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Ethionamide FDA Label
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Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
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Trimethoprim FDA Label
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ClinicalTrials.gov (NCT01061593) Phase III, Double-blind, Placebo-controlled, Randomized, 1-month Clinical Trial of Immunoxel Combined With Anti-TB Therapy Versus Anti-TB Therapy With Placebo. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT05824871) A Multicenter, Randomized, Double-blind, Positive Control Study to Evaluate the Efficacy and Safety of Sudapyridine (WX-081) Tables in Patients With Rifampicin-resistant Pulmonary Tuberculosis. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT04044001) A Prospective Phase Ib/IIa, Active-controlled, Randomized, Open-label Study to Evaluate the Safety, Tolerability, Extended Early Bactericidal Activity and Pharmacokinetics of Multiple Oral Doses of BTZ-043 Tablets in Subjects With Newly Diagnosed, Uncomplicated, Smear-positive, Drug-susceptible Pulmonary Tuberculosis. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT05473195) A Phase 2 Trial to Evaluate the EBA, Safety and Tolerability of Ethionamide Alone and in Combination With BVL-GSK098 Administered Orally to Adults With Newly Diagnosed, Rifampicin- and Isoniazid-Susceptible Pulmonary Tuberculosis. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT03557281) An Early Bactericidal Activity, Safety and Tolerability of GSK3036656 in Subjects With Drug-sensitive Pulmonary Tuberculosis. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT03199339) A Phase 1 Study to Evaluate Safety, Tolerability, PK, and PK Interactions of TBA-7371. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT03678688) A Phase 1/2 Trial of Multiple Oral Doses of OPC-167832 for Uncomplicated Pulmonary Tuberculosis. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT05537038) A Phase Ia, Randomized, Placebo-controlled, Double-blind, Dose-finding Evaluation Trial to Describe the Safety, Reactogenicity, and Immunogenicity of Two Investigational Vaccines Against Tuberculosis in IGRA-negative, BCG na?ve Subjects. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT04472897) A Randomised, Double Blind (Sponsor Unblinded), Placebo-controlled, First Time in Human Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Single and Repeat Oral Doses and the Food Effect of GSK2556286 in Healthy Adult Participants. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT02288481) A Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TBA-354 in Healthy Adult Subjects. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT04890535) Phase 1, Partially Blinded, Placebo-Controlled, Randomized, Combined Single Ascending Dose With Food Effect Cohort Trial and Multiple Ascending Dose Trial to Evaluate the Safety, Tolerability, and PK of TBAJ-587 in Healthy Adults. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT03758612) A Phase 1, Partially-Blinded, Placebo-Controlled, Randomized, Single Ascending Dose (SAD) With a Food Effect Cohort Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TBI-223 in Healthy Adult Participants. U.S.National Institutes of Health.
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Clinical pipeline report, company report or official report of TB
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Fine mapping of a putative tuberculosis-susceptibility locus on chromosome 15q11-13 in African families.Hum Mol Genet. 2002 Jul 1;11(14):1599-603. doi: 10.1093/hmg/11.14.1599.
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Transcript levels of major MMPs and ADAMTS-4 in relation to the clinicopathological profile of patients with tuberculous intervertebral discs and healthy controls.Clin Biochem. 2013 May;46(7-8):603-11. doi: 10.1016/j.clinbiochem.2013.02.006. Epub 2013 Feb 26.
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Host cell-induced components of the sulfate assimilation pathway are major protective antigens of Mycobacterium tuberculosis.J Infect Dis. 2013 Mar 1;207(5):778-85. doi: 10.1093/infdis/jis751. Epub 2012 Dec 7.
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Hypothesis: Cystic fibrosis carrier geography reflects interactions of tuberculosis and hypertension with vitamin D deficiency, altitude and temperature. Vitamin D deficiency effects and CF carrier advantage.J Cyst Fibros. 2012 Jan;11(1):68-70. doi: 10.1016/j.jcf.2011.09.007. Epub 2011 Oct 2.
