Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT50QJ3)

• DTT Name: Influenza Neuraminidase (Influ NA) DTT Info
• Gene Name: Influ NA

Molecule-Related Drug & Molecule List

3 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Oseltamivir	DMGO72P	Influenza	1E30-1E32	Approved	[1]
Peramivir	DMNXY5K	Influenza virus infection	1E30-1E32	Approved	[2]
Zanamivir	DMFMBZ4	Influenza	1E30-1E32	Approved	[1]

4 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CS-8958	DM4CSDH	Influenza virus infection	1E30-1E32	Phase 3	[2]
UX-001	DMD2O0L	Hereditary inclusion body myositis	4A41.2	Phase 3	[3]
DAS-181	DM0Y8JP	Influenza virus infection	1E30-1E32	Phase 2	[4]
Lactose	DMO4GPK	Discovery agent	N.A.	Phase 1	[3]

2 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BCX-140	DMBJERO	Influenza virus infection	1E30-1E32	Terminated	[5]
GS-3435	DMV7JC6	Influenza virus infection	1E30-1E32	Terminated	[6]

62 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(E,E)-1,7-Diphenyl-4,6-heptadien-3-one	DMWU17O	Discovery agent	N.A.	Investigative	[7]
(E,E)-5-Hydroxy-1,7-diphenyl-4,6-heptadien-3-one	DMBIV6M	Discovery agent	N.A.	Investigative	[7]
(S)-1,7-Diphenyl-6(E)-hepten-3-ol	DM1U7MC	Discovery agent	N.A.	Investigative	[7]
2,4-Deoxy-4-Guanidino-5-N-Acetyl-Neuraminic Acid	DMZO0EI	Discovery agent	N.A.	Investigative	[8]
2-Deoxy-2,3-Dehydro-N-Acetyl-Neuraminic Acid	DMIAM5L	N. A.	N. A.	Investigative	[3]
4-(Acetylamino)-3-Amino Benzoic Acid	DMR37FN	Discovery agent	N.A.	Investigative	[3]
4-(ACETYLAMINO)-3-HYDROXY-5-NITROBENZOIC ACID	DM8F0N5	Discovery agent	N.A.	Investigative	[9]
4-(ACETYLAMINO)-5-AMINO-3-HYDROXYBENZOIC ACID	DM1DKSV	Discovery agent	N.A.	Investigative	[9]
4-Amino-2-Deoxy-2,3-Dehydro-N-Neuraminic Acid	DMINUHD	Discovery agent	N.A.	Investigative	[8]
8-DEOXYGARTANIN	DMEOP4J	Discovery agent	N.A.	Investigative	[10]
A-192558	DMV03NS	Discovery agent	N.A.	Investigative	[11]
A-315675	DMSQLZF	Discovery agent	N.A.	Investigative	[11]
Alpha-D-Mannose	DMF5DLW	Discovery agent	N.A.	Investigative	[3]
APIGENIN	DMI3491	Discovery agent	N.A.	Investigative	[12]
BCX-1827	DMVOS2C	Discovery agent	N.A.	Investigative	[11]
BCX-1898	DM6JB32	Discovery agent	N.A.	Investigative	[11]
BCX-1923	DM8G4HS	Discovery agent	N.A.	Investigative	[11]
Beta-D-Mannose	DMHIG9K	Discovery agent	N.A.	Investigative	[3]
CALOPOCARPIN	DMVXKLF	Discovery agent	N.A.	Investigative	[13]
Cristacarpin	DMYPLZ8	Discovery agent	N.A.	Investigative	[13]
CUDRATRICUSXANTHONE	DMBL46A	Discovery agent	N.A.	Investigative	[14]
Cudratricusxanthone F	DM10BOC	Discovery agent	N.A.	Investigative	[14]
Cudraxanthone D	DMBQ1VO	Discovery agent	N.A.	Investigative	[14]
Cudraxanthone L	DMP1D5Q	Discovery agent	N.A.	Investigative	[14]
Cudraxanthone M	DMIQFAU	Discovery agent	N.A.	Investigative	[14]
Cyclopentane amide derivatives 1	DM78PR5	Discovery agent	N.A.	Investigative	[11]
Cyclopentane amide derivatives 2	DMGU97P	Discovery agent	N.A.	Investigative	[11]
Cyclopentane amide derivatives 3	DMHTVRL	Discovery agent	N.A.	Investigative	[11]
Cyclopentane amide derivatives 4	DMOA7EP	Discovery agent	N.A.	Investigative	[11]
DEMETHYLMEDICARPIN	DMUVR5T	Discovery agent	N.A.	Investigative	[13]
ERYSTAGALLIN A	DMCHVIG	Discovery agent	N.A.	Investigative	[13]
Erysubin D	DMVA9F7	Discovery agent	N.A.	Investigative	[13]
Erysubin E	DMXWK1A	Discovery agent	N.A.	Investigative	[13]
Erythribyssin D	DMBVSKZ	Discovery agent	N.A.	Investigative	[13]
Erythribyssin L	DMUL4AP	Discovery agent	N.A.	Investigative	[13]
Erythribyssin M	DMWEK8I	Discovery agent	N.A.	Investigative	[13]
Erythribyssin O	DM8LEJ4	Discovery agent	N.A.	Investigative	[13]
Eryvarin D	DM8BS5C	Discovery agent	N.A.	Investigative	[13]
FANA	DM45K8W	Discovery agent	N.A.	Investigative	[11]
Fucose	DMAHMSV	N. A.	N. A.	Investigative	[3]
Gamma-mangostin	DMC0OVP	Discovery agent	N.A.	Investigative	[10]
GARCINONE D	DMQDV3U	Discovery agent	N.A.	Investigative	[10]
GARTANIN	DMZ5AD8	Discovery agent	N.A.	Investigative	[10]
GOSSYPETIN	DMMT05U	Discovery agent	N.A.	Investigative	[12]
GS4071	DMG0OUD	Discovery agent	N.A.	Investigative	[11]
HERBACETIN	DM8MD52	Discovery agent	N.A.	Investigative	[12]
ISONEORAUTENOL	DM69XT3	Discovery agent	N.A.	Investigative	[13]
KAEMPFEROL	DMHEMUB	Discovery agent	N.A.	Investigative	[12]
KATSUMADAIN A	DM513QY	Discovery agent	N.A.	Investigative	[7]
MACLURAXANTHONE	DMOMG7S	Discovery agent	N.A.	Investigative	[14]
MANGIFERIN	DMWAF5Z	Discovery agent	N.A.	Investigative	[14]
MANGOSTANIN	DMOWZUB	Discovery agent	N.A.	Investigative	[10]
MANGOSTANOL	DMG3DUE	Discovery agent	N.A.	Investigative	[10]
MANGOSTENONE F	DMNRZ3S	Discovery agent	N.A.	Investigative	[10]
MANGOSTENONE G	DM4I2NR	Discovery agent	N.A.	Investigative	[10]
MANGOSTIN	DMYQGDV	Discovery agent	N.A.	Investigative	[10]
NEORAUTENOL	DM5GMOJ	Discovery agent	N.A.	Investigative	[13]
O-Sialic Acid	DMCAR7B	Discovery agent	N.A.	Investigative	[9]
PHASEOLIN	DM7H5KY	Discovery agent	N.A.	Investigative	[13]
PHASEOLLIDIN	DMSQ10I	Discovery agent	N.A.	Investigative	[13]
RHODIOLININ	DMH9QAF	Discovery agent	N.A.	Investigative	[12]
SMEATHXANTHONE A	DMZC2BT	Discovery agent	N.A.	Investigative	[10]

