Trovafloxacin DM6AN32 Minor Decreased absorption of Chlorambucil due to intestinal mucosa variation caused by Trovafloxacin. Bacterial infection [1A00-1C4Z] [20]
Sparfloxacin DMB4HCT Minor Decreased absorption of Chlorambucil due to intestinal mucosa variation caused by Sparfloxacin. Bacterial infection [1A00-1C4Z] [20]
Gemifloxacin DMHT34O Minor Decreased absorption of Chlorambucil due to intestinal mucosa variation caused by Gemifloxacin. Bacterial infection [1A00-1C4Z] [20]
Norfloxacin DMIZ6W2 Minor Decreased absorption of Chlorambucil due to intestinal mucosa variation caused by Norfloxacin. Bacterial infection [1A00-1C4Z] [20]
ABT-492 DMJFD2I Minor Decreased absorption of Chlorambucil due to intestinal mucosa variation caused by ABT-492. Bacterial infection [1A00-1C4Z] [20]
Levofloxacin DMS60RB Minor Decreased absorption of Chlorambucil due to intestinal mucosa variation caused by Levofloxacin. Bacterial infection [1A00-1C4Z] [20]
Lomefloxacin DMVRH9C Minor Decreased absorption of Chlorambucil due to intestinal mucosa variation caused by Lomefloxacin. Bacterial infection [1A00-1C4Z] [20]
Grepafloxacin DMGLX0T Minor Decreased absorption of Chlorambucil due to intestinal mucosa variation caused by Grepafloxacin. Bronchitis [CA20] [20]
Amphotericin B DMTAJQE Moderate Increased risk of nephrotoxicity by the combination of Chlorambucil and Amphotericin B. Fungal infection [1F29-1F2F] [21]
Teriflunomide DMQ2FKJ Major Additive myelosuppressive effects by the combination of Chlorambucil and Teriflunomide. Hyper-lipoproteinaemia [5C80] [22]
Givosiran DM5PFIJ Moderate Increased risk of nephrotoxicity by the combination of Chlorambucil and Givosiran. Inborn porphyrin/heme metabolism error [5C58] [21]
Denosumab DMNI0KO Moderate Additive myelosuppressive effects by the combination of Chlorambucil and Denosumab. Low bone mass disorder [FB83] [23]
Thalidomide DM70BU5 Major Additive thrombogenic effects by the combination of Chlorambucil and Thalidomide. Multiple myeloma [2A83] [24]
Tecfidera DM2OVDT Moderate Additive immunosuppressive effects by the combination of Chlorambucil and Tecfidera. Multiple sclerosis [8A40] [25]
Siponimod DM2R86O Major Additive immunosuppressive effects by the combination of Chlorambucil and Siponimod. Multiple sclerosis [8A40] [21]
Fingolimod DM5JVAN Major Additive immunosuppressive effects by the combination of Chlorambucil and Fingolimod. Multiple sclerosis [8A40] [26]
Ocrelizumab DMEZ2KH Moderate Additive immunosuppressive effects by the combination of Chlorambucil and Ocrelizumab. Multiple sclerosis [8A40] [27]
Ozanimod DMT6AM2 Major Additive immunosuppressive effects by the combination of Chlorambucil and Ozanimod. Multiple sclerosis [8A40] [19]
Omacetaxine mepesuccinate DMPU2WX Moderate Additive myelosuppressive effects by the combination of Chlorambucil and Omacetaxine mepesuccinate. Myeloproliferative neoplasm [2A20] [28]
Gatifloxacin DMSL679 Minor Decreased absorption of Chlorambucil due to intestinal mucosa variation caused by Gatifloxacin. Respiratory infection [CA07-CA4Z] [20]
Canakinumab DM8HLO5 Moderate Additive immunosuppressive effects by the combination of Chlorambucil and Canakinumab. Rheumatoid arthritis [FA20] [29]
Rilonacept DMGLUQS Moderate Additive immunosuppressive effects by the combination of Chlorambucil and Rilonacept. Rheumatoid arthritis [FA20] [29]
Golimumab DMHZV7X Major Additive immunosuppressive effects by the combination of Chlorambucil and Golimumab. Rheumatoid arthritis [FA20] [30]
Leflunomide DMR8ONJ Major Additive immunosuppressive effects by the combination of Chlorambucil and Leflunomide. Rheumatoid arthritis [FA20] [22]
Anthrax vaccine DM9GSWY Moderate Antagonize the effect of Chlorambucil when combined with Anthrax vaccine. Sepsis [1G40-1G41] [31]
Azathioprine DMMZSXQ Moderate Additive myelosuppressive effects by the combination of Chlorambucil and Azathioprine. Transplant rejection [NE84] [21]
Cinoxacin DM4EWNS Minor Decreased absorption of Chlorambucil due to intestinal mucosa variation caused by Cinoxacin. Urinary tract infection [GC08] [20]
Plazomicin DMKMBES Moderate Increased risk of nephrotoxicity by the combination of Chlorambucil and Plazomicin. Urinary tract infection [GC08] [21]
Enoxacin DMYTE6L Minor Decreased absorption of Chlorambucil due to intestinal mucosa variation caused by Enoxacin. Urinary tract infection [GC08] [20]
Ganciclovir DM1MBYQ Moderate Additive myelosuppressive effects by the combination of Chlorambucil and Ganciclovir. Virus infection [1A24-1D9Z] [21]
Valganciclovir DMS2IUH Moderate Additive myelosuppressive effects by the combination of Chlorambucil and Valganciclovir. Virus infection [1A24-1D9Z] [21]
⏷ Show the Full List of 34 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Stearic acid E00079 5281 Emulsifying agent; Solubilizing agent; Viscosity-controlling agent; lubricant
Beta-D-lactose E00099 6134 Diluent; Dry powder inhaler carrier; Lyophilization aid
Eisenoxyd E00585 56841934 Colorant
Ferric hydroxide oxide yellow E00539 23320441 Colorant
Silicon dioxide E00670 Not Available Anticaking agent; Opacifying agent; Viscosity-controlling agent
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
⏷ Show the Full List of 6 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Chlorambucil 2 mg tablet 2 mg Oral Tablet Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

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