Details of the Drug

General Information of Drug (ID: DMTA5OE)

• Drug Name: Azacitidine
• Synonyms: Azacitidina; Azacitidinum; Azacytidine; Ladakamycin; Mylosar; Vidaza; Mylo sar; Pharmion Brand of Azacitidine;A 2385; Antibiotic U 18496; U 18496; Wr 183027; Azacitidina [INN-Spanish]; Azacitidine [USAN:INN]; Azacitidinum [INN-Latin]; NS-17; Pyrimidine antimetabolite: inhibits nucleic acid replication; U-18496; Vidaz (TN); Vidaza (TN); WR-183027; Azacitidine (JAN/USAN/INN); S-Triazin-2(1H)-one, 4-amino-1-beta-D-ribofuranosyl-(8CI); 2-(beta-D-Ribofuranosyl)-4-amino-1,3,5-triazin-2-one; 4-Amino-1-(beta-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one; 4-Amino-1-beta-D-ribofuranosyl-1,3,5-traizin-2(1H)-one; 4-Amino-1-beta-D-ribofuranosyl-1,3,5-triazine-2(1H)-one; 4-Amino-1-beta-D-ribofuranosyl-s-triazin-2(1H)-one; 4-Amino-1-beta-d-ribofuranosyl-1,3,5-triazin-2(1H)-one; 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triaz; 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one; 4-amino-1-beta-L-ribofuranosyl-1,3,5-triazin-2(1H)-one; 5 AZC; 5 Azacytidine; 5-AC; 5-AZAC; 5-AZCR; 5-aza-CR; 5-azacitidine; 5-azacytidine; 5-azacytidine, Mylosar, Ladakamycin, Vidaza, Azacitidine; 5AzaC

Indication

Disease Entry	ICD 11	Status	REF
Acute myelogenous leukaemia	2A41	Approved	[1]
Chronic myelomonocytic leukemia	N.A.	Approved	[1]
Leukemia	N.A.	Approved	[1]
Myelodysplastic syndrome	2A37	Approved	[2]
Myeloproliferative neoplasm	2A20	Approved	[1]
Plasma cell myeloma	2A83.1	Approved	[1]

• Therapeutic Class: Anticancer Agents
• Affected Organisms: Humans and other mammals
• ATC Code:
  L01BC07: Azacitidine
  L01BC: Pyrimidine analogues
  L01B: ANTIMETABOLITES
  L01: ANTINEOPLASTIC AGENTS
  L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 1:
  Molecular Weight (mw); 244.2
  Logarithm of the Partition Coefficient (xlogp); -2.2
  Rotatable Bond Count (rotbonds); 2
  Hydrogen Bond Donor Count (hbonddonor); 4
  Hydrogen Bond Acceptor Count (hbondacc); 5
• ADMET Property:
  BDDCS Class: Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 3: high solubility and low permeability [3]
  Clearance: The clearance of drug is 167 +/- 49 L/h []
  Elimination: 62% of drug is excreted from urine in the unchanged form [3]
  Half-life: The concentration or amount of drug in body reduced by one-half in 4 hours [4]
  Metabolism: The drug is metabolized via the liver []
  MRTD: The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 177.10271 micromolar/kg/day [5]
  Vd: The volume of distribution (Vd) of drug is 76 +/- 26 L []
  Water Solubility: The ability of drug to dissolve in water is measured as 89 mg/mL [3]
• Chemical Identifiers:
  Formula: C8H12N4O5
  IUPAC Name: 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
  Canonical SMILES: C1=NC(=NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)N
  InChI: InChI=1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1
  InChIKey: NMUSYJAQQFHJEW-KVTDHHQDSA-N
• Cross-matching ID:
  PubChem CID: 9444
  ChEBI ID: CHEBI:2038
  CAS Number: 320-67-2
  UNII: M801H13NRU
  DrugBank ID: DB00928
  TTD ID: D09FAZ
  VARIDT ID: DR00983
  INTEDE ID: DR0163
• Repurposed Drugs (RPD): Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
DNA [cytosine-5]-methyltransferase (DNMT)	TTHVCUP	NOUNIPROTAC	Inhibitor	[6]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytidine aminohydrolase (CDA)	DEKEDRC	CDD_HUMAN	Substrate	[7]
Cytidine deaminase (cdd)	DEYILK4	E0TLJ6_MYCHH	Substrate	[8]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1)	OT9HYT7A	PLCB1_HUMAN	Gene/Protein Processing	[9]
15-hydroxyprostaglandin dehydrogenase (HPGD)	OTYZI6JB	PGDH_HUMAN	Post-Translational Modifications	[10]
5'-nucleotidase (NT5E)	OT7J5LT6	5NTD_HUMAN	Gene/Protein Processing	[11]
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1)	OTTLJH8W	ATS1_HUMAN	Gene/Protein Processing	[11]
Acyl-CoA 6-desaturase (FADS2)	OTUX531P	FADS2_HUMAN	Gene/Protein Processing	[11]
Adenylate kinase isoenzyme 5 (AK5)	OTTGXLOT	KAD5_HUMAN	Gene/Protein Processing	[11]
Afadin- and alpha-actinin-binding protein (SSX2IP)	OTEIZ7N1	ADIP_HUMAN	Gene/Protein Processing	[11]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Gene/Protein Processing	[12]
Alpha-2,8-sialyltransferase 8B (ST8SIA2)	OTRBBBD8	SIA8B_HUMAN	Gene/Protein Processing	[11]
Alpha-fetoprotein (AFP)	OT9GG3ZI	FETA_HUMAN	Gene/Protein Processing	[12]

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 50 Cell Line(s) in Bone Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
RPMI-3460/CS1	GDSC2	4.2461	6.7261	3.0561	8.2359
TC-71	GDSC2	1.1126	3.2606	1.0419	32.5576
MG-63	GDSC2	1.9458	7.633	0.4263	31.2233
HOS	GDSC2	2.2649	6.1589	1.4028	25.2846
ES1	GDSC2	2.3669	6.7659	1.2428	25.676
EW-3	GDSC2	2.4505	17.99	-4.1282	39.5844
CAL-72	GDSC2	2.5159	6.4809	1.5214	23.5967
NOS-1 [Human HNSCC]	GDSC2	2.7182	6.9583	1.5091	22.8432
A-673	GDSC2	2.859	6.1993	1.9961	19.5595
U2OS	CTRP2	2.9081	8.2669	1.8348	24.7355
ES8	GDSC2	3.3449	6.8156	2.19	16.5823
CHSA8926	GDSC2	3.8601	10.1676	1.0058	21.3454
SK-ES-1	GDSC2	3.9015	7.5542	2.3433	13.7529
H-EMC-SS	GDSC2	3.9526	6.7239	2.8008	10.755
G-292 clone A141B1	GDSC2	4.0153	10.4908	0.9784	20.9829
SK-PN-DW	GDSC2	4.3381	5.988	3.5024	5.142
EW-22	GDSC2	4.3519	8.5757	2.2199	13.1158
NY	GDSC2	4.4158	12.1194	0.5011	21.9774
EW-1	GDSC2	4.4524	6.3579	3.4106	5.4018
SJSA-1	GDSC2	4.4669	9.6225	1.7914	15.2906
MHH-ES-1	GDSC2	4.5891	8.7127	2.345	11.6807
CADO-ES1	GDSC2	4.6017	7.8574	2.7816	8.9545
ES4	GDSC2	4.6408	8.3812	2.5515	10.2751
U2OS	GDSC2	4.6746	7.2968	3.1172	6.6596
SaOS-2	GDSC2	4.7473	9.2545	2.2005	12.1152
HuO-3N1	GDSC2	5.0348	10.4848	1.8126	13.5983
ES6	GDSC2	5.0417	9.1768	2.4651	9.7578
EW-11	GDSC2	5.0744	8.6432	2.7518	7.9336
EW-7	GDSC2	5.1318	7.4916	3.3506	4.1553
EW-24	GDSC2	5.2173	7.5195	3.3935	3.7275
CAL-78	GDSC2	5.2909	8.0256	3.202	4.7167
MHH-ES-1	CTRP2	5.291	6.5484	5.0454	5.9246
EW-16	GDSC2	5.5799	9.5196	2.682	7.2108
ES7	GDSC2	5.8497	8.9019	3.1452	4.0025
A-673	CTRP2	5.8631	6.746	5.533	2.5271
EW-18	GDSC2	6.0281	8.3064	3.5077	1.8357
SK-ES-1	CTRP2	6.0862	7.1146	5.5437	2.0254
CAL-78	CTRP2	6.1235	7.2173	5.5225	2.0459
Hs 888.T	CTRP2	6.143	8.1041	5.0955	3.8023
G-292 clone A141B1	CTRP2	6.2094	8.0963	5.1524	3.4427
HuO9	GDSC2	6.2747	12.8966	1.5328	12.1506
TC71	CTRP2	6.5212	7.7923	5.5287	1.4014
SaOS-2	CTRP2	6.5917	9.417	4.7896	4.3075
SJSA-1	CTRP2	6.674	8.2472	5.4131	1.6559
Hs 822.T	CTRP2	6.7206	9.7284	4.7311	4.344
EW-13	GDSC2	6.7924	8.5133	3.7625	0.3285
SK-N-MC	CTRP2	6.8196	7.9808	5.6204	0.7309
HOS	CTRP2	6.9812	11.3057	4.1478	6.3319
MG-63	CTRP2	7.1617	9.1913	5.2757	1.6064
SW1353	CTRP2	8.8286	15.4472	3.4113	6.652

