Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTTK3BH)

• DTT Name: Vacuolar-type proton ATPase (v-ATPase) DTT Info
• Gene Name: v-ATPase

Molecule-Related Drug & Molecule List

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
WY-47766	DM7VCDZ	Osteoporosis	FB83.0	Discontinued in Phase 2	[1]

3 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
FR167356	DMF53Z7	Osteoporosis	FB83.0	Preclinical	[2]
Salicylihalamide A	DMGXVRZ	Solid tumour/cancer	2A00-2F9Z	Preclinical	[3]
SB 242784	DMFXJDL	Arterial calcification	BD52.Y	Preclinical	[4]

9 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bafilomycin A1	DMUNK59	B-cell acute lymphoblastic leukaemia	2B33.3	Investigative	[5]
BRD1240	DMIZ9ON	Solid tumour/cancer	2A00-2F9Z	Investigative	[6]
Lobatamide A	DM2GBEW	Discovery agent	N.A.	Investigative	[3]
Lobatamide B	DMD91RI	Discovery agent	N.A.	Investigative	[3]
Lobatamide C	DMFIDJS	Discovery agent	N.A.	Investigative	[3]
Lobatamide D	DMG706J	Discovery agent	N.A.	Investigative	[3]
Lobatamide F	DM6BWGQ	Discovery agent	N.A.	Investigative	[3]
Oximidine I	DMG6O0L	Discovery agent	N.A.	Investigative	[3]
Oximidine II	DMW6K80	Discovery agent	N.A.	Investigative	[3]

References

• [1] A pharmacological assessment of the mammalian osteoclast vacuolar H(+)-ATPase. Bone Miner. 1994 Nov;27(2):159-66.
• [2] Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36.
• [3] Discovery of a novel antitumor benzolactone enamide class that selectively inhibits mammalian vacuolar-type (H+)-atpases. J Pharmacol Exp Ther. 2001 Apr;297(1):114-20.
• [4] SB 242784, a selective inhibitor of the osteoclastic V-H+ATPase, inhibits arterial calcification in the rat. Circ Res. 2002 Sep 20;91(6):547-52.
• [5] Molecular basis of V-ATPase inhibition by bafilomycin A1. Nat Commun. 2021 Mar 19;12(1):1782.
• [6] Lysosomes as a therapeutic target. Nat Rev Drug Discov. 2019 Dec;18(12):923-948.