Details of the Drug

General Information of Drug (ID: DM7ICNU)

Drug Name

Doxycycline

Synonyms

Atridox; Azudoxat; DOXY; Deoxymykoin; Dossiciclina; Doxiciclina; Doxitard; Doxivetin; Doxycen; Doxychel; Doxycin; Doxycyclin; Doxycyclinum; Doxysol; Doxytec; Doxytetracycline; Hydramycin; Investin; Jenacyclin; Liviatin; Monodox; Oracea; Ronaxan; Spanor; Supracyclin; Vibramycin; Vibramycine; Vibravenos; DOXCYCLINE ANHYDROUS; DOXYCYCLINE CALCIUM; DOXYCYCLINE MONOHYDRATE; Dossiciclina [DCIT]; Doxiciclina [Italian]; Doxycycline anhydrous; Doxycycline hyclate; Vibramycin Novum; Alpha-Doxycycline; Alti-Doxycycline; Apo-Doxy; BMY-28689; BU-3839T; Doxiciclina [INN-Spanish]; Doxy-Caps; Doxy-Puren; Doxy-Tabs; Doxychel (TN); Doxycycline (INN); Doxycycline (TN); Doxycycline (anhydrous); Doxycycline (internal use); Doxycycline-Chinoin; Doxycyclinum [INN-Latin]; Novo-Doxylin; Nu-Doxycycline; Periostat (TN); Vibra-tabs; Alpha-6-Deoxyoxytetracycline; DMSC (*Fosfatex); Doxycycline (200mg/day) or Placebo; Monodox (*monohydrate); Vibramycin (*monohydrate); Vivox (*Hyclate); GS-3065 (*monohydrate); Alpha-6-Deoxy-5-hydroxytetracycline; (2E,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; (2Z)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; (2Z,4S,4aR,5S,5aR,6R)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; (2Z,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; (4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide; 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aR,5S,5aR,6R,12aS); 5-Hydroxy-alpha-6-deoxytetracycline; 6-Deoxyoxytetracycline; 6-Deoxytetracycline; 6-alpha-Deoxy-5-oxytetracycline; 6alpha-Deoxy-5-oxytetracycline

Indication

Disease Entry	ICD 11	Status	REF
Acne vulgaris	ED80	Approved	[1]
Actinomycosis	N.A.	Approved	[1]
Acute gonococcal cervicitis	N.A.	Approved	[1]
Acute gonococcal epididymo-orchitis	N.A.	Approved	[1]
Advanced gum disease	DA0D	Approved	[2]
Anthrax	1B97	Approved	[1]
Bartonellosis	N.A.	Approved	[1]
Boutonneuse fever	N.A.	Approved	[1]
Brill-Zinsser disease	N.A.	Approved	[1]
Bronchitis	CA20	Approved	[1]
Brucellosis	N.A.	Approved	[1]
Chancroid	N.A.	Approved	[1]
Chlamydiaceae infections	N.A.	Approved	[1]
Chronic periodontitis	DA0C.Y	Approved	[2]
Colorectal carcinoma	N.A.	Approved	[1]
Cutaneous anthrax	N.A.	Approved	[1]
Endemic typhus	N.A.	Approved	[1]
Epidemic louse-borne typhus	N.A.	Approved	[1]
Gastrointestinal anthrax	N.A.	Approved	[1]
Inhalational anthrax	N.A.	Approved	[1]
Listeriosis	N.A.	Approved	[1]
Lymphogranuloma venereum	N.A.	Approved	[1]
Mycoplasma pneumoniae pneumonia	N.A.	Approved	[1]
Ornithosis	N.A.	Approved	[1]
Q fever	N.A.	Approved	[1]
Relapsing fever	N.A.	Approved	[1]
Rickettsialpox	N.A.	Approved	[1]
Rickettsiosis	N.A.	Approved	[1]
Rocky mountain spotted fever	N.A.	Approved	[1]
Syphilis	N.A.	Approved	[1]
Trachoma	N.A.	Approved	[1]
Tularemia	1B94	Approved	[1]
Typhus	N.A.	Approved	[1]
Yaws	N.A.	Approved	[1]
Diabetic foot ulcer	BD54	Phase 2	[3]
Sinusitis	CA0A.Z	Investigative	[1]
Vibrio cholerae infection	1A00	Investigative	[1]
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⏷ Show the Full List of Indication(s)