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A polymorphism in human CD1A is associated with susceptibility to tuberculosis.Genes Immun. 2014 Apr-May;15(3):195-8. doi: 10.1038/gene.2014.5. Epub 2014 Feb 6.
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Plasmacytoid dendritic cells infiltrate the skin in positive tuberculin skin test indurations.J Invest Dermatol. 2012 Jan;132(1):114-23. doi: 10.1038/jid.2011.246. Epub 2011 Aug 18.
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Biochemical characterization of recombinant guaA-encoded guanosine monophosphate synthetase (EC 6.3.5.2) from Mycobacterium tuberculosis H37Rv strain.Arch Biochem Biophys. 2012 Jan 1;517(1):1-11. doi: 10.1016/j.abb.2011.11.013. Epub 2011 Nov 18.
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Gamma interferon receptor defect presenting as recurrent tuberculosis.Indian J Pediatr. 2014 Jul;81(7):696-8. doi: 10.1007/s12098-013-1060-5. Epub 2013 May 17.
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Induction of protective immunity against Mycobacterium tuberculosis by delivery of ESX antigens into airway dendritic cells.Mucosal Immunol. 2013 May;6(3):522-34. doi: 10.1038/mi.2012.92. Epub 2012 Oct 3.
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Genetic variants of MARCO are associated with susceptibility to pulmonary tuberculosis in a Gambian population.BMC Med Genet. 2013 Apr 23;14:47. doi: 10.1186/1471-2350-14-47.
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The endothelial protein C receptor and activated protein C play a limited role in host defense during experimental tuberculosis.Thromb Haemost. 2013 Apr;109(4):726-37. doi: 10.1160/TH12-11-0859. Epub 2013 Jan 24.
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Suppression of breast tumor growth by DNA vaccination against phosphatase of regenerating liver 3.Gene Ther. 2013 Aug;20(8):834-45. doi: 10.1038/gt.2013.5. Epub 2013 Jan 31.
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Polymorphisms in the gene that encodes the iron transport protein ferroportin 1 influence susceptibility to tuberculosis.J Infect Dis. 2012 Apr 1;205(7):1043-7. doi: 10.1093/infdis/jis026. Epub 2012 Feb 21.
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A novel MtHSP70-FPR1 fusion protein enhances cytotoxic T lymphocyte responses to cervical cancer cells by activating human monocyte-derived dendritic cells via the p38 MAPK signaling pathway.Biochem Biophys Res Commun. 2018 Sep 10;503(3):2108-2116. doi: 10.1016/j.bbrc.2018.07.167. Epub 2018 Aug 8.
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Circulating HLA-DR+CD4+ effector memory T cells resistant to CCR5 and PD-L1 mediated suppression compromise regulatory T cell function in tuberculosis.PLoS Pathog. 2018 Sep 19;14(9):e1007289. doi: 10.1371/journal.ppat.1007289. eCollection 2018 Sep.
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Differential expression and predictive value of monocyte scavenger receptor CD163 in populations with different tuberculosis infection statuses.BMC Infect Dis. 2019 Nov 28;19(1):1006. doi: 10.1186/s12879-019-4525-y.
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HIV-associated benign lymphoepithelial cysts of the parotid glands confirmed by HIV-1 p24 antigen immunostaining.BMJ Case Rep. 2017 Sep 28;2017:bcr2017221869. doi: 10.1136/bcr-2017-221869.
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Genetic polymorphism in association with susceptibility to tuberculosis: a study in a Pakistani population.Braz J Microbiol. 2019 Apr;50(2):429-434. doi: 10.1007/s42770-019-00048-8. Epub 2019 Feb 25.
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Activating KIRs alter susceptibility to pulmonary tuberculosis in a South African population.Tuberculosis (Edinb). 2015 Dec;95(6):817-821. doi: 10.1016/j.tube.2015.09.003. Epub 2015 Oct 17.
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Hepcidin exerts a negative immunological effect in pulmonary tuberculosis without HIV co-infection, prolonging the time to culture-negative.Int J Infect Dis. 2019 Sep;86:47-54. doi: 10.1016/j.ijid.2019.06.023. Epub 2019 Jun 25.