Cancer Drug Sensitivity Data Curated from 258 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
JK1	CTRP2	5.4158	7.3989	4.7917	6.619
MEC1	CTRP2	5.5452	6.245	5.4341	3.7277
JM1	CTRP2	4.4534	5.6336	4.4005	10.7799
SU-DHL-5	GDSC2	-1.2891	0.3653	-1.29	56.2884
P32/ISH	GDSC2	-1.2561	1.8282	-1.3079	55.6326
OCI-M1	GDSC2	-0.4029	2.9708	-0.5382	47.6085
KY821	GDSC2	-0.3592	2.2034	-0.4006	47.0595
Mono-Mac-6	GDSC2	-0.1485	1.5213	-0.1527	44.8767
KMS-12-BM	GDSC2	-0.1138	3.8569	-0.4003	45.1758
697	GDSC2	-0.1065	3.1768	-0.2533	44.8302
WSU-DLCL2	GDSC2	-0.0668	4.1816	-0.43	44.8938
Jiyoye	GDSC2	0.03	8.5999	-1.9595	46.0979
MOLM-13	GDSC2	0.2795	2.9384	0.1966	40.8987
SUP-M2	GDSC2	0.3152	3.622	0.1185	40.9415
KE-37	GDSC2	0.4226	3.4404	0.2707	39.7481
BL-41	GDSC2	0.5087	4.1961	0.1942	39.4927
Namalwa	GDSC2	0.707	4.9759	0.1807	38.3669
H9	GDSC2	0.7087	2.4252	0.6935	36.3333
ATN-1	GDSC2	0.7615	2.4274	0.7478	35.7965
IM-9	GDSC2	0.762	2.9954	0.7025	36.0086
JURL-MK1	GDSC2	0.8066	5.8594	-0.0218	38.4494
SU-DHL-10	GDSC2	0.8946	3.6515	0.741	35.1196
EoL-1	GDSC2	0.9234	2.553	0.9084	34.1795
SU-DHL-8	GDSC2	0.9273	2.898	0.8875	34.2617
SCC-3	GDSC2	0.9495	5.4725	0.2736	36.6879
OCI-AML-2	GDSC2	1.0115	3.4223	0.9091	33.7205
KOPN-8	GDSC2	1.0623	3.4367	0.9613	33.2075
WSU-NHL	GDSC2	1.0721	5.1942	0.5039	35.1606
GDM-1	GDSC2	1.0901	2.7821	1.0673	32.5454
HL-60	GDSC2	1.094	3.0412	1.0488	32.6176
EM-2	GDSC2	1.101	3.1518	1.0436	32.608
DB	GDSC2	1.1139	5.1387	0.5682	34.6804
MEG-01	GDSC2	1.1333	2.9961	1.0948	32.1905
A3/Kawakami	GDSC2	1.2796	3.9212	1.1019	31.4165
VAL	GDSC2	1.3052	6.5418	0.2392	34.9528
BC-1	GDSC2	1.3295	3.5835	1.2241	30.5601
MV4-11	GDSC2	1.3423	3.1789	1.2963	30.1327
ST486	GDSC2	1.4822	4.0653	1.289	29.4785
OCI-AML-3	GDSC2	1.5392	4.352	1.2768	29.2622
BALL-1	GDSC2	1.5835	4.5099	1.28	29.0312
SR	GDSC2	1.6161	4.1152	1.4227	28.1455
BV-173	GDSC2	1.6773	4.4628	1.3962	27.9881
Karpas-299	GDSC2	1.7016	2.7957	1.6965	26.3212
NCI-H929	GDSC2	1.7438	4.2497	1.5277	26.9896
JJN-3	GDSC2	1.7689	4.9456	1.3435	27.8247
WIL2 NS	GDSC2	1.7854	4.3874	1.5356	26.7511
SU-DHL-6	GDSC2	1.7992	4.1573	1.612	26.2857
MOLT-16	GDSC2	1.8114	3.2155	1.7867	25.3186
Ramos.2G6.4C10	GDSC2	1.8607	4.5789	1.5616	26.2609
DEL	GDSC2	1.9116	8.6588	-0.0792	33.2424
RPMI-8226	GDSC2	1.928	5.0763	1.4705	26.4283
ML-2	GDSC2	1.9772	4.6808	1.6567	25.2168
OPM-2	GDSC2	2.0725	4.5657	1.7964	24.0304
Karpas-620	GDSC2	2.0754	5.6875	1.3979	26.141
LAMA-84	GDSC2	2.1145	4.3605	1.9023	23.2665
Ku812	GDSC2	2.1314	4.4522	1.8945	23.2305
GR-ST	GDSC2	2.1481	6.7054	1.0461	27.5893
DG-75	GDSC2	2.1753	4.5361	1.9175	22.9054
MOLT-13	GDSC2	2.1847	4.8303	1.8332	23.3208
MLMA	GDSC2	2.1967	5.0135	1.7828	23.5422
KCL-22	GDSC2	2.2057	6.3881	1.2433	26.3623
CML-T1	GDSC2	2.2078	5.4033	1.65	24.2152
ALL-PO	GDSC2	2.208	5.6946	1.5354	24.8305
RPMI-8866	GDSC2	2.2218	6.5642	1.1836	26.5936
ARH-77	GDSC2	2.2497	5.8615	1.5115	24.7766
SUP-T1	GDSC2	2.3012	4.844	1.9548	22.1339
KG-1	GDSC2	2.3045	4.9614	1.9176	22.3237
Loucy	GDSC2	2.3098	6.8288	1.1566	26.3511
JSC-1	GDSC2	2.3101	5.0221	1.902	22.3854
SUP-B15	GDSC2	2.3217	4.704	2.0239	21.662
NOMO-1	GDSC2	2.3328	4.5638	2.0805	21.3016
P30/OHK	GDSC2	2.3425	4.7627	2.027	21.5519
K-562	GDSC2	2.3669	6.5504	1.3384	25.1854
P31/FUJ	GDSC2	2.438	4.293	2.2737	19.7691
Jurkat	GDSC2	2.4425	4.8546	2.1042	20.6809
U-698-M	GDSC2	2.4668	8.0076	0.772	27.5278
CA46	GDSC2	2.4883	5.6555	1.8468	21.9236
DND-41	GDSC2	2.5555	4.6285	2.3025	19.0788
BE-13	GDSC2	2.592	5.5664	1.9924	20.6677
JVM-3	GDSC2	2.6433	7.4266	1.2175	24.6697
NALM-6	GDSC2	2.7245	5.105	2.3161	18.2668
KMOE-2	GDSC2	2.7249	5.1984	2.2805	18.4684
ME1	GDSC2	2.7885	6.2739	1.8911	20.4412
RS4;11	GDSC2	2.8029	6.35	1.8716	20.4948
Karpas-422	GDSC2	2.8038	5.3432	2.3065	17.9888
HAL-01	GDSC2	2.8187	5.6685	2.1869	18.6185
YT	GDSC2	2.8746	5.2312	2.4264	17.0022
LC4-1	GDSC2	2.8818	5.4484	2.3454	17.4417
PF-382	GDSC2	2.8942	5.6741	2.2629	17.8708
OCI-AML-5	GDSC2	2.905	5.0346	2.5358	16.2454
Karpas-1106P	GDSC2	2.9451	5.6479	2.3268	17.2933
A4/Fukuda	GDSC2	2.9594	5.6368	2.3464	17.1211
NKM-1	GDSC2	2.9654	5.5937	2.3711	16.9523
ALL-SIL	CTRP2	3.0517	4.041	3.0505	19.9419
VL51	GDSC2	3.0575	5.7717	2.3886	16.4829
MN-60	GDSC2	3.0585	5.9957	2.2898	17.0627
CCRF-CEM	GDSC2	3.0652	5.9141	2.3331	16.7806
SUP-HD1	GDSC2	3.1143	6.3903	2.1654	17.583
L-1236	GDSC2	3.1188	6.2023	2.2566	17.0265
JVM-2	GDSC2	3.1282	6.0144	2.3517	16.4262
HDLM-2	GDSC2	3.2527	6.008	2.4795	15.188
P12-Ichikawa	GDSC2	3.2671	6.5711	2.2311	16.6215
GA-10	GDSC2	3.3242	11.5078	-0.133	28.0258
Raji	GDSC2	3.5962	6.2779	2.6886	12.6579
L-363	GDSC2	3.6109	5.4896	3.0754	10.2359
EB2	GDSC2	3.6522	7.4683	2.1608	15.6809
KM-H2	GDSC2	3.6625	7.5595	2.1254	15.8577
MOLT-4	GDSC2	3.7054	5.3641	3.2273	8.9595
TUR	GDSC2	3.7578	6.8991	2.5376	13.0323
OPM-2	CTRP2	3.7883	5.2395	3.7463	15.1725
OCI-AML-2	CTRP2	3.8035	5.1462	3.7731	15.0317
EJM	GDSC2	3.8035	7.2074	2.4273	13.5584
NU-DHL-1	CTRP2	3.8172	6.0111	3.6228	15.5167
Karpas-231	GDSC2	3.9448	5.6721	3.3115	7.5851
KE-37	CTRP2	3.9905	4.7713	3.9883	13.6909
MOLP-8	GDSC2	4.0306	6.7132	2.8756	10.0364
THP-1	CTRP2	4.0394	5.6	3.9596	13.6306
MHH-CALL-2	GDSC2	4.0661	8.1558	2.1878	14.1737
RPMI-6666	GDSC2	4.0709	7.3101	2.6138	11.547
Reh	GDSC2	4.0764	6.3028	3.1201	8.3541
CESS	GDSC2	4.0838	5.9626	3.2956	7.2251
SU-DHL-1	CTRP2	4.1138	4.9054	4.1105	12.8728
L-540	GDSC2	4.1593	6.1563	3.2659	7.174
MHH-PREB-1	GDSC2	4.1862	6.1797	3.2776	7.0175
KM-H2	CTRP2	4.1903	5.4016	4.1534	12.4772
REC-1	CTRP2	4.2104	9.9757	2.3993	19.1573
EoL-1	CTRP2	4.2457	5.5655	4.1884	12.1785
ALL-SIL	GDSC2	4.2466	7.0688	2.8852	9.3118
NU-DUL-1	CTRP2	4.2736	5.5377	4.2229	11.9697
Hs 445	GDSC2	4.3062	5.8616	3.539	5.0032
CTV-1	GDSC2	4.3365	6.067	3.4615	5.4056
SK-MM-2	CTRP2	4.3457	5.6966	4.2726	11.5676
MM1.S	GDSC2	4.3826	6.0421	3.5119	4.9548
TK [Human B-cell lymphoma]	GDSC2	4.4469	6.9827	3.0942	7.4157
Karpas-620	CTRP2	4.457	11.4428	1.9301	20.3145
NCO2	CTRP2	4.4839	5.9079	4.3766	10.7682
RPMI-8402	GDSC2	4.4866	6.6761	3.2791	6.1389
Granta-519	GDSC2	4.4953	6.9131	3.1678	6.8175
Mono-Mac-1	CTRP2	4.5016	7.031	4.0169	12.0615
Daudi	GDSC2	4.5448	6.6616	3.3323	5.6472
A4/Fukuda	CTRP2	4.5501	5.6549	4.5011	10.1224
RC-K8	GDSC2	4.5642	7.5644	2.8979	8.3282
Ri-1	CTRP2	4.5866	6.6111	4.2694	10.8592
MOLM-13	CTRP2	4.6128	6.3277	4.3964	10.308
SU-DHL-8	CTRP2	4.6426	5.9117	4.5487	9.6646
KMS-18	CTRP2	4.6483	5.9339	4.5495	9.6437
SU-DHL-6	CTRP2	4.6639	5.6621	4.6223	9.3389
SK-MM-2	GDSC2	4.6791	6.6974	3.4172	4.7699
GA-10	CTRP2	4.7198	5.9057	4.6342	9.1211
L-428	GDSC2	4.7954	8.0925	2.8153	8.234
Karpas-45	GDSC2	4.7976	8.4331	2.6481	9.263
SR	CTRP2	4.7981	5.8142	4.7395	8.5041
DEL	CTRP2	4.8329	5.393	4.8285	8.0861
HC-1	GDSC2	4.841	7.817	2.9858	7.0592
MOLM-6	CTRP2	4.8425	6.0388	4.7342	8.3858
Pfeiffer	CTRP2	4.847	5.8115	4.7931	8.1621
Granta-519	CTRP2	4.8554	6.5788	4.5698	8.9588
RPMI-8226	CTRP2	4.8973	6.027	4.7973	7.9914
Ki-JK	CTRP2	4.9331	6.0826	4.8209	7.7975
Hs 611.T	CTRP2	4.9379	6.6457	4.6323	8.4892
Daudi	CTRP2	4.964	5.9753	4.8834	7.478
KE-97	CTRP2	4.9699	6.467	4.7343	8.011
MV4-11	CTRP2	4.9869	6.1012	4.8744	7.4407
BV-173	CTRP2	4.9886	6.4233	4.7703	7.8216
EM-2	CTRP2	5.03	6.4877	4.7911	7.6248
DB	CTRP2	5.0323	6.0202	4.9463	7.0428
BL-70	CTRP2	5.0725	5.8967	5.0202	6.6551
KMS-12-BM	CTRP2	5.0833	6.2192	4.9431	6.9016
JURL-MK1	CTRP2	5.1059	6.0262	5.025	6.5348
SUP-T11	CTRP2	5.1078	6.1892	4.9794	6.6952
SEM	CTRP2	5.1135	6.7637	4.7704	7.4739
P31/FUJ	CTRP2	5.1225	5.8676	5.0804	6.2863
NOMO-1	CTRP2	5.1572	6.448	4.9423	6.6915
SU-DHL-10	CTRP2	5.1589	6.1668	5.042	6.3134
HPB-ALL	CTRP2	5.1807	6.5661	4.9216	6.7052
LP-1	CTRP2	5.1918	7.9375	4.3189	9.0856
NALM-6	CTRP2	5.1922	7.2482	4.6399	7.7847
MOTN-1	CTRP2	5.2061	7.4345	4.5685	8.0373
HEL	CTRP2	5.2598	6.1904	5.1442	5.6384
PL21	CTRP2	5.2894	6.2345	5.1617	5.4867
HuT 78	CTRP2	5.2961	7.2121	4.7606	7.0385
RPMI-8402	CTRP2	5.3026	6.4668	5.0902	5.7197
KCL-22	CTRP2	5.3203	6.9889	4.8863	6.4735
ST486	CTRP2	5.3623	7.0893	4.8832	6.3798
RS4;11	CTRP2	5.3755	6.7265	5.0588	5.6454
KYO-1	CTRP2	5.4423	6.2771	5.3118	4.4832
Raji	CTRP2	5.4608	6.1755	5.3674	4.2212
L-428	CTRP2	5.4611	6.809	5.1098	5.2214
HDLM-2	CTRP2	5.4819	6.6241	5.2129	4.7579
Peer	CTRP2	5.482	7.3178	4.8944	6.0413
Karpas-422	CTRP2	5.4838	6.4593	5.2847	4.4717
KO52	CTRP2	5.4885	6.4378	5.2985	4.4056
Ku812	CTRP2	5.5104	6.9238	5.1071	5.1079
NB4	CTRP2	5.537	6.0361	5.4929	3.5345
P12-Ichikawa	CTRP2	5.5423	6.7528	5.2173	4.5849
JVM-3	CTRP2	5.589	7.1693	5.0685	5.0747
KMS-11	CTRP2	5.6015	6.8808	5.2173	4.4379
Mino	CTRP2	5.6018	6.7445	5.2807	4.1809
Karpas-299	CTRP2	5.6217	6.2753	5.5045	3.2448
KMS-21-BM	CTRP2	5.6529	7.3241	5.0548	4.9826
M-07e	CTRP2	5.6576	6.6443	5.3825	3.6312
LAMA-84	CTRP2	5.6601	7.3083	5.0693	4.9061
OCI-AML-3	CTRP2	5.672	6.347	5.5285	3.0144
NCI-H929	CTRP2	5.7248	8.0855	4.7466	6.1049
Ci-1	CTRP2	5.7339	6.2722	5.6245	2.4735
SUP-HD1	CTRP2	5.7895	7.1534	5.2654	3.8019
L-540	CTRP2	5.8057	6.6037	5.5473	2.6009
PF-382	CTRP2	5.8276	7.5359	5.111	4.3629
MOLT-16	CTRP2	5.828	6.6664	5.5387	2.5837
SKM-1	CTRP2	5.8305	6.6342	5.5566	2.5044
SU-DHL-4	CTRP2	5.8322	6.6569	5.5473	2.5384
JeKo-1	CTRP2	5.8431	6.7611	5.507	2.6801
HEL 92.1.7	CTRP2	5.8484	7.1528	5.3194	3.448
F-36P	CTRP2	5.8668	7.7913	5.0189	4.6662
P3HR-1	CTRP2	5.8686	6.7583	5.5321	2.5187
JJN-3	CTRP2	5.8703	6.9911	5.4191	2.9847
JVM-2	CTRP2	5.8725	7.899	4.9702	4.8583
Jurkat	CTRP2	5.8892	7.178	5.3436	3.2597
AML-193	CTRP2	5.9016	7.8995	4.9953	4.6931
SIG-M5	CTRP2	5.958	6.5442	5.7193	1.5431
K-562	CTRP2	5.9618	7.4722	5.2605	3.4579
OCI-Ly3	CTRP2	5.9855	7.146	5.4438	2.6405
Kasumi-2	CTRP2	5.9956	6.8464	5.602	1.9559
L-363	CTRP2	6.0089	7.1725	5.4505	2.5656
KMS-34	CTRP2	6.0414	9.5979	4.2652	7.4835
WSU-DLCL2	CTRP2	6.0743	6.8362	5.6732	1.5035
HT	CTRP2	6.1029	6.9108	5.659	1.5106
DND-41	CTRP2	6.1207	7.7907	5.234	3.262
Reh	CTRP2	6.162	7.7564	5.2843	2.9751
HD-MY-Z	CTRP2	6.1785	7.744	5.3036	2.8644
SUP-B15	CTRP2	6.2158	7.4919	5.4581	2.1528
HL-60	CTRP2	6.2389	7.2603	5.59	1.566
RCH-ACV	CTRP2	6.2409	7.6384	5.4047	2.3328
MHH-CALL-4	CTRP2	6.2442	7.6799	5.3866	2.4026
KMS-26	CTRP2	6.2507	7.3603	5.5495	1.7145
MOLP-2	CTRP2	6.3221	8.2849	5.1463	3.2719
MJ	CTRP2	6.3937	8.5061	5.0912	3.3809
KHM-1B	CTRP2	6.4183	8.3271	5.1977	2.8989
U266B1	GDSC2	6.6054	8.8306	3.5682	1.0138
MHH-CALL-3	CTRP2	6.6098	8.5534	5.2241	2.4973
OCI-AML-5	CTRP2	6.6478	8.0422	5.4924	1.3812
EHEB	CTRP2	6.6488	9.0642	5.0038	3.3363
KMS-20	CTRP2	6.7071	9.1861	4.9857	3.3221
U266B1	CTRP2	6.8037	11.4295	3.9555	7.4118
HH [Human lymphoma]	GDSC2	6.8118	8.9053	3.6272	0.6763
EJM	CTRP2	6.8831	11.9094	3.7781	8.0098
TF-1	CTRP2	6.948	8.4376	5.4905	1.057
SET-2	CTRP2	7.0435	8.3183	5.5926	0.6354
RL	CTRP2	7.0861	8.4772	5.5473	0.744
OCI-Ly19	CTRP2	7.3143	15.3503	2.4028	12.7416
AMO1	CTRP2	7.7762	9.0001	5.646	0.1621
MM1.S	CTRP2	7.853	9.285	5.5727	0.282
TALL-1 [Human adult T-ALL]	CTRP2	7.9311	10.1724	5.2601	0.9928
KMS-27	CTRP2	7.9694	9.2299	5.6368	0.1311
OCI-M1	CTRP2	8.0157	8.9753	5.7393	0.0317
CMK	CTRP2	8.0916	9.2268	5.6814	0.0648
MOLM-16	CTRP2	8.2254	9.8616	5.5086	0.2584
L-1236	CTRP2	8.8496	10.9726	5.3485	0.3691

Cancer Drug Sensitivity Data Curated from 45 Cell Line(s) in Oesophagus Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
TE15	CTRP2	6.0517	7.1715	5.4869	2.3293
TE8	CTRP2	6.6771	8.2281	5.424	1.6095
KYSE-150	GDSC2	2.7395	8.546	0.7801	26.4043
TE-6	GDSC2	2.9668	7.2896	1.5988	21.386
EC-GI-10	GDSC2	3.0592	7.6719	1.5056	21.5462
T.T	GDSC2	3.3409	8.4048	1.4146	21.0093
TE-5	GDSC2	3.4087	9.4319	0.9709	23.0359
KYSE-270	GDSC2	3.6949	9.7741	1.0572	21.6348
TE-15	GDSC2	3.7494	8.1358	1.9191	16.7839
OE21	GDSC2	4.097	8.1115	2.2366	13.7837
OE33	GDSC2	4.158	8.7674	1.9612	15.2344
KYSE-180	GDSC2	4.3186	7.7903	2.585	10.978
TE-4	CTRP2	4.6714	6.3097	4.466	9.8783
TE-4	GDSC2	4.7377	7.9088	2.8621	8.092
KYSE-450	GDSC2	4.7601	10.7965	1.4422	16.3805
KYSE-70	GDSC2	4.778	8.5759	2.562	9.8437
KYSE-520	GDSC2	4.8715	7.4154	3.2059	5.6186
OE19	GDSC2	4.9793	9.2443	2.3848	10.3995
KYSE-140	GDSC2	5.1764	11.4756	1.4298	15.3195
TE-8	GDSC2	5.2056	9.0467	2.6494	8.2453
TE-9	GDSC2	5.3101	14.0566	0.2516	20.5661
KYSE-410	GDSC2	5.3336	10.6019	1.98	11.8874
OE21	CTRP2	5.5763	6.9503	5.16	4.7319
KYSE-410	CTRP2	5.5915	6.8834	5.2062	4.5073
TE-14	CTRP2	5.6468	6.4328	5.4659	3.3267
COLO 680N	GDSC2	5.7891	12.1147	1.5703	13.0518
KYSE-70	CTRP2	5.9441	6.9859	5.4877	2.7295
TE-6	CTRP2	6.0208	7.3134	5.3901	2.7961
TE-5	CTRP2	6.2392	8.2142	5.1173	3.5368
KYSE-450	CTRP2	6.2731	8.5007	5.0012	3.9627
TE-10	CTRP2	6.3455	7.7256	5.4396	2.0165
TE-11	CTRP2	6.4565	8.7006	5.0421	3.4812
KYSE-520	CTRP2	6.6358	8.3716	5.3291	2.0385
KYSE-140	CTRP2	6.6676	8.4095	5.3322	1.9827
OE33	CTRP2	6.7843	9.7842	4.7495	4.1699
EC-GI-10	CTRP2	6.8136	8.5761	5.3478	1.7338
TE-1	GDSC2	7.0399	8.6725	3.7974	0.1898
KYSE-180	CTRP2	7.2773	9.1205	5.3716	1.1568
TE-9	CTRP2	7.6049	9.0966	5.5406	0.4328
KYSE-30	CTRP2	7.6583	11.4172	4.5543	3.7468
KYSE-510	CTRP2	7.7332	11.2257	4.6893	3.1431
OE19	CTRP2	7.7468	9.0838	5.6044	0.2398
KYSE-150	CTRP2	7.8643	9.0556	5.6592	0.1238
COLO 680N	CTRP2	8.1418	9.7725	5.5083	0.2846
TE-1	CTRP2	8.4505	10.1455	5.4928	0.2388

