Details of Disease

General Information of Disease (ID: DIS7V594)

Disease Name	Colon polyp
Synonyms	colonic polyp; polyp of the colon; colon polyp
Disease Class	DB35: Large intestine polyp
Definition	A polyp that involves the colon.
Disease Hierarchy	DISRE1MK: Polyp of large intestine DISXXS3L: Colonic disorder DISRSLYF: Polyp DIS7V594: Colon polyp
ICD Code	ICD-11 ICD-11: DB35 ICD-10 ICD-10: K62.1, K63.5 Expand ICD-11 'DB35.Z
Disease Identifiers	MONDO ID MONDO_0021400 MESH ID D003111 UMLS CUI C0009376 MedGen ID 3166 SNOMED CT ID 68496003

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Tilmacoxib	DMPWSRA	Discontinued in Phase 2	Small molecular drug	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 6 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
TRPM7	TTFPVZO	Limited	Biomarker	[2]
HDAC2	TTSHTOI	moderate	Therapeutic	[3]
ALOX5	TTSJ6Q4	Strong	Altered Expression	[4]
CYSLTR1	TTGKOY9	Strong	Biomarker	[5]
FFAR2	TT0FYAN	Strong	Altered Expression	[6]
ILK	TT7ALZG	Strong	Biomarker	[7]
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⏷ Show the Full List of 6 DTT(s)

This Disease Is Related to 7 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ABI1	OT5H4M62	Strong	Altered Expression	[8]
FOXD3	OTXYV6GO	Strong	Genetic Variation	[9]
GUCA2A	OTUSF75G	Strong	Biomarker	[10]
GUCA2B	OTZERX04	Strong	Biomarker	[10]
MFAP5	OT46VXSG	Strong	Biomarker	[11]
PMS2	OTNLWTMI	Strong	Genetic Variation	[12]
CDX2	OTCG4TSY	Definitive	Altered Expression	[13]
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⏷ Show the Full List of 7 DOT(s)

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009145)
2	The relation of magnesium and calcium intakes and a genetic polymorphism in the magnesium transporter to colorectal neoplasia risk.Am J Clin Nutr. 2007 Sep;86(3):743-51. doi: 10.1093/ajcn/86.3.743.
3	Chemopreventive effects of an HDAC2-selective inhibitor on rat colon carcinogenesis and APCmin/+ mouse intestinal tumorigenesis.J Pharmacol Exp Ther. 2014 Jan;348(1):59-68. doi: 10.1124/jpet.113.208645. Epub 2013 Nov 11.
4	Overexpression of 5-lipoxygenase in colon polyps and cancer and the effect of 5-LOX inhibitors in vitro and in a murine model.Clin Cancer Res. 2008 Oct 15;14(20):6525-30. doi: 10.1158/1078-0432.CCR-07-4631.
5	Cysteinyl leukotriene receptor 1 facilitates tumorigenesis in a mouse model of colitis-associated colon cancer.Oncotarget. 2017 May 23;8(21):34773-34786. doi: 10.18632/oncotarget.16718.
6	Loss of free fatty acid receptor 2 enhances colonic adenoma development and reduces the chemopreventive effects of black raspberries in ApcMin/+ mice.Carcinogenesis. 2017 Jan;38(1):86-93. doi: 10.1093/carcin/bgw122. Epub 2016 Nov 19.
7	Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis. Oncogene. 2001 Sep 27;20(43):6250-7. doi: 10.1038/sj.onc.1204791.
8	Expression of Abelson interactor 1 (Abi1) correlates with inflammation, KRAS mutation and adenomatous change during colonic carcinogenesis.PLoS One. 2012;7(7):e40671. doi: 10.1371/journal.pone.0040671. Epub 2012 Jul 10.
9	Genetic Biopsy for Prediction of Surveillance Intervals after Endoscopic Resection of Colonic Polyps: Results of the GENESIS Study.United European Gastroenterol J. 2018 Mar;6(2):290-299. doi: 10.1177/2050640617723810. Epub 2017 Jul 28.
10	Uroguanylin treatment suppresses polyp formation in the Apc(Min/+) mouse and induces apoptosis in human colon adenocarcinoma cells via cyclic GMP.Cancer Res. 2000 Sep 15;60(18):5151-7.
11	Loss of microfibril-associated protein 5 (MFAP5) expression in colon cancer stroma.Virchows Arch. 2020 Mar;476(3):383-390. doi: 10.1007/s00428-019-02649-y. Epub 2019 Aug 18.
12	Caf-au-lait macules and pediatric malignancy caused by biallelic mutations in the DNA mismatch repair (MMR) gene PMS2.Pediatr Blood Cancer. 2008 Jun;50(6):1268-70. doi: 10.1002/pbc.21514.
13	Suppression of colonic polyposis by homeoprotein CDX2 through its nontranscriptional function that stabilizes p27Kip1.Cancer Res. 2011 Jan 15;71(2):593-602. doi: 10.1158/0008-5472.CAN-10-2842. Epub 2011 Jan 11.