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Mechanism of HrcA function in heat shock regulation in Mycobacterium tuberculosis.Biochimie. 2020 Jan;168:285-296. doi: 10.1016/j.biochi.2019.11.012. Epub 2019 Nov 22.
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Transcriptional landscape of Mycobacterium tuberculosis infection in macrophages.Sci Rep. 2018 Apr 30;8(1):6758. doi: 10.1038/s41598-018-24509-6.
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The increased protection and pathology in Mycobacterium tuberculosis-infected IL-27R-alpha-deficient mice is supported by IL-17A and is associated with the IL-17A-induced expansion of multifunctional T cells.Mucosal Immunol. 2018 Jul;11(4):1168-1180. doi: 10.1038/s41385-018-0026-3. Epub 2018 May 4.
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IL-32 and its splice variants are associated with protection againstMycobacterium tuberculosis infectionand skewing of Th1/Th17 cytokines.J Leukoc Biol. 2020 Jan;107(1):113-118. doi: 10.1002/JLB.4AB0219-071R. Epub 2019 Aug 4.
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Interferon regulatory factor 1 eliminates mycobacteria by suppressing p70 S6 kinase via mechanistic target of rapamycin signaling.J Infect. 2019 Sep;79(3):262-276. doi: 10.1016/j.jinf.2019.06.007. Epub 2019 Jun 18.
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Tuberculosis, onychomycosis and immune deficiency in complicated Crohn's disease.BMJ Case Rep. 2019 Aug 4;12(8):e228986. doi: 10.1136/bcr-2018-228986.
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Association of the TLR1 variant rs5743557 with susceptibility to tuberculosis.J Thorac Dis. 2019 Feb;11(2):583-594. doi: 10.21037/jtd.2019.01.74.
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Molecular profiling of drug resistant isolates of Mycobacterium tuberculosis in the state of Santa Catarina, southern Brazil.Mem Inst Oswaldo Cruz. 2015 Aug;110(5):618-23. doi: 10.1590/0074-02760150100. Epub 2015 Jul 7.
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ACR Appropriateness Criteria() Imaging ofPossible Tuberculosis.J Am Coll Radiol. 2017 May;14(5S):S160-S165. doi: 10.1016/j.jacr.2017.02.022.
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Serum concentrations of A disintegrin and metalloproteinase 9 (ADAM9) mRNA as a promising novel marker for the detection of pulmonary sarcoidosis.J Int Med Res. 2013 Aug;41(4):1236-41. doi: 10.1177/0300060513489471. Epub 2013 Jul 15.
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Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase.PLoS One. 2019 Jun 14;14(6):e0218449. doi: 10.1371/journal.pone.0218449. eCollection 2019.
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CD4+ T cell cytokine responses to the DAR-901 booster vaccine in BCG-primed adults: A randomized, placebo-controlled trial.PLoS One. 2019 May 23;14(5):e0217091. doi: 10.1371/journal.pone.0217091. eCollection 2019.
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Time-Dependent Changes in Urinary Metabolome Before and After Intensive Phase Tuberculosis Therapy: A Pharmacometabolomics Study.OMICS. 2019 Nov;23(11):560-572. doi: 10.1089/omi.2019.0140. Epub 2019 Oct 15.
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PPAR is critical for Mycobacterium tuberculosis induction of Mcl-1 and limitation of human macrophage apoptosis.PLoS Pathog. 2018 Jun 21;14(6):e1007100. doi: 10.1371/journal.ppat.1007100. eCollection 2018 Jun.
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Preparation and characterization of the antibody recognizing AMACR inside its catalytic center.Int J Oncol. 2018 Feb;52(2):547-559. doi: 10.3892/ijo.2017.4220. Epub 2017 Dec 11.
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Molecular modeling studies to explore the binding affinity of virtually screened inhibitor toward different aminoglycoside kinases from diverse MDR strains.J Cell Biochem. 2018 Mar;119(3):2679-2695. doi: 10.1002/jcb.26435. Epub 2017 Dec 4.