Cancer Drug Sensitivity Data Curated from 65 Cell Line(s) in Pancreas Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
N2a-PK1	CTRP2	6.1326	7.9418	5.1682	3.5162
MIA PaCa-2	GDSC2	1.9185	5.5026	1.3031	27.3377
PSN1	GDSC2	2.5035	5.5462	1.9074	21.5195
PL4	GDSC2	3.0673	7.7268	1.487	21.6165
Capan-1	GDSC2	3.4052	6.8357	2.238	16.0781
Hs 766T	GDSC2	3.5363	10.0578	0.7756	23.5255
KP-4	GDSC2	3.7704	7.3174	2.343	14.1836
BxPC-3	GDSC2	3.8073	6.0495	2.999	10.0018
PaTu 8988t	GDSC2	4.0106	8.1236	2.1558	14.54
HPAC	GDSC2	4.216	9.4801	1.654	16.8127
PaTu 8902	GDSC2	4.3102	7.6858	2.6302	10.7214
HuP-T4	CTRP2	4.4523	6.745	4.0755	12.8621
HuP-T3	GDSC2	4.6461	7.2724	3.1074	6.7953
YAPC	GDSC2	4.6831	10.1205	1.7178	15.0877
SU.86.86	GDSC2	4.7639	9.7672	1.9583	13.4935
DAN-G	GDSC2	4.8495	6.968	3.4087	4.4168
SUIT-2	GDSC2	4.8581	8.2634	2.7783	8.3036
KP-3	GDSC2	4.882	9.9905	1.9398	13.2796
HuP-T4	GDSC2	5.0359	11.7365	1.1915	16.9303
Panc 04.03	GDSC2	5.043	6.9532	3.5477	3.1591
Panc 03.27	GDSC2	5.0784	8.4027	2.8725	7.185
SW1990	GDSC2	5.1685	8.8096	2.7385	7.7915
KP-2	GDSC2	5.2155	6.7243	3.7583	1.6589
KP-1N	GDSC2	5.2504	9.1475	2.6323	8.2432
Panc 10.05	GDSC2	5.4131	9.2557	2.6946	7.4987
PaTu 8988s	CTRP2	5.5029	7.3442	4.9021	5.9599
HPAF-II	GDSC2	5.5603	10.5943	2.1483	10.3799
CFPAC-1	GDSC2	5.6071	10.0393	2.4505	8.5166
Panc 08.13	GDSC2	5.6329	13.1658	0.9393	16.6349
AsPC-1	GDSC2	5.68	8.2605	3.3363	3.2234
Panc 02.03	GDSC2	5.693	12.4589	1.3319	14.53
Capan-2	GDSC2	5.8436	10.1282	2.568	7.3281
PSN1	CTRP2	5.9693	7.162	5.4219	2.7653
QGP-1	CTRP2	6.2816	7.5615	5.4733	1.9796
MIA PaCa-2	CTRP2	6.3183	7.7085	5.4281	2.1072
SNU-410	CTRP2	6.3781	8.2556	5.2031	2.9422
Panc 10.05	CTRP2	6.5565	8.5168	5.2046	2.6556
YAPC	CTRP2	6.608	8.0889	5.445	1.7363
Panc 08.13	CTRP2	6.7081	8.904	5.1228	2.7649
Panc 03.27	CTRP2	6.8232	8.5441	5.3686	1.6426
PaTu 8988t	CTRP2	6.9523	8.274	5.5643	0.8005
Hs 766T	CTRP2	6.9884	9.6197	4.969	2.9898
HuP-T3	CTRP2	7.0238	9.566	5.0176	2.7512
KP-2	CTRP2	7.3092	8.8943	5.4844	0.7678
Panc 04.03	CTRP2	7.3278	9.1155	5.4005	1.0175
L3.3	CTRP2	7.4182	17.4807	1.4269	17.0387
PK-45H	CTRP2	7.4303	10.754	4.7201	3.391
KP-4	CTRP2	7.4697	8.7239	5.6257	0.3008
SUIT-2	CTRP2	7.6206	8.8355	5.6454	0.207
SNU-213	CTRP2	7.6519	8.8882	5.6385	0.2093
DAN-G	CTRP2	7.7057	9.0617	5.5961	0.2695
HPAC	CTRP2	7.7069	10.6584	4.9314	2.4481
SW1990	CTRP2	7.741	10.5223	5.0113	1.9607
CFPAC-1	CTRP2	7.7498	18.6506	1.1	16.5966
Capan-2	CTRP2	7.8877	9.7343	5.4162	0.5922
Panc 05.04	CTRP2	7.8925	9.0473	5.6724	0.1101
SU.86.86	CTRP2	7.967	9.407	5.5729	0.2263
KP-3	CTRP2	7.9744	10.2087	5.2661	0.9461
AsPC-1	CTRP2	8.0701	10.7475	5.0894	1.41
TCC-Pan2	CTRP2	8.0809	9.5589	5.5621	0.2276
HPAF-II	CTRP2	8.2574	9.9863	5.4757	0.3058
PK-59	CTRP2	8.291	9.8705	5.5305	0.2211
BxPC-3	CTRP2	8.6447	10.5795	5.4113	0.2984
Panc 02.03	CTRP2	8.8082	10.2493	5.5849	0.0641
PaTu 8902	CTRP2	12.3026	31.5711	-1.9554	18.3405

Cancer Drug Sensitivity Data Curated from 77 Cell Line(s) in Skin Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SH4	CTRP2	5.0515	17.7117	-0.636	26.827
A101D	GDSC2	1.4685	5.0237	0.9915	31.0045
RPMI-7951	GDSC2	1.9022	6.0157	1.0827	28.5098
A-375	GDSC2	2.0523	5.1776	1.5681	25.3477
WM1552C	GDSC2	2.1881	10.0585	-0.4735	33.3667
LOX-IMVI	GDSC2	2.4623	6.1069	1.6298	23.2323
A2058	GDSC2	2.5406	5.5423	1.9481	21.134
CHL-1	GDSC2	2.7502	6.3856	1.8022	21.0976
SH-4	GDSC2	2.8456	5.7829	2.1658	18.6321
SK-MEL-1	GDSC2	3.2436	6.2136	2.3755	15.8453
HT-144	GDSC2	3.2972	7.7169	1.7097	19.5457
M14	GDSC2	3.3307	6.9127	2.1298	16.9914
UACC-62	GDSC2	3.3371	5.2136	2.9191	12.2342
WM793	GDSC2	3.5292	8.1499	1.7129	18.7104
G-361	GDSC2	3.5327	6.9279	2.3143	15.1674
HMV-II	GDSC2	3.903	8.1643	2.0414	15.5638
IGR-37	GDSC2	4.0564	7.81	2.352	13.208
COLO 679	GDSC2	4.0988	8.0553	2.2662	13.5986
SK-MEL-2	GDSC2	4.2295	9.7442	1.5334	17.4377
Mel JuSo	GDSC2	4.2722	6.658	3.1122	7.8042
IST-MEL1	GDSC2	4.3413	9.6689	1.6646	16.3758
MeWo	GDSC2	4.3739	8.0629	2.4946	11.3762
IGR-1	GDSC2	4.378	7.5086	2.775	9.6197
COLO 792	GDSC2	4.3815	7.0406	3.0119	8.1198
GAK	GDSC2	4.4021	7.0669	3.0157	8.0374
WM35	GDSC2	4.6478	7.1715	3.1588	6.4684
UACC-257	GDSC2	4.7966	7.4187	3.1491	6.1528
WT2-iPS	GDSC2	4.973	8.6201	2.6883	8.5696
WM115	GDSC2	5.1321	9.7368	2.2565	10.7797
SK-MEL-24	GDSC2	5.4036	9.5207	2.5595	8.327
COLO 829	GDSC2	5.4798	13.2614	0.7767	17.7922
WM278	GDSC2	5.6607	12.5211	1.2775	14.8876
LOX-IMVI	CTRP2	5.7087	6.3874	5.5495	2.8343
WM88	CTRP2	5.8012	7.1897	5.2583	3.8059
MeWo	CTRP2	5.9315	7.0594	5.44	2.7673
IPC-298	CTRP2	6.0183	6.7238	5.6827	1.6878
SK-MEL-1	CTRP2	6.1278	7.1524	5.5583	1.888
Mel JuSo	CTRP2	6.1639	7.4328	5.4471	2.2895
RPMI-7951	CTRP2	6.1677	7.4499	5.4416	2.3055
WT2-iPS	CTRP2	6.5852	8.5985	5.1851	2.6919
Hs 940.T	CTRP2	6.6343	9.9888	4.5396	5.2732
SK-MEL-31	CTRP2	6.637	8.064	5.4754	1.4604
Hs 839.T	CTRP2	6.674	8.1147	5.4751	1.4159
WM266-4	CTRP2	6.6761	8.1386	5.4653	1.451
Hs 934.T	CTRP2	6.6998	8.4987	5.311	2.0233
Hs 936.T	CTRP2	6.7283	8.152	5.4913	1.3849
IGR-39	CTRP2	6.8196	8.7182	5.2851	1.9687
G-361	CTRP2	6.8981	8.6165	5.381	1.6198
HMCB	CTRP2	6.9267	8.1762	5.593	0.7281
UACC-62	CTRP2	6.9978	8.4836	5.4978	0.9843
CJM [Human melanoma]	CTRP2	7.0972	9.601	5.0482	2.5381
SK-MEL-28	CTRP2	7.1022	7.9224	5.7748	0.1421
WM115	CTRP2	7.128	9.399	5.1611	2.0689
SK-MEL-30	CTRP2	7.1345	8.4019	5.6026	0.5808
Hs 895.T	CTRP2	7.1391	8.4988	5.5648	0.649
Hs 688(A).T	CTRP2	7.3909	8.6086	5.6364	0.3116
HT-144	CTRP2	7.4832	9.1253	5.4738	0.6779
COLO 800	CTRP2	7.5604	9.2906	5.4432	0.7142
K029AX	CTRP2	7.6883	9.1843	5.5427	0.3885
SK-MEL-3	CTRP2	7.7662	8.8534	5.6939	0.1
IGR-37	CTRP2	7.8042	9.0004	5.6564	0.1403
Mel Ho	CTRP2	7.8255	9.1858	5.5981	0.226
MDA-MB-435S	CTRP2	7.872	9.154	5.6274	0.1783
WM983B	CTRP2	7.9124	9.8992	5.3621	0.7187
UACC-257	CTRP2	8.009	9.3112	5.6229	0.141
Hs 294T	CTRP2	8.0431	9.432	5.593	0.1746
A2058	CTRP2	8.0686	9.0837	5.7213	0.0383
Hs 944.T	CTRP2	8.0979	9.6556	5.5337	0.2539
SK-MEL-5	CTRP2	8.099	9.1582	5.7069	0.0449
A101D	CTRP2	8.1201	9.2372	5.6877	0.0566
RVH-421	CTRP2	8.1526	9.5589	5.589	0.1554
A-375	CTRP2	8.1659	9.6555	5.5598	0.1934
COLO 792	CTRP2	8.1958	9.812	5.5151	0.2562
WM1799	CTRP2	8.3489	9.5657	5.6562	0.0613
COLO 829	CTRP2	8.3672	10.3349	5.3908	0.43
WM793	CTRP2	8.4317	9.7673	5.6171	0.0848
IGR-1	CTRP2	11.5529	25.3889	0.4872	13.0378

Cancer Drug Sensitivity Data Curated from 9 Cell Line(s) in Aero Dig Tract Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
OACM5.1 C	GDSC2	2.3046	5.4672	1.7283	23.3657
KYSE-50	GDSC2	2.5546	5.3684	2.0327	20.598
ESO-51	GDSC2	2.6408	4.3706	2.4738	17.7525
FLO-1	GDSC2	2.9493	8.2181	1.1381	23.8798
KYSE-220	GDSC2	3.2439	7.9053	1.5681	20.525
OACP4 C	GDSC2	3.5247	6.8885	2.3259	15.1251
ESO-26	GDSC2	4.5438	6.5932	3.3655	5.4404
SK-GT-4	GDSC2	5.2593	10.1055	2.1693	10.9774
KYAE-1	GDSC2	5.3134	7.9344	3.2601	4.3267

Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Ascites Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
COLO 684	GDSC2	4.5235	8.7221	2.2875	12.2132
COLO 684	CTRP2	6.6261	10.0201	4.518	5.3765

Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Autonomic Ganglia Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SJNB-13	GDSC2	1.8598	4.1804	1.6722	25.6819
NB69	GDSC2	1.8759	4.4911	1.6044	25.9643
SJNB-14	GDSC2	1.9982	6.1018	1.1483	27.7538
SK-N-DZ	GDSC2	2.1845	6.1126	1.3386	25.9678
Kelly	GDSC2	2.2708	5.3099	1.7532	23.3765
SK-N-BE(2)-M17	GDSC2	2.3744	5.7793	1.6762	23.3501
SJNB-10	GDSC2	2.5832	6.1756	1.7248	22.2073
NH-12	GDSC2	2.663	5.435	2.1208	19.6407
CHP-212	GDSC2	3.0998	6.6741	2.0188	18.4977
TGW	GDSC2	3.6944	6.3961	2.7246	12.093
SJNB-12	GDSC2	3.7288	7.6576	2.1372	15.5644
SJNB-7	GDSC2	3.809	7.8867	2.0959	15.5459
SK-N-SH	GDSC2	3.8185	5.9678	3.0493	9.6513
GI-ME-N	GDSC2	4.1973	7.533	2.6114	11.1749
SK-N-AS	GDSC2	4.2346	9.451	1.6843	16.5871
GOTO	GDSC2	4.2789	7.0008	2.9465	8.8302
SiMa	GDSC2	4.392	7.6331	2.7244	9.8966
NB(TU)1	GDSC2	4.4036	7.5128	2.794	9.4277
SK-N-FI	GDSC2	4.423	9.6795	1.7269	15.7844
IMR-5	GDSC2	4.574	7.2405	3.0671	7.2391
CHP-134	GDSC2	5.2072	8.5594	2.8879	6.7935
IMR-32	CTRP2	5.5485	6.0029	5.514	3.4233
SK-N-DZ	CTRP2	5.5987	6.8073	5.2487	4.3174
NH-6	CTRP2	5.6411	6.4761	5.4412	3.439
Kelly	CTRP2	5.686	6.452	5.4978	3.0981
SK-N-BE(2)	CTRP2	5.9268	7.6375	5.1479	4.0017
SK-N-FI	CTRP2	6.0504	7.0336	5.5548	2.0466
NB1	CTRP2	6.0799	6.8786	5.6565	1.5634
KP-N-SI9s	CTRP2	6.1724	7.151	5.5938	1.661
SK-N-SH	CTRP2	6.4915	8.246	5.2902	2.4041
KP-N-YN	CTRP2	7.3297	24.2445	-2.0079	25.6149

Cancer Drug Sensitivity Data Curated from 7 Cell Line(s) in Biliary Tract Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
HuCC-T1	GDSC2	5.0057	8.7783	2.6347	8.817
HuCC-T1	CTRP2	5.6096	7.0346	5.1527	4.6812
SNU-478	CTRP2	6.3559	7.702	5.4587	1.9219
SNU-1196	CTRP2	7.0225	9.5472	5.0256	2.7216
SNU-1079	CTRP2	7.6576	9.6649	5.3362	0.9609
SNU-308	CTRP2	7.9523	9.4054	5.5678	0.2395
SNU-869	CTRP2	11.0003	25.469	0.0871	14.8695

