Details of Disease

General Information of Disease (ID: DIS7YFRP)

• Disease Name: Actinomycosis
• Synonyms: Actinomycetes; Actinomyces israeli; Keratoactinomycosis; canaliculitis; infections, Actinomyces; anaerobic Actinomyces infection; actinomycetoma; boil; actinomycotic mycetoma of foot; actinomycotic madura foot; Madura foot due to Actinomadura; actinomycotic mycetema; Actinomyces infection
• Definition: Actinomycosis is a chronic bacterial infection that commonly affects the face and neck. It is usually caused by an anaerobic bacteria called Actinomyces israelii. Actinomyces are normal inhabitants of the mouth, gastrointestinal tract, and female genital tract, and do not cause an infection unless there is a break in the skin or mucosa. The infection usually occurs in the face and neck, but can sometimes occur in the chest, abdomen, pelvis, or other areas of the body. The infection is not contagious.
• Disease Hierarchy:
  DISJJ0OF: Commensal bacterial infectious disease
  DISWA09C: Actinomycetales infectious disease
  DISEM33Q: Infectious disease
  DIS7YFRP: Actinomycosis
• Disease Identifiers:
  MONDO ID: MONDO_0005631
  MESH ID: D000196
  UMLS CUI: C0001261
  MedGen ID: 1733
  Orphanet ID: 457095
  SNOMED CT ID: 11817007

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 7 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Amphotericin B	DMTAJQE	Approved	Small molecular drug	[1]
Demeclocycline	DMZEPFJ	Approved	Small molecular drug	[2]
Doxycycline	DM7ICNU	Approved	Small molecular drug	[3]
Fusidic Acid	DMWVCF3	Approved	Small molecular drug	[4]
Minocycline	DMVN5OH	Approved	Small molecular drug	[5]
Oxytetracycline	DMOVH1M	Approved	Small molecular drug	[6]
Tetracycline	DMZA017	Approved	Small molecular drug	[7]

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Benzylpenicillin	DMS9503	Phase 3	Small molecular drug	[8]

Molecular Interaction Atlas (MIA) of This Disease

References

• [1] Amphotericin B FDA Label
• [2] Demeclocycline FDA Label
• [3] Doxycycline FDA Label
• [4] [In vitro sensitivity of Actinomyces israelii, Actinobacillus actinomycetem-comitans and Bacteroides melaninogenicus to cephalothin, cephaloridine, gentamicin, fusidic acid and lincomycin]. Int Z Klin Pharmakol Ther Toxikol. 1970 Oct;3(4):318-20.
• [5] Minocycline FDA Label
• [6] Oxytetracycline FDA Label
• [7] Tetracycline FDA Label
• [8] Abdominal actinomycosis after reparative surgery for cholecystogastric fistula in an immunosuppressed patient. BMJ Case Rep. 2021 Jul 23;14(7):e243445.