Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DEA3U9Y)

• DME Name: Myeloperoxidase (MPO) DME Info
• Gene Name: MPO

Molecule-Related Drug & Molecule List

7 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carboplatin	DMG281S	Adenocarcinoma	2D40	Approved	[1]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[2]
Cysteamine	DMSYFM8	Nephropathic cystinosis	5C60	Approved	[3]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[4]
Glutethimide	DMGE0CW	Insomnia	7A00-7A0Z	Approved	[5]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[1]
Ticlopidine	DMO946V	Acute coronary syndrome	BA41	Approved	[4]

References

• [1] PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150642262)
• [2] Cisplatin reduces Brucella melitensis-infected cell number by inducing apoptosis, oxidant and pro-inflammatory cytokine production. Res Vet Sci. 2010 Apr;88(2):218-26.
• [3] Thiols as peroxidase substrates. Free Radic Biol Med. 1993 Feb;14(2):167-75.
• [4] Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
• [5] Proteomic profile of aminoglutethimide-induced apoptosis in HL-60 cells: role of myeloperoxidase and arylamine free radicals. Chem Biol Interact. 2015 Sep 5;239:129-38.