Details of Disease

General Information of Disease (ID: DIS5ACCI)

• Disease Name: Disruptive behavior disorder
• Synonyms: disruptive disorder
• Definition: A mental disorder that includes conduct disorder (CD), oppositional defiant disorder (ODD), and attention Deficit Hyperactivity Disorder (ADHD). Features may include frequent aggression, deceitfulness, and defiance, and often persist through the lifespan.
• Disease Hierarchy:
  DIS3J5R8: Mental disorder
  DIS5ACCI: Disruptive behavior disorder
• Disease Identifiers:
  MONDO ID: MONDO_0800106
  MESH ID: D019958
  UMLS CUI: C0012734
  MedGen ID: 41619
  SNOMED CT ID: 54319003

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Chlorpromazine	DMBGZI3	Approved	Small molecular drug	[1]
Promazine	DMZAL7W	Approved	Small molecular drug	[2]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
DRD4	TTE0A2F	Strong	Genetic Variation	[3]
S100B	TTQ0V86	Strong	Biomarker	[4]

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
OSR1	OTB19LEQ	Strong	Biomarker	[5]

References

• [1] Chlorpromazine FDA Label
• [2] Promazine FDA Label
• [3] Dopamine D4 receptor VNTR polymorphism associated with greater risk for substance abuse among adolescents with disruptive behavior disorders: Preliminary results.Am J Addict. 2016 Jan;25(1):56-61. doi: 10.1111/ajad.12320. Epub 2015 Dec 20.
• [4] S100 in heavy metal-related child attention-deficit hyperactivity disorder in an informal e-waste recycling area.Neurotoxicology. 2014 Dec;45:185-91. doi: 10.1016/j.neuro.2014.10.013. Epub 2014 Nov 1.
• [5] Oppositional Defiant Disorder Is Better Conceptualized as a Disorder of Emotional Regulation.J Atten Disord. 2017 Mar;21(5):381-389. doi: 10.1177/1087054713520221. Epub 2016 Jul 28.