Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTC70AJ)

• DTT Name: Granulocyte colony-stimulating factor receptor (G-CSF-R) DTT Info
• Gene Name: CSF3R

Molecule-Related Drug & Molecule List

2 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pegfilgrastim	DM7UP8X	Central nervous system neoplasm		Approved	[1]
Tbo-Filgrastim	DML6OE7	Neutropenia	4B00.0	Approved	[2]

9 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Peg-G-CSF	DMBKWAF	Solid tumour/cancer	2A00-2F9Z	Phase 3	[3]
AX-200	DMTAEMB	Cardiovascular disease	BA00-BE2Z	Phase 2	[4]
BLZ-945	DMG1LVA	Amyotrophic lateral sclerosis	8B60.0	Phase 2	[3]
MAXY-G34	DMWLIPJ	Neutropenia	4B00.0	Phase 2	[5]
SBC-014	DMG1VXR	Neutropenia	4B00.0	Phase 2	[6]
AMG 820	DMB6Q19	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
MK-6302	DMZUA5C	Neutropenia	4B00.0	Phase 1	[8]
PLX-5622	DMK4PWM	Autoimmune diabetes	5A10	Phase 1	[9]
PLX7486	DM0IVGU	Pancreatic cancer	2C10	Phase 1	[10]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ZD-6003	DMU2F6Q	Solid tumour/cancer	2A00-2F9Z	Terminated	[3]

7 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AC-710	DMXS72J	Autoimmune diabetes	5A10	Investigative	[3]
AZD-7507	DMLJPDW	Solid tumour/cancer	2A00-2F9Z	Investigative	[3]
CSL-324	DMTN1P2	Inflammation	1A00-CA43.1	Investigative	[3]
G-CSF	DMVFDYU	leukaemia	2A60-2B33	Investigative	[3]
N-(2-morpholinophenyl)-5-nitrofuran-2-carboxamide	DMI4KNB	Discovery agent	N.A.	Investigative	[11]
TG-3003	DMHTEMP	Solid tumour/cancer	2A00-2F9Z	Investigative	[3]
ZP-G-CSF	DM9XFYZ	Neutropenia	4B00.0	Investigative	[3]

References

• [1] Evidence that the granulocyte colony-stimulating factor (G-CSF) receptor plays a role in the pharmacokinetics of G-CSF and PegG-CSF using a G-CSF-R KO model. Pharmacol Res. 2004 Jul;50(1):55-8.
• [2] Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1719).
• [4] Granulocyte colony-stimulating factor in patients with acute ischemic stroke: results of the AX200 for Ischemic Stroke trial. Stroke. 2013 Oct;44(10):2681-7.
• [5] Survival efficacy of the PEGylated G-CSFs Maxy-G34 and neulasta in a mouse model of lethal H-ARS, and residual bone marrow damage in treated survivors. Health Phys. 2014 Jan;106(1):21-38.
• [6] A glycosylated recombinant human granulocyte colony stimulating factor produced in a novel protein production system (AVI-014) in healthy subjects: a first-in human, single dose, controlled study. BMC Clin Pharmacol. 2009; 9: 2.
• [7] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [8] Merck ditches biogeneric. Nat Biotechnol. 2010 Jul;28(7):636.
• [9] Microglial Stimulation of Glioblastoma Invasion Involves Epidermal Growth Factor Receptor (EGFR) and Colony Stimulating Factor 1 Receptor (CSF-1R) Signaling. Mol Med. 2012; 18(1): 519-527.
• [10] National Cancer Institute Drug Dictionary (drug id 747694).
• [11] Potent 2'-aminoanilide inhibitors of cFMS as potential anti-inflammatory agents. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6070-4.