Therapeutic Class

Antiinflammatory Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 1

Molecular Weight (mw)

444.4

Logarithm of the Partition Coefficient (xlogp)

-0.7

Rotatable Bond Count (rotbonds)

Hydrogen Bond Donor Count (hbonddonor)

Hydrogen Bond Acceptor Count (hbondacc)

ADMET Property

BDDCS Class: Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 3: high solubility and low permeability [4]
Bioavailability: 93% of drug becomes completely available to its intended biological destination(s) [5]
Clearance: The clearance of drug is 75 mL/min []
Elimination: Between 40% and 60% of an administered dose can be accounted for in the urine by 92 hours, and approximately 30% can be accounted for in the feces []
Half-life: The concentration or amount of drug in body reduced by one-half in 16.33 +/- 4.53 hours []
Metabolism: The drug is metabolized via the liver []
MRTD: The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 6.4285 micromolar/kg/day [6]
Unbound Fraction: The unbound fraction of drug in plasma is 0.12% [7]
Vd: The volume of distribution (Vd) of drug is 0.7 L/kg []

Chemical Identifiers

Formula: C22H24N2O8
IUPAC Name: (4S,4aR,5S,5aR,6R,12aR)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide
Canonical SMILES: C[C@@H]1[C@H]2[C@@H]([C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O
InChI: InChI=1S/C22H24N2O8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29/h4-7,10,14-15,17,25-27,30,32H,1-3H3,(H2,23,31)/t7-,10+,14+,15-,17-,22-/m0/s1
InChIKey: SGKRLCUYIXIAHR-AKNGSSGZSA-N

Cross-matching ID

PubChem CID: 54671203
ChEBI ID: CHEBI:50845
CAS Number: 564-25-0
DrugBank ID: DB00254
TTD ID: D0S0LZ
VARIDT ID: DR00666
INTEDE ID: DR0547
ACDINA ID: D00215

Combinatorial Drugs (CBD)

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Repurposed Drugs (RPD)