Cancer Drug Sensitivity Data Curated from 114 Cell Line(s) in Breast Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
DU4475	GDSC2	0.0738	2.7383	0.0029	42.8828
MDA-MB-468	GDSC2	1.5595	7.974	-0.118	34.9456
HCC1187	GDSC2	1.7269	4.1279	1.5404	27.0042
MFM-223	GDSC2	2.1966	5.9566	1.4164	25.5104
MDA-MB-157	CTRP2	2.6033	8.8326	1.2812	27.5216
MCF-7	GDSC2	2.6625	6.6436	1.5971	22.5878
OCUB-M	GDSC2	2.8249	5.479	2.273	18.0943
CAL-51	GDSC2	3.0564	6.2401	2.1768	17.7371
MDA-MB-453	GDSC2	3.079	5.8024	2.3969	16.3494
AU565	GDSC2	3.2154	8.3888	1.306	22.0335
MRK-nu-1	GDSC2	3.2548	5.8801	2.5402	14.8158
CAMA-1	GDSC2	3.3174	6.3093	2.4035	15.4024
HCC38	GDSC2	3.4882	7.2647	2.1087	16.5567
Hs 578T	GDSC2	3.534	8.9513	1.3218	20.8261
MDA-MB-157	GDSC2	3.5731	7.2823	2.1793	15.8407
MDA-MB-436	GDSC2	3.6502	9.3603	1.2232	20.9442
MDA-MB-231	GDSC2	3.814	9.0817	1.5065	18.8982
HDQ-P1	GDSC2	3.9073	7.8228	2.2149	14.513
HCC70	GDSC2	4.2468	6.1139	3.3626	6.2959
Evsa-T	GDSC2	4.2608	7.0674	2.8979	9.1897
CAL-120	GDSC2	4.2664	8.54	2.1665	13.6899
HCC1395	GDSC2	4.2896	9.5075	1.7021	16.3206
CAL-148	GDSC2	4.2898	6.313	3.2995	6.5671
HCC1428	GDSC2	4.4262	7.0032	3.0672	7.6442
UACC-812	GDSC2	4.4487	7.4409	2.8668	8.8433
MDA-MB-175-VII	GDSC2	4.5547	7.8625	2.7417	9.3311
MDA-MB-361	GDSC2	4.564	6.7956	3.2806	5.922
T-47D	GDSC2	4.607	8.5167	2.4571	10.9481
SK-BR-3	CTRP2	4.6717	6.7006	4.3272	10.3992
HCC1954	GDSC2	4.6999	8.075	2.7504	8.8859
BT-549	GDSC2	4.7024	8.4857	2.548	10.1303
MDA-MB-415	GDSC2	4.7387	8.4982	2.5702	9.8975
COLO 824	GDSC2	4.7443	8.1589	2.743	8.8149
JIMT-1	GDSC2	4.8045	9.8581	1.945	13.4596
BT-20	GDSC2	4.8497	8.716	2.5477	9.7441
HCC1806	GDSC2	4.86	12.403	0.7205	19.7058
T-47D	CTRP2	5.0056	7.9401	4.1352	10.2839
EFM-192A	CTRP2	5.0594	8.1364	4.0958	10.3131
HCC1500	GDSC2	5.1366	9.1558	2.5458	9.0366
CAL-85-1	GDSC2	5.1488	11.8849	1.2055	16.5575
EFM-19	GDSC2	5.2358	9.3127	2.5411	8.8269
EFM-192A	GDSC2	5.2438	8.1527	3.1097	5.3693
AU565	CTRP2	5.3161	6.9091	4.9177	6.3594
HCC2218	CTRP2	5.3763	27.5658	-5.278	34.3339
HCC202	CTRP2	5.4249	7.6076	4.7012	6.9673
ZR-75-30	GDSC2	5.437	8.2814	3.1765	4.5765
HCC1428	CTRP2	5.4917	6.3708	5.3288	4.2797
DU4475	CTRP2	5.5543	6.7728	5.2202	4.5432
BT-474	GDSC2	5.5655	12.1481	1.3907	14.537
HCC1143	GDSC2	5.5824	9.009	2.9272	5.756
BT-483	GDSC2	5.6217	10.7004	2.1403	10.2844
MDA-MB-453	CTRP2	5.6349	7.3129	5.0433	5.0715
ZR-75-30	CTRP2	5.6449	7.4959	4.9638	5.377
JIMT-1	CTRP2	5.6939	7.6079	4.9543	5.3068
MCF-7	CTRP2	5.6939	7.0726	5.2153	4.2261
MDA-MB-231	CTRP2	5.7208	6.9141	5.3173	3.7442
HCC1954	CTRP2	5.8289	7.3958	5.1817	4.0648
MDA-MB-361	CTRP2	5.8301	7.3131	5.2236	3.8872
CAL-120	CTRP2	5.8386	7.4815	5.1479	4.1853
HCC38	CTRP2	5.8542	7.7456	5.0305	4.6435
Hs 578Bst	CTRP2	5.9386	8.7324	4.6113	6.2312
Hs 578T	CTRP2	5.9639	7.9015	5.048	4.3463
HCC1419	GDSC2	5.9662	7.7189	3.7198	0.9592
HCC1806	CTRP2	5.9882	6.8698	5.584	2.0466
BT-549	CTRP2	5.9975	6.9427	5.5556	2.1466
CAL-148	CTRP2	6.0653	7.1858	5.491	2.286
KPL-1	CTRP2	6.0943	7.4881	5.3637	2.7661
HCC1500	CTRP2	6.1818	8.1844	5.0866	3.7684
HMC-1-8	CTRP2	6.2214	7.4905	5.4631	2.1225
MDA-MB-468	CTRP2	6.2246	7.3768	5.5217	1.8727
BT-474	CTRP2	6.4409	7.7112	5.5138	1.571
CAMA-1	CTRP2	6.5561	21.1377	-1.0802	24.9038
BT-20	CTRP2	6.7378	9.0039	5.0951	2.8338
HCC1395	CTRP2	6.7447	8.4358	5.3698	1.7346
HCC1419	CTRP2	6.8197	12.4108	3.4819	9.3299
HCC1937	GDSC2	7.0758	16.1345	0.5233	15.2754
HDQ-P1	CTRP2	7.2017	9.961	4.9461	2.8025
CAL-85-1	CTRP2	7.4236	9.9765	5.0741	2.0613
MDA-MB-415	CTRP2	7.8667	17.222	1.892	13.6969
CAL-51	CTRP2	7.8787	9.447	5.5228	0.3507
HCC1937	CTRP2	8.3532	9.9201	5.5362	0.183
HCC1143	CTRP2	9.2648	11.1835	5.4283	0.1544
BT 440	CTRP2	4.2287	6.5632	3.9003	13.2744
BT 504	CTRP2	5.6493	6.6987	5.3492	3.786
BT 482	CTRP2	5.8156	7.0128	5.3584	3.3578
BT 416	CTRP2	5.8483	6.5264	5.6253	2.1808
BT 159	CTRP2	5.8756	13.5116	2.1692	16.2961
BT 498	CTRP2	5.9766	9.5786	4.2205	7.7974
BT 179	CTRP2	6.0538	7.2124	5.4682	2.4039
BT 145	CTRP2	6.2974	7.6479	5.4425	2.0816
BT 172	CTRP2	6.3523	8.0428	5.2887	2.6292
BT164	CTRP2	6.3561	7.7969	5.4124	2.1121
BT 330	CTRP2	6.47	8.7338	5.0358	3.4855
BT 286	CTRP2	6.4993	8.4644	5.1894	2.8051
BT 320	CTRP2	6.5587	9.5861	4.6817	4.8083
BT147	CTRP2	6.5677	9.7343	4.6154	5.0691
BT 131	CTRP2	6.6121	8.1502	5.4187	1.7149
BT 328	CTRP2	6.6286	7.805	5.5901	1.033
BT 422	CTRP2	6.6838	8.5209	5.29	2.1285
BT 224	CTRP2	6.7431	8.9865	5.107	2.778
BT 228	CTRP2	6.8514	10.211	4.5893	4.7231
BT 139	CTRP2	6.8621	11.1694	4.1274	6.6064
BT 333	CTRP2	6.9283	8.4372	5.4796	1.1152
BT 112	CTRP2	7.0354	8.552	5.4884	0.9816
BT 271	CTRP2	7.085	9.0017	5.3165	1.5397
BT 231	CTRP2	7.2168	9.9704	4.9512	2.7636
BT 232	CTRP2	7.3177	9.1947	5.3611	1.1561
BT 340	CTRP2	7.3329	9.139	5.3931	1.0372
BT 444	CTRP2	7.5081	8.6551	5.667	0.2045
BT 239	CTRP2	7.5378	11.5955	4.393	4.5313
BT 216	CTRP2	7.6777	9.1875	5.5369	0.4063
BT 359	CTRP2	7.9132	9.3644	5.5674	0.2524
BT 245	CTRP2	7.9799	9.4686	5.5556	0.2522
BT 248	CTRP2	8.3576	15.861	2.9045	9.2027

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Tongue Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
YD-38	CTRP2	5.5804	6.896	5.1894	4.6025

Cancer Drug Sensitivity Data Curated from 81 Cell Line(s) in Central Nervous System Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
D283 Med	GDSC2	0.7941	3.4729	0.6661	35.999
MOG-G-UVW	GDSC2	1.0911	5.1093	0.5534	34.8612
H4	GDSC2	1.1402	5.2879	0.5449	34.6365
SF539	GDSC2	2.0784	5.0405	1.6455	24.816
GI-1	GDSC2	2.0895	6.0431	1.2683	26.7453
U-251MG	GDSC2	2.5496	8.8426	0.456	28.5693
Daoy	GDSC2	2.6482	6.5579	1.6214	22.5129
LNZTA3WT4	GDSC2	2.6733	6.9046	1.489	23.1302
T98G	GDSC2	2.7225	7.8101	1.1148	24.8719
D-263MG	GDSC2	2.9738	7.2379	1.6301	21.1866
U-87MG ATCC	GDSC2	2.996	8.0742	1.2518	23.1252
U-118MG	GDSC2	3.1827	6.354	2.25	16.8239
SW1783	GDSC2	3.2512	8.6318	1.2204	22.3471
KS-1 [Human Krukenberg tumour]	GDSC2	3.4152	7.7304	1.8135	18.5364
8-MG-BA	GDSC2	3.4649	6.9731	2.2285	15.9227
LN-18	GDSC2	3.6315	6.6323	2.5507	13.3821
A-172	GDSC2	3.7671	9.9184	1.0489	21.4368
AM-38	GDSC2	4.0748	6.4832	3.029	8.9322
ONS-76	GDSC2	4.198	8.2097	2.2738	13.249
YH-13	GDSC2	4.2356	9.2972	1.762	16.1452
CAS-1	GDSC2	4.3347	7.7026	2.6423	10.5747
KNS-60	CTRP2	4.3467	6.5147	4.0448	12.3927
M059J	GDSC2	4.4307	7.2149	2.965	8.2757
D-392MG	GDSC2	4.434	7.9788	2.586	10.638
SF268	GDSC2	4.6021	8.192	2.6152	9.9876
Becker	GDSC2	4.6199	9.1669	2.1431	12.8078
GaMG	GDSC2	4.6337	12.3765	0.5514	21.1179
LN-405	GDSC2	4.7096	8.6626	2.4656	10.6162
DK-MG	GDSC2	4.8061	6.8712	3.4248	4.4174
SK-MG-1	GDSC2	4.8393	9.1194	2.3396	11.0354
GB-1	GDSC2	5.0519	10.4396	1.8481	13.3528
KINGS-1	GDSC2	5.1615	8.1312	3.0635	5.8282
LN-229	GDSC2	5.1706	10.0005	2.1552	11.2794
DBTRG-05MG	GDSC2	5.3779	9.5323	2.5357	8.528
D283 Med	CTRP2	5.4281	11.4038	2.8352	14.6372
42-MG-BA	GDSC2	5.5092	11.4425	1.6961	13.0432
MOG-G-CCM	GDSC2	5.5828	12.3264	1.3157	14.8827
SF268	CTRP2	5.7873	7.4898	5.0977	4.5051
AM-38	CTRP2	5.7957	7.3331	5.1826	4.1329
KALS-1	CTRP2	5.9731	6.9301	5.5408	2.2584
SNU-738	CTRP2	6.0396	7.3848	5.3702	2.8431
SF539	CTRP2	6.0426	7.6527	5.2387	3.3899
GB-1	CTRP2	6.0708	7.6905	5.2432	3.317
42-MG-BA	CTRP2	6.1523	7.7891	5.2602	3.0937
U-87MG ATCC	CTRP2	6.1668	7.9164	5.2084	3.2849
KALS-1	GDSC2	6.1873	11.6333	2.0796	9.3924
SF295	CTRP2	6.2968	7.5595	5.4856	1.9043
LN-229	CTRP2	6.3063	8.0552	5.2481	2.8744
SNU-626	CTRP2	6.3254	8.4365	5.0737	3.569
CCF-STTG1	CTRP2	6.3626	7.4712	5.5756	1.4344
SNU-466	CTRP2	6.4138	7.5818	5.5575	1.4336
LN-18	CTRP2	6.4241	7.89	5.4157	1.9934
T98G	CTRP2	6.437	7.8513	5.4435	1.8609
NMC-G1	CTRP2	6.5243	8.1517	5.3589	2.0762
KG-1-C	CTRP2	6.563	11.2463	3.862	8.2104
Hs 683	CTRP2	6.5974	8.1679	5.4006	1.8063
SW1088	GDSC2	6.6009	13.0043	1.7015	10.5828
GaMG	CTRP2	6.6329	8.4922	5.2694	2.2814
DBTRG-05MG	CTRP2	6.6487	8.0412	5.4934	1.3765
U-251MG	CTRP2	6.6666	9.4493	4.8285	4.028
Becker	CTRP2	6.6845	8.0628	5.5057	1.2862
SF126	CTRP2	6.7443	8.6685	5.2598	2.1665
DK-MG	CTRP2	6.805	8.8766	5.201	2.3179
SW1088	CTRP2	6.8084	8.4211	5.4163	1.4788
KNS-81	CTRP2	6.8349	8.4157	5.4348	1.3788
GMS-10	CTRP2	6.8361	8.8782	5.2205	2.1998
SNU-489	CTRP2	6.8621	8.8593	5.2461	2.0666
SNU-1105	CTRP2	6.9265	8.0886	5.6301	0.609
YH-13	CTRP2	6.933	8.8712	5.285	1.8295
ONS-76	CTRP2	7.038	8.3218	5.5883	0.6528
U-118MG	CTRP2	7.0771	10.7276	4.4976	4.7575
TM-31	CTRP2	7.1541	8.4601	5.5882	0.5691
Daoy	CTRP2	7.1563	8.9008	5.4018	1.1655
CAS-1	CTRP2	7.3119	11.8989	4.0943	6.0438
SNU-201	CTRP2	7.3471	8.804	5.5399	0.5795
GOS-3	CTRP2	7.3576	10.2845	4.8932	2.8139
8-MG-BA	CTRP2	7.3578	9.2802	5.3455	1.1726
M059K	CTRP2	7.8662	9.1796	5.616	0.1847
SNB-75	CTRP2	8.2083	16.8483	2.3223	11.5998
A-172	CTRP2	8.2853	19.5772	1.0426	15.9018
SW1783	CTRP2	9.0322	28.0404	-2.5737	24.0696

Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
TGBC1TKB	GDSC2	4.2844	10.8729	1.0151	19.9682
ETK-1	GDSC2	4.6863	8.2863	2.6346	9.6398
TGBC24TKB	GDSC2	4.7471	7.1763	3.2317	5.7596

Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Endometrium Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
RL95-2	GDSC2	0.1517	4.296	-0.2221	42.9602
MFE-319	GDSC2	3.1989	7.7795	1.5867	20.5866
KLE	GDSC2	3.8307	7.2218	2.4447	13.3622
AN3-CA	GDSC2	4.0214	6.1513	3.1461	8.3667
MFE-296	GDSC2	4.037	5.6238	3.4206	6.5932
MFE-280	GDSC2	4.4702	8.9364	2.1371	13.268
ESS-1	GDSC2	4.6376	7.6973	2.8895	8.1833
EN	GDSC2	4.853	6.964	3.413	4.382
RL95-2	CTRP2	5.0915	6.4087	4.8863	7.09
JHUEM-2	CTRP2	5.683	7.1293	5.1776	4.4064
HEC-265	CTRP2	5.7011	6.2513	5.5982	2.6647
HEC-6	CTRP2	5.894	6.9176	5.4768	2.6928
AN3-CA	CTRP2	6.2976	7.7893	5.3729	2.3698
EN	CTRP2	6.9576	9.5077	5.0019	2.9011
MFE-296	CTRP2	6.9734	11.3503	4.1202	6.4575
MFE-319	CTRP2	6.9801	8.6285	5.4237	1.2621
HEC-251	CTRP2	7.3268	10.002	5.0047	2.427
HEC-108	CTRP2	7.4151	9.0195	5.4844	0.6928
HEC-1-B	CTRP2	7.5032	9.7332	5.227	1.4411
HEC-50B	CTRP2	7.6628	13.0351	3.7886	6.7579
HEC-1-A	CTRP2	7.6811	10.6041	4.9409	2.2719
JHUEM-1	CTRP2	7.8015	8.7382	5.7455	0.0457
ESS-1	CTRP2	7.8042	9.4866	5.4761	0.4882
KLE	CTRP2	7.8096	9.4941	5.4756	0.4868
HEC-59	CTRP2	7.9839	9.2894	5.6213	0.1484
JHUEM-7	CTRP2	8.2223	9.7414	5.5505	0.1932
EFE-184	CTRP2	8.5045	10.2031	5.4927	0.2094
JHUEM-3	CTRP2	8.7607	10.8328	5.3646	0.3431
HEC-151	CTRP2	11.4572	23.536	1.2926	10.7438
Ishikawa (Heraklio) 02 ER-	CTRP2	6.8394	8.2578	5.509	1.1012

