Details of the Drug

General Information of Drug (ID: DMG281S)

Drug Name
Carboplatin
Synonyms
Azanide; Carbopaltin; Carboplatine; Carboplatino; Carboplatinum; Cbdca; Ercar; Paraplatin; Carboplatine [French]; Carboplatino [Spanish]; Carboplatinum [Latin]; C 2538; JM 8; Carboplatin (USAN); IUPAC: Azane; JM-8; Paraplatin (TN); Paraplatin, Carboplatin; Paraplatin-AQ; Cis-Diammine(cyclobutanedicarboxylato)platinumII; Platinum(+2) Cation; Carboplatin (JAN/USP/INN); Carboplatin [USAN:INN:BAN:JAN]; Cyclobutane-1,1-dicarboxylate; Cyclobutane-1,1-dicarboxylic acid; Diammine-1,1-cyclobutane dicarboxylate platinum II; Cis-Diamine[1,1-cyclobutanedicarboxylato]platinum(II); Cis-Diammine(1,1-cyclobutanedicarboxylato) platinum; Cis-Diammine(1,1-cyclobutanedicarboxylato)platinum; Cis-Diammine[1,1-cyclobutane-dicarboxylato] platinum; Diammine(1,1-cyclobutanedicarboxylato)platinum (II); Platinum, {diammine[1,1-cyclobut; Cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II); Cis-Diamine(1,1-cyclobutanedicarboxylato)platinum(II); Cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II); Platinum(II), (1, 1-cyclobutanedicar; Diammine[cyclobutane-1,1-dicarboxylato(2-)-k2O1,O1]platinum; Diammine(cyclobutane-1,1-dicarboxylato(2-)-O,O')platinum; Platinum, diammine(1,1-cyclobutanedicarboxylato(2-)-O,O')-, (SP-4-2); (SP-4-2)-diammine[cyclobutane-1,1-dicarboxylato(2-)-kappa(2)O,O']platinum; 1,1-Cyclobutanedicarboxylate diammine platinum (II); 1,1-Cyclobutanedicarboxylate diammine platinum(II)
Indication
Disease Entry ICD 11 Status REF
Adenocarcinoma 2D40 Approved [1]
Carcinoma 2A00-2F9Z Approved [1]
Cholangiocarcinoma 2C12.10 Approved [1]
Cutaneous melanoma 2C30 Approved [1]
Epithelial ovarian cancer 2B5D Approved [1]
Fallopian tube neoplasm N.A. Approved [1]
Gastroesophageal junction adenocarcinoma 2B71 Approved [1]
Lung adenocarcinoma N.A. Approved [1]
Lung cancer 2C25.0 Approved [1]
Non-small-cell lung cancer 2C25.Y Approved [1]
Ovarian cancer 2C73 Approved [2]
Ovarian disorder N.A. Approved [1]
Ovarian neoplasm N.A. Approved [1]
Ovarian serous cystadenocarcinoma N.A. Approved [1]
Small-cell lung cancer 2C25.Y Approved [1]
Lung large cell carcinoma N.A. Investigative [1]
Neuroblastoma 2D11.2 Investigative [1]
⏷ Show the Full List of Indication(s)
Therapeutic Class
Anticancer Agents
Affected Organisms
Humans and other mammals
ATC Code
L01XA02: Carboplatin
L01XA: Platinum compounds
L01X: OTHER ANTINEOPLASTIC AGENTS
L01: ANTINEOPLASTIC AGENTS
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski):
0		 Molecular Weight 371.25
Logarithm of the Partition Coefficient Not Available
Rotatable Bond Count 0
Hydrogen Bond Donor Count 4
Hydrogen Bond Acceptor Count 6
ADMET Property
Absorption AUC
The area under the plot of plasma concentration (AUC) of drug is 27.18 +/- 11.28 mgh/L [3]
Absorption Cmax
The maximum plasma concentration (Cmax) of drug is 9.06 +/- 0.74 mg/L [3]
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 3: high solubility and low permeability [4]
Clearance
The total body clearance of drug is 4.4 L/h [3]
Elimination
Carboplatin is 65% eliminated in the urine within 12 hours, and 71% eliminated within 24 hours [5]
Half-life
The concentration or amount of drug in body reduced by one-half in 1.1 - 2 hours [3]
Metabolism
The drug is not metabolised [6]
Unbound Fraction
The unbound fraction of drug in plasma is 1% [7]
Vd
The volume of distribution (Vd) of drug is 16 L [3]
Water Solubility
The ability of drug to dissolve in water is measured as 14 mg/mL [4]
Chemical Identifiers
Formula
C6H12N2O4Pt
IUPAC Name
azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+)
Canonical SMILES
C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]
InChI
InChI=1S/C6H8O4.2H2N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H2;/q;2*-1;+2
InChIKey
VSRXQHXAPYXROS-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
426756
ChEBI ID
CHEBI:31355
CAS Number
41575-94-4
UNII
BG3F62OND5
DrugBank ID
DB00958
TTD ID
D0X7HM
VARIDT ID
DR00469
INTEDE ID
DR0272
ACDINA ID
D00913
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Human Deoxyribonucleic acid (hDNA) TTUTN1I NOUNIPROTAC Modulator [8]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
High affinity copper uptake protein 1 (SLC31A1) DTP8L4F COPT1_HUMAN Substrate [9]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Quinone reductase 1 (NQO1) DENP5RY NQO1_HUMAN Substrate [10]
Glutathione S-transferase pi (GSTP1) DEK6079 GSTP1_HUMAN Substrate [10]
Metallothionein-1A (MT1A) DE5ME8A MT1A_HUMAN Substrate [10]
Myeloperoxidase (MPO) DEA3U9Y PERM_HUMAN Substrate [10]
Metallothionein-2A (MT2A) DEFKGT7 MT2_HUMAN Substrate [10]
Glutathione S-transferase mu-1 (GSTM1) DEYZEJA GSTM1_HUMAN Substrate [10]
Glutathione S-transferase theta-1 (GSTT1) DE3PKUG GSTT1_HUMAN Substrate [10]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 152 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JK1 CTRP2 5.4206 8.7619 4.1363 9.3108
MEC1 CTRP2 6.1272 8.2785 4.9956 4.2511
JM1 CTRP2 5.2779 6.9561 4.8578 6.696
HuT 78 CTRP2 2.2108 15.5133 -2.1698 36.8044
Kasumi-2 CTRP2 2.7217 4.5148 2.6944 22.2279
Namalwa CTRP2 2.9094 5.043 2.8353 21.1372
697 CTRP2 2.9409 4.3507 2.9308 20.7099
MOLT-3 CTRP2 3.0114 4.4201 3.0002 20.244
EoL-1 CTRP2 3.2106 5.5104 3.0795 19.3297
OCI-Ly19 CTRP2 3.7213 5.7537 3.5822 15.9578
SET-2 CTRP2 3.747 5.5741 3.6481 15.645
EB1 CTRP2 3.7572 6.6545 3.3586 16.6646
Daudi CTRP2 3.8283 5.8119 3.6852 15.2594
GA-10 CTRP2 3.8468 6.3009 3.5714 15.6144
DoHH2 CTRP2 4.0384 7.8688 3.1836 16.5506
ALL-SIL CTRP2 4.2644 8.9992 2.9091 17.0406
NU-DHL-1 CTRP2 4.3184 6.7336 3.936 12.8829
KE-37 CTRP2 4.3243 6.3684 4.0697 12.3654
A3/Kawakami CTRP2 4.4613 5.2937 4.4499 10.5852
OCI-Ly3 CTRP2 4.6241 6.279 4.4245 10.1711
OCI-AML-3 CTRP2 4.6452 6.9046 4.2194 10.8855
Granta-519 CTRP2 4.6708 6.9154 4.2422 10.7276
NU-DUL-1 CTRP2 4.7524 8.9919 2.1649 7.9051
RS4;11 CTRP2 4.8595 7.138 4.3478 10.5336
SU-DHL-1 CTRP2 4.9122 6.1081 4.7909 7.9693
MHH-CALL-4 CTRP2 5.0232 7.4798 4.3646 9.3155
SUP-M2 CTRP2 5.0389 6.2597 4.8816 7.2596
MOLT-16 CTRP2 5.073 6.9183 4.6631 8.002
KO52 CTRP2 5.0934 6.3401 4.9131 6.9839
MOLM-13 CTRP2 5.1025 7.8347 4.2799 9.4604
P12-Ichikawa CTRP2 5.1184 6.2315 4.9771 6.6726
SEM CTRP2 5.1237 7.2823 4.5553 8.297
MOLP-8 CTRP2 5.2071 7.4011 4.5849 7.9684
KMS-21-BM CTRP2 5.3234 7.5147 4.6468 7.4322
MV4-11 CTRP2 5.3403 7.0367 4.885 6.4279
RCH-ACV CTRP2 5.422 8.0225 4.4985 7.8084
