Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT23XQV)

• DTT Name: PD-1-PD-L1 interaction (PD-1/PD-L1 PPI) DTT Info
• Gene Name: PDCD1-CD274

Molecule-Related Drug & Molecule List

73 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1,2,4-oxadiazole derivative 4	DMT6EDP	Hepatitis	DB97.Z	Patented	[1]
1,2,4-oxadiazole derivative 5	DM683R7	Hepatitis	DB97.Z	Patented	[1]
1,2,4-oxadiazole derivative 6	DMFYKBJ	Hepatitis	DB97.Z	Patented	[1]
1,2,4-oxadiazole derivative 7	DMBT4RJ	Hepatitis	DB97.Z	Patented	[1]
1,3,4-oxadiazole derivative 3	DMSR0X6	Hepatitis	DB97.Z	Patented	[1]
1,3,4-oxadiazole derivative 4	DM4GR2C	Hepatitis	DB97.Z	Patented	[1]
1,3,4-oxadiazole derivative 5	DMI5VZN	Hepatitis	DB97.Z	Patented	[1]
1,3,4-oxadiazole derivative 6	DMIEZ6L	Hepatitis	DB97.Z	Patented	[1]
1,3,4-thiadiazole derivative 1	DMAB8QF	Hepatitis	DB97.Z	Patented	[1]
1,3,4-thiadiazole derivative 2	DMXIG07	Hepatitis	DB97.Z	Patented	[1]
1,3-dihydroxy phenyl derivative 1	DMUS7O3	Hepatitis	DB97.Z	Patented	[1]
1,3-dihydroxy phenyl derivative 2	DM63NX5	Hepatitis	DB97.Z	Patented	[1]
3-substituted-1,2,4-oxadiazole derivative 1	DMWCT04	Hepatitis	DB97.Z	Patented	[1]
3-substituted-1,2,4-oxadiazole derivative 2	DMB3806	Hepatitis	DB97.Z	Patented	[1]
Aromatic acetylene derivative 1	DMGR6X1	Hepatitis	DB97.Z	Patented	[1]
Aromatic ethylene derivative 1	DMSRKON	Hepatitis	DB97.Z	Patented	[1]
Benzyl phenyl ether derivative 1	DM6PTOX	Hepatitis	DB97.Z	Patented	[1]
Benzyl phenyl ether derivative 2	DMMS4EI	Hepatitis	DB97.Z	Patented	[1]
Biaryl compound 1	DMHEAJQ	Hepatitis	DB97.Z	Patented	[1]
Biaryl compound 2	DMS8VYE	Hepatitis	DB97.Z	Patented	[1]
Bromo benzyl ether derivative 1	DMMXQJU	Hepatitis	DB97.Z	Patented	[1]
Bromo benzyl ether derivative 2	DMVBAUC	Hepatitis	DB97.Z	Patented	[1]
Cyclic peptidomimetic derivative 1	DMV2UQ5	Hepatitis	DB97.Z	Patented	[1]
Cyclic peptidomimetic derivative 2	DMWH3FP	Hepatitis	DB97.Z	Patented	[1]
Cyclic peptidomimetic derivative 3	DMI7KG4	Hepatitis	DB97.Z	Patented	[1]
Macrocycle derivative 1	DMN7I9C	Hepatitis	DB97.Z	Patented	[1]
Macrocycle derivative 2	DM5OEQZ	Hepatitis	DB97.Z	Patented	[1]
Macrocycle derivative 3	DMYGFTI	Hepatitis	DB97.Z	Patented	[1]
Macrocycle derivative 4	DMOQBN4	Hepatitis	DB97.Z	Patented	[1]
Macrocycle derivative 5	DMK3UJY	Hepatitis	DB97.Z	Patented	[1]
Macrocycle derivative 6	DMQ84KW	Hepatitis	DB97.Z	Patented	[1]
Macrocycle derivative 7	DMP2JF0	Hepatitis	DB97.Z	Patented	[1]
Macrocycle derivative 8	DMOMTBE	Hepatitis	DB97.Z	Patented	[1]
Macrocycle derivative 9	DMARU0E	Hepatitis	DB97.Z	Patented	[1]
Macrocyclic peptide analog 1	DMS65IT	Hepatitis	DB97.Z	Patented	[1]
Macrocyclic peptide analog 2	DMOGLBZ	Hepatitis	DB97.Z	Patented	[1]
Macrocyclic peptide analog 3	DMV172W	Hepatitis	DB97.Z	Patented	[1]
N-phenyl-pyridine-2-carboxamide derivative 1	DMMDYAV	Hepatitis	DB97.Z	Patented	[1]
N-phenyl-pyridine-2-carboxamide derivative 2	DM6OG2Y	Hepatitis	DB97.Z	Patented	[1]
Peptide analog 1	DMF3LIX	Hepatitis	DB97.Z	Patented	[1]
Peptide analog 2	DMYFUM6	Hepatitis	DB97.Z	Patented	[1]
Peptide analog 3	DMYMJV3	Hepatitis	DB97.Z	Patented	[1]
Peptide analog 4	DM5KEVG	Hepatitis	DB97.Z	Patented	[1]
Peptide analog 5	DM8B13I	Hepatitis	DB97.Z	Patented	[1]
Peptide analog 6	DM68M0G	Hepatitis	DB97.Z	Patented	[1]
Phenylate derivative 1	DMEO9QB	Hepatitis	DB97.Z	Patented	[1]
Phenylate derivative 2	DMG0ZSY	Hepatitis	DB97.Z	Patented	[1]
PMID30107136-Compound-Example11	DMD65GU	Hepatitis	DB97.Z	Patented	[1]
PMID30107136-Compound-Example12	DMN2K10	Hepatitis	DB97.Z	Patented	[1]
PMID30107136-Compound-Example13	DM4CN9K	Hepatitis	DB97.Z	Patented	[1]
PMID30107136-Compound-Example14	DMAUFS7	Hepatitis	DB97.Z	Patented	[1]
PMID30107136-Compound-Example3	DMDCN43	Hepatitis	DB97.Z	Patented	[1]
PMID30107136-Compound-Example4	DMRKLTE	Hepatitis	DB97.Z	Patented	[1]
PMID30107136-Compound-Example41	DMQPIK4	Hepatitis	DB97.Z	Patented	[1]
PMID30107136-Compound-Example42	DM95FIN	Hepatitis	DB97.Z	Patented	[1]
PMID30107136-Compound-Example43	DMJSH0F	Hepatitis	DB97.Z	Patented	[1]
PMID30107136-Compound-Example44	DM8KAIY	Hepatitis	DB97.Z	Patented	[1]
PMID30107136-Compound-Example45	DMC075A	Hepatitis	DB97.Z	Patented	[1]
PMID30107136-Compound-Example46	DMYFSAD	Hepatitis	DB97.Z	Patented	[1]
PMID30107136-Compound-Example47	DM1TCBQ	Hepatitis	DB97.Z	Patented	[1]
PMID30107136-Compound-Example48	DMH57FG	Hepatitis	DB97.Z	Patented	[1]
PMID30107136-Compound-Example49	DM4D1WK	Hepatitis	DB97.Z	Patented	[1]
PMID30107136-Compound-Example50	DMV15GM	Hepatitis	DB97.Z	Patented	[1]
PMID30107136-Compound-Example51	DM08CBJ	Hepatitis	DB97.Z	Patented	[1]
PMID30107136-Compound-Example52	DMJ1C0A	Hepatitis	DB97.Z	Patented	[1]
PMID30107136-Compound-Example53	DM39FDV	Hepatitis	DB97.Z	Patented	[1]
PMID30107136-Compound-Example54	DM9DL1E	Hepatitis	DB97.Z	Patented	[1]
PMID30107136-Compound-Example57	DMZXC0D	Hepatitis	DB97.Z	Patented	[1]
PMID30107136-Compound-Example58	DM3AY9K	Hepatitis	DB97.Z	Patented	[1]
PMID30107136-Compound-Example59	DM6XWL9	Hepatitis	DB97.Z	Patented	[1]
PMID30107136-Compound-Example60	DMUZ85A	Hepatitis	DB97.Z	Patented	[1]
PMID30107136-Compound-Example7	DMS42KH	Hepatitis	DB97.Z	Patented	[1]
PMID30107136-Compound-Example8	DMBIK28	Hepatitis	DB97.Z	Patented	[1]