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Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial 30S ribosomal RNA (Bact 30S rRNA)	TTOVFH2	NOUNIPROTAC	Modulator	[8]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[9]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)_{Main DME}	DE4LYSA	CP3A4_HUMAN	Substrate	[10]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[11]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Gene/Protein Processing	[12]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[13]
Collagenase 3 (MMP13)	OTY8BZIE	MMP13_HUMAN	Gene/Protein Processing	[14]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Gene/Protein Processing	[12]
HLA class I histocompatibility antigen, B alpha chain (HLA-B)	OTNXFWY2	HLAB_HUMAN	Gene/Protein Processing	[15]
Neutrophil collagenase (MMP8)	OTZXH19L	MMP8_HUMAN	Gene/Protein Processing	[11]
Stromelysin-1 (MMP3)	OTGBI74Z	MMP3_HUMAN	Gene/Protein Processing	[11]
TAR DNA-binding protein 43 (TARDBP)	OTVOSFWW	TADBP_HUMAN	Gene/Protein Processing	[16]
UDP-glucuronosyltransferase 1A10	OTOTZVEY	UD110_HUMAN	Gene/Protein Processing	[12]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Doxycycline (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Remdesivir	DMBFZ6L	Moderate	Increased risk of hepatotoxicity by the combination of Doxycycline and Remdesivir.	1D6YCoronavirus Disease 2019 [1D6YCoronavirus Disease 2019]	[17]
Sodium bicarbonate	DMMU6BJ	Moderate	as urine pH determines the ionization state of weakly acidic or weakly alkaline drugs. Doxycycline caused by Sodium bicarbonate mediated altered urine pH.	Acidosis [5C73]	[18]
Tromethamine	DMOBLGK	Moderate	as urine pH determines the ionization state of weakly acidic or weakly alkaline drugs. Doxycycline caused by Tromethamine mediated altered urine pH.	Acidosis [5C73]	[18]
Tretinoin	DM49DUI	Major	Increased risk of pseudotumor cerebri by the combination of Doxycycline and Tretinoin.	Acne vulgaris [ED80]	[19]
Isotretinoin	DM4QTBN	Major	Increased risk of pseudotumor cerebri by the combination of Doxycycline and Isotretinoin.	Acne vulgaris [ED80]	[19]
Sucralfate	DMP9HBO	Moderate	Decreased absorption of Doxycycline due to formation of complexes caused by Sucralfate.	Acne vulgaris [ED80]	[20]
Magnesium Sulfate	DMVEK07	Moderate	Decreased absorption of Doxycycline due to formation of complexes caused by Magnesium Sulfate.	Acute pain [MG31]	[21]
Bedaquiline	DM3906J	Moderate	Increased risk of hepatotoxicity by the combination of Doxycycline and Bedaquiline.	Antimicrobial drug resistance [MG50-MG52]	[22]
Methylphenobarbital	DMDSWAG	Moderate	Increased metabolism of Doxycycline caused by Methylphenobarbital mediated induction of CYP450 enzyme.	Anxiety disorder [6B00-6B0Z]	[23]
Aminophylline	DML2NIB	Moderate	Decreased metabolism of Doxycycline caused by Aminophylline mediated inhibition of CYP450 enzyme.	Asthma [CA23]	[24]
Pexidartinib	DMS2J0Z	Major	Increased risk of hepatotoxicity by the combination of Doxycycline and Pexidartinib.	Bone/articular cartilage neoplasm [2F7B]	[25]
Secobarbital	DM14RF5	Moderate	Increased metabolism of Doxycycline caused by Secobarbital mediated induction of CYP450 enzyme.	Chronic insomnia [7A00]	[23]
Mestranol	DMG3F94	Moderate	Decreased absorption of Doxycycline due to formation of complexes caused by Mestranol.	Contraceptive management [QA21]	[26]
Mivacurium	DM473VD	Moderate	Additive neuromuscular blocking effects by the combination of Doxycycline and Mivacurium.	Corneal disease [9A76-9A78]	[27]
Methohexital	DM7YMIT	Moderate	Increased metabolism of Doxycycline caused by Methohexital mediated induction of CYP450 enzyme.	Corneal disease [9A76-9A78]	[23]
Pancuronium	DMB0VY8	Moderate	Additive neuromuscular blocking effects by the combination of Doxycycline and Pancuronium.	Corneal disease [9A76-9A78]	[27]
Thiopental	DMGP8AX	Moderate	Increased metabolism of Doxycycline caused by Thiopental mediated induction of CYP450 enzyme.	Corneal disease [9A76-9A78]	[23]
Oxtriphylline	DMLHSE3	Moderate	Decreased metabolism of Doxycycline caused by Oxtriphylline mediated inhibition of CYP450 enzyme.	Cough [MD12]	[24]
Mycophenolic acid	DMRBMAU	Moderate	Altered absorption of Doxycycline due to GI flora changes caused by Mycophenolic acid.	Crohn disease [DD70]	[28]
PMID28870136-Compound-48	DMPIM9L	Moderate	Decreased metabolism of Doxycycline caused by PMID28870136-Compound-48 mediated inhibition of CYP450 enzyme.	Discovery agent [N.A.]	[24]
Primidone	DM0WX6I	Moderate	Increased metabolism of Doxycycline caused by Primidone mediated induction of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[23]
Mephenytoin	DM5UGDK	Moderate	Increased metabolism of Doxycycline caused by Mephenytoin mediated induction of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[29]