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Genome-wide DNA methylation and transcriptome and proteome changes in Mycobacterium tuberculosis with para-aminosalicylic acid resistance.Chem Biol Drug Des. 2020 Jan;95(1):104-112. doi: 10.1111/cbdd.13625. Epub 2019 Nov 7.
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Secondary metabolites from Triclisia gilletii (De Wild) Staner (Menispermaceae) with antimycobacterial activity against Mycobacterium tuberculosis.Nat Prod Res. 2019 Mar;33(5):642-650. doi: 10.1080/14786419.2017.1402324. Epub 2017 Nov 16.
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The association between BACH1 polymorphisms and anti-tuberculosis drug-induced hepatotoxicity in a Chinese cohort.Infect Genet Evol. 2018 Dec;66:217-221. doi: 10.1016/j.meegid.2018.10.006. Epub 2018 Oct 11.
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HIV Infection Is Associated With Downregulation of BTLA Expression on Mycobacterium tuberculosis-Specific CD4 T Cells in Active Tuberculosis Disease.Front Immunol. 2019 Aug 21;10:1983. doi: 10.3389/fimmu.2019.01983. eCollection 2019.
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Circulating and tumor-associated caspase-4: a novel diagnostic and prognostic biomarker for non-small cell lung cancer.Oncotarget. 2018 Apr 10;9(27):19356-19367. doi: 10.18632/oncotarget.25049. eCollection 2018 Apr 10.
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CCL3L1 copy number, CCR5 genotype and susceptibility to tuberculosis.BMC Med Genet. 2014 Jan 9;15:5. doi: 10.1186/1471-2350-15-5.
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A novel role for C-C motif chemokine receptor 2 during infection with hypervirulent Mycobacterium tuberculosis.Mucosal Immunol. 2018 Nov;11(6):1727-1742. doi: 10.1038/s41385-018-0071-y. Epub 2018 Aug 16.
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Study of CD27 and CCR4 Markers on Specific CD4(+) T-Cells as Immune Tools for Active and Latent Tuberculosis Management.Front Immunol. 2019 Jan 9;9:3094. doi: 10.3389/fimmu.2018.03094. eCollection 2018.
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Differential expression of CXCR3 and CCR6 on CD4(+) T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome.Sci Rep. 2019 Feb 6;9(1):1502. doi: 10.1038/s41598-018-37846-3.
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CD27 expression of T-cells discriminates IGRA-negative TB patients from healthy contacts in Ghana.Microbes Infect. 2020 Jan-Feb;22(1):65-68. doi: 10.1016/j.micinf.2019.07.003. Epub 2019 Aug 12.
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High expression of BTLA and B7-H4 on the surface of myeloid dendritic cells has a negative regulatory effect on their anti-tuberculosis immunity activity in pleural tuberculosis patients.Tuberculosis (Edinb). 2019 Dec;119:101877. doi: 10.1016/j.tube.2019.101877. Epub 2019 Oct 11.
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Blood tolerogenic monocytes and low proportions of dendritic cell subpopulations are hallmarks of human tuberculosis.J Leukoc Biol. 2018 May;103(5):945-954. doi: 10.1002/JLB.4A1117-448R. Epub 2018 Feb 28.
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Collaborative drug discovery for More Medicines for Tuberculosis (MM4TB).Drug Discov Today. 2017 Mar;22(3):555-565. doi: 10.1016/j.drudis.2016.10.009. Epub 2016 Nov 22.
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Sequential pulmonary immunization with heterologous recombinant influenza A virus tuberculosis vaccines protects against murine M. tuberculosis infection.Vaccine. 2018 Apr 25;36(18):2462-2470. doi: 10.1016/j.vaccine.2018.03.037. Epub 2018 Mar 27.
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An evolutionary recent IFN/IL-6/CEBP axis is linked to monocyte expansion and tuberculosis severity in humans.Elife. 2019 Oct 22;8:e47013. doi: 10.7554/eLife.47013.
