Details of the Drug

General Information of Drug (ID: DMQ8FR2)

Drug Name

Prednisolone

Synonyms

Nanocort; Prednisolone (injectable liposome formulation, rheumatoid arthritis); Prednisolone (injectable liposome formulation, rheumatoid arthritis), Enceladus; Prednisolone (injectable liposome formulation, rheumatoid arthritis), Galapagos

Indication

Disease Entry	ICD 11	Status	REF
Acute adrenal insufficiency	N.A.	Approved	[1]
Acute asthma	CA23	Approved	[1]
Addison disease	5A74.0	Approved	[1]
Allergic rhinitis	CA08.0	Approved	[1]
Angioedema	4A00.15	Approved	[1]
Aspiration pneumonitis	N.A.	Approved	[1]
Autoimmune haemolytic anaemia	3A20	Approved	[1]
Blepharoconjunctivitis	N.A.	Approved	[1]
Bursitis	N.A.	Approved	[1]
Cerebral edema	8D60.1	Approved	[1]
Chronic graft versus host disease	N.A.	Approved	[1]
Congenital adrenal hyperplasia	5A71.01	Approved	[1]
Corneal abrasion	NA06.4	Approved	[1]
Corneal ulcer	9A76	Approved	[1]
Crohn disease	DD70	Approved	[1]
Dacryocystitis	N.A.	Approved	[1]
Demodex blepharitis	1G07	Approved	[1]
Dermatitis herpetiformis	EB44	Approved	[1]
Diamond-Blackfan anemia	N.A.	Approved	[1]
Disorder of orbital region	N.A.	Approved	[1]
Epicondylitis	N.A.	Approved	[1]
Erythema multiforme	N.A.	Approved	[1]
Exanthem	N.A.	Approved	[1]
Fever	MG26	Approved	[1]
Granuloma annulare	N.A.	Approved	[1]
Hypersensitivity pneumonitis	N.A.	Approved	[1]
Inflammatory bowel disease	DD72	Approved	[1]
Ischemia-reperfusion injury	DB98.B	Approved	[1]
Keratitis	N.A.	Approved	[1]
Leukemia	N.A.	Approved	[1]
Lupus nephritis	4A40.0Y	Approved	[1]
Microscopic polyangiitis	N.A.	Approved	[1]
Miliary tuberculosis	N.A.	Approved	[1]
Mycosis fungoides	2B01	Approved	[1]
Myeloproliferative neoplasm	2A20	Approved	[1]
Pneumocystis pneumonia	CA40.20	Approved	[1]
Polymyalgia rheumatica	N.A.	Approved	[1]
Primary cutaneous T-cell lymphoma	N.A.	Approved	[1]
Psoriasis	EA90	Approved	[1]
Psoriatic arthritis	FA21	Approved	[1]
Rheumatic heart disease	N.A.	Approved	[1]
Rosacea	ED90.0	Approved	[1]
Sarcoidosis	4B20.5	Approved	[1]
Serum sickness	N.A.	Approved	[1]
Severe asthma	CA23	Approved	[1]
Skin disease	EA00-EM0Z	Approved	[1]
Solid tumour/cancer	2A00-2F9Z	Approved	[2]
Sympathetic ophthalmia	N.A.	Approved	[1]
Systemic lupus erythematosus	4A40.0	Approved	[1]
Ulcerative colitis	DD71	Approved	[1]
Multiple sclerosis	8A40	Phase 3	[3]
Acquired thrombocytopenia	N.A.	Investigative	[1]
Asthma	CA23	Investigative	[1]
Beta-thalassemia major	N.A.	Investigative	[1]
Classic Hodgkin lymphoma	N.A.	Investigative	[1]
Follicular lymphoma	2A80	Investigative	[1]
Iridocyclitis	N.A.	Investigative	[1]
Sjogren syndrome	4A43.20	Investigative	[1]
Synovitis	N.A.	Investigative	[1]
Uveitis	9A96.Z	Investigative	[1]
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⏷ Show the Full List of Indication(s)

Therapeutic Class

Anticancer Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

360.4

Logarithm of the Partition Coefficient (xlogp)

1.6

Rotatable Bond Count (rotbonds)

Hydrogen Bond Donor Count (hbonddonor)

Hydrogen Bond Acceptor Count (hbondacc)

