Details of Disease

General Information of Disease (ID: DIS5IW5K)

• Disease Name: Hypersensitivity pneumonitis
• Synonyms: allergic interstitial pneumonitis; extrinsic allergic pneumonia hypersensitivity pneumonitis; alveolitis, extrinsic allergic; hypersensitivity pneumonitis; allergic form of pneumonitis; extrinsic allergic alveolitis; HP; exogen allergic alveolitis; allergic pneumonitis; alveolitis
• Definition: Hypersensitivity pneumonitis (HP) is a pulmonary disease with symptoms of dyspnea and cough resulting from the inhalation of an antigen to which the subject has been previously sensitized.
• Disease Hierarchy:
  DIS88E0K: Pneumonitis
  DISWSHC6: Interstitial lung disease
  DISAAZU9: Respiratory allergy
  DIS5IW5K: Hypersensitivity pneumonitis
• Disease Identifiers:
  MONDO ID: MONDO_0017853
  MESH ID: D000542
  UMLS CUI: C0002390
  MedGen ID: 1446
  HPO ID: HP:0006516
  Orphanet ID: 31740
  SNOMED CT ID: 37471005

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Prednisolone	DMQ8FR2	Approved	Small molecular drug	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
IL13	TT0GVCH	Limited	Biomarker	[2]
CEL	TTTRNQW	Strong	Biomarker	[3]

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC27A5	DT0TQS3	Strong	Biomarker	[3]

This Disease Is Related to 9 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
MUC5B	OTPW6K5C	Disputed	Genetic Variation	[4]
CCL15	OTOGZ85M	Strong	Altered Expression	[5]
CUL9	OTPUCLZT	Strong	Altered Expression	[6]
CXCL5	OTZOUPCA	Strong	Altered Expression	[7]
MMP28	OTHQZXM1	Strong	Altered Expression	[8]
NELFCD	OTOLTZPU	Strong	Altered Expression	[7]
PARN	OTTG4PE3	Strong	Biomarker	[9]
PARP9	OT7K4494	Strong	Biomarker	[3]
TOLLIP	OTYEO4NR	Strong	Genetic Variation	[10]

References

• [1] Prednisolone FDA Label
• [2] Regulation of acute lung inflammatory injury by endogenous IL-13.J Immunol. 1999 Jan 15;162(2):1071-6.
• [3] Impaired Immunosuppressive Effect of Bronchoalveolar Mesenchymal Stem Cells in Hypersensitivity Pneumonitis: Preliminary Findings.Cytometry B Clin Cytom. 2018 Mar;94(2):363-368. doi: 10.1002/cyto.b.21490. Epub 2016 Nov 17.
• [4] Integrating Genomics Into Management ofFibrotic Interstitial Lung Disease.Chest. 2019 May;155(5):1026-1040. doi: 10.1016/j.chest.2018.12.011. Epub 2019 Jan 17.
• [5] C-C Motif Chemokine Ligand 15 May Be a Useful Biomarker for Predicting the Prognosis of Patients with Chronic Hypersensitivity Pneumonitis.Respiration. 2019;98(3):212-220. doi: 10.1159/000500576. Epub 2019 Aug 15.
• [6] CCL18/DC-CK-1/PARC up-regulation in hypersensitivity pneumonitis.J Leukoc Biol. 2001 Oct;70(4):610-6.
• [7] Interleukin-17A and Neutrophils in a Murine Model of Bird-Related Hypersensitivity Pneumonitis.PLoS One. 2015 Sep 14;10(9):e0137978. doi: 10.1371/journal.pone.0137978. eCollection 2015.
• [8] Identification of MMP28 as a biomarker for the differential diagnosis of idiopathic pulmonary fibrosis.PLoS One. 2018 Sep 12;13(9):e0203779. doi: 10.1371/journal.pone.0203779. eCollection 2018.
• [9] Telomere-related lung fibrosis is diagnostically heterogeneous but uniformly progressive.Eur Respir J. 2016 Dec;48(6):1710-1720. doi: 10.1183/13993003.00308-2016. Epub 2016 Aug 18.
• [10] The MUC5B promoter polymorphism and telomere length in patients with chronic hypersensitivity pneumonitis: an observational cohort-control study.Lancet Respir Med. 2017 Aug;5(8):639-647. doi: 10.1016/S2213-2600(17)30216-3. Epub 2017 Jun 22.