Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTD1WIG)

DTT Name	Nicotinamide phosphoribosyltransferase (NAMPT) DTT Info
Gene Name	NAMPT

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Clinical Trial Drug(s)

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4 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Daporinad	DMCU74R	leukaemia	2A60-2B33	Phase 2	[1]
CHS-828	DMTV4L7	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[1]
GMX1777	DMIFSN2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]
OT-82	DMI24RF	Lymphoma	2A80-2A86	Phase 1	[3]
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Molecule Interaction Atlas

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References

1	Anticancer agent CHS-828 inhibits cellular synthesis of NAD. Biochem Biophys Res Commun. 2008 Mar 21;367(4):799-804.
2	The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-... Mol Cell Biol. 2009 Nov;29(21):5872-88.
3	OT-82, a novel anticancer drug candidate that targets the strong dependence of hematological malignancies on NAD biosynthesis. Leukemia. 2020 Jul;34(7):1828-1839.