ADMET Property

Absorption Cmax: The maximum plasma concentration (Cmax) of drug is 113-1343 mcg/L [4]
Absorption Tmax: The time to maximum plasma concentration (Tmax) is 1.0-2.6 h [4]
BDDCS Class: Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 1: high solubility and high permeability [5]
Bioavailability: The bioavailability of drug is 70% [4]
Clearance: The clearance of drug is 0.09 L/h/kg [4]
Elimination: The drug is over 98% eliminated in urine [4]
Half-life: The concentration or amount of drug in body reduced by one-half in 2.1 - 3.5 hours [4]
MRTD: The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 9.23834 micromolar/kg/day [6]
Unbound Fraction: The unbound fraction of drug in plasma is 0.25% [7]
Vd: The volume of distribution (Vd) of drug is 29.3 L [4]
Water Solubility: The ability of drug to dissolve in water is measured as 0.38 mg/mL [5]

Adverse Drug Reaction (ADR)

ADR Term	Variation	Related DOT	DOT ID	REF
Apoptosis	Not Available	TOP1	OT51O0CF	[8]
Metabolic disorder	Not Available	SMAD1 BSP1 MADH1 MADR1	OTQSHR25	[8]
Metabolic disorder	Not Available	CTNNB1 CTNNB OK/SW-cl.35 PRO2286	OTZ932A3	[8]
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Chemical Identifiers

Formula: C21H28O5
IUPAC Name: (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
Canonical SMILES: C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)CO)O)CCC4=CC(=O)C=C[C@]34C)O
InChI: InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
InChIKey: OIGNJSKKLXVSLS-VWUMJDOOSA-N

Cross-matching ID

PubChem CID: 5755
ChEBI ID: CHEBI:8378
CAS Number: 50-24-8
DrugBank ID: DB00860
TTD ID: D0D1SG
VARIDT ID: DR00428
INTEDE ID: DR1332
ACDINA ID: D00551

Combinatorial Drugs (CBD)

Click to Jump to the Detailed CBD Information of This Drug

Repurposed Drugs (RPD)

Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glucocorticoid receptor (NR3C1)	TTYRL6O	GCR_HUMAN	Modulator	[9]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[10]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[11]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Substrate	[12]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1)	OTO7FJA9	DHI1_HUMAN	Gene/Protein Processing	[13]
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)	OTHF4H9U	DHI2_HUMAN	Regulation of Drug Effects	[14]
2'-5'-oligoadenylate synthase 1 (OAS1)	OT8ZLOCY	OAS1_HUMAN	Gene/Protein Processing	[13]
2'-5'-oligoadenylate synthase-like protein (OASL)	OTZ05YRP	OASL_HUMAN	Gene/Protein Processing	[13]
Adenosine receptor A2a (ADORA2A)	OTVRBZ0I	AA2AR_HUMAN	Gene/Protein Processing	[13]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Gene/Protein Processing	[15]
Aldehyde oxidase (AOX1)	OT2FZP6H	AOXA_HUMAN	Gene/Protein Processing	[13]
Amphoterin-induced protein 2 (AMIGO2)	OTPAIT1O	AMGO2_HUMAN	Gene/Protein Processing	[13]
Anthrax toxin receptor 1 (ANTXR1)	OT5W1GPC	ANTR1_HUMAN	Gene/Protein Processing	[13]
Antiviral innate immune response receptor RIG-I (RIGI)	OTFIIC43	RIGI_HUMAN	Gene/Protein Processing	[13]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Prednisolone