Fosphenytoin	DMOX3LB	Moderate	Increased metabolism of Doxycycline caused by Fosphenytoin mediated induction of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[29]
Phenobarbital	DMXZOCG	Moderate	Increased metabolism of Doxycycline caused by Phenobarbital mediated induction of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[23]
Carbamazepine	DMZOLBI	Moderate	Increased metabolism of Doxycycline caused by Carbamazepine mediated induction of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[29]
Digoxin	DMQCTIH	Moderate	Altered absorption of Doxycycline due to GI flora changes caused by Digoxin.	Heart failure [BD10-BD1Z]	[30]
Digitoxin	DMWVIGP	Moderate	Altered absorption of Doxycycline due to GI flora changes caused by Digitoxin.	Heart failure [BD10-BD1Z]	[30]
Rifampin	DMA8J1G	Moderate	Increased metabolism of Doxycycline caused by Rifampin mediated induction of CYP450 enzyme.	HIV-infected patients with tuberculosis [1B10-1B14]	[31]
Mipomersen	DMGSRN1	Major	Increased risk of hepatotoxicity by the combination of Doxycycline and Mipomersen.	Hyper-lipoproteinaemia [5C80]	[32]
BMS-201038	DMQTAGO	Major	Increased risk of hepatotoxicity by the combination of Doxycycline and BMS-201038.	Hyper-lipoproteinaemia [5C80]	[33]
Quinapril	DMR8H31	Moderate	Decreased absorption of Doxycycline due to formation of complexes caused by Quinapril.	Hypertension [BA00-BA04]	[34]
Sodium acetate anhydrous	DMH21E0	Moderate	as urine pH determines the ionization state of weakly acidic or weakly alkaline drugs. Doxycycline caused by Sodium acetate anhydrous mediated altered urine pH.	Hypo-osmolality/hyponatraemia [5C72]	[18]
Amobarbital	DM0GQ8N	Moderate	Increased metabolism of Doxycycline caused by Amobarbital mediated induction of CYP450 enzyme.	Insomnia [7A00-7A0Z]	[23]
Pentobarbital	DMFNH7L	Moderate	Increased metabolism of Doxycycline caused by Pentobarbital mediated induction of CYP450 enzyme.	Insomnia [7A00-7A0Z]	[23]
Iron	DMAP8MV	Moderate	Decreased absorption of Doxycycline due to formation of complexes caused by Iron.	Iron deficiency anaemia [3A00]	[35]
Methotrexate	DM2TEOL	Moderate	Increased plasma concentration of Doxycycline and Methotrexate due to competitive binding of plasma proteins.	Leukaemia [2A60-2B33]	[36]
Porfimer Sodium	DM7ZWNY	Moderate	Increased risk of photosensitivity reactions by the combination of Doxycycline and Porfimer Sodium.	Lung cancer [2C25]	[37]
Quinine	DMSWYF5	Minor	Decreased metabolism of Doxycycline caused by Quinine mediated inhibition of CYP450 enzyme.	Malaria [1F40-1F45]	[38]
Calaspargase pegol	DMQZBXI	Moderate	Increased risk of hepatotoxicity by the combination of Doxycycline and Calaspargase pegol.	Malignant haematopoietic neoplasm [2B33]	[39]
Idelalisib	DM602WT	Moderate	Increased risk of hepatotoxicity by the combination of Doxycycline and Idelalisib.	Mature B-cell leukaemia [2A82]	[40]
Ethinyl estradiol	DMODJ40	Moderate	Decreased absorption of Doxycycline due to formation of complexes caused by Ethinyl estradiol.	Menopausal disorder [GA30]	[26]
Lanthanum carbonate	DMMJQSH	Moderate	Decreased absorption of Doxycycline due to formation of complexes caused by Lanthanum carbonate.	Mineral absorption/transport disorder [5C64]	[36]
Rifabutin	DM1YBHK	Moderate	Increased metabolism of Doxycycline caused by Rifabutin mediated induction of CYP450 enzyme.	Mycobacterium infection [1B10-1B21]	[31]
Methoxsalen	DME8FZ9	Moderate	Increased risk of photosensitivity reactions by the combination of Doxycycline and Methoxsalen.	Mycosis fungoides [2B01]	[17]
Ranitidine	DM0GUSX	Moderate	Decreased absorption of Doxycycline due to formation of complexes caused by Ranitidine.	Peptic ulcer [DA61]	[41]
Acitretin	DM8BKU9	Major	Increased risk of pseudotumor cerebri by the combination of Doxycycline and Acitretin.	Psoriasis [EA90]	[19]
Verteporfin	DMIY6DB	Moderate	Increased risk of photosensitivity reactions by the combination of Doxycycline and Verteporfin.	Psoriasis [EA90]	[34]
Vecuronium	DMP0UK2	Moderate	Additive neuromuscular blocking effects by the combination of Doxycycline and Vecuronium.	Tonus and reflex abnormality [MB47]	[27]
Cisatracurium	DMUZPJ5	Moderate	Additive neuromuscular blocking effects by the combination of Doxycycline and Cisatracurium.	Tonus and reflex abnormality [MB47]	[27]
Rocuronium	DMY9BMK	Moderate	Additive neuromuscular blocking effects by the combination of Doxycycline and Rocuronium.	Tonus and reflex abnormality [MB47]	[27]
Mycophenolate mofetil	DMPQAGE	Moderate	Altered absorption of Doxycycline due to GI flora changes caused by Mycophenolate mofetil.	Transplant rejection [NE84]	[28]
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⏷ Show the Full List of 51 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG

DIG Name	DIG ID	PubChem CID	Functional Classification
Acetic acid	E00002	176	Acidulant; Buffering agent
Allura red AC dye	E00338	33258	Colorant
D&C red no. 28	E00491	6097185	Colorant
Docusate sodium	E00563	23673837	Surfactant
FD&C blue no. 1	E00263	19700	Colorant
FD&C blue no. 2	E00446	2723854	Colorant
Hydrazine yellow	E00409	164825	Colorant
Mannitol	E00103	6251	Diluent; Flavoring agent; Lyophilization aid; Plasticizing agent; Tonicity agent
Quinoline yellow WS	E00309	24671	Colorant
Sodium benzoate	E00432	517055	Antimicrobial preservative; lubricant
Sodium lauryl sulfate	E00464	3423265	Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
Stearic acid	E00079	5281	Emulsifying agent; Solubilizing agent; Viscosity-controlling agent; lubricant
Sunset yellow FCF	E00255	17730	Colorant
Ammonia	E00007	222	Alkalizing agent
Beta-D-lactose	E00099	6134	Diluent; Dry powder inhaler carrier; Lyophilization aid
Butyl alcohol	E00011	263	Flavoring agent; Solvent
Carmellose sodium	E00625	Not Available	Disintegrant
Crospovidone	E00626	Not Available	Disintegrant
Eisenoxyd	E00585	56841934	Colorant
FD&C red no. 3	E00629	Not Available	Colorant
Ferric hydroxide oxide yellow	E00539	23320441	Colorant
Ferrosoferric oxide	E00231	14789	Colorant
Hypromellose	E00634	Not Available	Coating agent
Lactose monohydrate	E00393	104938	Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate	E00208	11177	lubricant
Polyethylene glycol 3350	E00652	Not Available	Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polyethylene glycol 400	E00653	Not Available	Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polyethylene glycol 6000	E00655	Not Available	Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polysorbate 80	E00665	Not Available	Dispersing agent; Emollient; Emulsifying agent; Plasticizing agent; Solubilizing agent; Surfactant; Suspending agent
Polyvinyl alcohol	E00666	Not Available	Coating agent; Emulsion stabilizing agent; Film/Membrane-forming agent
Potassium hydroxide	E00233	14797	Alkalizing agent
Povidone	E00667	Not Available	Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
Propylene glycol	E00040	1030	Antimicrobial preservative; Humectant; Plasticizing agent; Solvent
Propylene glycol monostearate	E00239	14878	Emollient; Emulsifying agent; Surfactant
Saccharose	E00091	5988	Binding agent; Coating agent; Cryoprotectant; Diluent; Flavoring agent; Suspending agent; Viscosity-controlling agent
Silicon dioxide	E00670	Not Available	Anticaking agent; Opacifying agent; Viscosity-controlling agent
Sodium chloride	E00077	5234	Diluent; Tonicity agent
Talc	E00520	16211421	Anticaking agent; Diluent; Glidant; lubricant
Titanium dioxide	E00322	26042	Coating agent; Colorant; Opacifying agent
Triacetin	E00080	5541	Humectant; Plasticizing agent; Solvent
Triethyl citrate	E00128	6506	Plasticizing agent; Solvent
Vinylpyrrolidone	E00668	Not Available	Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
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⏷ Show the Full List of 42 Pharmaceutical Excipients of This Drug

