Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DEKEDRC)

• DME Name: Cytidine aminohydrolase (CDA) DME Info
• Gene Name: CDA

Molecule-Related Drug & Molecule List

5 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[1]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[2]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[3]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[4]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[5]

References

• [1] A pilot pharmacokinetic study of oral azacitidine. Leukemia. 2008 Sep;22(9):1680-4.
• [2] Augmentation of the antitumor activity of capecitabine by a tumor selective dihydropyrimidine dehydrogenase inhibitor, RO0094889. Int J Cancer. 2003 Sep 20;106(5):799-805.
• [3] Genetic factors influencing cytarabine therapy. Pharmacogenomics. 2009 Oct;10(10):1657-74.
• [4] Tracking decitabine incorporation into malignant myeloid cell DNA in vitro and in vivo by LC-MS/MS with enzymatic digestion. Sci Rep. 2019 Mar 14;9(1):4558.
• [5] Equilibrative nucleoside transporter 1 genotype, cytidine deaminase activity and age predict gemcitabine plasma clearance in patients with solid tumours. Br J Clin Pharmacol. 2011 Mar;71(3):437-44.