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Disease	REF
Larotrectinib	DM26CQR	Moderate	Decreased metabolism of Prednisolone caused by Larotrectinib mediated inhibition of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[16]
Armodafinil	DMGB035	Minor	Increased metabolism of Prednisolone caused by Armodafinil mediated induction of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[17]
LEE011	DMMX75K	Moderate	Decreased metabolism of Prednisolone caused by LEE011 mediated inhibition of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[18]
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Coadministration of a Drug Treating the Disease Different from Prednisolone (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Sodium bicarbonate	DMMU6BJ	Minor	Decreased absorption of Prednisolone due to altered gastric pH caused by Sodium bicarbonate.	Acidosis [5C73]	[19]
Arn-509	DMT81LZ	Moderate	Accelerated clearance of Prednisolone due to the transporter induction by Arn-509.	Acute myeloid leukaemia [2A60]	[20]
Posaconazole	DMUL5EW	Moderate	Decreased metabolism of Prednisolone caused by Posaconazole mediated inhibition of CYP450 enzyme.	Aspergillosis [1F20]	[21]
Levalbuterol	DM5YBO1	Minor	Increased risk of hypokalemia by the combination of Prednisolone and Levalbuterol.	Asthma [CA23]	[16]
Terbutaline	DMD4381	Minor	Increased risk of hypokalemia by the combination of Prednisolone and Terbutaline.	Asthma [CA23]	[21]
Pirbuterol	DMI5678	Minor	Increased risk of hypokalemia by the combination of Prednisolone and Pirbuterol.	Asthma [CA23]	[21]
Salbutamol	DMN9CWF	Minor	Increased risk of hypokalemia by the combination of Prednisolone and Salbutamol.	Asthma [CA23]	[16]
Roflumilast	DMPGHY8	Moderate	Additive immunosuppressive effects by the combination of Prednisolone and Roflumilast.	Asthma [CA23]	[20]
Formoterol	DMSOURV	Minor	Increased risk of hypokalemia by the combination of Prednisolone and Formoterol.	Asthma [CA23]	[21]
Ofloxacin	DM0VQN3	Major	Increased risk of tendinitis/tendon rupture by the combination of Prednisolone and Ofloxacin.	Bacterial infection [1A00-1C4Z]	[22]
Dalfopristin	DM4LTKV	Moderate	Decreased metabolism of Prednisolone caused by Dalfopristin mediated inhibition of CYP450 enzyme.	Bacterial infection [1A00-1C4Z]	[23]
Clarithromycin	DM4M1SG	Moderate	Decreased metabolism of Prednisolone caused by Clarithromycin mediated inhibition of CYP450 enzyme.	Bacterial infection [1A00-1C4Z]	[21]
Sparfloxacin	DMB4HCT	Major	Increased risk of tendinitis/tendon rupture by the combination of Prednisolone and Sparfloxacin.	Bacterial infection [1A00-1C4Z]	[22]
Gemifloxacin	DMHT34O	Major	Increased risk of tendinitis/tendon rupture by the combination of Prednisolone and Gemifloxacin.	Bacterial infection [1A00-1C4Z]	[22]
Norfloxacin	DMIZ6W2	Major	Increased risk of tendinitis/tendon rupture by the combination of Prednisolone and Norfloxacin.	Bacterial infection [1A00-1C4Z]	[22]
ABT-492	DMJFD2I	Major	Increased risk of tendinitis/tendon rupture by the combination of Prednisolone and ABT-492.	Bacterial infection [1A00-1C4Z]	[22]
Levofloxacin	DMS60RB	Major	Increased risk of tendinitis/tendon rupture by the combination of Prednisolone and Levofloxacin.	Bacterial infection [1A00-1C4Z]	[22]
Troleandomycin	DMUZNIG	Moderate	Decreased metabolism of Prednisolone caused by Troleandomycin mediated inhibition of CYP450 enzyme.	Bacterial infection [1A00-1C4Z]	[24]
Lomefloxacin	DMVRH9C	Major	Increased risk of tendinitis/tendon rupture by the combination of Prednisolone and Lomefloxacin.	Bacterial infection [1A00-1C4Z]	[22]
Telithromycin	DMZ4P3A	Moderate	Decreased metabolism of Prednisolone caused by Telithromycin mediated inhibition of CYP450 enzyme.	Bacterial infection [1A00-1C4Z]	[21]
Tucatinib	DMBESUA	Moderate	Decreased metabolism of Prednisolone caused by Tucatinib mediated inhibition of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[21]
Vilanterol	DMF5EK1	Minor	Increased risk of hypokalemia by the combination of Prednisolone and Vilanterol.	Chronic obstructive pulmonary disease [CA22]	[16]
Salmeterol	DMIEU69	Minor	Increased risk of hypokalemia by the combination of Prednisolone and Salmeterol.	Chronic obstructive pulmonary disease [CA22]	[21]
Indacaterol	DMQJHR7	Minor	Increased risk of hypokalemia by the combination of Prednisolone and Indacaterol.	Chronic obstructive pulmonary disease [CA22]	[21]
