Drug Information

Drug General Information
Drug ID
D09TAB
Former ID
DIB008584
Drug Name
PLX-3397
Synonyms
Fms/Kit/Flt-3-ITD inhibitor (cancer/inflammatory disease), Plexxikon
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Phase 3 [525099]
Company
Plexxikon Inc
Target and Pathway
Target(s) Mast/stem cell growth factor receptor Target Info Inhibitor [550447]
Macrophage colony-stimulating factor receptor Target Info Inhibitor [550447]
FL cytokine receptor Target Info Inhibitor [550447]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
Endocytosis
PI3K-Akt signaling pathway
Hematopoietic cell lineage
Melanogenesis
Pathways in cancer
Acute myeloid leukemia
Central carbon metabolism in cancerhsa04060:Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Pathways in cancerhsa04060:Cytokine-cytokine receptor interaction
Transcriptional misregulation in cancer
Central carbon metabolism in cancer
NetPath Pathway IL3 Signaling Pathway
IL4 Signaling Pathway
KitReceptor Signaling PathwayNetPath_22:Leptin Signaling Pathway
RANKL Signaling Pathway
Pathway Interaction Database C-MYB transcription factor network
Signaling events mediated by Stem cell factor receptor (c-Kit)
Reactome PIP3 activates AKT signaling
Regulation of KIT signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
WikiPathways Kit receptor signaling pathway
Differentiation Pathway
Signaling by SCF-KIT
PIP3 activates AKT signaling
Cardiac Progenitor Differentiation
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
References
Ref 525099ClinicalTrials.gov (NCT02371369) PLX3397 Phase 3 Study for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS). U.S. National Institutes of Health.
Ref 550447National Cancer Institute Drug Dictionary (drug id 659167).