1 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MAX-10129	DM1XYGF	N. A.	N. A.	Preclinical	[2]

23 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID30247903-Compound-General structure18	DMZBQ5R	N. A.	N. A.	Investigative	[2]
PMID30247903-Compound-General structure19	DM8LS3I	N. A.	N. A.	Investigative	[2]
PMID30247903-Compound-General structure26	DM4BF1P	N. A.	N. A.	Investigative	[2]
PMID30247903-Compound-General structure27	DMYSWO4	N. A.	N. A.	Investigative	[2]
PMID30247903-Compound-General structure28	DMALSIW	N. A.	N. A.	Investigative	[2]
PMID30247903-Compound-General structure29	DM9FEB6	N. A.	N. A.	Investigative	[2]
PMID30247903-Compound-General structure30	DMHQ1ZD	N. A.	N. A.	Investigative	[2]
PMID30247903-Compound-General structure31	DMSLWBI	N. A.	N. A.	Investigative	[2]
PMID30247903-Compound-General structure32	DMD04TR	N. A.	N. A.	Investigative	[2]
PMID30247903-Compound-General structure33	DMFLQ96	N. A.	N. A.	Investigative	[2]
PMID30247903-Compound-General structure34	DM1YOVG	N. A.	N. A.	Investigative	[2]
PMID30247903-Compound-General structure35	DMF9HIJ	N. A.	N. A.	Investigative	[2]
PMID30247903-Compound-General structure36	DMI4EU5	N. A.	N. A.	Investigative	[2]
PMID30247903-Compound-General structure37	DMDWHIN	N. A.	N. A.	Investigative	[2]
PMID30247903-Compound-General structure38	DMDB9FT	N. A.	N. A.	Investigative	[2]
PMID30247903-Compound-General structure39	DMKLATO	N. A.	N. A.	Investigative	[2]
PMID30247903-Compound-General structure40	DMPZ3AY	N. A.	N. A.	Investigative	[2]
PMID30247903-Compound-General structure41	DM0UMSF	N. A.	N. A.	Investigative	[2]
PMID30247903-Compound-General structure42	DMRNF96	N. A.	N. A.	Investigative	[2]
PMID30247903-Compound-General structure43	DMY971M	N. A.	N. A.	Investigative	[2]
PMID30247903-Compound-General structure44	DMRAFSB	N. A.	N. A.	Investigative	[2]
PMID30247903-Compound-General structure45	DMHMUNB	N. A.	N. A.	Investigative	[2]
PMID30247903-Compound-General structure46	DMWYCOB	N. A.	N. A.	Investigative	[2]

References

• [1] A patent review on PD-1/PD-L1 antagonists: small molecules, peptides, and macrocycles (2015-2018).Expert Opin Ther Pat. 2018 Sep;28(9):665-678.
• [2] Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway.J Med Chem. 2019 Feb 28;62(4):1715-1730.