Cancer Drug Sensitivity Data Curated from 35 Cell Line(s) in Kidney Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
LB996-RCC	GDSC2	1.7322	6.0658	0.8831	30.2386
KTCTL-195	GDSC2	2.6108	9.0091	0.4347	28.4159
786-O	GDSC2	2.6961	6.4147	1.7343	21.6953
SW13	GDSC2	2.8535	6.4381	1.8827	20.2315
A-498	GDSC2	2.9132	7.6088	1.3953	22.6899
KMRC-20	GDSC2	3.1167	8.6646	1.0794	23.5485
CAL-54	GDSC2	3.2454	7.4248	1.8022	19.2087
ACHN	GDSC2	3.6806	9.5752	1.1434	21.2497
BFTC-909	GDSC2	4.1253	7.9845	2.3243	13.1638
KMRC-1	GDSC2	4.3956	7.6183	2.7348	9.821
769-P	GDSC2	4.4192	9.7054	1.7108	15.8857
TUHR10TKB	CTRP2	5.0966	6.7816	4.7452	16.3593
A-704	GDSC2	5.2845	11.4173	1.541	14.4464
SN12C	GDSC2	5.3101	8.4733	3.0009	5.8831
VMRC-RCZ	GDSC2	5.3698	13.3181	0.6645	18.5949
BFTC-909	CTRP2	5.4825	7.1051	4.9952	5.6296
RCC10RGB	GDSC2	5.6177	13.8213	0.6042	18.2379
OS-RC-2	GDSC2	5.6301	11.4461	1.7825	12.2782
TK-10	GDSC2	5.6726	11.4251	1.8234	11.9518
786-O	CTRP2	5.7522	7.1723	5.2217	4.0668
KMRC-3	CTRP2	5.975	7.5382	5.2389	3.5224
KMRC-20	CTRP2	5.9993	7.1673	5.4449	2.6082
TUHR4TKB	CTRP2	6.2146	9.2105	4.6008	5.7471
TUHR14TKB	CTRP2	6.47	10.0227	4.3978	6.1412
KMRC-1	CTRP2	6.524	8.0467	5.4092	1.8739
KMRC-2	CTRP2	6.559	8.5377	5.1962	2.686
RCC10RGB	CTRP2	6.5943	9.8228	4.5916	5.1235
ACHN	CTRP2	7.1514	8.8968	5.4009	1.1732
UO-31	CTRP2	7.4481	10.3195	4.9325	2.5582
769-P	CTRP2	7.5973	9.0639	5.5499	0.4143
Caki-2	CTRP2	7.6526	9.1188	5.5525	0.3823
OS-RC-2	CTRP2	7.8753	9.6556	5.4416	0.5359
SNU-1272	CTRP2	7.9397	9.3828	5.5711	0.2377
VMRC-RCZ	CTRP2	8.2951	10.1554	5.4284	0.382
Caki-1	CTRP2	8.3946	11.2487	5.0418	1.3124

Cancer Drug Sensitivity Data Curated from 90 Cell Line(s) in Large Intestine Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
LoVo	GDSC2	1.0813	5.619	0.3623	35.6564
HCT 116	GDSC2	1.286	3.7639	1.1427	31.1835
SW48	GDSC2	1.9266	5.5003	1.3126	27.2527
CW-2	GDSC2	2.2808	5.567	1.6636	23.8222
RKO	GDSC2	2.3119	5.6958	1.6446	23.7909
CCK-81	GDSC2	2.4308	4.8503	2.093	20.7951
MDST8	GDSC2	2.75	4.9067	2.4175	17.5811
GP5d	GDSC2	2.7655	5.0472	2.382	17.7169
SW620	GDSC2	2.7855	6.9776	1.567	22.2626
HT-29	GDSC2	2.8389	6.3467	1.9095	20.1365
SNU-175	GDSC2	2.8966	7.6686	1.3508	22.9884
COLO 320HSR	GDSC2	2.9412	7.3037	1.5672	21.657
HCT 15	GDSC2	3.0107	6.8161	1.8647	19.7259
SW948	GDSC2	3.0658	7.3189	1.6809	20.5569
DiFi	GDSC2	3.1606	7.4311	1.7182	19.9948
SNU-407	GDSC2	3.1764	8.6144	1.1596	22.9277
CL-11	GDSC2	3.2489	6.1379	2.4159	15.5834
SNU-C5	GDSC2	3.3472	7.4485	1.887	18.3551
KM12	GDSC2	3.3758	7.5447	1.8672	18.3669
HCC2998	GDSC2	3.4801	7.4973	1.9877	17.2991
SW1463	GDSC2	3.5151	5.9848	2.7498	12.5749
SNU-C1	GDSC2	3.8131	7.3089	2.3858	13.7807
LS180	GDSC2	3.8366	8.0216	2.0535	15.7072
NCI-H716	GDSC2	4.0434	5.3224	3.5741	5.6123
C2BBe1	GDSC2	4.2114	6.9738	2.9029	9.3063
LS411N	GDSC2	4.231	6.8405	2.9861	8.7233
LS513	GDSC2	4.3096	6.6994	3.1229	7.6267
SK-CO-1	GDSC2	4.4307	8.4385	2.3536	12.0769
SW626	GDSC2	4.4631	8.3217	2.4384	11.4655
T84	GDSC2	4.5898	7.2221	3.0886	7.0619
COLO205	GDSC2	4.6895	6.9014	3.3243	5.3249
SW1417	GDSC2	4.7013	8.4709	2.5546	10.0932
SNU-C2B	GDSC2	4.7337	8.9841	2.3244	11.409
NCI-H747	GDSC2	4.7402	7.2238	3.2031	5.9557
CaR-1	GDSC2	4.7819	9.3238	2.1932	12.0649
RCM-1 [Human ESC]	GDSC2	4.8371	10.0127	1.8937	13.6657
SW48	CTRP2	4.8415	5.9223	4.7629	8.286
SW837	GDSC2	4.8461	8.3673	2.7178	8.7077
LS1034	GDSC2	4.9193	7.7565	3.0734	6.3247
NCI-H508	CTRP2	4.9213	11.9729	2.099	18.6063
HT-55	GDSC2	5.0933	8.926	2.6268	8.6503
SNU-61	GDSC2	5.2083	8.518	2.9088	6.6641
SNU-C1	CTRP2	5.4669	6.4801	5.2585	4.6193
LS123	GDSC2	5.5287	14.2464	0.326	19.6866
T84	CTRP2	5.5584	7.1633	5.0419	5.2561
SW620	CTRP2	5.6515	7.4555	4.9896	5.6445
CW-2	CTRP2	5.7174	7.2311	5.1606	4.3983
HT-55	CTRP2	5.8255	6.6317	5.5531	2.718
LS1034	CTRP2	5.8528	6.63	5.5798	2.3574
HCT 15	CTRP2	5.8667	6.8873	5.467	2.793
SW1116	GDSC2	5.9067	7.3403	3.8416	0.553
LS123	CTRP2	5.9175	6.7021	5.6046	2.1093
SNU-61	CTRP2	5.9345	7.3811	5.2824	3.4217
KM12	CTRP2	5.9454	18.8484	-0.4403	24.4769
COLO 320	CTRP2	6.0189	9.552	4.2693	7.5098
SNU-C5	CTRP2	6.0223	7.2547	5.4207	2.6647
NCI-H716	CTRP2	6.0426	7.7116	5.2093	3.5138
SNU-81	CTRP2	6.0597	7.5181	5.3203	3.0145
SW1463	CTRP2	6.1602	7.7519	5.2852	2.9747
SW948	CTRP2	6.1765	7.8777	5.2354	3.1539
CL-11	CTRP2	6.2505	7.4552	5.5025	1.9096
SNU-407	CTRP2	6.29	7.6247	5.4484	2.069
DLD-1	CTRP2	6.2976	7.7159	5.4091	2.2198
COLO 678	GDSC2	6.3667	9.4737	3.1844	2.9979
SK-CO-1	CTRP2	6.5732	8.2447	5.3476	2.0517
COLO 678	CTRP2	6.6022	13.9476	2.5475	13.4464
C2BBe1	CTRP2	6.6559	8.4671	5.297	2.139
SNU-C2A	CTRP2	6.8605	9.4027	4.987	3.0942
HCC-56	CTRP2	7.1108	8.4822	5.5576	0.6922
GP2d	CTRP2	7.1655	8.8829	5.4146	1.1129
SNU-1033	CTRP2	7.2818	10.0189	4.9693	2.6148
RKO	CTRP2	7.3275	8.7529	5.5514	0.56
LS513	CTRP2	7.3365	9.5124	5.232	1.5834
HCT 8	CTRP2	7.3443	8.7264	5.5698	0.4997
NCI-H747	CTRP2	7.3536	9.582	5.2107	1.6418
LS411N	CTRP2	7.4676	8.6583	5.6495	0.2522
MDST8	CTRP2	7.5783	8.6607	5.6921	0.1533
HT-29	CTRP2	7.6347	8.7572	5.679	0.1481
HT115	CTRP2	7.704	8.9794	5.6257	0.2155
HCT 116	CTRP2	7.7221	8.9934	5.6276	0.2065
SNU-C4	CTRP2	7.7293	8.8846	5.6694	0.1393
SW1417	CTRP2	7.7561	9.5892	5.4141	0.6721
OUMS-23	CTRP2	7.7834	8.8268	5.7092	0.0802
COLO201	CTRP2	7.9204	9.1268	5.6549	0.1181
RCM-1 [Human ESC]	CTRP2	8.0309	9.2383	5.6562	0.0972
SNU-503	CTRP2	8.032	9.3602	5.6142	0.1476
LS180	CTRP2	8.1786	9.5482	5.6023	0.1332
COLO205	CTRP2	8.2392	9.4566	5.6551	0.0696
CCK-81	CTRP2	8.4418	10.217	5.4638	0.27
LoVo	CTRP2	8.4676	10.3943	5.4094	0.3838

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
MO-T	GDSC2	4.9816	6.9289	3.5187	3.4569

Cancer Drug Sensitivity Data Curated from 34 Cell Line(s) in Liver Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
JHH-4	GDSC2	2.2971	5.8324	1.5732	24.2406
JHH-1	GDSC2	2.612	5.4797	2.0488	20.264
SNU-449	GDSC2	2.8099	5.7585	2.1394	18.9288
HuH-1	GDSC2	3.3664	9.0889	1.1018	22.5386
HLE	GDSC2	3.6216	7.6138	2.0613	16.3776
SK-HEP-1	GDSC2	4.1971	11.2088	0.7739	21.3958
JHH-6	GDSC2	4.2693	7.2724	2.8026	9.7638
JHH-7	GDSC2	4.3311	7.4459	2.7676	9.8016
Hep-G2/C3A	GDSC2	4.3312	7.1001	2.9406	8.7144
SNU-398	GDSC2	4.5565	8.1088	2.6202	10.082
JHH-2	GDSC2	4.7628	11.1812	1.2524	17.3699
SNU-398	CTRP2	4.7997	6.8168	4.4181	9.6947
SNU-387	GDSC2	5.0236	7.7737	3.1401	5.6697
SNU-423	GDSC2	5.4872	14.3552	0.2402	20.1567
HuH-6	CTRP2	5.495	6.7268	5.1811	4.8501
Hep-G2	CTRP2	5.7027	6.3376	5.5646	2.9979
JHH-5	CTRP2	5.7643	7.2036	5.2175	4.0568
Huh-7	GDSC2	6.2125	9.1564	3.2391	2.9323
SNU-182	CTRP2	6.254	8.916	4.7793	4.9268
SNU-449	CTRP2	6.2748	7.7248	5.3876	2.3467
HLF	CTRP2	6.2954	9.5825	4.4799	6.1069
SK-HEP-1	CTRP2	6.5654	8.3452	5.2939	2.2796
SNU-475	CTRP2	6.5873	8.1435	5.4055	1.8005
SNU-387	CTRP2	7.2329	8.9061	5.4405	0.9669
SNU-878	CTRP2	7.3723	9.8035	5.1222	1.9406
Hep 3B2.1-7	CTRP2	7.3996	9.0899	5.4478	0.8122
JHH-6	CTRP2	7.4312	8.3224	5.7567	0.087
PLC/PRF/5	CTRP2	7.543	9.0425	5.5344	0.4797
SNU-423	CTRP2	7.6	9.644	5.3161	1.0667
HuH-1	CTRP2	7.7972	8.9677	5.6653	0.1298
JHH-4	CTRP2	7.9249	9.741	5.4301	0.5387
SNU-761	CTRP2	7.9388	9.1458	5.655	0.1145
JHH-2	CTRP2	8.4614	9.9947	5.5499	0.1434
Li-7	CTRP2	10.6983	24.7645	0.2212	14.8855

