Details of Disease

General Information of Disease (ID: DIS7B9UY)

Disease Name	Osteonecrosis
Synonyms	ischemic bone disease; aseptic necrosis; bone necrosis; ischaemic bone disease; osteonecrosis
Disease Class	FB81: Osteonecrosis
Definition	A none disease characterized by death of bone tissue due to a lack of blood supply.
Disease Hierarchy	DISE1F82: Bone disease DIS7B9UY: Osteonecrosis
ICD Code	ICD-11 ICD-11: FB81 ICD-9 ICD-9: 733.4 Expand ICD-11 'FB81 Expand ICD-10 'M87; 'M87.8; 'M87.9 Expand ICD-9 733.4
Disease Identifiers	MONDO ID MONDO_0005380 MESH ID D010020 UMLS CUI C0029445 MedGen ID 45249 Orphanet ID 399158 SNOMED CT ID 240196003

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Osteoblast cell therapy	DMDZIL4	Phase 2	NA	[1]
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This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
KLS-Bfr	DM9R213	Investigative	NA	[2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 3 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
MMP2	TTLM12X	Limited	Biomarker	[3]
BACH1	TT2ME4S	Strong	Genetic Variation	[4]
GRIK1	TT0MYE2	Strong	Genetic Variation	[4]
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This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
CYP2C8	DES5XRU	Strong	Genetic Variation	[5]
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References

1	ClinicalTrials.gov (NCT02205138) Phase 2a Study on Allogeneic Osteoblastic Cells Implantation in Lumbar Spinal Fusion. U.S. National Institutes of Health.
2	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
3	Bisphosphonate-induced osteonecrosis of the jaws, bone markers, and a hypothesized candidate gene.J Oral Maxillofac Surg. 2009 Jan;67(1):159-61. doi: 10.1016/j.joms.2008.09.015.
4	Genetics of glucocorticoid-associated osteonecrosis in children with acute lymphoblastic leukemia.Blood. 2015 Oct 8;126(15):1770-6. doi: 10.1182/blood-2015-05-643601. Epub 2015 Aug 11.
5	Bisphosphonate-related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in multiple myeloma: a genome-wide single nucleotide polymorphism analysis.Blood. 2008 Oct 1;112(7):2709-12. doi: 10.1182/blood-2008-04-147884. Epub 2008 Jul 1.