Details of Disease

General Information of Disease (ID: DIS5ICKE)

Disease Name Central retinal vein occlusion
Synonyms retinal vein occlusion of central retinal vein; central retinal vein retinal vein occlusion; central retinal Venous occlusion
Definition Blockage of the central retinal vein.
Disease Hierarchy
DISJQJNZ: Vein disorder
DISMU050: Retina venous occlusion
DIS5ICKE: Central retinal vein occlusion
Disease Identifiers
MONDO ID
MONDO_0002303
UMLS CUI
C0154841
MedGen ID
509679
HPO ID
HP:0020166
Orphanet ID
411527
SNOMED CT ID
68478007

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 2 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
SERPINF1 TTR59S1 Limited Biomarker [1]
SERPINC1 TT4QPUL Strong Altered Expression [2]
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This Disease Is Related to 7 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
CIAO3 OT0V91PK Strong Biomarker [3]
LOXL1 OTA0NEJU Strong Genetic Variation [4]
LUC7L3 OTKDED8A Strong Biomarker [5]
MTMR11 OTHL2O08 Strong Biomarker [5]
NDUFAB1 OTF906UR Strong Biomarker [6]
PRXL2A OTR4X7UH Strong Genetic Variation [7]
RAMP2 OTGQXLH5 Strong Biomarker [8]
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⏷ Show the Full List of 7 DOT(s)

References

1 Effects of intravitreal triamcinolone acetonide on retinal gene expression in a rat model of central retinal vein occlusion.Graefes Arch Clin Exp Ophthalmol. 2011 Aug;249(8):1175-83. doi: 10.1007/s00417-011-1683-z. Epub 2011 Apr 13.
2 LABORATORY EVALUATION OF HYPERCOAGULABLE STATES IN PATIENTS WITH CENTRAL RETINAL VEIN OCCLUSION WHO ARE LESS THAN 56 YEARS OF AGE.Retina. 2018 Jun;38(6):1175-1179. doi: 10.1097/IAE.0000000000001661.
3 Pre-treatment clinical features in central retinal vein occlusion that predict visual outcome following intravitreal ranibizumab.BMC Ophthalmol. 2018 Feb 9;18(1):37. doi: 10.1186/s12886-018-0701-x.
4 Lack of association of LOXL1 gene variants in Japanese patients with central retinal vein occlusion without clinically detectable pseudoexfoliation material deposits.Acta Ophthalmol. 2015 May;93(3):e214-7. doi: 10.1111/aos.12534. Epub 2014 Aug 12.
5 Two-Year Efficacy of Ranibizumab Plus Laser-Induced Chorioretinal Anastomosis vs Ranibizumab Monotherapy for Central Retinal Vein Occlusion: A Randomized Clinical Trial.JAMA Ophthalmol. 2018 Dec 1;136(12):1391-1397. doi: 10.1001/jamaophthalmol.2018.4973.
6 Activated protein C resistance, factor V Leiden, and central retinal vein occlusion in young adults.Arch Ophthalmol. 1998 May;116(5):577-9. doi: 10.1001/archopht.116.5.577.
7 Cilioretinal artery hypoperfusion and its association with paracentral acute middle maculopathy.Br J Ophthalmol. 2019 Aug;103(8):1137-1145. doi: 10.1136/bjophthalmol-2018-312774. Epub 2018 Sep 26.
8 Development of a Novel Model of Central Retinal Vascular Occlusion and the Therapeutic Potential of the Adrenomedullin-Receptor Activity-Modifying Protein 2 System.Am J Pathol. 2019 Feb;189(2):449-466. doi: 10.1016/j.ajpath.2018.10.021. Epub 2019 Jan 15.