Pharmaceutical Formulation

Formulation Name	Drug Dosage	Dosage Form	Route
Doxycycline 100 mg capsule	100 mg	Oral Capsule	Oral
Doxycycline 50 mg capsule	50 mg	Oral Capsule	Oral
Doxycycline 75 mg capsule	75 mg	Oral Capsule	Oral
Doxycycline 20 mg tablet	20 mg	Oral Tablet	Oral
Doxycycline 150 mg capsule	150 mg	Oral Capsule	Oral
Doxycycline 200 mg tablet	200 mg	Delayed Release Oral Tablet	Oral
Doxycycline 50 mg tablet	50 mg	Delayed Release Oral Tablet	Oral
Doxycycline 100 mg tablet	100 mg	Delayed Release Oral Tablet	Oral
Doxycycline 120 mg tablet	120 mg	Delayed Release Oral Tablet	Oral
Doxycycline 150 mg tablet	150 mg	Delayed Release Oral Tablet	Oral
Doxycycline 60 mg tablet	60 mg	Delayed Release Oral Tablet	Oral
Doxycycline 75 mg tablet	75 mg	Delayed Release Oral Tablet	Oral
Doxycycline 100 mg tablet	100 mg	Oral Tablet	Oral
Doxycycline 150 mg tablet	150 mg	Oral Tablet	Oral
Doxycycline 50 mg tablet	50 mg	Oral Tablet	Oral
Doxycycline 75 mg tablet	75 mg	Oral Tablet	Oral
Doxycycline 40 mg capsule	40 mg	Delayed Release Oral Capsule	Oral

Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1	Doxycycline FDA Label
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6464).
3	ClinicalTrials.gov (NCT00764361) Safety Study of Topical Doxycycline Gel for Adult Diabetic Lower Extremity Ulcers. U.S. National Institutes of Health.
4	BDDCS applied to over 900 drugs
5	Critical Evaluation of Human Oral Bioavailability for Pharmaceutical Drugs by Using Various Cheminformatics Approaches
6	Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose
7	Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
8	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
9	Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
10	A further interaction study of quinine with clinically important drugs by human liver microsomes: determinations of inhibition constant (Ki) and type of inhibition. Eur J Drug Metab Pharmacokinet. 1999 Jul-Sep;24(3):272-8.
11	Synthesis and in vitro evaluation of targeted tetracycline derivatives: effects on inhibition of matrix metalloproteinases. Bioorg Med Chem. 2007 Mar 15;15(6):2368-74. doi: 10.1016/j.bmc.2007.01.026. Epub 2007 Jan 19.
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