SU-DHL-4 CTRP2 5.4432 6.6448 5.164 5.0527
JURL-MK1 CTRP2 5.5053 7.176 4.9843 5.6187
HEL 92.1.7 CTRP2 5.5066 6.0094 5.4667 3.7216
MOLM-6 CTRP2 5.6201 8.7167 4.34 8.0274
NALM-6 CTRP2 5.6605 8.2519 4.6064 6.8288
BV-173 CTRP2 5.7462 7.066 5.2679 3.889
KMS-34 CTRP2 5.7986 7.6202 5.0433 4.7078
SK-MM-2 CTRP2 5.8029 9.0363 4.3427 8.1979
SUP-T11 CTRP2 5.8809 8.2242 4.8154 5.4902
L-1236 CTRP2 5.9647 8.9554 4.5219 6.5547
HuNS1 CTRP2 5.9699 7.2999 5.3536 3.0508
A4/Fukuda CTRP2 5.9734 7.6597 5.1768 3.7863
KMS-27 CTRP2 6.0128 7.6892 5.1955 3.6298
KMS-20 CTRP2 6.0322 7.541 5.2859 3.2117
SR CTRP2 6.0448 7.0725 5.5307 2.1584
SIG-M5 CTRP2 6.0883 9.6743 4.2659 7.3904
Mino CTRP2 6.134 7.8271 5.2266 3.2682
OCI-M1 CTRP2 6.1608 8.0066 5.1586 3.5047
AML-193 CTRP2 6.1811 7.3084 5.5224 1.9441
CA46 CTRP2 6.1927 11.0022 3.688 9.6081
L-428 CTRP2 6.1987 8.4864 4.9495 4.3131
DEL CTRP2 6.2056 8.4605 4.9679 4.2231
SUP-HD1 CTRP2 6.2171 7.9674 5.2227 3.1346
HD-MY-Z CTRP2 6.2209 7.5305 5.4428 2.2079
SUP-B15 CTRP2 6.2226 7.6425 5.3885 2.4316
HL-60 CTRP2 6.2233 7.4628 5.4782 2.0563
OCI-AML-5 CTRP2 6.227 7.1219 5.6492 1.3403
SU-DHL-8 CTRP2 6.2851 8.0005 5.259 2.8649
KYO-1 CTRP2 6.3644 8.9182 4.8647 4.3746
KE-97 CTRP2 6.3687 7.9479 5.3475 2.3595
TALL-1 [Human adult T-ALL] CTRP2 6.3693 12.7995 2.9337 12.3587
OPM-2 CTRP2 6.3731 8.1489 5.252 2.7477
Mono-Mac-6 CTRP2 6.3943 10.7435 3.9797 8.0208
CMK CTRP2 6.4 7.772 5.456 1.8655
SU-DHL-10 CTRP2 6.4015 7.551 5.5639 1.4257
L-540 CTRP2 6.41 8.6549 5.0299 3.6087
NCO2 CTRP2 6.4496 11.8296 3.4821 9.983
KMS-12-BM CTRP2 6.4603 9.4609 4.6692 5.0256
Ri-1 CTRP2 6.4617 9.6254 4.5887 5.3592
OCI-AML-2 CTRP2 6.4618 7.9152 5.4299 1.8801
ST486 CTRP2 6.4899 10.2396 4.3055 6.492
SUP-T1 CTRP2 6.4902 8.4632 5.1834 2.8439
RPMI-6666 CTRP2 6.4905 8.3291 5.2491 2.5738
DB CTRP2 6.4949 10.449 4.2053 6.901
SKM-1 CTRP2 6.5271 7.8863 5.488 1.5548
MJ CTRP2 6.5545 11.4854 3.7365 8.7451
BL-41 CTRP2 6.5631 9.1589 4.8954 3.9161
Ku812 CTRP2 6.5668 9.6661 4.6483 4.9338
KMS-26 CTRP2 6.5675 8.8817 5.0346 3.3353
MOTN-1 CTRP2 6.5938 8.9356 5.0271 3.3249
MHH-CALL-3 CTRP2 6.6342 11.7985 3.6429 8.9915
WSU-DLCL2 CTRP2 6.6408 8.217 5.4059 1.7275
KMS-11 CTRP2 6.7101 9.5663 4.8027 4.0662
Hs 611.T CTRP2 6.7152 10.2441 4.474 5.4132
Toledo CTRP2 6.7352 13.1088 3.0701 11.1448
BL-70 CTRP2 6.7605 7.9052 5.6212 0.7827
MC116 CTRP2 6.7611 12.581 3.3525 9.9585
Mono-Mac-1 CTRP2 6.7749 9.2945 4.9805 3.2433
PF-382 CTRP2 6.8231 9.0007 5.154 2.4795
RPMI-8226 CTRP2 6.8589 9.2425 5.0626 2.7944
AMO1 CTRP2 6.877 9.5228 4.9407 3.2571
Reh CTRP2 6.9482 9.5061 4.9965 2.9353
ME1 CTRP2 7.0483 9.2835 5.1654 2.1472
THP-1 CTRP2 7.077 9.1842 5.2287 1.8735
EJM CTRP2 7.1241 9.28 5.2133 1.8777
KMM-1 CTRP2 7.1312 10.4746 4.6565 4.0393
HEL CTRP2 7.1487 11.1878 4.3248 5.3527
KMS-18 CTRP2 7.1494 10.5382 4.6383 4.0868
NOMO-1 CTRP2 7.1498 9.0939 5.3126 1.4857
JJN-3 CTRP2 7.1618 9.4848 5.1422 2.101
RPMI-8402 CTRP2 7.1658 12.8453 3.5272 8.5696
MM1.S CTRP2 7.1718 10.265 4.7835 3.4777
MOLT-13 CTRP2 7.2037 9.2451 5.2758 1.5624
KM-H2 CTRP2 7.2163 12.8777 3.5484 8.4028
M-07e CTRP2 7.217 8.8781 5.4442 0.9685
Ci-1 CTRP2 7.2234 7.9843 5.7987 0.0754
HT CTRP2 7.2369 9.0356 5.3867 1.1424
TF-1 CTRP2 7.2377 8.5937 5.5735 0.5553
EM-2 CTRP2 7.2673 10.074 4.9347 2.765
NCI-H929 CTRP2 7.2866 11.6467 4.1988 5.6591
EHEB CTRP2 7.29 12.3026 3.8828 6.9331
Raji CTRP2 7.2965 10.1895 4.8992 2.8655
L-363 CTRP2 7.4473 8.801 5.5865 0.4009
KHM-1B CTRP2 7.4748 12.3144 4.0066 6.1584
LAMA-84 CTRP2 7.4899 10.1029 5.0556 2.0577
P31/FUJ CTRP2 7.522 12.9128 3.75 7.1182
U-937 CTRP2 7.5366 9.3905 5.3905 0.8853
Karpas-422 CTRP2 7.5384 9.1148 5.5037 0.5615
Karpas-299 CTRP2 7.5438 10.8964 4.725 3.2319
KCL-22 CTRP2 7.5466 11.5864 4.4031 4.4796
SU-DHL-6 CTRP2 7.5618 9.8615 5.2028 1.4697
Jurkat CTRP2 7.5813 10.8262 4.7806 2.9759
Kasumi-1 CTRP2 7.5947 11.6954 4.3829 4.4955
LP-1 CTRP2 7.606 12.27 4.1172 5.5304
Karpas-620 CTRP2 7.6114 8.9367 5.6043 0.2885
JVM-3 CTRP2 7.6331 16.5172 2.0658 13.4557
HH [Human lymphoma] CTRP2 7.6456 9.5319 5.3853 0.8235
NB4 CTRP2 7.6513 8.6813 5.7119 0.0998
PL21 CTRP2 7.6991 9.2299 5.5298 0.4128
HDLM-2 CTRP2 7.7164 10.5314 4.9935 2.0479
K-562 CTRP2 7.7308 15.2755 2.7477 10.7456
GDM-1 CTRP2 7.7386 12.8844 3.9125 6.1579
CML-T1 CTRP2 7.756 13.4748 3.6407 7.2105
U266B1 CTRP2 7.8374 9.6884 5.4117 0.6312
Pfeiffer CTRP2 7.9445 9.5446 5.5133 0.3445
MOLP-2 CTRP2 8.0347 9.7841 5.4605 0.4185
OCI-Ly10 CTRP2 8.0436 10.3287 5.2501 0.9458
REC-1 CTRP2 8.0515 12.9287 4.0966 5.0199
Peer CTRP2 8.0549 13.5932 3.7853 6.2245
RL CTRP2 8.2249 9.399 5.6695 0.0596
JeKo-1 CTRP2 8.249 9.6951 5.5767 0.1512
DND-41 CTRP2 8.2988 9.9877 5.4914 0.2656
F-36P CTRP2 8.3346 10.1953 5.4295 0.3654
Ki-JK CTRP2 8.3423 9.9815 5.5103 0.2233
P3HR-1 CTRP2 8.4459 9.8498 5.5941 0.0981
HPB-ALL CTRP2 8.9681 15.6833 3.389 6.5621
⏷ Show the Full List of 152 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE15 CTRP2 5.8672 7.9794 4.9256 5.0563
TE8 CTRP2 7.1168 12.4508 3.6851 8.589
TE-5 CTRP2 6.6514 9.5422 4.772 4.2847
COLO 680N CTRP2 7.3322 10.5799 4.739 3.4421
EC-GI-10 CTRP2 7.4946 10.9635 4.6628 3.7932
TE-6 CTRP2 7.5664 9.3822 5.4085 0.8702
OE21 CTRP2 7.6314 10.2083 5.0889 1.9291
KYSE-70 CTRP2 7.652 9.8606 5.2509 1.2323
TE-10 CTRP2 7.7421 9.6806 5.3707 0.8009
TE-11 CTRP2 7.8004 9.5039 5.4678 0.5102
KYSE-450 CTRP2 7.8836 9.2039 5.614 0.1969
KYSE-510 CTRP2 7.8979 9.333 5.5728 0.2476
OE19 CTRP2 8.0418 9.3028 5.6378 0.1245
KYSE-150 CTRP2 8.0929 9.3968 5.6237 0.1234
KYSE-30 CTRP2 8.2196 9.6739 5.5734 0.1619
KYSE-410 CTRP2 8.2744 9.9426 5.4983 0.2613
TE-9 CTRP2 8.2872 9.5437 5.6424 0.0747
TE-4 CTRP2 8.3155 10.4678 5.3184 0.658
TE-14 CTRP2 8.3619 9.8465 5.5652 0.1434
TE-1 CTRP2 8.4277 9.9063 5.5683 0.128
KYSE-520 CTRP2 8.4829 10.4386 5.3992 0.3987
OE33 CTRP2 8.6118 10.2414 5.5188 0.1639
KYSE-140 CTRP2 9.8404 19.2536 2.2719 9.5008
KYSE-180 CTRP2 11.2139 20.527 2.5226 7.0666
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 35 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
N2a-PK1 CTRP2 8.8204 10.2206 5.5986 0.0581
PSN1 CTRP2 5.8949 8.5214 4.6792 6.0336
SW1990 CTRP2 6.8351 10.1355 4.6145 4.6448
Capan-1 CTRP2 6.9664 9.5044 5.0093 2.8601
Panc 03.27 CTRP2 7.2977 9.3185 5.2962 1.3963
MIA PaCa-2 CTRP2 7.3323 9.1362 5.394 1.0349
TCC-Pan2 CTRP2 7.333 9.3271 5.3118 1.3092
KP-4 CTRP2 7.4751 9.4367 5.3399 1.0914
PK-45H CTRP2 7.5317 9.7924 5.2166 1.5578
DAN-G CTRP2 7.5889 9.4075 5.409 0.7933