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Rv0646c, an esterase from M. tuberculosis, up-regulates the host immune response in THP-1 macrophages cells.Mol Cell Biochem. 2018 Oct;447(1-2):189-202. doi: 10.1007/s11010-018-3303-2. Epub 2018 Jan 31.
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Platelets Regulate Pulmonary Inflammation and Tissue Destruction in Tuberculosis.Am J Respir Crit Care Med. 2018 Jul 15;198(2):245-255. doi: 10.1164/rccm.201710-2102OC.
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The BCG Moreau RD16 deletion inactivates a repressor reshaping transcription of an adjacent gene.Tuberculosis (Edinb). 2014 Jan;94(1):26-33. doi: 10.1016/j.tube.2013.11.004. Epub 2013 Nov 26.
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CFD simulations for paper-based DNA amplification reaction (LAMP) of Mycobacterium tuberculosis-point-of-care diagnostic perspective.Med Biol Eng Comput. 2020 Feb;58(2):271-289. doi: 10.1007/s11517-019-02082-y. Epub 2019 Dec 16.
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Thiol modified chitosan self-assembled monolayer platform for nucleic acid biosensor.Appl Biochem Biotechnol. 2014 Oct;174(3):1201-13. doi: 10.1007/s12010-014-1177-7. Epub 2014 Sep 10.
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Deciphering the molecular basis of mycobacteria and lipoglycan recognition by the C-type lectin Dectin-2.Sci Rep. 2018 Nov 15;8(1):16840. doi: 10.1038/s41598-018-35393-5.
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CLEC9A modulates macrophage-mediated neutrophil recruitment in response to heat-killed Mycobacterium tuberculosis H37Ra.PLoS One. 2017 Oct 24;12(10):e0186780. doi: 10.1371/journal.pone.0186780. eCollection 2017.
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The role of variants from the innate immune system genes in tuberculosis and skin test response in a Native American population.Hum Immunol. 2016 Oct;77(10):981-984. doi: 10.1016/j.humimm.2016.06.017. Epub 2016 Jun 23.
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Macro-geographical specificities of the prevailing tuberculosis epidemic as seen through SITVIT2, an updated version of the Mycobacterium tuberculosis genotyping database.Infect Genet Evol. 2019 Aug;72:31-43. doi: 10.1016/j.meegid.2018.12.030. Epub 2018 Dec 26.
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PD-1-expressing MAIT cells from patients with tuberculosis exhibit elevated production of CXCL13.Scand J Immunol. 2020 Apr;91(4):e12858. doi: 10.1111/sji.12858. Epub 2020 Jan 8.
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Genetic polymorphisms of CCL2 associated with susceptibility to latent tuberculous infection in Thailand.Int J Tuberc Lung Dis. 2016 Sep;20(9):1242-8. doi: 10.5588/ijtld.16.0017.
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TLR4-NOX2 axis regulates the phagocytosis and killing of Mycobacterium tuberculosis by macrophages.BMC Pulm Med. 2017 Dec 12;17(1):194. doi: 10.1186/s12890-017-0517-0.
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Lack of association between genetic polymorphisms of CYP3A4, CYP2C9 and CYP2C19 and antituberculosis drug-induced liver injury in a community-based Chinese population.Clin Exp Pharmacol Physiol. 2013 May;40(5):326-32. doi: 10.1111/1440-1681.12074.
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Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes.Angew Chem Int Ed Engl. 2017 Oct 9;56(42):13011-13015. doi: 10.1002/anie.201707324. Epub 2017 Sep 7.
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Mycobactericidal activity of bedaquiline plus rifabutin or rifampin in ex vivo whole blood cultures of healthy volunteers: A randomized controlled trial.PLoS One. 2018 May 2;13(5):e0196756. doi: 10.1371/journal.pone.0196756. eCollection 2018.
