Details of Disease

Disease Name

Paracoccidioidomycosis

lobo disease; Lutz-Splendore-Almeida disease; Paracoccidioidal granuloma; South American blastomycosis; PCM; mucocutaneous-lymphangitic paracoccidioidomycosis; paracoccidioidal mycosis

Definition

A systemic fungal infection caused by Paracoccidioides brasiliensis that is most often seen in immunocompromised patients. It affects the mucous membranes, lymph nodes, lungs and bones.

Disease Hierarchy

DISIP7GM: Primary systemic mycosis

DIS88F55: Paracoccidioidomycosis

Disease Identifiers

MONDO ID

MONDO_0005894

MESH ID

D010229

UMLS CUI

C0030409

MedGen ID

14601

Orphanet ID

73260

SNOMED CT ID

36866003

General Information of Disease (ID: DIS88F55)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Ketoconazole	DMPZI3Q	Approved	Small molecular drug	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
APOA2	TTGQA9W	Strong	Altered Expression	[2]
CD209	TTBXIM9	Strong	Biomarker	[3]
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This Disease Is Related to 4 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
EXOSC3	OTNCF906	Strong	Biomarker	[4]
NLN	OTFRITPU	Strong	Biomarker	[5]
OPN4	OT1LZ7TS	Strong	Biomarker	[5]
S100A10	OTI71243	Strong	Biomarker	[4]
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References

1	Ketoconazole FDA Label
2	Ceruloplasmin, transferrin and apolipoprotein A-II play important role in treatment's follow-up of paracoccidioidomycosis patients.PLoS One. 2018 Oct 25;13(10):e0206051. doi: 10.1371/journal.pone.0206051. eCollection 2018.
3	DC-SIGN and VDR polymorphisms are associated with chronic form of paracoccidioidomycosis with oral manifestations.Mycoses. 2019 Feb;62(2):186-192. doi: 10.1111/myc.12866. Epub 2018 Nov 19.
4	Dendritic Cells Primed with Paracoccidioides brasiliensis Peptide P10 Are Therapeutic in Immunosuppressed Mice with Paracoccidioidomycosis.Front Microbiol. 2017 Jun 14;8:1057. doi: 10.3389/fmicb.2017.01057. eCollection 2017.
5	Case report of myeloperoxidase deficiency associated with disseminated paracoccidioidomycosis and peritoneal tuberculosis.Rev Soc Bras Med Trop. 2017 Jul-Aug;50(4):568-570. doi: 10.1590/0037-8682-0462-2016.