YAPC CTRP2 7.5922 9.5177 5.3651 0.9215
BxPC-3 CTRP2 7.6421 14.6618 2.9838 9.9725
SUIT-2 CTRP2 7.7329 10.4041 5.0589 1.8031
PaTu 8988t CTRP2 7.7456 9.0029 5.6333 0.1902
KP-2 CTRP2 7.7638 8.8687 5.6877 0.1079
QGP-1 CTRP2 7.808 14.6815 3.0928 9.2907
L3.3 CTRP2 7.8387 9.0316 5.6582 0.1303
SU.86.86 CTRP2 7.9623 9.0906 5.6824 0.0867
PaTu 8902 CTRP2 7.9723 9.5438 5.5249 0.3113
Panc 02.03 CTRP2 8.0111 9.3328 5.6161 0.1496
Panc 05.04 CTRP2 8.0575 15.1103 3.0597 9.0454
HPAF-II CTRP2 8.1173 10.8252 5.0805 1.4007
PaTu 8988s CTRP2 8.2937 9.7597 5.5706 0.1501
HuP-T4 CTRP2 8.3409 10.3564 5.3718 0.4804
HPAC CTRP2 8.3552 10.2701 5.4101 0.3958
Hs 766T CTRP2 8.3613 10.0474 5.494 0.2438
CFPAC-1 CTRP2 8.4766 10.0358 5.5411 0.1511
KP-3 CTRP2 8.5183 15.0314 3.4075 7.0651
HuP-T3 CTRP2 8.5945 13.8996 3.9837 4.7897
Panc 04.03 CTRP2 8.6549 10.0072 5.6134 0.0585
Capan-2 CTRP2 8.7532 10.3728 5.5242 0.123
Panc 08.13 CTRP2 8.7575 10.4796 5.4889 0.1614
AsPC-1 CTRP2 9.1756 11.1378 5.4121 0.1759
PK-59 CTRP2 10.0219 18.1931 2.8778 7.1598
SNU-213 CTRP2 11.4183 28.002 -0.8431 16.8058
⏷ Show the Full List of 35 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 49 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SH4 CTRP2 8.7273 11.0285 5.2788 0.5572
RPMI-7951 CTRP2 5.5874 7.4486 4.9327 5.6366
LOX-IMVI CTRP2 6.0682 7.9818 5.0955 3.9429
WM266-4 CTRP2 6.4122 7.982 5.3624 2.2297
COLO 800 CTRP2 6.5784 8.5947 5.1822 2.7141
WM115 CTRP2 6.6534 9.9246 4.5855 5.0519
Hs 839.T CTRP2 6.8532 8.5321 5.3925 1.5162
Hs 944.T CTRP2 6.8778 11.2516 4.0985 6.7002
IGR-37 CTRP2 6.8802 9.5025 4.9525 3.2049
WT2-iPS CTRP2 7.0296 11.4639 4.1054 6.4292
UACC-257 CTRP2 7.1971 9.9943 4.9275 2.8803
SK-MEL-28 CTRP2 7.2114 7.9772 5.7968 0.0802
SK-MEL-24 CTRP2 7.2705 10.559 4.7089 3.641
COLO 792 CTRP2 7.3443 10.8785 4.6059 3.9493
COLO 829 CTRP2 7.3844 10.9415 4.6023 3.9101
A2058 CTRP2 7.446 8.8467 5.5681 0.4468
Hs 688(A).T CTRP2 7.4517 8.6441 5.6483 0.2607
G-361 CTRP2 7.4689 10.0662 5.06 2.0644
WM1799 CTRP2 7.4741 10.2862 4.9633 2.4139
Hs 934.T CTRP2 7.4779 8.8996 5.5615 0.4463
SK-MEL-3 CTRP2 7.4979 9.1457 5.4724 0.6722
Hs 852.T CTRP2 7.5042 9.5668 5.2995 1.198
K029AX CTRP2 7.5075 8.9148 5.5686 0.4445
SK-MEL-2 CTRP2 7.5286 8.4811 5.7369 0.0926
MeWo CTRP2 7.5375 10.7454 4.791 2.988
IGR-1 CTRP2 7.5695 9.4803 5.3694 0.9251
SK-MEL-30 CTRP2 7.585 9.0605 5.5459 0.4297
MDA-MB-435S CTRP2 7.5891 10.5192 4.9256 2.4261
HT-144 CTRP2 7.6201 9.8715 5.2296 1.3286
Hs 294T CTRP2 7.6392 11.0191 4.7271 3.1101
A-375 CTRP2 7.6487 12.1675 4.1945 5.1656
UACC-62 CTRP2 7.6758 8.8302 5.6686 0.1535
Mel Ho CTRP2 7.7677 11.9021 4.3969 4.2177
WM793 CTRP2 7.7876 12.0864 4.3232 4.4781
IPC-298 CTRP2 7.8183 9.0848 5.6317 0.173
Hs 936.T CTRP2 7.8193 12.1502 4.3135 4.4756
SK-MEL-31 CTRP2 7.8203 9.6183 5.4318 0.5893
CJM [Human melanoma] CTRP2 7.8727 8.7872 5.7534 0.0341
A101D CTRP2 7.8987 8.9679 5.7017 0.071
HMCB CTRP2 7.9004 8.8109 5.7548 0.0311
WM88 CTRP2 8.069 13.4802 3.8481 5.9611
Hs 895.T CTRP2 8.0696 9.327 5.6395 0.1092
SK-MEL-1 CTRP2 8.0894 9.098 5.7236 0.0353
SK-MEL-5 CTRP2 8.1233 9.6993 5.5277 0.2564
Mel JuSo CTRP2 8.2309 9.9126 5.4922 0.2848
Hs 940.T CTRP2 8.2858 9.927 5.5083 0.2416
RVH-421 CTRP2 8.4 9.7819 5.6011 0.0979
WM983B CTRP2 8.9848 10.7559 5.4753 0.138
IGR-39 CTRP2 9.9196 49.0548 -12.3228 34.7523
⏷ Show the Full List of 49 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 CTRP2 7.2361 13.0513 3.4777 8.6563
Cancer Drug Sensitivity Data Curated from 14 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SiMa CTRP2 1.2899 11.6825 -1.3079 38.0899
IMR-32 CTRP2 2.1091 3.0353 2.109 26.218
SK-N-SH CTRP2 6.058 8.9526 4.6016 6.0383
SK-N-DZ CTRP2 6.2149 8.2947 5.058 3.8286
CHP-212 CTRP2 6.2488 8.3622 5.0511 3.7972
NH-6 CTRP2 6.3963 7.856 5.4125 2.0489
KP-N-YN CTRP2 6.8596 10.7862 4.3138 5.842
Kelly CTRP2 6.9625 9.4721 5.022 2.8149
KP-N-SI9s CTRP2 7.0966 10.7715 4.4899 4.7602
SK-N-AS CTRP2 7.117 9.4965 5.1093 2.2788
SK-N-BE(2) CTRP2 7.1362 11.3552 4.2347 5.7372
NB1 CTRP2 7.2551 9.0537 5.3887 1.1194
CHP-126 CTRP2 8.1156 32.974 -5.7357 30.6137
SK-N-FI CTRP2 8.506 9.993 5.5664 0.1172
⏷ Show the Full List of 14 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-478 CTRP2 7.394 9.7494 5.159 1.785
HuCC-T1 CTRP2 7.4056 9.095 5.4486 0.8055
SNU-1196 CTRP2 7.6776 9.425 5.4437 0.6393
HuH-28 CTRP2 7.7259 9.2877 5.5191 0.4249
SNU-308 CTRP2 7.7617 9.7026 5.371 0.7873
SNU-869 CTRP2 8.0865 9.8269 5.4659 0.3861
SNU-1079 CTRP2 8.5425 10.3465 5.456 0.2549
⏷ Show the Full List of 7 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 15 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-673 CTRP2 3.7653 5.8698 3.6026 15.7488
SK-ES-1 CTRP2 3.9374 6.1164 3.7249 14.7828
SK-N-MC CTRP2 5.6526 6.6547 5.3727 3.6834
Hs 822.T CTRP2 6.4358 7.8532 5.4418 1.8697
Hs 888.T CTRP2 6.6094 8.5535 5.2238 2.4994
SaOS-2 CTRP2 6.7581 8.287 5.4474 1.4204
SJSA-1 CTRP2 7.3186 9.7391 5.1199 2.1558
TC71 CTRP2 7.5702 8.8304 5.6271 0.2583
CAL-78 CTRP2 7.5738 9.9627 5.1652 1.5869
U2OS CTRP2 7.79 9.8715 5.3156 0.928
SW1353 CTRP2 7.9396 12.2986 4.3203 4.2989
HOS CTRP2 8.0816 9.3515 5.6354 0.1118
G-292 clone A141B1 CTRP2 8.1279 10.2024 5.3394 0.6568
MG-63 CTRP2 8.2148 9.6211 5.5901 0.1412
MHH-ES-1 CTRP2 9.8479 17.6804 3.0077 6.9011
⏷ Show the Full List of 15 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 69 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MDA-MB-157 CTRP2 5.8402 9.1162 4.3352 7.5878
DU4475 CTRP2 6.0373 9.6425 4.2394 7.5995
UACC-812 CTRP2 6.1515 8.3572 4.976 4.2881
MDA-MB-468 CTRP2 6.3198 8.7841 4.8968 4.3178
KPL-1 CTRP2 7.0867 8.959 5.3368 1.6918
CAL-51 CTRP2 7.1197 10.3105 4.7272 3.7725
CAL-148 CTRP2 7.344 9.092 5.4189 0.9452
CAL-85-1 CTRP2 7.3764 12.9623 3.6229 7.8503
HCC38 CTRP2 7.4018 9.4987 5.2743 1.4752
EFM-192A CTRP2 7.5501 9.4046 5.3913 0.8731
CAL-120 CTRP2 7.5899 9.0516 5.5515 0.4142
HCC1419 CTRP2 7.5943 9.1166 5.5281 0.4683
HCC2218 CTRP2 7.7073 9.9973 5.2213 1.2821
HCC1500 CTRP2 7.7362 9.0527 5.6115 0.2303
HCC1143 CTRP2 7.7578 12.2473 4.2283 4.8871
HMC-1-8 CTRP2 7.8456 9.4769 5.4977 0.4189
HDQ-P1 CTRP2 7.8635 10.163 5.2308 1.1294
HCC1954 CTRP2 7.9647 12.3764 4.2998 4.3469
JIMT-1 CTRP2 8.001 9.259 5.6382 0.1231
HCC1395 CTRP2 8.0103 11.075 4.9169 2.0309
BT-474 CTRP2 8.0235 9.3621 5.6104 0.1546
HCC1806 CTRP2 8.201 10.6247 5.2044 0.9728
HCC1937 CTRP2 8.2119 10.9408 5.0796 1.3316
Hs 578T CTRP2 8.3191 10.6988 5.2293 0.8333
ZR-75-30 CTRP2 8.3363 9.9816 5.508 0.2284
