Details of Disease

Disease Name

Polymyalgia rheumatica

polymyalgia rheumatica; rhizomelic pseudopolyarthritis

Definition

A syndrome characterized by pain, stiffness, and tenderness of the proximal muscle groups including the shoulder, pelvic girdle and the neck. There is no muscle atrophy and muscle biopsies do not reveal pathologic changes. Additional signs and symptoms include low grade fever, fatigue and depression.

Disease Hierarchy

DIS6SVEE: Syndromic disease

DIS77ACK: Rheumatic disorder

DIS5F36E: Polymyalgia rheumatica

Disease Identifiers

MONDO ID

MONDO_0019735

MESH ID

D011111

UMLS CUI

C0032533

MedGen ID

19393

Orphanet ID

93569

SNOMED CT ID

65323003

General Information of Disease (ID: DIS5F36E)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Prednisolone	DMQ8FR2	Approved	Small molecular drug	[1]
Prednisone	DM2HG4X	Approved	Small molecular drug	[2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ACR	TTAHE2N	Disputed	Biomarker	[3]
CCL5	TT9DWLC	Strong	Altered Expression	[4]
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This Disease Is Related to 5 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
FIP1L1	OTF91GTL	Strong	Genetic Variation	[5]
KRT15	OTS6WLF7	Strong	Biomarker	[6]
MX1	OT6X8G5T	Strong	Altered Expression	[7]
RHCE	OTS18IZ5	Strong	Genetic Variation	[5]
TSBP1	OT5GE8IO	Strong	Genetic Variation	[8]
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References

1	Prednisolone FDA Label
2	Prednisone FDA Label
3	Predictors of positive (18)F-FDG PET/CT-scan for large vessel vasculitis in patients with persistent polymyalgia rheumatica.Semin Arthritis Rheum. 2019 Feb;48(4):720-727. doi: 10.1016/j.semarthrit.2018.05.007. Epub 2018 May 18.
4	Are polymyalgia rheumatica and giant cell arteritis the same disease?.Semin Arthritis Rheum. 2004 Apr;33(5):294-301. doi: 10.1016/j.semarthrit.2003.09.008.
5	Incidence of rheumatoid arthritis, psoriatic arthritis and polymyalgia rheumatica in an inland area of central Italy: results of the CAMPO-RHE study.Postgrad Med. 2018 Jan;130(1):137-141. doi: 10.1080/00325481.2018.1399774. Epub 2017 Nov 3.
6	Analysis of the B cell repertoire against autoantigens in patients with giant cell arteritis and polymyalgia rheumatica.Clin Exp Immunol. 2002 Feb;127(2):379-85. doi: 10.1046/j.1365-2249.2002.01751.x.
7	Expression of the class I interferon-related MxA protein in temporal arteries in polymyalgia rheumatica and temporal arteritis.Scand J Rheumatol. 2009 Mar-Apr;38(2):144-8. doi: 10.1080/03009740802448841.
8	Identifying genetically driven clinical phenotypes using linear mixed models.Nat Commun. 2016 Apr 25;7:11433. doi: 10.1038/ncomms11433.