Cancer Drug Sensitivity Data Curated from 259 Cell Line(s) in Lung Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
NCI-H82	GDSC2	0.7907	2.6017	0.7683	35.5461
NCI-H2122	GDSC2	0.8672	3.8564	0.6679	35.5916
NCI-H524	GDSC2	1.0937	5.0021	0.5922	34.6888
DMS 273	GDSC2	1.2534	7.6802	-0.2996	36.9536
LCLC-97TM1	GDSC2	1.3294	4.8371	0.9022	32.1149
HCC15	GDSC2	1.6458	7.349	0.2483	33.2744
SBC-3	GDSC2	1.6991	5.1521	1.1965	28.8958
NCI-H1792	GDSC2	1.8279	5.2174	1.3121	27.7098
NCI-H2461	GDSC2	1.8659	6.4727	0.8546	29.7495
NCI-H650	GDSC2	1.9645	5.829	1.224	27.5291
NCI-H446	GDSC2	2.0075	5.1074	1.5451	25.6726
NCI-H1944	GDSC2	2.0554	6.0959	1.2106	27.188
KNS-62	GDSC2	2.0874	6.2244	1.1903	27.1474
NCI-H847	GDSC2	2.0998	4.4961	1.8472	23.6308
A-549	GDSC2	2.2145	5.197	1.7353	23.7224
NCI-H2170	GDSC2	2.2772	6.9198	1.0828	26.854
NCI-H1581	GDSC2	2.3127	5.9759	1.5298	24.4069
NCI-H322M	GDSC2	2.4849	7.7543	0.9083	26.8241
SK-MES-1	GDSC2	2.5931	6.846	1.4354	23.74
HCC44	GDSC2	2.5963	5.4932	2.0268	20.4548
NCI-H520	GDSC2	2.6339	8.0136	0.9323	26.1099
LXF 289	GDSC2	2.7483	7.1971	1.4282	23.1564
NCI-H1341	GDSC2	2.8005	5.0452	2.4202	17.3496
Ms-1	GDSC2	2.8129	6.3779	1.8691	20.4696
NCI-H810	GDSC2	2.8212	6.9304	1.6243	21.8085
NCI-H2023	GDSC2	2.8813	7.3272	1.4977	22.2652
SBC-5	GDSC2	2.9346	5.8049	2.2479	17.7964
NCI-H1975	GDSC2	3.2738	9.0983	1.0124	23.3097
NCI-H1355	GDSC2	3.4967	9.2431	1.1438	21.8727
EBC-1	GDSC2	3.5907	6.5682	2.5433	13.5695
NCI-H522	GDSC2	3.6008	9.6463	1.0372	22.0499
NCI-H209	GDSC2	3.6357	6.7936	2.4762	13.8247
Calu-6	GDSC2	3.6445	7.3352	2.2192	15.3563
NCI-H1648	GDSC2	3.735	8.7413	1.6059	18.6128
NCI-H69	GDSC2	3.7606	7.6894	2.1502	15.3811
NCI-H2087	GDSC2	3.7996	6.4985	2.7727	11.4354
NCI-H2066	GDSC2	3.8194	9.5766	1.2649	20.1665
NCI-H1048	GDSC2	3.8622	6.3825	2.8873	10.5119
PC-14	GDSC2	3.8996	7.7625	2.2382	14.3975
Lu-99A	GDSC2	3.9701	7.9793	2.1924	14.4484
HCC827	GDSC2	3.9902	7.2718	2.5621	12.1219
HCC1833	CTRP2	4.0546	6.6997	3.6643	14.6614
NCI-H1651	GDSC2	4.0565	10.0876	1.215	19.6645
COR-L279	GDSC2	4.0916	10.4922	1.0428	20.425
NCI-H1299	GDSC2	4.0917	6.9786	2.7972	10.337
NCI-H1876	GDSC2	4.1458	6.3863	3.1395	8.014
NCI-H358	GDSC2	4.1491	9.6512	1.5119	17.8018
NCI-H526	GDSC2	4.1819	6.5455	3.0914	8.2065
NCI-H1963	GDSC2	4.1896	7.3612	2.6906	10.7038
COR-L105	GDSC2	4.2454	7.1325	2.8524	9.5218
LC-1/sq	GDSC2	4.2506	5.948	3.4488	5.7392
COLO 668	GDSC2	4.2508	6.5385	3.1538	7.6048
UMC-11	GDSC2	4.2646	6.0092	3.43	5.8159
HARA [Human squamous cell lung carcinoma]	GDSC2	4.3144	7.3521	2.8006	9.6441
Lu-65	GDSC2	4.318	6.7757	3.0918	7.7983
HOP-62	GDSC2	4.3386	7.6806	2.6565	10.4747
Calu-3	GDSC2	4.3426	8.9533	2.0234	14.3132
NCI-H211	GDSC2	4.3729	6.2858	3.3822	5.8034
COR-L23	GDSC2	4.4103	7.7509	2.6805	10.1179
NCI-H2009	GDSC2	4.4134	8.5085	2.3044	12.4261
NCI-H1838	GDSC2	4.4423	7.9126	2.6259	10.3667
DMS 114	GDSC2	4.4479	6.3027	3.4345	5.2632
NCI-H841	GDSC2	4.4486	10.9841	1.0958	19.0737
COR-L95	GDSC2	4.4844	7.0054	3.1131	7.1924
NCI-H1869	GDSC2	4.4959	11.0318	1.1109	18.8587
HCC78	GDSC2	4.5169	7.8679	2.7087	9.6417
NCI-H2369	GDSC2	4.5213	6.3886	3.4497	4.9697
RERF-LC-Sq1	GDSC2	4.5295	7.4476	2.9286	8.2305
NCI-H1155	GDSC2	4.5296	8.0302	2.6379	10.047
HCC44	CTRP2	4.5515	5.9856	4.4309	10.366
NCI-H513	GDSC2	4.5518	6.3489	3.493	4.6169
NCI-H1781	GDSC2	4.5619	6.1379	3.6053	3.8855
NCI-H2085	GDSC2	4.577	9.6673	1.8587	14.5895
NCI-H1755	GDSC2	4.5799	7.0248	3.179	6.519
EMC-BAC-2	GDSC2	4.5837	7.4152	2.9876	7.7123
NCI-H1694	GDSC2	4.5843	7.0301	3.1799	6.5021
COR-L88	GDSC2	4.6163	12.1474	0.6517	20.7142
NCI-H2141	GDSC2	4.6328	7.1171	3.1742	6.4105
NCI-H1666	GDSC2	4.6554	8.8861	2.3115	11.7005
DMS 53	GDSC2	4.6566	7.3212	3.0913	6.8687
NCI-H1993	GDSC2	4.675	7.3252	3.1034	6.7451
Sq-1	CTRP2	4.685	6.3706	4.4605	9.8587
SHP-77	GDSC2	4.7116	6.0852	3.7401	2.6934
VMRC-LCD	GDSC2	4.7509	8.7025	2.4781	10.4296
LCLC-103H	GDSC2	4.7661	7.567	3.053	6.8279
NCI-H2405	GDSC2	4.7686	8.8158	2.4355	10.6423
NCI-H720	GDSC2	4.8184	7.3301	3.2089	5.7273
NCI-H2373	GDSC2	4.8186	10.8509	1.4615	16.1143
NCI-H441	GDSC2	4.8464	7.9835	2.9078	7.5305
NCI-H1623	GDSC2	4.8633	7.7513	3.0348	6.6998
NCI-H1568	GDSC2	4.8802	8.4985	2.6787	8.8618
EBC-1	CTRP2	4.9004	6.7721	4.5425	9.6003
NCI-H1915	GDSC2	4.9216	9.7042	2.1128	12.1682
HCC827	CTRP2	4.9601	7.1544	4.4448	9.1594
NCI-H1435	GDSC2	4.976	7.8137	3.0866	6.1093
COR-L311	GDSC2	5.001	7.6066	3.2053	5.3212
Lu-135	GDSC2	5.0028	7.1223	3.4405	3.8842
Lu-139	GDSC2	5.0256	7.1355	3.4495	3.7817
NCI-H2228	GDSC2	5.026	12.4833	0.8121	18.8201
PaCa-3	GDSC2	5.055	10.7574	1.6929	14.2138
LK-2	GDSC2	5.0564	8.0206	3.0432	6.189
NCI-H226	GDSC2	5.0597	11.1508	1.5011	15.2473
NCI-H1573	GDSC2	5.0757	7.5687	3.2757	4.7258
NCI-H1341	CTRP2	5.0791	6.1459	4.9616	6.8457
NCI-H1092	GDSC2	5.1042	7.3835	3.3838	4.0131
NCI-H64	GDSC2	5.1103	6.707	3.7047	2.1232
HCC2108	CTRP2	5.1266	6.8412	4.7516	7.5124
NCI-H2818	GDSC2	5.1408	11.3107	1.4843	15.1228
NCI-H23	GDSC2	5.1708	8.1858	3.0435	5.9285
NCI-H1703	GDSC2	5.1717	10.9414	1.691	13.9195
NCI-H1693	GDSC2	5.1822	8.5236	2.8877	6.8518
PC-14	CTRP2	5.1892	6.4687	4.9687	6.501
CPC-N	GDSC2	5.2902	8.0403	3.1946	4.7627
EPLC-272H	GDSC2	5.3212	9.7476	2.3901	9.5266
NCI-H196	GDSC2	5.3552	9.4663	2.5517	8.4845
LOU-NH91	GDSC2	5.3879	11.1026	1.7737	12.914
NCI-H2347	GDSC2	5.3883	8.4339	3.0724	5.2906
NCI-H1793	GDSC2	5.4107	8.3437	3.1299	4.9031
NCI-H1373	CTRP2	5.4115	6.5053	5.1899	5.0362
NCI-H2731	GDSC2	5.4274	9.1263	2.7669	7.0341
NCI-H211	CTRP2	5.4299	6.8843	5.0444	5.5625
LXF 289	CTRP2	5.435	6.3564	5.2741	4.9913
NCI-H2591	GDSC2	5.4371	8.7654	2.9467	5.9386
NCI-H2030	CTRP2	5.4435	6.3352	5.2913	4.5577
NCI-H2342	GDSC2	5.4488	8.8696	2.9048	6.1642
IA-LM	GDSC2	5.4844	7.4443	3.59	2.1511
NCI-H2595	GDSC2	5.5596	9.9962	2.4384	8.6931
NCI-H1694	CTRP2	5.5623	7.3778	4.943	5.6527
SW1573	GDSC2	5.5788	9.534	2.6743	7.2586
HCC1195	CTRP2	5.5872	7.1239	5.0884	4.9975
NCI-H2722	GDSC2	5.6138	11.6043	1.6932	12.8062
Lu-165	GDSC2	5.618	7.2639	3.7391	1.2264
HOP-92	GDSC2	5.6181	10.1905	2.385	8.8751
NCI-H2795	GDSC2	5.6657	9.8444	2.5844	7.6033
NCI-H1734	CTRP2	5.6678	6.9965	5.227	4.2391
EPLC-272H	CTRP2	5.691	7.0926	5.2029	4.2839
NCI-H1688	GDSC2	5.7005	9.4826	2.7802	6.3818
NCI-H835	GDSC2	5.7391	8.5998	3.2169	3.7897
NCI-H2087	CTRP2	5.7559	6.947	5.3348	3.5907
SW1271	GDSC2	5.7576	10.942	2.1186	10.1001
HCC78	CTRP2	5.7826	7.4755	5.1004	4.504
NCI-H1792	CTRP2	5.7885	7.3648	5.1604	4.241
NCI-H1915	CTRP2	5.7904	8.2527	4.722	6.0689
NCI-H3122	GDSC2	5.795	8.8191	3.1501	4.069
NCI-H810	CTRP2	5.8113	6.7309	5.4917	2.8161
NCI-H1563	CTRP2	5.8164	7.0103	5.3604	3.3478
NCI-H2228	CTRP2	5.8493	6.7245	5.5306	2.5681
NCI-H526	CTRP2	5.8556	7.1881	5.3084	3.4784
SW1271	CTRP2	5.8613	6.8488	5.481	2.7471
NCI-H1755	CTRP2	5.8719	8.3388	4.7505	6.2094
NCI-H2405	CTRP2	5.91	7.6525	5.1258	4.1289
NCI-H727	GDSC2	5.9176	9.2752	3.015	4.6167
NCI-H2081	CTRP2	5.9223	8.617	4.655	6.0802
NCI-H520	CTRP2	5.9264	6.8969	5.5162	2.4591
NCI-H1092	CTRP2	5.9404	11.5075	3.2258	12.0029
NCI-H1650	GDSC2	5.9421	9.0626	3.127	3.948
NCI-H358	CTRP2	5.9547	7.2156	5.3825	2.9602
NCI-H1395	CTRP2	5.9749	13.5546	2.2312	15.8623
RERF-LC-KJ	GDSC2	5.9764	9.3619	3.0109	4.537
VMRC-LCD	CTRP2	6.0097	7.509	5.2829	3.2684
NCI-H1869	CTRP2	6.016	8.0103	5.0377	4.2867
HCC95	CTRP2	6.0177	8.0408	5.0238	4.3416
SK-LU-1	GDSC2	6.0236	15.1524	0.2512	18.787
MOR/CPR	CTRP2	6.0261	6.5765	5.7629	1.2188
NCI-H1563	GDSC2	6.0281	11.4479	2.0611	9.8312
NCI-H1581	CTRP2	6.0345	7.816	5.1503	3.7773
Calu-6	CTRP2	6.0375	7.4774	5.3222	3.275
NCI-H522	CTRP2	6.0402	8.4471	4.8396	5.0724
HARA [Human squamous cell lung carcinoma]	CTRP2	6.045	7.1047	5.5147	2.2252
SK-LU-1	CTRP2	6.0516	7.2619	5.4416	2.7065
NCI-H441	CTRP2	6.0766	7.6543	5.2661	3.2099
DV-90	CTRP2	6.0817	7.3951	5.3999	2.638
IA-LM	CTRP2	6.0872	7.5635	5.3202	2.9623
NCI-H1155	CTRP2	6.1235	7.4558	5.4035	2.5452
NCI-H1573	CTRP2	6.1321	7.9583	5.1595	3.5534
LK2	CTRP2	6.157	7.1401	5.5873	1.7145
SK-MES-1	CTRP2	6.1592	7.9803	5.1704	3.4582
HOP-92	CTRP2	6.1653	9.2221	4.5551	6.0302
Lu-65	CTRP2	6.1695	10.0602	4.1398	7.7651
NCI-H2106	CTRP2	6.1844	7.4956	5.4319	2.3164
NCI-H889	CTRP2	6.2139	7.5557	5.4249	2.2945
NCI-H2342	CTRP2	6.2379	9.5024	4.4739	6.2369
Calu-3	CTRP2	6.2673	8.0847	5.2035	3.1271
HOP-62	CTRP2	6.2682	8.3278	5.0834	3.6274
NCI-H2170	CTRP2	6.282	7.6537	5.4281	2.1663
NCI-H446	CTRP2	6.2844	7.3733	5.5678	1.5851
Lu-99	CTRP2	6.3005	7.3803	5.576	1.526
LUDLU-1	CTRP2	6.3023	8.1373	5.2043	3.0635
NCI-H23	CTRP2	6.3056	8.316	5.1182	3.4171
NCI-H2286	CTRP2	6.3237	7.622	5.4745	1.9073
NCI-H1666	CTRP2	6.3423	8.5405	5.0351	3.7013
NCI-H2291	CTRP2	6.3545	8.2792	5.1737	3.1031
NCI-H1568	CTRP2	6.3869	7.9615	5.3542	2.3033
NCI-H2122	CTRP2	6.4171	8.1641	5.2768	2.5742
A-549	CTRP2	6.4345	8.9291	4.9129	4.0542
NCI-H596	GDSC2	6.4769	17.2581	-0.4499	20.4977
NCI-H650	CTRP2	6.4788	40.9212	-11.0334	37.8194
NCI-H2085	CTRP2	6.4816	8.7856	5.0189	3.5364
HCC4006	CTRP2	6.5134	7.9022	5.4713	1.6401
COR-L95	CTRP2	6.5655	8.6803	5.1315	2.9408
BEN	CTRP2	6.5971	23.3579	-2.1562	27.2066
HCC1588	CTRP2	6.6172	8.165	5.4151	1.7224
NCI-H1703	CTRP2	6.626	9.3696	4.8381	4.0523
NCI-H1435	CTRP2	6.6393	8.2894	5.3706	2.0073
LCLC-103H	CTRP2	6.7088	8.1275	5.4906	1.3146
NCI-H1650	CTRP2	6.7155	8.3666	5.3836	1.718
NCI-H2023	CTRP2	6.7249	8.2897	5.4255	1.6586
NCI-H2196	CTRP2	6.7651	9.3648	4.9397	3.423
NCI-H661	GDSC2	6.801	8.5306	3.7596	0.3317
NCI-H1793	CTRP2	6.9225	9.3043	5.0753	2.6577
HCC1438	CTRP2	6.9274	9.5817	4.9465	3.1631
COLO 699	CTRP2	6.9316	8.846	5.2958	1.79
DMS 53	CTRP2	6.9403	8.9736	5.242	1.9849
CAL-12T	CTRP2	6.9583	8.8889	5.2924	1.7715
NCI-H1339	CTRP2	7.0086	8.6069	5.4495	1.1417
HCC2935	CTRP2	7.0255	9.2309	5.1757	2.1355
NCI-H2444	CTRP2	7.0783	8.6283	5.4783	0.9765
NCI-H1299	CTRP2	7.1405	9.7683	4.9974	2.6803
RERF-LC-A1	CTRP2	7.1508	9.1855	5.2719	1.6319
DMS 114	CTRP2	7.1747	8.8603	5.4294	1.0546
COR-L88	CTRP2	7.2642	13.3222	3.3652	9.0638
T3M-10	CTRP2	7.2954	9.5863	5.1754	1.829
HCC15	CTRP2	7.348	11.3401	4.3883	4.809
LOU-NH91	CTRP2	7.3504	9.0416	5.4434	0.8629
SBC-5	CTRP2	7.3632	8.4085	5.7	0.1922
HCC1171	CTRP2	7.4513	10.2403	4.9707	2.4122
NCI-H460	CTRP2	7.4567	9.6642	5.2318	1.4677
RERF-LC-MS	CTRP2	7.4625	9.1965	5.4345	0.8065
Calu-1	CTRP2	7.4746	12.0268	4.1449	5.6044
COLO 668	CTRP2	7.6627	9.491	5.4102	0.741
ChaGo-K-1	CTRP2	7.6637	9.8661	5.2546	1.2107
KNS-62	CTRP2	7.6747	10.0058	5.2006	1.3772
NCI-H1651	CTRP2	7.7497	9.9821	5.2495	1.1586
NCI-H647	CTRP2	7.7875	11.7631	4.4743	3.8953
NCI-H1838	CTRP2	7.8135	9.7738	5.3666	0.7666
NCI-H841	CTRP2	7.8169	9.3418	5.5369	0.3462
NCI-H226	CTRP2	7.8238	9.4605	5.4946	0.4357
DMS 454	CTRP2	7.8664	11.1289	4.8121	2.5431
NCI-H2126	CTRP2	7.8713	9.0372	5.6682	0.1195
RERF-LC-Ad2	CTRP2	7.8946	13.9383	3.5127	7.5163
SHP-77	CTRP2	7.9178	9.1058	5.6612	0.1109
NCI-H2172	CTRP2	7.9327	9.2723	5.6082	0.1794
NCI-H727	CTRP2	8.0262	9.8001	5.4508	0.4432
NCI-H1184	CTRP2	8.03	9.9093	5.4106	0.5729
NCI-H196	CTRP2	8.0382	9.4505	5.5846	0.1883
COR-L105	CTRP2	8.1736	10.5775	5.2106	0.9731
NCI-H1623	CTRP2	8.2018	11.0926	5.0106	1.5542
LC-1/sq-SF	CTRP2	8.2142	9.4696	5.642	0.0844
NCI-H2110	CTRP2	8.3196	10.49	5.3115	0.6268
NCI-H838	CTRP2	8.3502	9.5631	5.6576	0.056
NCI-H1944	CTRP2	8.3963	10.8878	5.1893	0.8942
EKVX	CTRP2	8.4121	19.124	1.3575	14.6675
HCC366	CTRP2	8.5352	10.3032	5.4686	0.2373
NCI-H322	CTRP2	8.6583	9.9847	5.622	0.0526
NCI-H1355	CTRP2	8.7675	10.4304	5.5095	0.1362
HCC2279	CTRP2	8.7693	10.6528	5.4326	0.2329
NCI-H661	CTRP2	11.6589	27.0667	-0.2366	14.9235
NCI-H292	CTRP2	13.6029	28.7177	0.2159	11.4909
Hs 888.Lu	CTRP2	6.6046	21.4672	-1.2053	25.1109