CAMA-1 CTRP2 8.3571 16.199 2.7413 9.8194
MDA-MB-361 CTRP2 8.4146 10.0181 5.5245 0.1854
BT-20 CTRP2 8.4277 9.8279 5.5951 0.0997
HCC1428 CTRP2 8.4638 9.8232 5.6094 0.0878
MCF-7 CTRP2 8.4641 15.1456 3.3179 7.4794
MDA-MB-231 CTRP2 8.4907 10.8523 5.2456 0.6999
T-47D CTRP2 8.5067 10.3515 5.4404 0.2902
BT-549 CTRP2 8.5831 10.1249 5.5487 0.133
MDA-MB-453 CTRP2 8.7125 10.2205 5.5617 0.0928
HCC202 CTRP2 8.8384 10.5727 5.4859 0.1616
BT 286 CTRP2 3.0258 9.4828 1.4388 25.7739
BT 271 CTRP2 5.6397 7.4537 4.9794 5.324
BT 330 CTRP2 5.7052 9.5054 4.0237 9.1697
BT 145 CTRP2 5.878 7.643 5.1025 4.6108
BT 112 CTRP2 5.9471 7.7085 5.1299 4.036
BT 232 CTRP2 5.9472 9.491 4.2394 7.7757
BT 428 CTRP2 6.1258 11.7935 3.2374 11.5933
BT164 CTRP2 6.1295 7.0326 5.6193 1.7499
BT 131 CTRP2 6.2809 9.4399 4.5395 5.8837
BT 498 CTRP2 6.4851 13.2631 2.7954 12.6929
BT 482 CTRP2 6.6817 8.7961 5.1566 2.6661
BT 245 CTRP2 6.7692 9.6242 4.8167 3.918
BT 248 CTRP2 6.8111 10.1443 4.593 4.7702
BT 320 CTRP2 6.836 15.9048 1.7573 15.9576
BT 333 CTRP2 6.8785 8.96 5.2093 2.189
BT 172 CTRP2 6.9322 8.9987 5.2253 2.0594
BT 444 CTRP2 7.135 9.6426 5.0526 2.4742
BT 340 CTRP2 7.2552 15.9248 2.0734 14.0683
BT 239 CTRP2 7.3089 11.6437 4.2157 5.5582
BT 422 CTRP2 7.4212 8.8011 5.575 0.4429
BT 139 CTRP2 7.4247 8.7119 5.6112 0.3534
BT 179 CTRP2 7.4842 8.6626 5.6546 0.2534
BT 159 CTRP2 7.9045 9.4436 5.5347 0.3169
BT 359 CTRP2 7.9318 9.1458 5.6524 0.119
BT 328 CTRP2 7.944 9.2149 5.6328 0.1417
BT 228 CTRP2 7.9513 10.1234 5.2899 0.8934
BT 504 CTRP2 8.0481 16.7001 2.2801 12.0029
BT 224 CTRP2 8.185 9.4617 5.6344 0.1032
BT 231 CTRP2 8.6647 10.6839 5.3813 0.3438
BT 187 CTRP2 9.0103 10.8951 5.4364 0.1773
BT 440 CTRP2 10.7586 20.8119 2.1217 8.8966
BT147 CTRP2 11.0195 36.3871 -5.2068 25.972
BT 416 CTRP2 11.1082 32.0236 -3.005 22.0416
BT 216 CTRP2 12.0487 26.3024 0.3751 12.7663
⏷ Show the Full List of 69 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
YD-38 CTRP2 7.505 8.4375 5.7435 0.0891
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
D283 Med CTRP2 5.6398 7.398 5.0066 5.2113
SF539 CTRP2 6.1331 8.3138 4.9827 4.2942
GB-1 CTRP2 6.3183 10.7549 3.9133 8.4359
Daoy CTRP2 6.6387 12.3687 3.3628 10.132
Hs 683 CTRP2 6.7633 10.5334 4.3672 5.7767
SNU-466 CTRP2 6.7943 10.8339 4.2422 6.2427
KNS-60 CTRP2 6.9203 8.6196 5.3928 1.5458
U-118MG CTRP2 6.9831 9.2884 5.1221 2.3953
SF295 CTRP2 6.9838 9.0366 5.2399 1.9406
KNS-81 CTRP2 6.9993 8.8859 5.3185 1.7471
YH-13 CTRP2 7.112 9.0164 5.3256 1.4783
SNU-201 CTRP2 7.2131 14.8339 2.5815 12.2332
KALS-1 CTRP2 7.2421 11.6142 4.1835 5.7867
SNU-626 CTRP2 7.349 8.7983 5.543 0.5696
U-251MG CTRP2 7.389 8.9017 5.52 0.6083
NMC-G1 CTRP2 7.4075 8.6813 5.6156 0.3514
CCF-STTG1 CTRP2 7.5042 9.5952 5.2873 1.3301
SF268 CTRP2 7.5156 9.5206 5.3251 1.1055
SNU-738 CTRP2 7.5591 8.7191 5.6637 0.1942
LN-18 CTRP2 7.6219 8.4988 5.7639 0.0506
GOS-3 CTRP2 7.6429 9.2243 5.5075 0.494
CAS-1 CTRP2 7.7444 9.7173 5.3569 0.9692
SF126 CTRP2 7.7708 10.6023 4.9925 1.9973
KNS-42 CTRP2 7.8489 9.3313 5.5539 0.2997
M059K CTRP2 7.8588 9.2897 5.5732 0.2596
TM-31 CTRP2 7.8933 8.917 5.7171 0.0581
DK-MG CTRP2 7.9007 9.2823 5.5923 0.2291
GMS-10 CTRP2 7.9636 9.4105 5.5703 0.2317
SNU-489 CTRP2 7.9877 9.2482 5.6371 0.127
A-172 CTRP2 8.002 9.772 5.4513 0.4529
KG-1-C CTRP2 8.0561 9.2414 5.664 0.0853
YKG-1 CTRP2 8.1006 9.3483 5.6432 0.0999
SW1088 CTRP2 8.1437 10.7719 5.1161 1.2707
SW1783 CTRP2 8.1532 10.511 5.2279 0.9376
ONS-76 CTRP2 8.1642 10.2058 5.3541 0.602
42-MG-BA CTRP2 8.1911 9.5033 5.6223 0.1078
GaMG CTRP2 8.1975 10.0544 5.4262 0.4242
Becker CTRP2 8.2513 10.0455 5.4514 0.353
8-MG-BA CTRP2 8.3194 9.9828 5.5012 0.2438
T98G CTRP2 8.3428 9.9287 5.5293 0.195
LN-229 CTRP2 8.5736 10.2289 5.5092 0.1718
DBTRG-05MG CTRP2 8.7692 10.6639 5.4286 0.2387
U-87MG ATCC CTRP2 10.5386 19.7271 2.4866 7.9217
SNU-1105 CTRP2 14.6861 33.9316 -1.5241 14.6967
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JHUEM-2 CTRP2 5.1737 9.1338 3.7252 11.5652
ESS-1 CTRP2 5.4366 7.6812 4.6771 7.0389
KLE CTRP2 6.2872 8.4362 5.0444 3.7575
JHUEM-3 CTRP2 6.5395 9.7296 4.5963 5.1952
JHUEM-7 CTRP2 6.9245 12.0858 3.7221 8.7654
HEC-59 CTRP2 7.0524 9.6382 5.0021 2.7748
HEC-265 CTRP2 7.3626 8.8229 5.5395 0.5707
JHUEM-1 CTRP2 7.4465 12.5545 3.8708 6.7454
HEC-6 CTRP2 7.6052 12.8582 3.8342 6.6593
HEC-251 CTRP2 7.732 11.178 4.7105 3.0649
HEC-108 CTRP2 7.7701 17.4816 1.6925 14.5595
EN CTRP2 7.9195 9.5675 5.4943 0.3942
EFE-184 CTRP2 7.9546 9.9828 5.3481 0.7312
MFE-296 CTRP2 8.0581 10.0222 5.379 0.5953
MFE-319 CTRP2 8.131 9.4917 5.6046 0.1396
AN3-CA CTRP2 8.1673 10.4561 5.2566 0.85
HEC-151 CTRP2 8.4418 9.876 5.5837 0.1091
HEC-1-A CTRP2 8.6043 10.3728 5.4699 0.2184
HEC-50B CTRP2 8.9993 10.6619 5.5123 0.1005
RL95-2 CTRP2 9.5761 17.1109 3.1041 6.8729
HEC-1-B CTRP2 11.148 23.841 0.9549 12.149
Ishikawa (Heraklio) 02 ER- CTRP2 7.8062 8.7418 5.7459 0.0449
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 20 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TUHR4TKB CTRP2 5.4976 6.2119 5.3948 4.012
OS-RC-2 CTRP2 7.4538 13.3602 3.4842 8.2871
CAL-54 CTRP2 7.56 10.0009 5.1408 1.6843
BFTC-909 CTRP2 7.6136 9.2934 5.4669 0.6154
TUHR10TKB CTRP2 7.7504 9.038 5.6225 0.2068
VMRC-RCW CTRP2 7.7543 11.0128 4.7991 2.7104
SNU-1272 CTRP2 7.8931 9.6318 5.4585 0.4866
RCC10RGB CTRP2 7.9304 9.3148 5.5921 0.2053
Caki-2 CTRP2 7.9738 9.0475 5.701 0.0622
A-498 CTRP2 8.1261 9.3807 5.6412 0.098
769-P CTRP2 8.1691 10.6241 5.1895 1.036
KMRC-20 CTRP2 8.238 9.6762 5.5793 0.1502
KMRC-1 CTRP2 8.2855 9.4801 5.6631 0.0583
UO-31 CTRP2 8.3104 10.2004 5.4178 0.3972
KMRC-2 CTRP2 8.3698 9.7593 5.5981 0.1053
KMRC-3 CTRP2 8.613 10.8971 5.2808 0.5619
VMRC-RCZ CTRP2 8.632 10.2649 5.5179 0.1499
ACHN CTRP2 8.7377 10.2082 5.5745 0.079
786-O CTRP2 9.2388 10.6628 5.5928 0.0311
Caki-1 CTRP2 9.2924 11.0519 5.4824 0.0916
⏷ Show the Full List of 20 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW1463 CTRP2 3.4733 8.1198 2.4887 20.7478
SK-CO-1 CTRP2 5.6192 7.3063 5.0316 5.156
CCK-81 CTRP2 6.7628 12.1701 3.5577 9.118
SNU-81 CTRP2 6.8482 10.9514 4.2243 6.2293
CL-11 CTRP2 6.9821 8.7218 5.3829 1.408
T84 CTRP2 7.0652 9.0669 5.2753 1.7131
CW-2 CTRP2 7.0797 9.3775 5.1413 2.2013
LoVo CTRP2 7.1161 12.5757 3.6232 8.2607
HCC-56 CTRP2 7.1754 8.5465 5.5629 0.6285
COLO205 CTRP2 7.2581 9.0113 5.4086 1.0505
SW948 CTRP2 7.2995 15.1333 2.4988 12.4027
GP2d CTRP2 7.3845 9.3446 5.3319 1.1945
HT-55 CTRP2 7.439 9.0368 5.4888 0.6642
COLO201 CTRP2 7.5472 10.4957 4.9114 2.5246