Arformoterol	DMYM974	Minor	Increased risk of hypokalemia by the combination of Prednisolone and Arformoterol.	Chronic obstructive pulmonary disease [CA22]	[21]
Ketoprofen	DMRKXPT	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Prednisolone and Ketoprofen.	Chronic pain [MG30]	[25]
Isoproterenol	DMK7MEY	Minor	Increased risk of hypokalemia by the combination of Prednisolone and Isoproterenol.	Conduction disorder [BC63]	[16]
Mivacurium	DM473VD	Moderate	Additive neuromuscular blocking effects by the combination of Prednisolone and Mivacurium.	Corneal disease [9A76-9A78]	[21]
Pancuronium	DMB0VY8	Moderate	Additive neuromuscular blocking effects by the combination of Prednisolone and Pancuronium.	Corneal disease [9A76-9A78]	[21]
Tubocurarine	DMBZIVP	Moderate	Additive neuromuscular blocking effects by the combination of Prednisolone and Tubocurarine.	Corneal disease [9A76-9A78]	[21]
Ivacaftor	DMZC1HS	Moderate	Decreased clearance of Prednisolone due to the transporter inhibition by Ivacaftor.	Cystic fibrosis [CA25]	[26]
MK-8228	DMOB58Q	Moderate	Decreased metabolism of Prednisolone caused by MK-8228 mediated inhibition of CYP450 enzyme.	Cytomegaloviral disease [1D82]	[27]
Nefazodone	DM4ZS8M	Moderate	Decreased metabolism of Prednisolone caused by Nefazodone mediated inhibition of CYP450 enzyme.	Depression [6A70-6A7Z]	[21]
Zonisamide	DM0DTF7	Moderate	Increased metabolism of Prednisolone caused by Zonisamide mediated induction of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[28]
Cenobamate	DM8KLU9	Moderate	Increased metabolism of Prednisolone caused by Cenobamate mediated induction of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[29]
Fosphenytoin	DMOX3LB	Moderate	Increased metabolism of Prednisolone caused by Fosphenytoin mediated induction of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[30]
Rufinamide	DMWE60C	Moderate	Increased metabolism of Prednisolone caused by Rufinamide mediated induction of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[20]
Phenobarbital	DMXZOCG	Moderate	Increased metabolism of Prednisolone caused by Phenobarbital mediated induction of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[31]
Tazemetostat	DMWP1BH	Moderate	Increased metabolism of Prednisolone caused by Tazemetostat mediated induction of CYP450 enzyme.	Follicular lymphoma [2A80]	[32]
Itraconazole	DMCR1MV	Moderate	Decreased metabolism of Prednisolone caused by Itraconazole mediated inhibition of CYP450 enzyme.	Fungal infection [1F29-1F2F]	[21]
Miconazole	DMPMYE8	Moderate	Decreased metabolism of Prednisolone caused by Miconazole mediated inhibition of CYP450 enzyme.	Fungal infection [1F29-1F2F]	[24]
Ketoconazole	DMPZI3Q	Moderate	Decreased metabolism of Prednisolone caused by Ketoconazole mediated inhibition of CYP450 enzyme.	Fungal infection [1F29-1F2F]	[21]
Boceprevir	DMBSHMF	Moderate	Decreased metabolism of Prednisolone caused by Boceprevir mediated inhibition of CYP450 enzyme.	Hepatitis virus infection [1E50-1E51]	[21]
Telaprevir	DMMRV29	Moderate	Decreased metabolism of Prednisolone caused by Telaprevir mediated inhibition of CYP450 enzyme.	Hepatitis virus infection [1E50-1E51]	[33]
Rifampin	DMA8J1G	Moderate	Increased metabolism of Prednisolone caused by Rifampin mediated induction of CYP450 enzyme.	HIV-infected patients with tuberculosis [1B10-1B14]	[34]
Rifapentine	DMCHV4I	Moderate	Increased metabolism of Prednisolone caused by Rifapentine mediated induction of CYP450 enzyme.	HIV-infected patients with tuberculosis [1B10-1B14]	[35]
Fosamprenavir	DM4W9B3	Moderate	Decreased metabolism of Prednisolone caused by Fosamprenavir mediated inhibition of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[21]
Cobicistat	DM6L4H2	Moderate	Decreased metabolism of Prednisolone caused by Cobicistat mediated inhibition of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[21]
Saquinavir	DMG814N	Moderate	Decreased metabolism of Prednisolone caused by Saquinavir mediated inhibition of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[21]
Etravirine	DMGV8QU	Moderate	Increased metabolism of Prednisolone caused by Etravirine mediated induction of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[36]
Darunavir	DMN3GCH	Moderate	Decreased metabolism of Prednisolone caused by Darunavir mediated inhibition of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[21]
