Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTG28O6)

DTT Name Adrenergic receptor Alpha-1 (ADRA1)
Synonyms Alpha1-adrenoceptor; Alpha(1)-adrenoceptor
Gene Name ADRA1
DTT Type
Successful target
 [1]
BioChemical Class
GPCR rhodopsin
UniProt ID
NOUNIPROTAC
TTD ID
T81183

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
6 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [2]
Ergotamine DMKR3C5 Cluster headache 8A81.0 Approved [3]
Labetalol DMK8U72 Hypertension BA00-BA04 Approved [2]
Midodrine DME2PY5 Orthostatic hypotension BA21 Approved [4]
Prazosin DMCD9YG Benign prostatic hyperplasia GA90 Approved [1]
Urapidil DMD59GI Hypertension BA00-BA04 Approved [5]
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⏷ Show the Full List of 6 Approved Drug(s)
3 Discontinued Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Phenylpropanolamine DMTFK3O Allergic rhinitis CA08.0 Withdrawn from market [6]
Metazosin DMAZ28C Cardiac disease BA00-BE2Z Discontinued in Phase 3 [7]
DC-015 DMCDMWJ N. A. N. A. Terminated [8]
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References

1 Adventitia removal does not modify the alphaID-adrenoceptors response in aorta during hypertension and ageing. Auton Autacoid Pharmacol. 2009 Jul;29(3):117-33.
2 Beta-blockers in the treatment of hypertension: are there clinically relevant differences Postgrad Med. 2009 May;121(3):90-8.
3 Reversal of ergotamine-induced vasospasm following methylprednisolone. Clin Toxicol (Phila). 2008 Dec;46(10):1074-6.
4 Orthostatic hypotension in patients with Parkinson's disease: pathophysiology and management. Drugs Aging. 2001;18(7):495-505.
5 Urapidil. A reappraisal of its use in the management of hypertension. Drugs. 1998 Nov;56(5):929-55.
6 Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist. J Med Chem. 2004 Jun 3;47(12):3220-35.
7 Metazosin tablets (Kenosin) in the treatment of chronic congestive heart failure. Cas Lek Cesk. 1995 Sep 20;134(18):590-3.
8 Antihypertensive and Hypolipidemic Effects of DC-015, a Novel, Potent and Specific alpha(1)-Adrenoceptor Antagonist: Comparison with Prazosin in Spontaneously Hypertensive Rats. J Biomed Sci. 1996 Apr;3(2):108-116.