Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTBW580)

• DTT Name: TAX transcriptionally-activated glycoprotein 1 (OX40) DTT Info
• Gene Name: TNFSF4

Molecule-Related Drug & Molecule List

7 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AMG 386	DMQJXL4	Breast cancer	2C60-2C65	Phase 3	[1]
Amlitelimab	DMKR3BQ	Asthma	CA23	Phase 2	[2]
RG7888	DM2SWI8	Solid tumour/cancer	2A00-2F9Z	Phase 2	[3]
MEDI6383	DM1YSMD	Solid tumour/cancer	2A00-2F9Z	Phase 1	[4]
mRNA-2416	DMFTAWU	Lymphoma	2A80-2A86	Phase 1	[5]
mRNA-2752	DMUKBI2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[6]
SAR442970	DM3DHWE	Inflammation	1A00-CA43.1	Phase 1	[7]

References

• [1] Clinical targeting of the TNF and TNFR superfamilies.Nat Rev Drug Discov.2013 Feb;12(2):147-68.
• [2] OX40-OX40L Inhibition for the Treatment of Atopic Dermatitis-Focus on Rocatinlimab and Amlitelimab. Pharmaceutics. 2022 Dec 8;14(12):2753.
• [3] Anti-tumor efficacy and biomarker evaluation of agonistic anti-OX40 antibodies in preclinical models. J Immunother Cancer. 2014; 2(Suppl 3): P105.
• [4] J Clin Oncol 33, 2015 (suppl; abstr 3056).
• [5] Clinical pipeline report, company report or official report of Moderna Therapeutics.
• [6] Clinical pipeline report, company report or official report of Moderna Therapeutics.
• [7] Clinical pipeline report, company report or official report of Sanofi