Details of Disease

General Information of Disease (ID: DIS7WJYB)

• Disease Name: Kidney Wilms tumor
• Synonyms: nonanaplastic renal Wilm's tumour; adult nephroblastoma; childhood renal Wilms tumour; childhood renal Wilms' cancer; embryonal nephroma; nonanaplastic renal Wilm's tumor; childhood renal Wilms tumor; adult renal Wilms' tumour; Wilms tumor; Wilms tumour; Wilms' tumor; Wilms' tumour; nephroblastoma, malignant; Wilms' tumor of the kidney; kidney Wilms tumor; renal Wilms' tumor; renal embryonic tumor; nephroblastoma; renal embryonic tumour; renal Wilms tumour; renal Wilms tumor; Wilms tumor of the kidney; renal Wilms' tumour; Wilms' Tumor; Wilms tumour of the kidney; Wilms' tumour of the kidney
• Definition: An embryonal pediatric tumor of the kidney which may also be seen rarely in adults. The peak incidence of Wilms tumor is between the second and fifth year of life. Microscopically, it is composed of a mixture of cellular elements (blastemal, stromal, and epithelial). The most common sites of metastasis include the regional lymph nodes, lungs, and liver.
• Disease Hierarchy:
  DISB6T16: Wilms tumor
  DISBIPKM: Kidney cancer
  DIS7WJYB: Kidney Wilms tumor

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
TRIM28	TTQ2BKV	Supportive	Autosomal dominant	[1]

This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
TRIM28	OTE38OBF	Supportive	Autosomal dominant	[1]
TRIP13	OTFM3TI9	Supportive	Autosomal dominant	[2]

References

• [1] Germline mutations and somatic inactivation of TRIM28 in Wilms tumour. PLoS Genet. 2018 Jun 18;14(6):e1007399. doi: 10.1371/journal.pgen.1007399. eCollection 2018 Jun.
• [2] Biallelic TRIP13 mutations predispose to Wilms tumor and chromosome missegregation. Nat Genet. 2017 Jul;49(7):1148-1151. doi: 10.1038/ng.3883. Epub 2017 May 29.