SW48 CTRP2 7.5561 12.5435 3.9521 6.2591
HCT 15 CTRP2 7.598 9.0492 5.5559 0.3999
OUMS-23 CTRP2 7.6007 8.5855 5.7268 0.0913
DLD-1 CTRP2 7.7038 8.5386 5.7786 0.0319
C2BBe1 CTRP2 7.7195 13.1108 3.791 6.6669
LS1034 CTRP2 7.72 9.5047 5.4314 0.6953
HT-29 CTRP2 7.7782 9.0269 5.6372 0.175
SNU-503 CTRP2 7.8127 9.9054 5.3126 0.9209
MDST8 CTRP2 7.8129 9.6274 5.4249 0.611
HT115 CTRP2 7.8214 8.9605 5.6767 0.1103
SNU-407 CTRP2 7.8276 12.4431 4.1811 4.98
LS123 CTRP2 7.8503 10.6726 5.0056 1.8761
LS513 CTRP2 7.8809 13.4111 3.7563 6.5764
KM12 CTRP2 8.0213 9.6513 5.5048 0.3326
SW1417 CTRP2 8.0272 9.7283 5.4784 0.3837
LS411N CTRP2 8.0809 9.5841 5.5529 0.2266
HCT 8 CTRP2 8.1048 9.3479 5.6449 0.0975
RCM-1 [Human ESC] CTRP2 8.1082 9.3477 5.6462 0.1027
SNU-C4 CTRP2 8.1403 9.1928 5.7093 0.0399
NCI-H716 CTRP2 8.1561 9.9949 5.4314 0.462
SNU-C1 CTRP2 8.2008 10.0543 5.4276 0.42
LS180 CTRP2 8.2273 10.2071 5.3808 0.5101
RKO CTRP2 8.2377 9.7648 5.548 0.1932
HCT 116 CTRP2 8.3136 9.7197 5.5917 0.1212
COLO 678 CTRP2 8.3964 10.187 5.4571 0.2948
SNU-1033 CTRP2 8.4231 10.4248 5.38 0.4303
SW620 CTRP2 8.4339 10.021 5.5306 0.1729
SNU-61 CTRP2 8.512 10.5309 5.3767 0.4037
SNU-C5 CTRP2 8.6072 10.3516 5.4785 0.2056
SNU-C2A CTRP2 8.7594 15.9187 3.1451 7.7406
NCI-H747 CTRP2 8.9102 10.605 5.5004 0.1236
⏷ Show the Full List of 45 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 22 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-878 CTRP2 5.4941 20.7428 -1.7683 28.4927
JHH-5 CTRP2 5.7621 8.3306 4.6583 6.3948
HLF CTRP2 6.5866 8.0888 5.4311 1.7
SNU-886 CTRP2 6.8794 8.7654 4.4003 0.6828
JHH-6 CTRP2 7.3337 8.0636 5.8107 0.0452
SNU-182 CTRP2 7.3481 14.3344 2.9293 10.6575
SNU-761 CTRP2 7.464 9.3828 5.3571 1.1228
Li-7 CTRP2 7.5098 26.3026 -2.8909 27.0742
Hep-G2 CTRP2 7.6776 9.2762 5.5025 0.4881
HuH-1 CTRP2 7.6898 9.1115 5.5709 0.3263
HuH-6 CTRP2 7.7014 9.6269 5.3732 0.8208
PLC/PRF/5 CTRP2 7.7221 9.1894 5.5549 0.3469
Hep 3B2.1-7 CTRP2 7.7345 9.4207 5.4712 0.536
SK-HEP-1 CTRP2 7.8037 9.4896 5.4748 0.4917
JHH-1 CTRP2 7.8571 9.1098 5.6375 0.1549
JHH-2 CTRP2 7.8633 9.6099 5.454 0.5118
SNU-423 CTRP2 8.0786 9.5162 5.5764 0.1904
SNU-449 CTRP2 8.1691 10.1616 5.3733 0.5951
SNU-398 CTRP2 8.476 11.092 5.1443 0.9674
SNU-475 CTRP2 8.599 9.889 5.6337 0.0501
SNU-387 CTRP2 8.7291 10.6224 5.4282 0.2491
JHH-4 CTRP2 8.88 10.3022 5.5917 0.0536
⏷ Show the Full List of 22 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 137 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 668 CTRP2 4.0213 6.7101 3.6246 14.9062
NCI-H1694 CTRP2 4.0275 6.4373 3.7247 14.5146
DV-90 CTRP2 4.204 8.8428 2.9208 17.1478
NCI-H1105 CTRP2 4.6974 9.0741 3.2998 14.4158
NCI-H1155 CTRP2 5.6861 7.9832 4.7623 6.123
NCI-H2170 CTRP2 5.8036 7.3213 5.1956 4.0615
NCI-H1975 CTRP2 5.979 7.1651 5.4286 2.7174
NCI-H1568 CTRP2 6.0879 8.2593 4.973 4.4201
NCI-H1341 CTRP2 6.118 7.9133 5.1705 3.5336
NCI-H146 CTRP2 6.1422 7.9926 5.1505 3.5727
NCI-H2444 CTRP2 6.2067 8.5354 4.9315 4.6982
COR-L51 CTRP2 6.2671 8.4844 5.0047 3.9588
NCI-H2081 CTRP2 6.2769 9.1301 4.6908 5.2564
NCI-H1339 CTRP2 6.2841 8.0665 5.2256 3.006
NCI-H2085 CTRP2 6.333 8.3268 5.1339 3.3051
COR-L95 CTRP2 6.3401 8.7975 4.9059 4.2444
COR-L88 CTRP2 6.3867 10.0914 4.2986 6.7022
DMS 53 CTRP2 6.3919 8.0631 5.3079 2.486
NCI-H2228 CTRP2 6.607 12.0135 3.5148 10.2588
NCI-H1184 CTRP2 6.6489 9.9619 4.5637 5.1495
NCI-H23 CTRP2 6.8212 8.9593 5.1724 2.409
NCI-H2087 CTRP2 6.8637 9.3909 4.9949 3.0581
LK2 CTRP2 6.8745 7.8592 5.6999 0.435
NCI-H196 CTRP2 6.9242 9.7573 4.8602 3.5138
DMS 273 CTRP2 6.9773 13.1863 3.218 10.1304
SK-LU-1 CTRP2 7.0034 8.8079 5.3564 1.4818
BEN CTRP2 7.0091 7.9715 5.7173 0.3058
NCI-H446 CTRP2 7.0333 10.5136 4.5707 4.5257
NCI-H522 CTRP2 7.0586 10.7094 4.4935 4.8014
NCI-H1092 CTRP2 7.0629 9.4287 5.107 2.3534
RERF-LC-Ad1 CTRP2 7.1112 8.7986 5.4218 1.1389
NCI-H841 CTRP2 7.1474 9.7955 4.9891 2.704
MOR/CPR CTRP2 7.1511 8.1759 5.6999 0.2769
LUDLU-1 CTRP2 7.1529 12.5522 3.6617 8.045
HCC366 CTRP2 7.1536 12.9683 3.4577 8.8706
NCI-H441 CTRP2 7.167 10.4436 4.6953 3.8344
SK-MES-1 CTRP2 7.2007 9.4023 5.2031 1.83
NCI-H1734 CTRP2 7.2157 11.0906 4.4181 4.8773
NCI-H1838 CTRP2 7.2733 9.4793 5.2108 1.7242
NCI-H69 CTRP2 7.2858 9.7118 5.1129 2.0694
Calu-3 CTRP2 7.3011 14.7332 2.6977 11.6373
NCI-H2029 CTRP2 7.3065 8.8099 5.5181 0.7187
SBC-5 CTRP2 7.3139 8.6615 5.5818 0.4855
NCI-H2196 CTRP2 7.3226 10.3349 4.8478 3.0316
NCI-H810 CTRP2 7.3243 9.7548 5.1162 2.0145
Lu-99 CTRP2 7.3284 13.0097 3.5653 8.1569
NCI-H226 CTRP2 7.3284 9.6864 5.1495 2.0282
DMS 454 CTRP2 7.3305 10.4502 4.7989 3.2109
NCI-H211 CTRP2 7.3707 12.6588 3.7668 7.2789
NCI-H2286 CTRP2 7.3816 10.1933 4.9502 2.569
NCI-H2126 CTRP2 7.3907 9.4007 5.3109 1.2592
NCI-H2106 CTRP2 7.4612 11.1168 4.5694 3.9386
LOU-NH91 CTRP2 7.4792 9.5841 5.2788 1.2881
LC-1/sq-SF CTRP2 7.5075 8.845 5.5956 0.3769
RERF-LC-MS CTRP2 7.558 9.1463 5.5001 0.5595
NCI-H2171 CTRP2 7.5995 9.0982 5.5376 0.4425
NCI-H2122 CTRP2 7.6059 11.1868 4.6288 3.5248
DMS 114 CTRP2 7.6089 9.5362 5.3656 0.9077
NCI-H526 CTRP2 7.6315 9.4676 5.4048 0.7766
Calu-6 CTRP2 7.6371 11.1791 4.6518 3.3989
PC-14 CTRP2 7.6519 10.5087 4.9669 2.3723
EBC-1 CTRP2 7.6594 10.458 4.9939 2.104
HCC2108 CTRP2 7.6715 10.0819 5.1661 1.4946
Sq-1 CTRP2 7.6765 9.0546 5.5868 0.2988
HARA [Human squamous cell lung carcinoma] CTRP2 7.7028 10.9233 4.8093 2.7299
KNS-62 CTRP2 7.7163 9.5904 5.3951 0.7487
NCI-H520 CTRP2 7.7237 9.958 5.2464 1.1886
NCI-H1623 CTRP2 7.7277 9.5778 5.4056 0.7127
HCC1588 CTRP2 7.7413 16.3462 2.2302 12.6761
SW1271 CTRP2 7.7508 11.5028 4.5722 3.829
CAL-12T CTRP2 7.7686 10.1354 5.1942 1.3189
NCI-H1792 CTRP2 7.8245 9.9674 5.2928 0.971
NCI-H727 CTRP2 7.8512 12.5483 4.1468 5.0833
RERF-LC-Ad2 CTRP2 7.8878 9.1688 5.6281 0.173
NCI-H1395 CTRP2 7.8921 11.9128 4.4698 3.7859
NCI-H322 CTRP2 7.9016 10.3097 5.1884 1.2313
NCI-H2291 CTRP2 7.9159 11.2513 4.7857 2.5865
SHP-77 CTRP2 7.9322 11.3023 4.7722 2.6182
HCC78 CTRP2 7.9465 10.4128 5.1678 1.2609
NCI-H1650 CTRP2 7.9897 11.7816 4.5891 3.2255
NCI-H292 CTRP2 7.9918 9.7747 5.4459 0.4695
COR-L105 CTRP2 8.0085 11.1797 4.8699 2.1949
EPLC-272H CTRP2 8.0266 9.9094 5.409 0.5387
LCLC-103H CTRP2 8.0622 9.0551 5.7286 0.0344
NCI-H2023 CTRP2 8.1112 10.593 5.1743 1.1197
HCC1438 CTRP2 8.1118 9.4315 5.6185 0.126
NCI-H1944 CTRP2 8.124 10.6049 5.1756 1.1068
NCI-H1563 CTRP2 8.1269 9.389 5.6386 0.1006
NCI-H1435 CTRP2 8.1279 14.6977 3.3069 7.9869
NCI-H460 CTRP2 8.1432 9.2994 5.6748 0.0643
NCI-H1793 CTRP2 8.1499 9.873 5.4745 0.3449