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
CBTCi002-A	GDSC2	2.8256	7.5313	1.3471	23.282

Cancer Drug Sensitivity Data Curated from 43 Cell Line(s) in Soft Tissue Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
Yamato-SS	CTRP2	6.3422	7.6153	5.4912	1.8095
Aska-SS	CTRP2	6.4532	7.9488	5.4076	1.9829
Hs 633.T	GDSC2	2.1848	6.2694	1.2725	26.3049
KYM-1	GDSC2	2.2383	5.9876	1.4472	25.1667
MES-SA	GDSC2	2.601	4.9565	2.239	19.2336
SW982	GDSC2	2.7922	6.5535	1.7686	21.1197
HT-1080	GDSC2	3.1623	7.4315	1.7197	19.98
SK-LMS-1	GDSC2	3.2216	6.949	2.0075	18.11
SW684	GDSC2	3.4969	10.1106	0.7143	23.9432
SW872	GDSC2	3.5004	6.9644	2.2662	15.571
SK-UT-1	GDSC2	3.6657	7.3362	2.2382	15.1701
VA-ES-BJ	GDSC2	4.1111	8.2727	2.1682	14.1521
G-402	GDSC2	4.1679	9.0003	1.8532	15.8311
RD	GDSC2	4.3447	8.498	2.2528	12.9383
G-401	GDSC2	4.4451	10.5364	1.3167	17.9505
EW-8	GDSC2	4.5712	8.6342	2.3698	11.58
A-204	GDSC2	4.6523	7.9429	2.7788	8.8353
GCT	GDSC2	4.6965	8.1113	2.7297	9.0235
MFH-ino	GDSC2	5.1062	10.8362	1.6931	14.0784
Rh41	GDSC2	5.1099	8.7511	2.7248	8.0138
Rh30	GDSC2	5.4105	8.2424	3.1777	4.6214
RKN	GDSC2	5.7551	12.6239	1.2963	14.5626
GCT	CTRP2	5.7902	7.3355	5.1764	4.1706
KYM-1	CTRP2	6.2012	7.5848	5.4007	2.4177
Hs 729.T	CTRP2	6.3044	7.5004	5.5201	1.75
G-402	CTRP2	6.3829	8.5494	5.0616	3.5221
SK-LMS-1	CTRP2	6.4164	8.0548	5.3298	2.3572
TE 617.T	CTRP2	6.6119	8.2907	5.3517	1.9812
MES-SA	CTRP2	6.6459	8.035	5.4945	1.3756
HT-1080	CTRP2	6.7387	8.0223	5.5567	1.035
BT-12	CTRP2	6.766	9.738	4.759	4.1592
Tm87-16	CTRP2	6.8124	8.3419	5.4551	1.3285
Rh41	CTRP2	6.9249	9.402	5.0306	2.8315
A-204	CTRP2	7.0575	9.9879	4.8396	3.41
G-401	CTRP2	7.0635	10.7352	4.4844	4.831
Rh18	CTRP2	7.3598	10.0967	4.9813	2.4771
BT-16	CTRP2	7.7172	9.2031	5.5477	0.3646
TTC-709	CTRP2	7.8792	9.5517	5.4833	0.436
SW982	CTRP2	7.899	9.1445	5.6408	0.1406
SK-UT-1	CTRP2	7.909	12.9552	3.992	5.612
RKN	CTRP2	8.0032	9.0206	5.7201	0.0479
TE 441.T	CTRP2	8.2131	9.4598	5.6449	0.0818
RD	CTRP2	8.8867	15.7277	3.3169	6.9324

Cancer Drug Sensitivity Data Curated from 2 Cell Line(s) in Thigh Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
H-STS	CTRP2	7.2943	8.3224	5.7041	0.2085
SYO-1	CTRP2	7.9752	9.4184	5.572	0.2255

Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Clivus Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
U-CH1	CTRP2	7.9764	9.5532	5.5231	0.3133

Cancer Drug Sensitivity Data Curated from 64 Cell Line(s) in Ovary Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
2004	CTRP2	8.1334	10.0243	5.4107	0.485
DOV13	GDSC2	2.4889	8.4852	0.5678	28.3392
TYK-nu	GDSC2	2.6015	7.2953	1.2372	24.7375
TOV-112D	GDSC2	2.7649	7.5464	1.2807	23.8641
TOV-21G	GDSC2	2.8447	8.6826	0.8146	25.8398
A2780	GDSC2	2.9707	6.6738	1.8916	19.7246
OVCAR-3	GDSC2	3.0572	5.2142	2.6261	15.089
ES-2	GDSC2	3.6416	8.1562	1.812	17.7633
OAW42	GDSC2	4.0586	7.7422	2.3877	12.9823
OVCAR-8	GDSC2	4.1672	11.1161	0.7951	21.3881
OV-90	GDSC2	4.3627	9.3284	1.8525	15.2475
IGROV-1	GDSC2	4.3723	8.1673	2.4411	11.7105
OVTOKO	GDSC2	4.4321	8.7243	2.2118	12.9305
OC 314	GDSC2	4.4472	8.2551	2.4587	11.3864
OV56	GDSC2	4.536	6.4296	3.4407	4.9875
FU-OV-1	GDSC2	4.5495	8.9102	2.2145	12.5791
Kuramochi	GDSC2	4.7117	8.2969	2.6492	9.4822
Caov-4	GDSC2	4.8519	7.4464	3.1763	5.8487
SK-OV-3	GDSC2	4.89	7.6452	3.1067	6.189
OVISE	GDSC2	4.9656	7.7776	3.0967	6.0709
OVCAR-4	GDSC2	4.9757	7.6256	3.1782	5.5458
OAW28	GDSC2	4.9946	9.1108	2.4624	9.8929
OVCAR-5	GDSC2	5.1816	18.2191	-1.9239	28.21
RMG-I	GDSC2	5.2323	10.4127	1.9979	12.0366
ES2	CTRP2	5.3738	6.6638	5.084	5.5509
HEY A8	CTRP2	5.3865	6.6437	5.1057	5.8346
EFO-21	GDSC2	5.4724	9.147	2.7878	6.8121
A2780	CTRP2	5.5149	6.4579	5.318	4.2581
OVKATE	GDSC2	5.6069	11.3628	1.8065	12.2006
MCAS	CTRP2	5.7323	7.5354	5.0251	4.9274
TYK-nu	CTRP2	5.741	7.4123	5.0936	4.6234
Caov-3	CTRP2	5.8268	6.579	5.5795	2.5983
OVCAR-8	CTRP2	5.9507	7.6154	5.1795	3.8205
OVSAHO	CTRP2	6.2483	8.4606	5.0017	4.0047
COV362	CTRP2	6.4575	7.8936	5.4374	1.8558
COV434	CTRP2	6.5253	9.7955	4.553	5.3996
OV7	CTRP2	6.5827	10.7375	4.13	7.0626
JHOS-2	CTRP2	6.7112	9.4569	4.8569	3.8421
SNU-840	CTRP2	6.9479	8.6669	5.3877	1.4275
EFO-21	CTRP2	6.9738	8.8121	5.337	1.5865
OC 314	CTRP2	7.0819	9.4272	5.1196	2.2817
OV56	CTRP2	7.2233	8.6096	5.5602	0.6033
TOV-112D	CTRP2	7.3262	9.3981	5.2769	1.4359
OVISE	CTRP2	7.3289	8.8893	5.4962	0.7181
SNU-119	CTRP2	7.3756	9.1336	5.4174	0.9246
SNU-8	CTRP2	7.5652	8.7214	5.6652	0.1896
JHOM-1	CTRP2	7.6205	9.2964	5.4689	0.606
OAW42	CTRP2	7.7529	8.7791	5.7147	0.0792
OVCAR-5	CTRP2	7.7735	9.9615	5.2701	1.0763
ONCO-DG-1	CTRP2	7.8206	9.2267	5.5812	0.2577
DOV13	CTRP2	7.8601	9.4695	5.5066	0.3929
TOV-21G	CTRP2	7.9224	9.3659	5.5704	0.2441
JHOC-5	CTRP2	7.9296	9.0179	5.6956	0.0726
Kuramochi	CTRP2	7.9916	9.7307	5.4627	0.4323
SK-OV-3	CTRP2	8.0096	9.4726	5.5657	0.2427
OVTOKO	CTRP2	8.0416	9.6934	5.4974	0.3397
OAW28	CTRP2	8.0674	10.1912	5.3165	0.749
FU-OV-1	CTRP2	8.1853	10.007	5.4389	0.4026
COV644	CTRP2	8.2446	9.7988	5.5385	0.2055
RMG-I	CTRP2	8.2838	10.3708	5.3421	0.6146
OV-90	CTRP2	8.4937	10.2981	5.4546	0.2704
OVCAR-4	CTRP2	8.8294	11.197	5.2576	0.522
EFO-27	CTRP2	8.9376	10.3958	5.5801	0.0562
IGROV-1	CTRP2	11.4895	27.3932	-0.5042	15.8446

Cancer Drug Sensitivity Data Curated from 13 Cell Line(s) in Pleura Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
MSTO-211H	GDSC2	3.2277	5.9479	2.482	15.2673
MPP 89	GDSC2	3.833	10.2608	0.9358	21.776
NCI-H2452	GDSC2	4.8348	12.1977	0.8028	19.3906
IST-Mes1	GDSC2	4.9192	9.7353	2.0955	12.2759
NCI-H2452	CTRP2	5.1458	6.3632	4.9614	6.6518
NCI-H2052	GDSC2	5.2574	9.4019	2.5131	8.9444
NCI-H28	GDSC2	5.2747	11.4684	1.5083	14.6471
MSTO-211H	CTRP2	6.0969	7.5281	5.3458	2.8366
NCI-H2052	CTRP2	6.1719	7.2809	5.529	1.9326
NCI-H28	CTRP2	6.6132	8.4654	5.2689	2.3115
IST-Mes1	CTRP2	7.3817	9.3346	5.3347	1.1877
JL-1	CTRP2	7.4873	9.5609	5.2932	1.2335
ACC-MESO-1	CTRP2	7.8968	9.0877	5.6599	0.1165

Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Prostate Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
VCaP	GDSC2	3.7093	7.7881	2.0551	16.1184
LNCaP clone FGC	GDSC2	4.1008	6.586	3.0007	9.0289
DU145	GDSC2	4.1517	8.378	2.1503	14.1343
PC-3	GDSC2	4.3961	10.5089	1.2901	18.2353
22Rv1	GDSC2	4.5112	9.622	1.8279	14.9542
NCI-H660	CTRP2	5.4567	7.0187	5.0098	5.6339
PaCa-3	CTRP2	6.0746	7.1343	5.5244	2.1283
22Rv1	CTRP2	6.3669	8.5605	5.044	3.6223
VCaP	CTRP2	6.6037	8.2612	5.3603	1.9582
DU145	CTRP2	7.1494	10.6715	4.5744	4.343
LNCaP clone FGC	CTRP2	7.9475	9.919	5.3702	0.6769

Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Salivary Gland Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
A-253	GDSC2	4.7799	10.6416	1.5351	15.8246
A-253	CTRP2	7.3258	10.1175	4.9508	2.6324
YD-15	CTRP2	7.7628	8.8618	5.6897	0.1056

Cancer Drug Sensitivity Data Curated from 57 Cell Line(s) in Stomach Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
HSC-39	GDSC2	1.083	2.3508	1.0789	32.5235
SNU-16	GDSC2	1.6923	4.3938	1.4322	27.7312
HGC-27	GDSC2	1.9624	6.3521	1.0061	28.6044
GCIY	GDSC2	2.066	4.7889	1.7183	24.4805
23132/87	GDSC2	2.1911	5.9366	1.4188	25.5214
SNU-1	GDSC2	2.1983	4.7815	1.8643	23.0906
SNU-5	GDSC2	2.5835	5.8194	1.8782	21.3484
MKN45	GDSC2	3.1197	6.8985	1.9327	18.9231
RF-48	GDSC2	3.3531	6.2172	2.4819	14.7977
OCUM-1	GDSC2	3.5785	8.5798	1.5456	19.4718
Fu97	GDSC2	3.6141	7.4038	2.1575	15.8301
AGS	GDSC2	3.7305	7.0151	2.4555	13.629
TGBC11TKB	GDSC2	3.8096	6.1064	2.9735	10.1527
NCI-N87	GDSC2	3.9854	9.0198	1.687	17.3467
ECC10	GDSC2	4.1988	5.9943	3.381	6.3253
MKN28	GDSC2	4.3981	7.9983	2.5468	10.9839
KATO III	GDSC2	4.4933	8.8659	2.1911	12.8788
MKN1	GDSC2	4.5782	9.1039	2.141	12.937
IM95	GDSC2	4.5975	7.0409	3.1847	6.437
NUGC-3	GDSC2	4.7562	11.4863	1.0949	18.1899
SNU-719	CTRP2	4.9814	7.1224	4.4807	8.9617
NUGC-4	GDSC2	4.9821	7.7359	3.129	5.8339
RERF-GC-1B	GDSC2	5.0046	8.9067	2.5707	9.2102
SK-GT-2	GDSC2	5.1688	7.7736	3.2407	4.7387
NCI-N87	CTRP2	5.19	6.7347	4.8626	6.9085
Hs 746.T	GDSC2	5.196	10.708	1.8248	13.1118
SNU-620	CTRP2	5.3095	6.0771	5.2332	5.164
HGC-27	CTRP2	5.4047	6.9579	4.9856	5.8619
NUGC-4	CTRP2	5.5988	7.9024	4.7222	6.4822
SNU-216	CTRP2	5.606	6.7293	5.2919	4.1249
SNU-16	CTRP2	5.8241	6.4776	5.6249	2.24
ECC10	CTRP2	6.0441	7.1615	5.4856	2.3494
Fu97	CTRP2	6.2155	9.4151	4.4994	6.1712
LMSU	CTRP2	6.2466	7.3404	5.5562	1.6932
MKN45	CTRP2	6.3857	8.9961	4.8424	4.4308
GSS	CTRP2	6.4288	7.5838	5.5666	1.3762
NUGC-3	CTRP2	6.46	7.8452	5.4624	1.8807
SH-10-TC	CTRP2	6.5715	7.8897	5.5153	1.3884
SNU-668	CTRP2	6.9236	8.5585	5.4225	1.3263
23132/87	CTRP2	7.0339	9.0456	5.2663	1.7822
MKN74	CTRP2	7.101	8.9182	5.3633	1.3544
HuG1-N	CTRP2	7.1701	8.9661	5.3807	1.2251
KE-39	CTRP2	7.2063	9.2484	5.2758	1.5596
AGS	CTRP2	7.2898	9.534	5.1957	1.7615
SNU-1	CTRP2	7.5138	9.7331	5.2328	1.4118
SNU-601	CTRP2	7.5548	10.5831	4.8761	2.6477
ECC12	CTRP2	7.6936	8.7251	5.712	0.0919
MKN7	CTRP2	7.8557	9.5589	5.4705	0.4765
IM95	CTRP2	7.8879	9.872	5.3617	0.7343
Hs 746.T	CTRP2	7.94	9.9208	5.3661	0.692
MKN1	CTRP2	8.4231	10.0903	5.5021	0.2152
NCC-StC-K140	CTRP2	8.688	11.2321	5.1842	0.749
GSU	CTRP2	11.0085	35.5932	-4.8248	25.3913
SNG-M	GDSC2	2.6053	5.4032	2.0726	20.1574
SNU-685	CTRP2	6.2316	7.2937	5.568	1.6688
SNU-1077	CTRP2	7.9221	9.5003	5.5207	0.3382
SNG-M	CTRP2	13.3306	29.6188	-0.3655	13.3182

Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Thyroid Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
IHH-4	GDSC2	0.5654	4.1567	0.2662	38.9035
BHT-101	GDSC2	2.0256	5.7086	1.3368	26.6798
ASH-3	GDSC2	2.155	5.1283	1.6966	24.1968
K5	GDSC2	2.2122	4.8542	1.8549	23.079
CAL-62	GDSC2	2.9055	6.0612	2.1051	18.7452
TT	GDSC2	3.5586	8.4821	1.5759	19.3736
FTC-133	GDSC2	3.6499	8.5772	1.6112	18.8682
HTC-C3	GDSC2	3.7028	8.0573	1.9162	16.9557
8305C	GDSC2	5.1027	12.9041	0.6629	19.3075
B-CPAP	GDSC2	5.1876	10.3608	1.9901	12.1939
TT2609-C02	GDSC2	5.262	7.7361	3.3203	4.0719
CGTH-W-1	GDSC2	5.3316	10.0968	2.2267	10.4656
8505C	GDSC2	5.4419	12.642	1.0544	16.5541
ML-1 [Human leukemia]	CTRP2	5.5116	6.9122	5.1136	5.079
CAL-62	CTRP2	5.5141	7.7075	4.7381	6.6081
WRO	GDSC2	5.9348	12.7492	1.3651	13.785
FTC-238	CTRP2	6.0094	6.6741	5.7	1.5167
8305C	CTRP2	6.3049	7.4303	5.5547	1.6066
TT	CTRP2	6.6233	8.2862	5.3615	1.9267
SW579	CTRP2	6.8105	8.2307	5.5044	1.1485
8505C	CTRP2	7.0793	9.5163	5.0765	2.4511
TT2609-C02	CTRP2	7.5511	11.5962	4.4014	4.4802
FTC-133	CTRP2	7.6099	9.189	5.5067	0.5136
CGTH-W-1	CTRP2	7.9543	9.4473	5.5533	0.2644
BHT-101	CTRP2	7.9959	9.3745	5.5956	0.1824
B-CPAP	CTRP2	8.1435	9.4314	5.63	0.1072

Cancer Drug Sensitivity Data Curated from 55 Cell Line(s) in Upper Aerodigestive Tract Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
SAS	GDSC2	1.5775	6.7538	0.4353	32.8815
FaDu	GDSC2	1.9296	7.5738	0.4368	31.2531
Ca9-22	GDSC2	2.0089	5.0825	1.5555	25.6108
HO-1-N-1	GDSC2	2.2392	6.7821	1.1054	26.906
Detroit 562	GDSC2	2.5714	7.1133	1.2914	24.5816
HSC-3	GDSC2	2.9966	6.0823	2.1881	17.9029
CAL-33	GDSC2	3.1124	9.308	0.7609	25.0878
HSC-2	GDSC2	3.1516	8.2518	1.3131	22.2291
HO-1-u-1	GDSC2	3.4663	9.8462	0.8179	23.5671
CAL-27	GDSC2	3.5418	7.1969	2.1918	15.8737
SCC-15	GDSC2	3.6092	7.9913	1.864	17.5741
DOK	GDSC2	3.7962	7.6683	2.1927	15.0087
BICR 78	GDSC2	3.8533	9.9403	1.1133	20.8325
BICR 10	GDSC2	3.9015	6.8098	2.7123	11.4735
NCI-H3118	GDSC2	4.2355	7.1205	2.85	9.5669
SKN-3	GDSC2	4.378	7.6409	2.7089	10.0333
PCI-30	GDSC2	4.4551	8.7474	2.2192	12.8197
BICR 22	GDSC2	4.7086	8.3254	2.6326	9.5924
LB771-HNC	GDSC2	4.804	8.206	2.7656	8.5203
OSC-20	GDSC2	4.8887	7.8535	3.0034	6.8327
HSC-4	GDSC2	4.8985	11.6959	1.1037	17.7486
YD-10B	CTRP2	5.014	6.0642	4.9144	7.2136
JHU-022	GDSC2	5.126	12.6416	0.8117	18.5522
SAT [Human HNSCC]	GDSC2	5.3176	11.912	1.3213	15.5216
SCC-4	GDSC2	5.6061	9.7575	2.5856	7.7238
BICR 56	CTRP2	5.9746	6.7154	5.6491	1.8014
HSC-4	CTRP2	6.0817	7.5673	5.3138	2.9994
SNU-1076	CTRP2	6.1478	7.3557	5.4728	2.2104
HSC-3	CTRP2	6.3034	7.5318	5.504	1.818
UPCI-SCC-090	GDSC2	6.3041	8.2912	3.6459	0.961
SCC-9	GDSC2	6.3565	9.0867	3.3453	2.2154
YD-8	CTRP2	6.4571	7.9579	5.406	1.9838
FaDu	CTRP2	6.4736	8.6286	5.0902	3.2545
SNU-1041	CTRP2	6.7514	8.4104	5.3859	1.6639
CAL-33	CTRP2	6.7518	8.775	5.2141	2.3375
PE/CA-PJ34 (clone C12)	CTRP2	6.9538	8.4102	5.5059	0.9979
SCC-25	CTRP2	6.9952	8.9728	5.2762	1.7894
BICR 22	CTRP2	7.133	8.623	5.5095	0.8267
PE/CA-PJ15	CTRP2	7.1606	9.2595	5.2442	1.7227
SNU-1214	CTRP2	7.2434	9.0407	5.388	1.1321
Detroit 562	CTRP2	7.2486	11.999	4.0012	6.5159
PE/CA-PJ49	CTRP2	7.3045	9.3802	5.2727	1.4718
BICR 6	CTRP2	7.5436	8.7212	5.6568	0.2113
SNU-899	CTRP2	7.5484	10.0211	5.1254	1.7492
BICR 16	CTRP2	7.6365	9.2202	5.5063	0.5003
HSC-2	CTRP2	7.6886	9.1047	5.573	0.3224
PE/CA-PJ41 (clone D2)	CTRP2	7.706	9.7532	5.3234	0.9644
CAL-27	CTRP2	7.9732	9.2665	5.6254	0.1453
BICR 31	CTRP2	7.9971	9.4682	5.5624	0.2352
BHY	CTRP2	8.1875	9.8706	5.4905	0.3019
SNU-1066	CTRP2	8.3714	9.6593	5.6326	0.073
SCC-9	CTRP2	8.3732	10.5899	5.2962	0.6371
SNU-46	CTRP2	8.4206	9.8088	5.5991	0.0968
SCC-4	CTRP2	8.4626	10.2983	5.4425	0.2998
BICR 18	CTRP2	8.5513	10.2346	5.499	0.19

Cancer Drug Sensitivity Data Curated from 38 Cell Line(s) in Urinary Tract Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
UM-UC-3	GDSC2	1.4624	5.1764	0.9322	31.3122
BFTC-905	GDSC2	2.3186	6.5392	1.2939	25.6198
639V	GDSC2	2.5205	4.9522	2.1539	20.0615
KU-19-19	GDSC2	3.6657	6.6156	2.5909	13.0167
RT-4	GDSC2	3.8447	8.4657	1.84	16.9283
CAL-29	GDSC2	4.043	6.7562	2.8652	10.0627
HT-1376	GDSC2	4.4475	9.0961	2.0387	13.9157
VM-CUB-1	CTRP2	4.4909	5.6895	4.431	10.5545
647V	GDSC2	4.5957	7.5635	2.9232	8.0845
5637	GDSC2	4.8396	9.7542	2.0242	12.9051
SW780	GDSC2	4.9448	7.1721	3.3766	4.3982
SW1710	GDSC2	4.9586	9.884	2.0521	12.426
J82	GDSC2	5.1796	11.2902	1.5242	14.8075
JMSU-1	CTRP2	5.1849	6.4775	4.9607	6.5438
TCCSUP	GDSC2	5.3952	12.0888	1.2927	15.4712
647V	CTRP2	5.5288	6.3495	5.3766	3.9932
RT-112	GDSC2	5.5397	9.3778	2.7228	7.0549
TCCSUP	CTRP2	5.5561	6.9623	5.1344	4.885
CAL-29	CTRP2	5.6023	7.4497	4.9462	5.5467
639V	CTRP2	5.6034	6.3519	5.4546	3.4873
HT-1376	CTRP2	5.9872	7.4381	5.2993	3.4843
UM-UC-3	CTRP2	6.0934	7.6152	5.2995	3.0378
T24	CTRP2	6.1315	7.9451	5.1656	3.529
KU-19-19	CTRP2	6.2626	16.2594	1.1176	19.2435
J82	CTRP2	6.5086	9.5736	4.6502	5.023
253J-BV	CTRP2	6.6047	8.9798	5.0135	3.3642
SW1710	CTRP2	6.6858	14.0604	2.5576	13.2544
BFTC-905	CTRP2	6.8286	8.546	5.371	1.6268
U-BLC1	CTRP2	6.9101	9.4997	4.9741	3.0768
HT-1197	CTRP2	7.3407	9.0039	5.4544	0.8363
UM-UC-1	CTRP2	7.6426	10.5647	4.9363	2.3291
253J	CTRP2	7.6953	9.0175	5.6082	0.25
SCaBER	CTRP2	8.0442	9.592	5.5358	0.2668
BC-3C	CTRP2	8.0456	13.8789	3.6432	6.7919
RT-112	CTRP2	8.2071	9.5613	5.608	0.1211
5637	CTRP2	8.388	9.9734	5.5304	0.1832
RT-4	CTRP2	8.6505	10.3311	5.5017	0.1784
KMBC-2	CTRP2	10.3117	22.4874	1.0495	12.9248

Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Urogenital System Tissue

Cell Line	Original Dataset	IC50	IC90	EC50	AUC
NEC8	GDSC2	-0.3223	2.0557	-0.3516	46.674
C-33 A	GDSC2	2.2535	6.4404	1.27	26.0205
KGN	GDSC2	2.6476	8.5924	0.6698	27.2614
NT2-D1	GDSC2	2.7023	22.9749	-6.3864	41.1936
PA-1	GDSC2	2.73	4.9452	2.382	17.8687
OVCA420	GDSC2	2.8078	7.5132	1.3382	23.3974
PEO1	GDSC2	2.8731	5.8782	2.1527	18.597
LB831-BLC	GDSC2	3.074	6.6249	2.0164	18.6093
SKN	GDSC2	3.1484	7.3547	1.7432	19.8995
Ca Ski	GDSC2	3.4498	7.8855	1.7698	18.6642
SKG-IIIa	GDSC2	3.6379	9.0635	1.3594	20.2743
PWR-1E	GDSC2	3.7045	7.5149	2.1857	15.3555
TC-YIK	GDSC2	3.7936	6.7671	2.6353	12.3083
HEY	GDSC2	3.905	7.4312	2.4075	13.3488
DSH1	GDSC2	4.0961	6.4872	3.0457	8.7604
HeLa	GDSC2	4.3321	5.3419	3.8204	3.1462
MS751	GDSC2	4.4709	7.4451	2.8827	8.6805
BPH-1	GDSC2	4.6046	7.4797	2.972	7.7547
SiSo	GDSC2	4.6227	9.4756	1.9912	13.6938
DoTc2 4510	GDSC2	4.6616	7.9355	2.7898	8.7418
NCC-IT	GDSC2	4.6818	7.6068	2.9689	7.5698
SW756	GDSC2	4.7062	8.0719	2.7568	8.8294
OVMIU	GDSC2	4.9014	7.5992	3.1375	5.9709
HEC-1	GDSC2	4.9355	11.5864	1.1875	17.2239
C-4-I	GDSC2	5.1124	11.7318	1.2534	16.4091
SiHa	GDSC2	5.1301	9.2974	2.4714	9.5013
CAL-39	GDSC2	5.2363	13.1038	0.6678	18.9292
HT-3	GDSC2	5.2912	10.0763	2.2071	10.6782
ME-180	GDSC2	5.3427	13.5977	0.5049	19.3854
HeLa	CTRP2	6.4262	8.2557	5.2385	2.7178

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Azacitidine (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Roflumilast	DMPGHY8	Moderate	Additive immunosuppressive effects by the combination of Azacitidine and Roflumilast.	Asthma [CA23]	[13]
Teriflunomide	DMQ2FKJ	Major	Additive myelosuppressive effects by the combination of Azacitidine and Teriflunomide.	Hyper-lipoproteinaemia [5C80]	[14]
Denosumab	DMNI0KO	Moderate	Additive myelosuppressive effects by the combination of Azacitidine and Denosumab.	Low bone mass disorder [FB83]	[15]
Thalidomide	DM70BU5	Major	Additive thrombogenic effects by the combination of Azacitidine and Thalidomide.	Multiple myeloma [2A83]	[16]
Tecfidera	DM2OVDT	Moderate	Additive immunosuppressive effects by the combination of Azacitidine and Tecfidera.	Multiple sclerosis [8A40]	[17]
Siponimod	DM2R86O	Major	Additive immunosuppressive effects by the combination of Azacitidine and Siponimod.	Multiple sclerosis [8A40]	[18]
Fingolimod	DM5JVAN	Major	Additive immunosuppressive effects by the combination of Azacitidine and Fingolimod.	Multiple sclerosis [8A40]	[19]
Ocrelizumab	DMEZ2KH	Moderate	Additive immunosuppressive effects by the combination of Azacitidine and Ocrelizumab.	Multiple sclerosis [8A40]	[20]
Ozanimod	DMT6AM2	Major	Additive immunosuppressive effects by the combination of Azacitidine and Ozanimod.	Multiple sclerosis [8A40]	[13]
Omacetaxine mepesuccinate	DMPU2WX	Moderate	Additive myelosuppressive effects by the combination of Azacitidine and Omacetaxine mepesuccinate.	Myeloproliferative neoplasm [2A20]	[21]
Canakinumab	DM8HLO5	Moderate	Additive immunosuppressive effects by the combination of Azacitidine and Canakinumab.	Rheumatoid arthritis [FA20]	[22]
Rilonacept	DMGLUQS	Moderate	Additive immunosuppressive effects by the combination of Azacitidine and Rilonacept.	Rheumatoid arthritis [FA20]	[22]
Golimumab	DMHZV7X	Major	Additive immunosuppressive effects by the combination of Azacitidine and Golimumab.	Rheumatoid arthritis [FA20]	[23]
Leflunomide	DMR8ONJ	Major	Additive immunosuppressive effects by the combination of Azacitidine and Leflunomide.	Rheumatoid arthritis [FA20]	[14]
Anthrax vaccine	DM9GSWY	Moderate	Antagonize the effect of Azacitidine when combined with Anthrax vaccine.	Sepsis [1G40-1G41]	[24]
Azathioprine	DMMZSXQ	Moderate	Additive myelosuppressive effects by the combination of Azacitidine and Azathioprine.	Transplant rejection [NE84]	[18]
Ganciclovir	DM1MBYQ	Moderate	Additive myelosuppressive effects by the combination of Azacitidine and Ganciclovir.	Virus infection [1A24-1D9Z]	[18]
Valganciclovir	DMS2IUH	Moderate	Additive myelosuppressive effects by the combination of Azacitidine and Valganciclovir.	Virus infection [1A24-1D9Z]	[18]

References

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• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6796).
• [3] BDDCS applied to over 900 drugs
• [4] Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
• [5] Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose
• [6] The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid l... Leukemia. 2009 Jun;23(6):1019-28.
• [7] A pilot pharmacokinetic study of oral azacitidine. Leukemia. 2008 Sep;22(9):1680-4.
• [8] Mycoplasma hyorhinis-encoded cytidine deaminase efficiently inactivates cytosine-based anticancer drugs. FEBS Open Bio. 2015 Aug 3;5:634-9.
• [9] Reduction of phosphoinositide-phospholipase C beta1 methylation predicts the responsiveness to azacitidine in high-risk MDS. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16811-6. doi: 10.1073/pnas.0907109106. Epub 2009 Sep 10.
• [10] 15-hydroxyprostaglandin dehydrogenase is down-regulated in gastric cancer. Clin Cancer Res. 2009 Jul 15;15(14):4572-80. doi: 10.1158/1078-0432.CCR-08-2518. Epub 2009 Jul 7.
• [11] The effect of DNA methylation inhibitor 5-Aza-2'-deoxycytidine on human endometrial stromal cells. Hum Reprod. 2010 Nov;25(11):2859-69.
• [12] Self-assembled 3D spheroids and hollow-fibre bioreactors improve MSC-derived hepatocyte-like cell maturation in vitro. Arch Toxicol. 2017 Apr;91(4):1815-1832.
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• [14] Product Information. Arava (leflunomide). Hoechst Marion-Roussel Inc, Kansas City, MO.
• [15] Product Information. Prolia (denosumab). Amgen USA, Thousand Oaks, CA.
• [16] Bennett CL, Nebeker JR, Samore MH, et al "The Research on Adverse Drug Events and Reports (RADAR) project." JAMA 293 (2005): 2131-40. [PMID: 15870417]
• [17] Product Information. Vumerity (diroximel fumarate). Alkermes, Inc, Cambridge, MA.
• [18] Cerner Multum, Inc. "Australian Product Information.".
• [19] Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
• [20] Product Information. Ocrevus (ocrelizumab). Genentech, South San Francisco, CA.
• [21] Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
• [22] Product Information. Arcalyst (rilonacept). Regeneron Pharmaceuticals Inc, Tarrytown, NY.
• [23] Product Information. Cimzia (certolizumab). UCB Pharma Inc, Smyrna, GA.
• [24] CDC. Centers for Disease Control and Prevention/ "Recommendations of the advisory committtee on immunization practices (ACIP): use of vaccines and immune globulins in persons with altered immunocompetence." MMWR Morb Mortal Wkly Rep 42(RR-04) (1993): 1-18. [PMID: 20300058]