General Information of Disease (ID: DIST1YEL)

Disease Name Arthritis
Synonyms inflammatory disorder of joint; arthritis; skeletal joint inflammation; inflammation of skeletal joint
Disease Class FA20: Rheumatoid arthritis
Definition
An inflammatory process affecting a joint. Causes include infection, autoimmune processes, degenerative processes, and trauma. Signs and symptoms may include swelling around the affected joint and pain.|Editor note: osteoarthritis is primarily non-inflammatory which causes issues if we classify arthritis as inflammatory.
Disease Hierarchy
DISVEERK: Arthropathy
DIS184KT: Skin inflammation
DISWD40R: Disease
DISTZXME: Bone inflammation disease
DIST1YEL: Arthritis
ICD Code
ICD-11
ICD-11: FA20
ICD-9
ICD-9: 714
Expand ICD-9
714
Disease Identifiers
MONDO ID
MONDO_0005578
MESH ID
D001168
UMLS CUI
C0003864
MedGen ID
2043
HPO ID
HP:0001369
SNOMED CT ID
3723001

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 19 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Benorilate DMGLN08 Approved Small molecular drug [1]
Citrofen DMTW2WW Approved NA [1]
Enbrel DM7RNP3 Approved NA [2]
Etanercept DMCV109 Approved Monoclonal antibody [3]
Felbinac DMKZEIB Approved Small molecular drug [1]
FENBUFEN DMXGDFK Approved Small molecular drug [1]
Halopredone acetate DMTJOZ2 Approved Small molecular drug [1]
IPI-145 DMWA24P Approved Small molecular drug [4]
Leflunomide DMR8ONJ Approved Small molecular drug [5]
Meclofenamate Sodium DMNL98G Approved Small molecular drug [1]
Meloxicam DM2AR7L Approved Small molecular drug [6]
Nafcillin DMN9RPO Approved Small molecular drug [7]
Orthokine DMR650I Approved NA [1]
Oxyphenbutazone DMPZS7U Approved Small molecular drug [1]
Rilonacept DMGLUQS Approved NA [8]
Rimexolone DMTAREC Approved Small molecular drug [9]
SK-1306X DMWDB27 Approved NA [1]
Sodium Succinate DMO1QX4 Approved Small molecular drug [1]
Zinc salts DMZ4R3Q Approved NA [1]
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⏷ Show the Full List of 19 Drug(s)
This Disease is Treated as An Indication in 19 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
CG-100649 DMIKMA9 Phase 3 Small molecular drug [10]
Esonarimod DM4YGWA Phase 3 Small molecular drug [11]
IR-201 DMERO2J Phase 3 NA [12]
TG-C DMLCXPD Phase 3 Small molecular drug [13]
FLUASTERONE DMMQ1YU Phase 2 Small molecular drug [14]
GSK2586184 DMA2IXQ Phase 2 NA [15]
MANOALIDE DMB4A8I Phase 2 Small molecular drug [16]
Natrunix DMBRSWJ Phase 2 NA [17]
TOK-8801 DMSCZ6C Phase 2 Small molecular drug [18]
TZI-41078 DMKJIDU Phase 2 NA [19]
VVZ-149 DM5L2FC Phase 2 NA [20]
Chondrogen DMK0FQX Phase 1/2 NA [21]
PRTX-100 DMF2XCC Phase 1/2 NA [22]
AMAP-102 DM7CD8Z Phase 1 NA [23]
DWP-422 DMVSZ2W Phase 1 NA [24]
HMR-1031 DM695QT Phase 1 NA [25]
KPE-06001 DMPC1I6 Phase 1 NA [26]
OPL-CCL2-LPM DM3HOUX Phase 1 NA [27]
RWJ-67657 DM6YAGE Phase 1 Small molecular drug [28]
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⏷ Show the Full List of 19 Drug(s)
This Disease is Treated as An Indication in 32 Discontinued Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Aurothioglucose DMFAQDL Withdrawn from market Small molecular drug [1]
Floctafenine DMD1HLC Withdrawn from market Small molecular drug [1]
M-5010 DMKR0H1 Discontinued in Phase 3 Small molecular drug [29]
CPA-926 DMH5LKS Discontinued in Phase 2 NA [30]
SINOMENINE DMYP3KI Discontinued in Phase 2 Small molecular drug [31]
SM-8849 DMYQJA1 Discontinued in Phase 2 Small molecular drug [32]
TA-383 DMISOUJ Discontinued in Phase 2 Small molecular drug [33]