NCI-H1915 CTRP2 8.1548 9.5423 5.5956 0.1462
NCI-H1651 CTRP2 8.162 9.7985 5.5067 0.2809
NCI-H1581 CTRP2 8.1863 9.4914 5.6246 0.1061
Lu-65 CTRP2 8.1929 9.6131 5.5848 0.1523
IA-LM CTRP2 8.1966 9.6897 5.5592 0.1868
NCI-H889 CTRP2 8.2145 9.8295 5.516 0.2492
NCI-H358 CTRP2 8.2185 10.9136 5.0942 1.2824
NCI-H1573 CTRP2 8.2333 9.7124 5.5649 0.1703
NCI-H1666 CTRP2 8.2452 10.1933 5.3935 0.474
NCI-H661 CTRP2 8.2744 10.384 5.333 0.5981
NCI-H2172 CTRP2 8.2782 9.9183 5.5085 0.2434
NCI-H2110 CTRP2 8.2853 10.4674 5.3054 0.6589
HCC1195 CTRP2 8.2993 10.9687 5.1109 1.1753
NCI-H838 CTRP2 8.3528 9.8412 5.5638 0.147
A-549 CTRP2 8.3763 10.5133 5.327 0.564
NCI-H1299 CTRP2 8.3793 11.3025 5.012 1.4134
DMS 79 CTRP2 8.4 9.7145 5.6239 0.077
VMRC-LCD CTRP2 8.4499 9.8303 5.6021 0.0967
NCI-H650 CTRP2 8.4559 9.9988 5.5464 0.1485
Calu-1 CTRP2 8.4805 10.0422 5.5403 0.1513
HCC4006 CTRP2 8.5044 10.138 5.5156 0.1778
NCI-H1703 CTRP2 8.5174 10.1461 5.5176 0.1726
HCC95 CTRP2 8.5258 10.1624 5.5149 0.1743
NCI-H1755 CTRP2 8.528 10.8101 5.278 0.6059
NCI-H1693 CTRP2 8.5965 10.4746 5.4306 0.2806
LXF 289 CTRP2 8.6021 10.3024 5.4939 0.1858
HCC827 CTRP2 8.6297 14.8157 3.5805 6.2643
T3M-10 CTRP2 8.6368 10.5077 5.4342 0.2639
NCI-H2030 CTRP2 8.643 10.2311 5.5336 0.1304
NCI-H647 CTRP2 8.6473 11.7794 4.9459 1.4181
ChaGo-K-1 CTRP2 8.6986 10.3378 5.5167 0.1397
HCC15 CTRP2 8.7411 10.8464 5.3519 0.3716
NCI-H1355 CTRP2 8.7911 10.4483 5.5118 0.13
LCLC-97TM1 CTRP2 8.9614 11.1387 5.3318 0.3388
NCI-H2405 CTRP2 8.9634 15.7046 3.3761 6.6159
NCI-H1869 CTRP2 8.9841 10.6679 5.505 0.109
NCI-H1373 CTRP2 9.0352 10.8578 5.4583 0.1481
NCI-H2342 CTRP2 9.0743 10.806 5.4897 0.1112
RERF-LC-A1 CTRP2 9.4578 16.2339 3.435 5.8164
HCC44 CTRP2 9.6053 17.9067 2.7531 8.0983
HCC1171 CTRP2 9.8115 18.0593 2.8108 7.6425
HCC1833 CTRP2 9.8158 21.1923 1.3361 12.6808
COLO 699 CTRP2 10.0291 17.7603 3.0799 6.442
HCC2279 CTRP2 10.1635 20.3696 1.9547 10.1765
NCI-H2009 CTRP2 11.5717 25.1517 0.6107 12.6569
Hs 888.Lu CTRP2 7.319 9.3778 5.2818 1.4257
⏷ Show the Full List of 137 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Thigh Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SYO-1 CTRP2 5.0514 10.4083 2.9882 14.8488
P-STS CTRP2 5.5874 7.7135 4.804 6.6257
H-STS CTRP2 6.2761 7.4743 5.5121 1.9634
Cancer Drug Sensitivity Data Curated from 40 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
2004 CTRP2 6.6967 27.1765 -3.9831 30.2985
OAW42 CTRP2 5.6637 8.0046 4.7314 6.3006
TOV-112D CTRP2 6.1002 7.9448 5.1403 3.6939
A2780 CTRP2 6.1662 10.2472 4.0436 8.174
OC 314 CTRP2 6.1969 7.1427 5.6166 1.5246
OV7 CTRP2 6.4346 10.9129 3.9272 8.1673
OV56 CTRP2 7.0787 8.1074 5.6948 0.325
TOV-21G CTRP2 7.2189 9.0708 5.3616 1.2448
OVK18 CTRP2 7.3794 12.7015 3.7521 7.3247
SNU-8 CTRP2 7.3856 9.5228 5.2548 1.4557
TYK-nu CTRP2 7.5099 9.3617 5.3892 0.909
FU-OV-1 CTRP2 7.5327 10.3478 4.9701 2.324
EFO-21 CTRP2 7.6181 9.3938 5.4285 0.7712
IGROV-1 CTRP2 7.6687 9.6592 5.344 0.9294
EFO-27 CTRP2 7.8031 9.9015 5.3096 0.9364
Caov-3 CTRP2 7.8576 9.2042 5.6039 0.2065
ONCO-DG-1 CTRP2 7.8922 9.4849 5.5142 0.3634
OVISE CTRP2 7.925 9.2886 5.5994 0.1951
COV644 CTRP2 7.9735 9.2751 5.6225 0.1492
ES2 CTRP2 7.9746 9.3093 5.6108 0.1653
DOV13 CTRP2 8.0626 9.5457 5.5598 0.2206
SNU-119 CTRP2 8.1103 16.3401 2.5002 11.0918
OAW28 CTRP2 8.1663 10.4853 5.2444 0.8838
HEY A8 CTRP2 8.1864 9.3572 5.6703 0.0632
COV362 CTRP2 8.2087 10.1463 5.396 0.4843
JHOM-1 CTRP2 8.2325 9.4868 5.6425 0.0875
COV434 CTRP2 8.2399 10.8368 5.1364 1.1418
Kuramochi CTRP2 8.2455 14.303 3.5739 6.7894
RMG-I CTRP2 8.2934 13.1065 4.1651 4.4625
SK-OV-3 CTRP2 8.2987 10.828 5.168 1.0121
OVCAR-4 CTRP2 8.3273 10.1537 5.442 0.3444
OVCAR-5 CTRP2 8.3688 9.8847 5.5544 0.1555
JHOS-2 CTRP2 8.4226 9.8971 5.5696 0.1274
SNU-840 CTRP2 8.4297 10.3728 5.4021 0.3843
JHOC-5 CTRP2 8.5338 10.0535 5.5556 0.1243
MCAS CTRP2 8.6934 10.2746 5.5366 0.1193
OVCAR-8 CTRP2 8.8384 10.5373 5.4981 0.137
OV-90 CTRP2 8.9165 10.8355 5.4229 0.2131
OVTOKO CTRP2 9.3612 16.1131 3.4322 5.9361
OVSAHO CTRP2 11.0027 19.3356 2.9346 5.919
⏷ Show the Full List of 40 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 23 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Yamato-SS CTRP2 7.4924 8.75 5.6253 0.2924
Aska-SS CTRP2 8.8308 16.3369 2.9939 8.2118
G-402 CTRP2 5.1131 9.5452 3.4681 12.7592
TE 441.T CTRP2 6.0576 9.2502 4.4525 6.6654
G-401 CTRP2 6.059 9.5857 4.2859 7.3623
KYM-1 CTRP2 6.1331 7.1328 5.5722 1.8198
MES-SA CTRP2 6.1704 7.4483 5.4445 2.2887
TE 617.T CTRP2 6.3083 8.8369 4.8615 4.4856
GCT CTRP2 6.3676 8.0611 5.2911 2.5946
A-204 CTRP2 6.5356 9.5761 4.6693 4.8981
TTC-709 CTRP2 6.8902 14.2152 2.6407 12.5654
BT-12 CTRP2 6.8967 8.0542 5.6295 0.6349
Rh18 CTRP2 7.229 9.6357 5.1136 2.1306
Hs 729.T CTRP2 7.3174 10.6728 4.6856 3.6707
HT-1080 CTRP2 7.3255 10.8903 4.5879 4.0454
RKN CTRP2 7.3377 9.6584 5.1675 1.8132
BT-16 CTRP2 7.7763 9.1197 5.6029 0.233
Tm87-16 CTRP2 7.9821 11.6463 4.6461 3.024
SK-LMS-1 CTRP2 8.0048 9.8385 5.427 0.5069
Rh41 CTRP2 8.0813 9.4274 5.6088 0.1443
SK-UT-1 CTRP2 8.7627 10.332 5.5414 0.1046
RD CTRP2 8.9458 10.7486 5.4638 0.1569
SW982 CTRP2 9.809 22.2946 0.8024 14.3747
⏷ Show the Full List of 23 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
U-CH1 CTRP2 8.1671 9.9119 5.467 0.3793
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MPP 89 CTRP2 6.6824 10.5046 4.3212 6.0999
MSTO-211H CTRP2 6.7343 10.2968 4.4622 5.4311
NCI-H28 CTRP2 6.8252 11.5044 3.9347 7.4616
NCI-H2452 CTRP2 7.6683 10.3852 5.0313 2.1075
IST-Mes1 CTRP2 7.7913 11.2661 4.7058 3.015
ACC-MESO-1 CTRP2 8.0919 9.3713 5.6322 0.1136
NCI-H2052 CTRP2 8.1792 10.1112 5.397 0.4953
JL-1 CTRP2 8.578 10.1634 5.5336 0.1519
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC CTRP2 6.7927 9.105 5.0839 2.8011
VCaP CTRP2 7.9192 9.6655 5.4568 0.4782
22Rv1 CTRP2 8.2185 19.1034 1.2263 15.4103
PaCa-3 CTRP2 8.5788 9.8151 5.6513 0.0412
DU145 CTRP2 8.6587 10.2246 5.5414 0.1197
Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 CTRP2 5.9576 7.6229 5.1817 3.7973
YD-15 CTRP2 7.7165 8.9451 5.6429 0.1827
Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ECC10 CTRP2 6.5439 9.6838 4.6223 5.0797
SNU-16 CTRP2 6.6376 9.1013 4.9777 3.4601
SNU-1 CTRP2 6.796 9.5065 4.8926 3.5687
SNU-5 CTRP2 6.9199 8.5095 5.4424 1.2576
GSU CTRP2 7.0837 7.7243 5.8382 0.0542
ECC12 CTRP2 7.1192 10.2909 4.7363 3.7372
OCUM-1 CTRP2 7.1375 9.5136 5.114 2.2362
NCI-N87 CTRP2 7.1401 13.4917 3.1898 9.9696
GSS CTRP2 7.1887 12.6454 3.6422 8.067