Atazanavir	DMSYRBX	Moderate	Decreased metabolism of Prednisolone caused by Atazanavir mediated inhibition of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[21]
Bempedoic acid	DM1CI9R	Major	Increased risk of tendinitis/tendon rupture by the combination of Prednisolone and Bempedoic acid.	Hyper-lipoproteinaemia [5C80]	[37]
Teriflunomide	DMQ2FKJ	Major	Additive immunosuppressive effects by the combination of Prednisolone and Teriflunomide.	Hyper-lipoproteinaemia [5C80]	[38]
Conivaptan	DM1V329	Moderate	Decreased metabolism of Prednisolone caused by Conivaptan mediated inhibition of CYP450 enzyme.	Hypo-osmolality/hyponatraemia [5C72]	[21]
Meclofenamic acid	DM05FXR	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Prednisolone and Meclofenamic acid.	Inflammatory spondyloarthritis [FA92]	[39]
Berotralstat	DMWA2DZ	Moderate	Decreased metabolism of Prednisolone caused by Berotralstat mediated inhibition of CYP450 enzyme.	Innate/adaptive immunodeficiency [4A00]	[40]
Amobarbital	DM0GQ8N	Moderate	Increased metabolism of Prednisolone caused by Amobarbital mediated induction of CYP450 enzyme.	Insomnia [7A00-7A0Z]	[31]
Zaleplon	DMGFWSM	Minor	Increased metabolism of Prednisolone caused by Zaleplon mediated induction of CYP450 enzyme.	Insomnia [7A00-7A0Z]	[41]
Denosumab	DMNI0KO	Moderate	Additive immunosuppressive effects by the combination of Prednisolone and Denosumab.	Low bone mass disorder [FB83]	[42]
Ceritinib	DMB920Z	Moderate	Decreased metabolism of Prednisolone caused by Ceritinib mediated inhibition of CYP450 enzyme.	Lung cancer [2C25]	[21]
PF-06463922	DMKM7EW	Moderate	Increased metabolism of Prednisolone caused by PF-06463922 mediated induction of CYP450 enzyme.	Lung cancer [2C25]	[43]
Selpercatinib	DMZR15V	Moderate	Decreased metabolism of Prednisolone caused by Selpercatinib mediated inhibition of CYP450 enzyme.	Lung cancer [2C25]	[20]
Idelalisib	DM602WT	Moderate	Decreased metabolism of Prednisolone caused by Idelalisib mediated inhibition of CYP450 enzyme.	Mature B-cell leukaemia [2A82]	[21]
IPI-145	DMWA24P	Moderate	Decreased metabolism of Prednisolone caused by IPI-145 mediated inhibition of CYP450 enzyme.	Mature B-cell leukaemia [2A82]	[44]
Nivolumab	DMAB9QE	Moderate	Additive immunosuppressive effects by the combination of Prednisolone and Nivolumab.	Melanoma [2C30]	[21]
Pembrolizumab	DMFQEA6	Moderate	Additive immunosuppressive effects by the combination of Prednisolone and Pembrolizumab.	Melanoma [2C30]	[21]
Ipilimumab	DMJTIYK	Moderate	Additive immunosuppressive effects by the combination of Prednisolone and Ipilimumab.	Melanoma [2C30]	[21]
Cemiplimab	DMKMJHE	Moderate	Additive immunosuppressive effects by the combination of Prednisolone and Cemiplimab.	Melanoma [2C30]	[21]
Dabrafenib	DMX6OE3	Moderate	Increased metabolism of Prednisolone caused by Dabrafenib mediated induction of CYP450 enzyme.	Melanoma [2C30]	[20]
Thalidomide	DM70BU5	Major	Additive thrombogenic effects by the combination of Prednisolone and Thalidomide.	Multiple myeloma [2A83]	[45]
Tecfidera	DM2OVDT	Moderate	Additive immunosuppressive effects by the combination of Prednisolone and Tecfidera.	Multiple sclerosis [8A40]	[46]
Siponimod	DM2R86O	Major	Additive immunosuppressive effects by the combination of Prednisolone and Siponimod.	Multiple sclerosis [8A40]	[16]
Fingolimod	DM5JVAN	Major	Additive immunosuppressive effects by the combination of Prednisolone and Fingolimod.	Multiple sclerosis [8A40]	[47]
Ocrelizumab	DMEZ2KH	Moderate	Additive immunosuppressive effects by the combination of Prednisolone and Ocrelizumab.	Multiple sclerosis [8A40]	[48]
Ozanimod	DMT6AM2	Major	Additive immunosuppressive effects by the combination of Prednisolone and Ozanimod.	Multiple sclerosis [8A40]	[20]
Fedratinib	DM4ZBK6	Moderate	Decreased metabolism of Prednisolone caused by Fedratinib mediated inhibition of CYP450 enzyme.	Myeloproliferative neoplasm [2A20]	[21]
Nilotinib	DM7HXWT	Moderate	Decreased metabolism of Prednisolone caused by Nilotinib mediated inhibition of CYP450 enzyme.	Myeloproliferative neoplasm [2A20]	[49]
Dasatinib	DMJV2EK	Moderate	Decreased metabolism of Prednisolone caused by Dasatinib mediated inhibition of CYP450 enzyme.	Myeloproliferative neoplasm [2A20]	[50]
Omacetaxine mepesuccinate	DMPU2WX	Moderate	Additive immunosuppressive effects by the combination of Prednisolone and Omacetaxine mepesuccinate.	Myeloproliferative neoplasm [2A20]	[51]
