Details of Disease

General Information of Disease (ID: DIS7E0I8)

• Disease Name: Malignant tumor of adrenal cortex
• Synonyms: malignant neoplasm of the adrenal cortex; adrenal cortex cancer; malignant adrenal cortex tumour; cancer of adrenal cortex; malignant adrenal cortex neoplasm; malignant adrenocortical tumour; malignant tumor of the adrenal cortex; malignant tumour of the adrenal cortex; malignant adrenocortical tumor; malignant adrenocortical neoplasm; malignant neoplasm of adrenal cortex; malignant adrenal cortex tumor
• Definition: A cancer that involves the adrenal cortex.
• Disease Hierarchy:
  DISNFZKJ: Adrenal gland cancer
  DISO17X1: Adrenal cortex neoplasm
  DISAT1Z9: Advanced cancer
  DIS7E0I8: Malignant tumor of adrenal cortex
• Disease Identifiers:
  MONDO ID: MONDO_0021312
  MESH ID: D000306
  UMLS CUI: C0346402
  MedGen ID: 83425
  SNOMED CT ID: 371964008

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 6 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CACNA1H	TTZPWGN	Strong	Genetic Variation	[1]
GHRHR	TTG4R8V	Strong	Biomarker	[2]
GIPR	TTYMKBE	Strong	Altered Expression	[3]
PDE11A	TTTWC79	Strong	Genetic Variation	[4]
PRKAR1A	TTNAHEX	Strong	Genetic Variation	[5]
RRM1	TTWP0NS	Strong	Biomarker	[6]

This Disease Is Related to 5 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ARMC5	OTO7IV74	Strong	Biomarker	[7]
JDP2	OTW35WKX	Strong	Altered Expression	[8]
MATR3	OTESJ5S7	Strong	Altered Expression	[9]
NDRG4	OTJBOTD8	Strong	Altered Expression	[10]
PELP1	OTVXQNOT	Strong	Biomarker	[11]

References

• [1] CACNA1H(M1549V) Mutant Calcium Channel Causes Autonomous Aldosterone Production in HAC15 Cells and Is Inhibited by Mibefradil.Endocrinology. 2016 Aug;157(8):3016-22. doi: 10.1210/en.2016-1170. Epub 2016 Jun 3.
• [2] Expression of neuropeptide hormone receptors in human adrenal tumors and cell lines: antiproliferative effects of peptide analogues.Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15879-84. doi: 10.1073/pnas.0907843106. Epub 2009 Aug 27.
• [3] The ectopic expression of the gastric inhibitory polypeptide receptor is frequent in adrenocorticotropin-independent bilateral macronodular adrenal hyperplasia, but rare in unilateral tumors.J Clin Endocrinol Metab. 2002 May;87(5):1980-5. doi: 10.1210/jcem.87.5.8458.
• [4] Phosphodiesterase 11A (PDE11A) and genetic predisposition to adrenocortical tumors.Clin Cancer Res. 2008 Jun 15;14(12):4016-24. doi: 10.1158/1078-0432.CCR-08-0106.
• [5] A large family with Carney complex caused by the S147G PRKAR1A mutation shows a unique spectrum of disease including adrenocortical cancer.J Clin Endocrinol Metab. 2012 Feb;97(2):351-9. doi: 10.1210/jc.2011-2244. Epub 2011 Nov 23.
• [6] RRM1 modulates mitotane activity in adrenal cancer cells interfering with its metabolization.Mol Cell Endocrinol. 2015 Feb 5;401:105-10. doi: 10.1016/j.mce.2014.11.027. Epub 2014 Dec 9.
• [7] An update on adrenal endocrinology: significant discoveries in the last 10years and where the field is heading in the next decade.Hormones (Athens). 2018 Dec;17(4):479-490. doi: 10.1007/s42000-018-0072-y. Epub 2018 Nov 19.
• [8] Jun Dimerization Protein 2 Activates Mc2r Transcriptional Activity: Role of Phosphorylation and SUMOylation.Int J Mol Sci. 2017 Jan 31;18(2):304. doi: 10.3390/ijms18020304.
• [9] MicroRNA signature in massive macronodular adrenocortical disease and implications for adrenocortical tumourigenesis.Clin Endocrinol (Oxf). 2010 Jun;72(6):744-51. doi: 10.1111/j.1365-2265.2009.03725.x. Epub 2009 Oct 22.
• [10] MiR-483-5p and miR-139-5p promote aggressiveness by targeting N-myc downstream-regulated gene family members in adrenocortical cancer.Int J Cancer. 2018 Aug 15;143(4):944-957. doi: 10.1002/ijc.31363. Epub 2018 Mar 30.
• [11] Role of Scaffold Protein Proline-, Glutamic Acid-, and Leucine-Rich Protein 1 (PELP1) in the Modulation of Adrenocortical Cancer Cell Growth.Cells. 2017 Nov 7;6(4):42. doi: 10.3390/cells6040042.