References

• [1] Current and future antiviral therapy of severe seasonal and avian influenza. Antiviral Res. 2008 Apr;78(1):91-102.
• [2] Developing new antiviral agents for influenza treatment: what does the future hold Clin Infect Dis. 2009 Jan 1;48 Suppl 1:S3-13.
• [3] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [4] Inhibition of neuraminidase inhibitor-resistant influenza virus by DAS181, a novel sialidase fusion protein. PLoS One. 2009 Nov 6;4(11):e7838.
• [5] CN patent application no. 104447481, Benzoic acid thiourea anti-influenza virus compounds as well as preparation method and use thereof.
• [6] US patent application no. 2010,0081,713, Compositions and methods for treating viral infections.
• [7] Antiviral potential and molecular insight into neuraminidase inhibiting diarylheptanoids from Alpinia katsumadai. J Med Chem. 2010 Jan 28;53(2):778-86.
• [8] DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
• [9] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [10] Xanthones with neuraminidase inhibitory activity from the seedcases of Garcinia mangostana. Bioorg Med Chem. 2010 Sep 1;18(17):6258-64.
• [11] Antiviral agents active against influenza A viruses. Nat Rev Drug Discov. 2006 Dec;5(12):1015-25.
• [12] Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities. Bioorg Med Chem. 2009 Oct 1;17(19):6816-23.
• [13] Prenylated pterocarpans as bacterial neuraminidase inhibitors. Bioorg Med Chem. 2010 May 1;18(9):3335-44.
• [14] Characteristic of neuraminidase inhibitory xanthones from Cudrania tricuspidata. Bioorg Med Chem. 2009 Apr 1;17(7):2744-50.