Bupropion	DM5PCS7	Major	Increased risk of lowers seizure threshold by the combination of Prednisolone and Bupropion.	Nicotine use disorder [6C4A]	[52]
Atezolizumab	DMMF8U0	Moderate	Additive immunosuppressive effects by the combination of Prednisolone and Atezolizumab.	Non-small cell lung cancer [2C25]	[21]
Rucaparib	DM9PVX8	Moderate	Decreased metabolism of Prednisolone caused by Rucaparib mediated inhibition of CYP450 enzyme.	Ovarian cancer [2C73]	[53]
Aspirin	DM672AH	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Prednisolone and Aspirin.	Pain [MG30-MG3Z]	[54]
Diflunisal	DM7EN8I	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Prednisolone and Diflunisal.	Pain [MG30-MG3Z]	[25]
Ibuprofen	DM8VCBE	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Prednisolone and Ibuprofen.	Pain [MG30-MG3Z]	[25]
Abametapir	DM2RX0I	Moderate	Decreased metabolism of Prednisolone caused by Abametapir mediated inhibition of CYP450 enzyme.	Pediculosis [1G00]	[55]
Lefamulin	DME6G97	Moderate	Decreased metabolism of Prednisolone caused by Lefamulin mediated inhibition of CYP450 enzyme.	Pneumonia [CA40]	[56]
Choline salicylate	DM8P137	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Prednisolone and Choline salicylate.	Postoperative inflammation [1A00-CA43]	[57]
Bromfenac	DMKB79O	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Prednisolone and Bromfenac.	Postoperative inflammation [1A00-CA43]	[25]
Lonafarnib	DMGM2Z6	Moderate	Decreased metabolism of Prednisolone caused by Lonafarnib mediated inhibition of CYP450 enzyme.	Premature ageing appearance [LD2B]	[21]
Ritodrine	DM4V6RL	Minor	Increased risk of hypokalemia by the combination of Prednisolone and Ritodrine.	Preterm labour/delivery [JB00]	[21]
Enzalutamide	DMGL19D	Moderate	Increased metabolism of Prednisolone caused by Enzalutamide mediated induction of CYP450 enzyme.	Prostate cancer [2C82]	[58]
Gatifloxacin	DMSL679	Major	Increased risk of tendinitis/tendon rupture by the combination of Prednisolone and Gatifloxacin.	Respiratory infection [CA07-CA4Z]	[22]
Salsalate	DM13P4C	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Prednisolone and Salsalate.	Rheumatoid arthritis [FA20]	[57]
Canakinumab	DM8HLO5	Moderate	Additive immunosuppressive effects by the combination of Prednisolone and Canakinumab.	Rheumatoid arthritis [FA20]	[59]
Oxaprozin	DM9UB0P	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Prednisolone and Oxaprozin.	Rheumatoid arthritis [FA20]	[25]
Rilonacept	DMGLUQS	Moderate	Additive immunosuppressive effects by the combination of Prednisolone and Rilonacept.	Rheumatoid arthritis [FA20]	[59]
Golimumab	DMHZV7X	Major	Additive immunosuppressive effects by the combination of Prednisolone and Golimumab.	Rheumatoid arthritis [FA20]	[60]
Leflunomide	DMR8ONJ	Major	Additive immunosuppressive effects by the combination of Prednisolone and Leflunomide.	Rheumatoid arthritis [FA20]	[38]
Salicyclic acid	DM2F8XZ	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Prednisolone and Salicyclic acid.	Seborrhoeic dermatitis [EA81]	[54]
Anthrax vaccine	DM9GSWY	Moderate	Antagonize the effect of Prednisolone when combined with Anthrax vaccine.	Sepsis [1G40-1G41]	[61]
Voxelotor	DMCS6M5	Moderate	Decreased metabolism of Prednisolone caused by Voxelotor mediated inhibition of CYP450 enzyme.	Sickle-cell disorder [3A51]	[21]
Telotristat ethyl	DMDIYFZ	Moderate	Increased metabolism of Prednisolone caused by Telotristat ethyl mediated induction of CYP450 enzyme.	Small intestine developmental anomaly [DA90]	[20]
Pitolisant	DM8RFNJ	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Prednisolone and Pitolisant.	Somnolence [MG42]	[20]
Fostamatinib	DM6AUHV	Moderate	Decreased clearance of Prednisolone due to the transporter inhibition by Fostamatinib.	Thrombocytopenia [3B64]	[62]
Pipecuronium	DM5F84A	Moderate	Additive neuromuscular blocking effects by the combination of Prednisolone and Pipecuronium.	Tonus and reflex abnormality [MB47]	[21]
Doxacurium	DMKE7L9	Moderate	Additive neuromuscular blocking effects by the combination of Prednisolone and Doxacurium.	Tonus and reflex abnormality [MB47]	[21]
Vecuronium	DMP0UK2	Moderate	Additive neuromuscular blocking effects by the combination of Prednisolone and Vecuronium.	Tonus and reflex abnormality [MB47]	[21]
Durvalumab	DM4PVDY	Moderate	Additive immunosuppressive effects by the combination of Prednisolone and Durvalumab.	Ureteral cancer [2C92]	[21]
-----------