NUGC-3 CTRP2 7.2636 9.628 5.1378 2.0016
SH-10-TC CTRP2 7.4911 8.5687 5.6918 0.1667
MKN45 CTRP2 7.5575 8.3422 5.7943 0.0342
HGC-27 CTRP2 7.6213 11.9103 4.2986 4.7918
SNU-620 CTRP2 7.652 8.9549 5.614 0.2542
23132/87 CTRP2 7.8008 9.1401 5.605 0.2215
LMSU CTRP2 7.8108 11.8696 4.4393 4.0011
MKN7 CTRP2 7.8165 9.4699 5.4879 0.4881
SNU-668 CTRP2 7.8503 9.2555 5.5824 0.2457
NUGC-4 CTRP2 7.8924 14.3888 3.2939 8.3785
SNU-601 CTRP2 7.9896 9.7296 5.4622 0.434
AGS CTRP2 7.9989 13.0149 4.0223 5.3753
HuG1-N CTRP2 8.1205 10.0262 5.4045 0.5049
MKN1 CTRP2 8.1439 9.8671 5.4743 0.4014
Hs 746.T CTRP2 8.2432 11.6452 4.7945 2.2329
KATO III CTRP2 8.2656 10.4618 5.2989 0.6851
Fu97 CTRP2 8.2847 10.0853 5.4502 0.3437
SNU-719 CTRP2 8.2883 12.7953 4.3051 3.9441
SNU-216 CTRP2 8.3676 9.7714 5.5932 0.1107
IM95 CTRP2 8.5929 10.2182 5.52 0.1547
MKN74 CTRP2 9.2341 11.1918 5.4144 0.1632
KE-39 CTRP2 9.3822 11.4345 5.384 0.1722
SNU-685 CTRP2 6.7863 8.6024 5.3181 2.0222
SNG-M CTRP2 8.1761 9.8122 5.5073 0.2755
SNU-1077 CTRP2 9.3466 15.6156 3.6503 5.164
⏷ Show the Full List of 34 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 12 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
ML-1 [Human leukemia] CTRP2 6.3455 9.8664 4.3782 6.9198
FTC-133 CTRP2 6.4268 8.261 5.2363 2.928
SW579 CTRP2 6.6538 8.2979 5.3761 1.8277
FTC-238 CTRP2 7.147 8.9579 5.3716 1.2793
8305C CTRP2 7.3139 8.8402 5.5092 0.6901
CGTH-W-1 CTRP2 7.383 8.9263 5.5071 0.6488
8505C CTRP2 7.4973 11.6122 4.3583 4.7227
B-CPAP CTRP2 7.7381 9.9178 5.2707 1.1013
BHT-101 CTRP2 7.8153 9.7304 5.3849 0.7155
CAL-62 CTRP2 8.2007 9.603 5.5912 0.1426
TT2609-C02 CTRP2 8.425 13.2704 4.1699 4.2915
TT CTRP2 11.2063 21.9365 1.8771 9.1846
⏷ Show the Full List of 12 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PE/CA-PJ34 (clone C12) CTRP2 6.2508 7.7683 5.3478 2.5528
PE/CA-PJ15 CTRP2 6.7825 10.4715 4.4118 5.5616
HSC-4 CTRP2 7.0155 9.485 5.0504 2.6333
BICR 6 CTRP2 7.091 8.5144 5.534 0.8405
SCC-25 CTRP2 7.1444 9.3093 5.2121 1.8592
PE/CA-PJ41 (clone D2) CTRP2 7.351 10.1905 4.9327 2.6714
CAL-33 CTRP2 7.4067 11.3008 4.4464 4.4966
SNU-1214 CTRP2 7.411 10.8935 4.6422 3.7187
SCC-9 CTRP2 7.4277 9.574 5.2555 1.4136
BICR 31 CTRP2 7.4511 10.9075 4.6614 3.5923
YD-10B CTRP2 7.5774 9.251 5.4672 0.6365
PE/CA-PJ49 CTRP2 7.6199 8.9456 5.6044 0.2848
BICR 18 CTRP2 7.6273 11.234 4.6202 3.5315
BICR 22 CTRP2 7.6328 9.6668 5.323 1.0198
FaDu CTRP2 7.6585 9.9469 5.2174 1.3359
HSC-2 CTRP2 7.8035 9.0805 5.6276 0.1833
SNU-1076 CTRP2 7.9039 9.1819 5.6295 0.1552
SNU-899 CTRP2 7.9928 9.1661 5.6674 0.0914
Detroit 562 CTRP2 8.0106 17.8635 1.6827 14.1997
CAL-27 CTRP2 8.0667 9.4198 5.6061 0.151
SNU-1066 CTRP2 8.1716 9.7187 5.5394 0.2233
SCC-4 CTRP2 8.2026 9.67 5.5684 0.1724
BHY CTRP2 8.3842 9.7622 5.6022 0.099
YD-8 CTRP2 8.4028 13.7758 3.9228 5.2481
BICR 56 CTRP2 8.4586 9.8038 5.6141 0.0783
SNU-1041 CTRP2 8.5611 15.4197 3.2517 7.6015
SNU-46 CTRP2 8.594 15.4744 3.2473 7.5743
BICR 16 CTRP2 8.6056 10.0161 5.5935 0.0784
HSC-3 CTRP2 12.1965 25.89 0.6598 11.7819
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
J82 CTRP2 6.5923 8.7179 5.1322 2.8972
JMSU-1 CTRP2 6.6537 9.3884 4.849 3.9638
639V CTRP2 6.7431 8.8988 5.1491 2.6091
253J CTRP2 6.8697 10.6413 4.3922 5.5037
647V CTRP2 7.0755 8.4148 5.5682 0.6867
U-BLC1 CTRP2 7.2774 9.4894 5.2086 1.7278
BC-3C CTRP2 7.3644 11.0182 4.5528 4.1321
KU-19-19 CTRP2 7.5263 8.8114 5.6162 0.2976
BFTC-905 CTRP2 7.5906 9.1573 5.5105 0.5144
UM-UC-1 CTRP2 7.6075 10.5122 4.9395 2.3549
HT-1376 CTRP2 7.7029 10.7492 4.8882 2.4398
SCaBER CTRP2 7.7495 9.0911 5.6027 0.2419
253J-BV CTRP2 7.8809 9.1739 5.6236 0.1693
CAL-29 CTRP2 7.9114 9.3053 5.5881 0.2171
HT-1197 CTRP2 8.0742 9.6521 5.5257 0.2753
RT-112 CTRP2 8.1375 11.3907 4.8482 2.1475
TCCSUP CTRP2 8.2131 14.0869 3.6551 6.5185
T24 CTRP2 8.3026 14.2614 3.631 6.4929
RT-4 CTRP2 8.3411 15.4483 3.0914 8.5148
UM-UC-3 CTRP2 8.4187 10.265 5.4374 0.3223
5637 CTRP2 8.4744 16.9899 2.4406 10.7655
KMBC-2 CTRP2 8.6474 10.4201 5.4693 0.2093
SW1710 CTRP2 8.6805 10.1536 5.5732 0.0867
VM-CUB-1 CTRP2 10.1849 17.4598 3.3064 5.4865
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HeLa CTRP2 7.8975 8.6482 5.8068 0.01

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Carboplatin (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Remdesivir DMBFZ6L Moderate Decreased renal excretion of Carboplatin caused by Remdesivir mediated nephrotoxicity. 1D6YCoronavirus Disease 2019 [1D6YCoronavirus Disease 2019] [11]
Framycetin DMF8DNE Moderate Increased risk of nephrotoxicity by the combination of Carboplatin and Framycetin. Alcoholic liver disease [DB94] [12]
Inotersen DMJ93CT Major Increased risk of nephrotoxicity by the combination of Carboplatin and Inotersen. Amyloidosis [5D00] [13]
Roflumilast DMPGHY8 Moderate Additive immunosuppressive effects by the combination of Carboplatin and Roflumilast. Asthma [CA23] [13]
Ofloxacin DM0VQN3 Minor Decreased absorption of Carboplatin due to intestinal mucosa variation caused by Ofloxacin. Bacterial infection [1A00-1C4Z] [14]
Kanamycin DM2DMPO Moderate Increased risk of nephrotoxicity by the combination of Carboplatin and Kanamycin. Bacterial infection [1A00-1C4Z] [12]
Sparfloxacin DMB4HCT Minor Decreased absorption of Carboplatin due to intestinal mucosa variation caused by Sparfloxacin. Bacterial infection [1A00-1C4Z] [14]
Streptomycin DME1LQN Moderate Increased risk of nephrotoxicity by the combination of Carboplatin and Streptomycin. Bacterial infection [1A00-1C4Z] [12]
Gemifloxacin DMHT34O Minor Decreased absorption of Carboplatin due to intestinal mucosa variation caused by Gemifloxacin. Bacterial infection [1A00-1C4Z] [14]
Norfloxacin DMIZ6W2 Minor Decreased absorption of Carboplatin due to intestinal mucosa variation caused by Norfloxacin. Bacterial infection [1A00-1C4Z] [14]
ABT-492 DMJFD2I Minor Decreased absorption of Carboplatin due to intestinal mucosa variation caused by ABT-492. Bacterial infection [1A00-1C4Z] [14]
Rabeprazole DMMZXIW Moderate Increased risk of hypomagnesemia by the combination of Carboplatin and Rabeprazole. Bacterial infection [1A00-1C4Z] [15]
Levofloxacin DMS60RB Minor Decreased absorption of Carboplatin due to intestinal mucosa variation caused by Levofloxacin. Bacterial infection [1A00-1C4Z] [14]
Lomefloxacin DMVRH9C Minor Decreased absorption of Carboplatin due to intestinal mucosa variation caused by Lomefloxacin. Bacterial infection [1A00-1C4Z] [14]
