Details of Disease

General Information of Disease (ID: DISO17X1)

• Disease Name: Adrenal cortex neoplasm
• Synonyms: tumor of adrenal cortex; adrenocortical tumour; adrenal cortex neoplasm; adrenal cortex tumour; adrenocortical tumor; tumour of adrenal cortex; neoplasm of adrenal cortex; adrenal cortex tumor; adrenocortical neoplasm
• Definition: A benign or malignant (primary or metastatic) neoplasm affecting the adrenal cortex. (NCI05)
• Disease Hierarchy:
  DISFK7RF: Adrenal gland neoplasm
  DIS6U5TM: Adrenal cortex disorder
  DISTBY9Z: Tumour
  DISO17X1: Adrenal cortex neoplasm
• Disease Identifiers:
  MONDO ID: MONDO_0036591
  MESH ID: D000306
  UMLS CUI: C0001618
  MedGen ID: 1350
  HPO ID: HP:0100641
  SNOMED CT ID: 127022002

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 5 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CDK3	TTMYWL7	moderate	Altered Expression	[1]
DDX5	TTZKPVC	Strong	Altered Expression	[2]
MC2R	TTPWFDX	Strong	Biomarker	[3]
TKT	TT04R7I	Strong	Posttranslational Modification	[2]
TP53	TT12KOD	Definitive	Genetic Variation	[4]

This Disease Is Related to 10 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
TCF21	OT393IMA	moderate	Altered Expression	[5]
AIP	OTDJ3OSV	Strong	Altered Expression	[6]
BMP5	OTC0Y6E0	Strong	Altered Expression	[7]
CCNB2	OTIEXTDK	Strong	Biomarker	[8]
CORO7	OTG7MEAJ	Strong	Altered Expression	[9]
DLGAP5	OTWCN39U	Strong	Altered Expression	[10]
GATAD2B	OTJL128N	Strong	Altered Expression	[2]
GRB10	OTCKXGRC	Strong	Altered Expression	[11]
INHA	OT7HWCO3	Strong	Biomarker	[11]
POLD3	OTEQEFQ2	Strong	Altered Expression	[2]

References

• [1] High expression of cyclin E and G1 CDK and loss of function of p57KIP2 are involved in proliferation of malignant sporadic adrenocortical tumors.J Clin Endocrinol Metab. 2000 Jan;85(1):322-30. doi: 10.1210/jcem.85.1.6303.
• [2] Amplification of the transketolase gene in desensitization-resistant mutant Y1 mouse adrenocortical tumor cells.J Biol Chem. 1996 Mar 1;271(9):4993-8. doi: 10.1074/jbc.271.9.4993.
• [3] Role of ACTH receptor in adrenocortical tumor formation.Braz J Med Biol Res. 2000 Oct;33(10):1249-52. doi: 10.1590/s0100-879x2000001000016.
• [4] Adrenocortical tumors associated with the TP53 p.R337H germline mutation can be identified during child-care consultations.J Pediatr (Rio J). 2018 Jul-Aug;94(4):432-439. doi: 10.1016/j.jped.2017.06.009. Epub 2017 Aug 30.
• [5] New evidences on the regulation of SF-1 expression by POD1/TCF21 in adrenocortical tumor cells.Clinics (Sao Paulo). 2017 Jun;72(6):391-394. doi: 10.6061/clinics/2017(06)10.
• [6] Isolated familial somatotropinoma: 11q13-loh and gene/protein expression analysis suggests a possible involvement of aip also in non-pituitary tumorigenesis.Clinics (Sao Paulo). 2010 Apr;65(4):407-15. doi: 10.1590/S1807-59322010000400010.
• [7] Bone morphogenetic proteins 2 and 5 are down-regulated in adrenocortical carcinoma and modulate adrenal cell proliferation and steroidogenesis.Cancer Res. 2009 Jul 15;69(14):5784-92. doi: 10.1158/0008-5472.CAN-08-4428. Epub 2009 Jul 7.
• [8] Expression profiles analysis identifies the values of carcinogenesis and the prognostic prediction of three genes in adrenocortical carcinoma.Oncol Rep. 2019 Apr;41(4):2440-2452. doi: 10.3892/or.2019.7021. Epub 2019 Feb 19.
• [9] POD-1/TCF21 Reduces SHP Expression, Affecting LRH-1 Regulation and Cell Cycle Balance in Adrenocortical and Hepatocarcinoma Tumor Cells.Biomed Res Int. 2015;2015:841784. doi: 10.1155/2015/841784. Epub 2015 Sep 2.
• [10] Gene expression profiling reveals a new classification of adrenocortical tumors and identifies molecular predictors of malignancy and survival.J Clin Oncol. 2009 Mar 1;27(7):1108-15. doi: 10.1200/JCO.2008.18.5678. Epub 2009 Jan 12.
• [11] GnRH antagonist treatment of malignant adrenocortical tumors.Endocr Relat Cancer. 2019 Jan 1;26(1):103-117. doi: 10.1530/ERC-17-0399.