⏷ Show the Full List of 110 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG

DIG Name	DIG ID	PubChem CID	Functional Classification
Alpha-tocopherol	E00243	14985	Antimicrobial preservative; Antioxidant
Butylated hydroxytoluene	E00336	31404	Antioxidant
Docusate sodium	E00563	23673837	Surfactant
Kyselina citronova	E00014	311	Acidulant; Antioxidant; Buffering agent; Complexing agent; Flavoring agent
Mannitol	E00103	6251	Diluent; Flavoring agent; Lyophilization aid; Plasticizing agent; Tonicity agent
Quinoline yellow WS	E00309	24671	Colorant
Sodium benzoate	E00432	517055	Antimicrobial preservative; lubricant
Sodium stearyl fumarate	E00545	23665634	lubricant
Sucralose	E00370	71485	Flavoring agent
Sunset yellow FCF	E00255	17730	Colorant
Beta-D-lactose	E00099	6134	Diluent; Dry powder inhaler carrier; Lyophilization aid
Citric acid monohydrate	E00271	22230	Acidulant; Antioxidant; Buffering agent; Complexing agent; Flavoring agent
Crospovidone	E00626	Not Available	Disintegrant
Lactose monohydrate	E00393	104938	Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate	E00208	11177	lubricant
Saccharose	E00091	5988	Binding agent; Coating agent; Cryoprotectant; Diluent; Flavoring agent; Suspending agent; Viscosity-controlling agent
Silicon dioxide	E00670	Not Available	Anticaking agent; Opacifying agent; Viscosity-controlling agent
Sodium bicarbonate	E00424	516892	Alkalizing agent; Diluent
--------------------


⏷ Show the Full List of 18 Pharmaceutical Excipients of This Drug

Pharmaceutical Formulation

Formulation Name	Drug Dosage	Dosage Form	Route
Prednisolone 10 mg tablet	10 mg	Disintegrating Oral Tablet	Oral
Prednisolone 15 mg tablet	15 mg	Disintegrating Oral Tablet	Oral
Prednisolone 30 mg tablet	30 mg	Disintegrating Oral Tablet	Oral
Prednisolone 20 mg tablet	20 mg	Oral Tablet	Oral
Prednisolone 5 mg tablet	5 mg	Oral Tablet	Oral

Jump to Detail Pharmaceutical Formulation Page of This Drug

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