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Association of the CYP2B6 gene with anti-tuberculosis drug-induced hepatotoxicity in a Brazilian Amazon population.Int J Infect Dis. 2015 Apr;33:28-31. doi: 10.1016/j.ijid.2014.04.011. Epub 2014 Sep 28.
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Characterization of G-Quadruplex Motifs in espB, espK, and cyp51 Genes of Mycobacterium tuberculosis as Potential Drug Targets.Mol Ther Nucleic Acids. 2019 Jun 7;16:698-706. doi: 10.1016/j.omtn.2019.04.022. Epub 2019 Apr 30.
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IL-32 is a molecular marker of a host defense network in human tuberculosis.Sci Transl Med. 2014 Aug 20;6(250):250ra114. doi: 10.1126/scitranslmed.3009546.
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Expansion of a novel lead targeting M. tuberculosis DHFR as antitubercular agents.Bioorg Med Chem. 2019 Apr 1;27(7):1421-1429. doi: 10.1016/j.bmc.2019.02.053. Epub 2019 Feb 26.
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Interaction of Erp Protein of Mycobacterium tuberculosis with Rv2212 Enhances Intracellular Survival of Mycobacterium smegmatis.J Bacteriol. 2016 Sep 22;198(20):2841-52. doi: 10.1128/JB.00120-16. Print 2016 Oct 15.
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Eosinophil peroxidase oxidizes isoniazid to form the active metabolite against M. tuberculosis, isoniazid-NAD(). Chem Biol Interact. 2019 May 25;305:48-53. doi: 10.1016/j.cbi.2019.03.019. Epub 2019 Mar 25.
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Polymorphism in the EREG gene confers susceptibility to tuberculosis.BMC Med Genet. 2019 Jan 11;20(1):7. doi: 10.1186/s12881-018-0729-z.
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Activity and thermal stability of Mycobacterium tuberculosis PE1 and PE2 proteins esterase domain in the presence of aprotic ionic liquids.Spectrochim Acta A Mol Biomol Spectrosc. 2020 Jan 15;225:117477. doi: 10.1016/j.saa.2019.117477. Epub 2019 Aug 19.
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Neutrophil CD64, TLR2 and TLR4 expression increases but phagocytic potential decreases during tuberculosis.Tuberculosis (Edinb). 2018 Jul;111:135-142. doi: 10.1016/j.tube.2018.06.010. Epub 2018 Jun 9.
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Antituberculosis Drug-Induced Adverse Events in the Liver, Kidneys, and Blood: Clinical Profiles and Pharmacogenetic Predictors.Clin Pharmacol Ther. 2018 Aug;104(2):326-334. doi: 10.1002/cpt.924. Epub 2017 Nov 23.
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Ferritin H Deficiency in Myeloid Compartments Dysregulates Host Energy Metabolism and Increases Susceptibility to Mycobacterium tuberculosis Infection.Front Immunol. 2018 May 3;9:860. doi: 10.3389/fimmu.2018.00860. eCollection 2018.
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Rv3634c from Mycobacterium tuberculosis H37Rv encodes an enzyme with UDP-Gal/Glc and UDP-GalNAc 4-epimerase activities.PLoS One. 2017 Apr 12;12(4):e0175193. doi: 10.1371/journal.pone.0175193. eCollection 2017.
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Streptococcal dTDP-L-rhamnose biosynthesis enzymes: functional characterization and lead compound identification.Mol Microbiol. 2019 Apr;111(4):951-964. doi: 10.1111/mmi.14197. Epub 2019 Jan 31.
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Expression of glyceraldehyde-3-phosphate dehydrogenase from M. tuberculosis in E. coli. Purification and characteristics of the untagged recombinant enzyme.Protein Expr Purif. 2019 May;157:28-35. doi: 10.1016/j.pep.2019.01.010. Epub 2019 Jan 30.
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Long-term protective efficacy with a BCG-prime ID93/GLA-SE boost regimen against the hyper-virulent Mycobacterium tuberculosis strain K in a mouse model.Sci Rep. 2019 Oct 29;9(1):15560. doi: 10.1038/s41598-019-52146-0.
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