Details of Disease | DrugMAP

General Information of Disease (ID: DIS6KM28)

Disease Name	Extrapulmonary tuberculosis
Definition	A tuberculosis that occurs at body sites other than the lung.
Disease Hierarchy	DIS2YIMD: Tuberculosis DIS6KM28: Extrapulmonary tuberculosis
Disease Identifiers	MONDO ID MONDO_0000368 MESH ID D000092225 UMLS CUI C0679362 MedGen ID 671310 HPO ID HP:0032271 SNOMED CT ID 423997002

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 6 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CFP	TTLA0VS	Limited	Biomarker	[1]
CSE1L	TTTRULD	moderate	Genetic Variation	[2]
CD209	TTBXIM9	Strong	Genetic Variation	[3]
LTA4H	TTXZEAJ	Strong	Genetic Variation	[4]
P2RX7	TT473XN	Strong	Genetic Variation	[5]
PTBP1	TTWMX0U	Strong	Genetic Variation	[6]
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⏷ Show the Full List of 6 DTT(s)

This Disease Is Related to 9 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CTSW	OTXSBXFM	Limited	Biomarker	[7]
BCAR1	OTKT2C2N	moderate	Genetic Variation	[8]
CTNND1	OTUMPSHR	moderate	Genetic Variation	[2]
SMIM10L2B	OT04IG2N	moderate	Biomarker	[9]
SP110	OTFW6WH7	moderate	Genetic Variation	[10]
CARD8	OTXXZYWU	Strong	Genetic Variation	[11]
NRTN	OT4PAKUY	Strong	Biomarker	[12]
PTBP2	OTF4S7NE	Strong	Genetic Variation	[6]
PRPF40A	OT6EXJZN	Definitive	Biomarker	[13]
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⏷ Show the Full List of 9 DOT(s)

References

1	Detection of Mycobacterium tuberculosis lipoarabinomannan and CFP-10 (Rv3874) from urinary extracellular vesicles of tuberculosis patients by immuno-PCR.Pathog Dis. 2019 Jul 1;77(5):ftz049. doi: 10.1093/femspd/ftz049.
2	Clinical, molecular and drug sensitivity pattern of mycobacterial isolates from extra-pulmonary tuberculosis cases in Addis Ababa, Ethiopia.BMC Infect Dis. 2015 Oct 26;15:456. doi: 10.1186/s12879-015-1177-4.
3	CCR2, MCP-1, SDF-1a & DC-SIGN gene polymorphisms in HIV-1 infected patients with & without tuberculosis.Indian J Med Res. 2009 Oct;130(4):444-50.
4	Relationship between human LTA4H polymorphisms and extra-pulmonary tuberculosis in an ethnic Han Chinese population in Eastern China.Tuberculosis (Edinb). 2014 Dec;94(6):657-63. doi: 10.1016/j.tube.2014.08.014. Epub 2014 Sep 7.
5	The effect of P2X7 receptor 1513 polymorphism on susceptibility to tuberculosis: A meta-analysis.Infect Genet Evol. 2014 Jun;24:82-91. doi: 10.1016/j.meegid.2014.03.006. Epub 2014 Mar 17.
6	Plasma levels of C-reactive protein, matrix metalloproteinase-7 and lipopolysaccharide-binding protein distinguish active pulmonary or extrapulmonary tuberculosis from uninfected controls in children.Cytokine. 2019 Nov;123:154773. doi: 10.1016/j.cyto.2019.154773. Epub 2019 Jul 9.
7	Microarray analysis of gene expression associated with extrapulmonary dissemination of tuberculosis.Respirology. 2006 Sep;11(5):557-65. doi: 10.1111/j.1440-1843.2006.00896.x.
8	Genetic diversity of Mycobacterium tuberculosis isolates causing pulmonary and extrapulmonary tuberculosis in the capital of Iran.Mol Phylogenet Evol. 2019 Mar;132:46-52. doi: 10.1016/j.ympev.2018.11.019. Epub 2018 Dec 2.
9	Comparison of GeneXpert MTB/RIF assay and LED-FM microscopy for the diagnosis of extra pulmonary tuberculosis in Khyber Pakhtunkhwa, Pakistan.Braz J Microbiol. 2018 Oct-Dec;49(4):909-913. doi: 10.1016/j.bjm.2018.02.011. Epub 2018 Apr 27.
10	Polymorphisms of SP110 are associated with both pulmonary and extra-pulmonary tuberculosis among the Vietnamese.PLoS One. 2014 Jul 9;9(7):e99496. doi: 10.1371/journal.pone.0099496. eCollection 2014.
11	Polymorphisms in CARD8 and NLRP3 are associated with extrapulmonary TB and poor clinical outcome in active TB in Ethiopia.Sci Rep. 2019 Feb 28;9(1):3126. doi: 10.1038/s41598-019-40121-8.
12	Prevalence of nontuberculous mycobacteria among extrapulmonary tuberculosis cases in tertiary care centers in Northern India.Biomed Res Int. 2015;2015:465403. doi: 10.1155/2015/465403. Epub 2015 Mar 26.
13	Mannose-binding lectin exon 1 and promoter polymorphisms in tuberculosis disease in a Mediterranean area.Int J Immunogenet. 2014 Aug;41(4):306-11. doi: 10.1111/iji.12126. Epub 2014 Jun 9.