Anisindione DM2C48U Moderate Increased plasma concentration of Carboplatin and Anisindione due to competitive binding of plasma proteins. Coagulation defect [3B10] [16]
Dexlansoprazole DM1DBV5 Moderate Increased risk of hypomagnesemia by the combination of Carboplatin and Dexlansoprazole. Gastro-oesophageal reflux disease [DA22] [15]
Brentuximab vedotin DMWLC57 Moderate Increased risk of peripheral neuropathy by the combination of Carboplatin and Brentuximab vedotin. Hodgkin lymphoma [2B30] [17]
Teriflunomide DMQ2FKJ Major Additive myelosuppressive effects by the combination of Carboplatin and Teriflunomide. Hyper-lipoproteinaemia [5C80] [18]
Denosumab DMNI0KO Moderate Additive myelosuppressive effects by the combination of Carboplatin and Denosumab. Low bone mass disorder [FB83] [19]
Thalidomide DM70BU5 Major Additive thrombogenic effects by the combination of Carboplatin and Thalidomide. Multiple myeloma [2A83] [20]
Tecfidera DM2OVDT Moderate Additive immunosuppressive effects by the combination of Carboplatin and Tecfidera. Multiple sclerosis [8A40] [21]
Siponimod DM2R86O Major Additive immunosuppressive effects by the combination of Carboplatin and Siponimod. Multiple sclerosis [8A40] [11]
Fingolimod DM5JVAN Major Additive immunosuppressive effects by the combination of Carboplatin and Fingolimod. Multiple sclerosis [8A40] [22]
Ocrelizumab DMEZ2KH Moderate Additive immunosuppressive effects by the combination of Carboplatin and Ocrelizumab. Multiple sclerosis [8A40] [23]
Ozanimod DMT6AM2 Major Additive immunosuppressive effects by the combination of Carboplatin and Ozanimod. Multiple sclerosis [8A40] [13]
Omacetaxine mepesuccinate DMPU2WX Moderate Additive immunosuppressive effects by the combination of Carboplatin and Omacetaxine mepesuccinate. Myeloproliferative neoplasm [2A20] [24]
Gatifloxacin DMSL679 Minor Decreased absorption of Carboplatin due to intestinal mucosa variation caused by Gatifloxacin. Respiratory infection [CA07-CA4Z] [14]
Canakinumab DM8HLO5 Moderate Additive immunosuppressive effects by the combination of Carboplatin and Canakinumab. Rheumatoid arthritis [FA20] [25]
Rilonacept DMGLUQS Moderate Additive immunosuppressive effects by the combination of Carboplatin and Rilonacept. Rheumatoid arthritis [FA20] [25]
Golimumab DMHZV7X Major Additive immunosuppressive effects by the combination of Carboplatin and Golimumab. Rheumatoid arthritis [FA20] [26]
Leflunomide DMR8ONJ Major Additive myelosuppressive effects by the combination of Carboplatin and Leflunomide. Rheumatoid arthritis [FA20] [18]
Anthrax vaccine DM9GSWY Moderate Antagonize the effect of Carboplatin when combined with Anthrax vaccine. Sepsis [1G40-1G41] [27]
Azathioprine DMMZSXQ Moderate Additive myelosuppressive effects by the combination of Carboplatin and Azathioprine. Transplant rejection [NE84] [11]
Ganciclovir DM1MBYQ Moderate Additive myelosuppressive effects by the combination of Carboplatin and Ganciclovir. Virus infection [1A24-1D9Z] [11]
Valganciclovir DMS2IUH Moderate Additive myelosuppressive effects by the combination of Carboplatin and Valganciclovir. Virus infection [1A24-1D9Z] [11]
⏷ Show the Full List of 35 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Mannitol E00103 6251 Diluent; Flavoring agent; Lyophilization aid; Plasticizing agent; Tonicity agent
Water E00035 962 Solvent
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Carboplatin 50mg/5ml injectable 50mg/5ml Injectable Injection
Carboplatin 50mg/5ml injectable 50mg/5ml Injectable Intravenous
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 Carboplatin FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7624).
3 Dailymed: Carboplatin Intravenous Injection
4 BDDCS applied to over 900 drugs
5 Oguri S, Sakakibara T, Mase H, Shimizu T, Ishikawa K, Kimura K, Smyth RD: Clinical pharmacokinetics of carboplatin. J Clin Pharmacol. 1988 Mar;28(3):208-15. doi: 10.1002/j.1552-4604.1988.tb03134.x.
6 Shin JM, Kim N: Pharmacokinetics and pharmacodynamics of the proton pump inhibitors. J Neurogastroenterol Motil. 2013 Jan;19(1):25-35. doi: 10.5056/jnm.2013.19.1.25. Epub 2013 Jan 8.
7 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
8 Inhibition of carboplatin-induced DNA interstrand cross-link repair by gemcitabine in patients receiving these drugs for platinum-resistant ovarian cancer.Clin Cancer Res.2010 Oct 1;16(19):4899-905.
9 Overcoming platinum drug resistance with copper-lowering agents. Anticancer Res. 2013 Oct;33(10):4157-61.
10 PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150642262)
11 Cerner Multum, Inc. "Australian Product Information.".
12 Product Information. Paraplatin (carboplatin). Bristol-Myers Squibb, Princeton, NJ.
13 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
14 Johnson EJ, MacGowan AP, Potter MN, et al "Reduced absorption of oral ciprofloxacin after chemotherapy for haematological malignancy." J Antimicrob Chemother 25 (1990): 837-42. [PMID: 2373666]
15 FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Low magnesium levels can be associated with long-term use of proton pump inhibitor drugs (PPIs).".
16 Le AT, Hasson NK, Lum BL "Enhancement of warfarin response in a patient receiving etoposide and carboplatin chemotherapy." Ann Pharmacother 31 (1997): 1006-8. [PMID: 9296241]
17 Carrion C, Espinosa E, Herrero A, Garcia B "Possible vincristine-isoniazid interaction." Ann Pharmacother 29 (1995): 201. [PMID: 7756727]
18 Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
19 Product Information. Prolia (denosumab). Amgen USA, Thousand Oaks, CA.
20 Bennett CL, Nebeker JR, Samore MH, et al "The Research on Adverse Drug Events and Reports (RADAR) project." JAMA 293 (2005): 2131-40. [PMID: 15870417]
21 Product Information. Vumerity (diroximel fumarate). Alkermes, Inc, Cambridge, MA.
22 Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
23 Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
24 Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
25 Product Information. Arcalyst (rilonacept). Regeneron Pharmaceuticals Inc, Tarrytown, NY.
26 Product Information. Cimzia (certolizumab). UCB Pharma Inc, Smyrna, GA.
27 CDC. Centers for Disease Control and Prevention/ "Recommendations of the advisory committtee on immunization practices (ACIP): use of vaccines and immune globulins in persons with altered immunocompetence." MMWR Morb Mortal Wkly Rep 42(RR-04) (1993): 1-18. [PMID: 20300058]