Details of Disease

General Information of Disease (ID: DIS37Y0J)

• Disease Name: Acinar cell carcinoma
• Synonyms: acinic cell tumor; acinic cell tumour; ACCC; acinic cell adenocarcinoma; acinic cell carcinoma; acinar cell carcinoma; acinar carcinoma; acinar cell adenocarcinoma; acinar adenocarcinoma; acinar cell carcinoma (morphologic abnormality); carcinoma, acinar cell, malignant; carcinoma of acinar cell
• Definition: A carcinoma that arises from epithelial cells of the acinar cell
• Disease Hierarchy:
  DIS3IHTY: Adenocarcinoma
  DISH9F1N: Carcinoma
  DIS37Y0J: Acinar cell carcinoma
• Disease Identifiers:
  MONDO ID: MONDO_0004965
  MESH ID: D018267
  UMLS CUI: C0206685
  MedGen ID: 61660
  SNOMED CT ID: 45410002

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 4 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ADK	TTL732K	Strong	Genetic Variation	[1]
NR4A3	TTJQB49	Strong	Altered Expression	[2]
NTRK3	TTXABCW	Strong	Biomarker	[3]
TMPRSS2	TT1GM2Z	Strong	Genetic Variation	[4]

This Disease Is Related to 12 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ETV6	OTCZMG61	moderate	Biomarker	[5]
APELA	OTYY0P69	Strong	Genetic Variation	[6]
BSND	OTYWZWPD	Strong	Biomarker	[7]
CASK	OT8EF7ZF	Strong	Biomarker	[8]
CENPF	OT7AG0SW	Strong	Altered Expression	[9]
ERG	OTOTX9VU	Strong	Altered Expression	[10]
HTN3	OTEUXA81	Strong	Genetic Variation	[11]
INSM1	OTG8RV8E	Strong	Biomarker	[12]
MARVELD2	OTKB96L5	Strong	Altered Expression	[13]
MSANTD3	OTO26804	Strong	Biomarker	[11]
NEUROG3	OT6DIPWC	Strong	Biomarker	[14]
S100A1	OT1F2G4J	Strong	Altered Expression	[15]

References

• [1] Vascular endothelial growth factor (VEGF) expression and microvascular density in salivary gland tumours.APMIS. 2014 May;122(5):418-26. doi: 10.1111/apm.12160. Epub 2013 Aug 13.
• [2] Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands.Nat Commun. 2019 Jan 21;10(1):368. doi: 10.1038/s41467-018-08069-x.
• [3] Pan-Trk immunohistochemistry reliably identifies ETV6-NTRK3 fusion in secretory carcinoma of the salivary gland.Virchows Arch. 2020 Feb;476(2):295-305. doi: 10.1007/s00428-019-02640-7. Epub 2019 Aug 19.
• [4] TMPRSS2-ERG gene fusions are infrequent in prostatic ductal adenocarcinomas.Mod Pathol. 2009 Mar;22(3):359-65. doi: 10.1038/modpathol.2008.236. Epub 2009 Jan 16.
• [5] The screening and electron microscopy observation of mammary analogue secretory carcinoma in Chinese.J Craniomaxillofac Surg. 2018 Jun;46(6):893-897. doi: 10.1016/j.jcms.2017.10.007. Epub 2017 Oct 19.
• [6] Acinar-to-ductal metaplasia accompanies c-myc-induced exocrine pancreatic cancer progression in transgenic rodents.Int J Cancer. 2012 Sep 1;131(5):1243-8. doi: 10.1002/ijc.27322. Epub 2012 Jan 11.
• [7] BSND is a Novel Immunohistochemical Marker for Oncocytic Salivary Gland Tumors.Pathol Oncol Res. 2018 Apr;24(2):439-444. doi: 10.1007/s12253-017-0248-9. Epub 2017 May 3.
• [8] Expression of human regenerating gene mRNA and its product in normal and neoplastic human pancreas.Cancer. 1992 Oct 1;70(7):1857-63. doi: 10.1002/1097-0142(19921001)70:7<1857::aid-cncr2820700708>3.0.co;2-8.
• [9] Correlation of CENP-F gene expression with tumor-proliferating activity in human salivary gland tumors.Oral Oncol. 2005 Aug;41(7):716-22. doi: 10.1016/j.oraloncology.2005.03.008.
• [10] Evaluation of ERG and PTEN protein expression in cribriform architecture prostate carcinomas.Pathol Res Pract. 2017 Jan;213(1):34-38. doi: 10.1016/j.prp.2016.10.007. Epub 2016 Oct 26.
• [11] The HTN3-MSANTD3 Fusion Gene Defines a Subset of Acinic Cell Carcinoma of the Salivary Gland.Am J Surg Pathol. 2019 Apr;43(4):489-496. doi: 10.1097/PAS.0000000000001200.
• [12] Insulinoma-associated protein 1 is a novel sensitive and specific marker for small cell carcinoma of the prostate.Hum Pathol. 2018 Sep;79:151-159. doi: 10.1016/j.humpath.2018.05.014. Epub 2018 Jun 6.
• [13] Tricellulin expression in normal and neoplastic human pancreas.Histopathology. 2012 May;60(6B):E76-86. doi: 10.1111/j.1365-2559.2012.04189.x. Epub 2012 Mar 6.
• [14] Prevention of pancreatic acinar cell carcinoma by Roux-en-Y Gastric Bypass Surgery.Nat Commun. 2018 Oct 10;9(1):4183. doi: 10.1038/s41467-018-06571-w.
• [15] Mammary analog secretory carcinoma, low-grade salivary duct carcinoma, and mimickers: a comparative study.Mod Pathol. 2015 Aug;28(8):1084-100. doi: 10.1038/modpathol.2015.64. Epub 2015 Jun 19.