Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTWK8D0)

• DTT Name: Sodium pump subunit alpha-1 (ATP1A1) DTT Info
• Gene Name: ATP1A1

Molecule-Related Drug & Molecule List

8 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetyldigitoxin	DMHAUO0	Congestive heart failure	BD10	Approved	[1]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[2]
Almitrine	DM0SYAN	Chronic obstructive pulmonary disease	CA22	Approved	[3]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[4]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[5]
Chloroprocaine	DMSOQK1	Anaesthesia	9A78.6	Approved	[6]
Deslanoside	DMB3ZSK	Arrhythmia	BC9Z	Approved	[2]
Lumefantrine	DM29GAD	Malaria	1F40-1F45	Approved	[5]

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
UNBS-1450	DMR38M4	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]

1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DIGITOXIGENIN	DM5AOFW	Discovery agent	N.A.	Investigative	[8]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [2] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [3] Almitrine, a new kind of energy-transduction inhibitor acting on mitochondrial ATP synthase. Biochim Biophys Acta. 1989 Aug 3;975(3):325-9.
• [4] The inhibitory effect of aluminium on the (Na+/K+)ATPase activity of rat brain cortex synaptosomes. J Inorg Biochem. 2003 Sep 15;97(1):143-50.
• [5] The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
• [6] Inhibition of the Na,K-ATPase of canine renal medulla by several local anesthetics. Pharmacol Res. 2001 Apr;43(4):399-403.
• [7] Early downregulation of Mcl-1 regulates apoptosis triggered by cardiac glycoside UNBS1450. Cell Death Dis. 2015 Jun 11;6:e1782.
• [8] 17beta-O-Aminoalkyloximes of 5beta-androstane-3beta,14beta-diol with digitalis-like activity: synthesis, cardiotonic activity, structure-activity r... J Med Chem. 2000 Jun 15;43(12):2332-49.