Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTG28O6)

• DTT Name: Adrenergic receptor Alpha-1 (ADRA1) DTT Info
• Gene Name: ADRA1

Molecule-Related Drug & Molecule List

6 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[1]
Ergotamine	DMKR3C5	Cluster headache	8A81.0	Approved	[2]
Labetalol	DMK8U72	Hypertension	BA00-BA04	Approved	[1]
Midodrine	DME2PY5	Orthostatic hypotension	BA21	Approved	[3]
Prazosin	DMCD9YG	Benign prostatic hyperplasia	GA90	Approved	[4]
Urapidil	DMD59GI	Hypertension	BA00-BA04	Approved	[5]

3 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenylpropanolamine	DMTFK3O	Allergic rhinitis	CA08.0	Withdrawn from market	[6]
Metazosin	DMAZ28C	Cardiac disease	BA00-BE2Z	Discontinued in Phase 3	[7]
DC-015	DMCDMWJ	N. A.	N. A.	Terminated	[8]

References

• [1] Beta-blockers in the treatment of hypertension: are there clinically relevant differences Postgrad Med. 2009 May;121(3):90-8.
• [2] Reversal of ergotamine-induced vasospasm following methylprednisolone. Clin Toxicol (Phila). 2008 Dec;46(10):1074-6.
• [3] Orthostatic hypotension in patients with Parkinson's disease: pathophysiology and management. Drugs Aging. 2001;18(7):495-505.
• [4] Adventitia removal does not modify the alphaID-adrenoceptors response in aorta during hypertension and ageing. Auton Autacoid Pharmacol. 2009 Jul;29(3):117-33.
• [5] Urapidil. A reappraisal of its use in the management of hypertension. Drugs. 1998 Nov;56(5):929-55.
• [6] Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist. J Med Chem. 2004 Jun 3;47(12):3220-35.
• [7] Metazosin tablets (Kenosin) in the treatment of chronic congestive heart failure. Cas Lek Cesk. 1995 Sep 20;134(18):590-3.
• [8] Antihypertensive and Hypolipidemic Effects of DC-015, a Novel, Potent and Specific alpha(1)-Adrenoceptor Antagonist: Comparison with Prazosin in Spontaneously Hypertensive Rats. J Biomed Sci. 1996 Apr;3(2):108-116.