General Information of Disease (ID: DIS8YJPR)

Disease Name Infective arthritis
Synonyms septic arthritis; infective arthritis
Definition The inflammation of one or more joints caused by any infectious pathogen within the joint space. Symptoms include pain, stiffness, and decreased range of motion in the affected joint.
Disease Hierarchy
DIST1YEL: Arthritis
DISEM33Q: Infectious disease
DIS8YJPR: Infective arthritis
Disease Identifiers
MONDO ID
MONDO_0042485
MESH ID
D001170
UMLS CUI
C0003869
MedGen ID
13918
HPO ID
HP:0003095
SNOMED CT ID
396234004

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 3 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
CD4 TTN2JFW moderate Therapeutic [1]
ACLY TT0Z6Y2 Strong Biomarker [2]
PPP3CA TTA4LDE Strong Biomarker [3]
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This Disease Is Related to 5 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
SUMF2 OT37I8JL Limited Biomarker [4]
CLEC3A OTTOAEGT Strong Biomarker [5]
MARCHF6 OTBTA03N Strong Biomarker [6]
PSTPIP1 OT4PGEAB Strong Genetic Variation [7]
ROM1 OTE7H0YV Strong Biomarker [8]
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References

1 Treatment of rats with monoclonal anti-CD4 induces long-term resistance to streptococcal cell wall-induced arthritis.Eur J Immunol. 1992 Jan;22(1):57-61. doi: 10.1002/eji.1830220110.
2 Post-arthroscopic septic arthritis of the knee. Analysis of the outcome after treatment in a case series and systematic literature review.Eur Rev Med Pharmacol Sci. 2019 Apr;23(2 Suppl):76-85. doi: 10.26355/eurrev_201904_17477.
3 Virulence potential of the staphylococcal adhesin CNA in experimental arthritis is determined by its affinity for collagen.J Infect Dis. 2004 Jun 15;189(12):2323-33. doi: 10.1086/420851. Epub 2004 May 25.
4 Staphylococcus aureus osteoarticular infections in children: an 8-year review of molecular microbiology, antibiotic resistance and clinical characteristics.J Med Microbiol. 2018 Dec;67(12):1753-1760. doi: 10.1099/jmm.0.000859. Epub 2018 Oct 23.
5 Antimicrobial peptides derived from the cartilage.-specific C-type Lectin Domain Family 3 Member A (CLEC3A) - potential in the prevention and treatment of septic arthritis.Osteoarthritis Cartilage. 2019 Oct;27(10):1564-1573. doi: 10.1016/j.joca.2019.06.007. Epub 2019 Jul 4.
6 Outbreak of Septic Arthritis Associated with Intra-Articular Injections at an Outpatient Practice - New Jersey, 2017.MMWR Morb Mortal Wkly Rep. 2017 Jul 28;66(29):777-779. doi: 10.15585/mmwr.mm6629a3.
7 A novel de novo PSTPIP1 mutation in a boy with pyogenic arthritis, pyoderma gangrenosum, acne (PAPA) syndrome.Clin Exp Rheumatol. 2014 Nov-Dec;32(6):956-8. Epub 2014 Jun 24.
8 Outcomes after Total Hip Arthroplasty Using a Cementless S-ROM Modular Stem for Patients with High Hip Dislocation Secondary to Hip Pyogenic Arthritis.Orthop Surg. 2019 Jun;11(3):460-466. doi: 10.1111/os.12485.