Zolimomab aritox DMUEH9D Discontinued in Phase 2 Monoclonal antibody [34]
AC-100 DMLIKM1 Discontinued in Phase 1 Small molecular drug [35]
ARRY-614 DMXD93K Discontinued in Phase 1 Small molecular drug [36]
D-1367 DMB24V7 Discontinued in Phase 1 Small molecular drug [37]
Eltenac DMWRQG7 Discontinued in Phase 1 Small molecular drug [38]
KB-2683 DM2LL5F Discontinued in Phase 1 NA [39]
LY-231617 DM2S8IO Discontinued in Phase 1 Small molecular drug [40]
MLN0415 DMG72VK Discontinued in Phase 1 Small molecular drug [41]
Oncolysin CD6 DMLY4ND Discontinued in Phase 1 NA [42]
RG-4934 DMOI037 Discontinued in Phase 1 Antibody [43]
SB-242235 DMKSFL0 Discontinued in Phase 1 Small molecular drug [44]
3-DEAZAADENOSINE DMO6BA0 Terminated Small molecular drug [45]
AG-2024 DMS7UPZ Terminated NA [46]
BB-1433 DMWAKC8 Terminated NA [47]
BCX-25 DM4GEUF Terminated NA [48]
BW A4C DMNUMDG Terminated Small molecular drug [49]
FR-111142 DMNRMF3 Terminated Small molecular drug [50]
FR-133605 DMXWL0N Terminated NA [51]
LY-221068 DMJ54E9 Terminated Small molecular drug [52]
Ro-31-4724 DM8B9YT Terminated Small molecular drug [53]
RWJ-63556 DMUDE1T Terminated NA [54]
S-33516 DMF710M Terminated NA [55]
SB220025 DMSBUET Terminated Small molecular drug [56]
Seprilose DM3PSB8 Terminated Small molecular drug [57]
ZK-90695 DMLBJFJ Terminated NA [58]
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⏷ Show the Full List of 32 Drug(s)
This Disease is Treated as An Indication in 18 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
BMS-345541 DM7D519 Investigative Small molecular drug [59]
CHR-4487 DM1YSP8 Investigative NA [60]
CT-340 DMCJRG9 Investigative NA [60]
DW-908 DMSAV5R Investigative NA [60]
KI-0906 DM6GKMH Investigative NA [60]
MDDR 217769 DMA5SO0 Investigative NA [60]
OCT-SG815 DMVY9YT Investigative NA [60]
PAC-10649 DMKL6IC Investigative NA [61]
Recombinant human TNF receptor DMLYQWV Investigative NA [62]
Silicon-modified indomethacin DM5ZILV Investigative NA [63]
SPX-601 DM9B0SN Investigative NA [60]
VVZ-138 DMXT3HX Investigative NA [60]
X-071-NAB DMKPAAB Investigative NA [60]
XGP-110 DM96FTS Investigative NA [63]
XGP-115 DMBA1A9 Investigative NA [60]
XGP-120 DMPXM9P Investigative NA [60]
XGP-125 DM40QZ8 Investigative NA [60]
YD-101 DMRT3VQ Investigative NA [60]
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⏷ Show the Full List of 18 Drug(s)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 244 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ADAMTS5 TTXSU2Y Limited Biomarker [64]
ARG2 TTV1AG6 Limited Altered Expression [65]
ASIC3 TTLGDIS Limited Biomarker [66]
ATP4A TTF1QVM Limited Genetic Variation [67]
CCN2 TTIL516 Limited Altered Expression [68]
CCR1 TTC24WT Limited Altered Expression [69]
CD22 TTM6QSK Limited Altered Expression [70]
CD46 TTMS7DF Limited Biomarker [71]
CD74 TTCMYP9 Limited Genetic Variation [72]
CDH11 TTRGWZC Limited Biomarker [73]
CHRM3 TTQ13Z5 Limited Genetic Variation [74]
CMKLR1 TT4UGZL Limited Biomarker [75]
CNTN2 TT2Z1WB Limited Biomarker [76]
COL1A2 TTUABC1 Limited Biomarker [77]
CR2 TT0HUN7 Limited Biomarker [78]
CTSC TT4H0V2 Limited Altered Expression [79]
CXCL9 TTWE5PB Limited Genetic Variation [80]
CYSLTR1 TTGKOY9 Limited Biomarker [81]
DHODH TTLVP78 Limited Biomarker [82]
EGLN2 TTMHFRY Limited Biomarker [83]
FCGR1A TTZK4I3 Limited Biomarker [84]
FCGR2A TTXT21W Limited Genetic Variation [85]
FCGRT TTKLPHO Limited Biomarker [86]
FPR2 TTOJ1NF Limited Biomarker [87]
GADD45B TTMDW9L Limited Biomarker [88]
GAS6 TT69QD2 Limited Biomarker [89]
GCH1 TTLSWP6 Limited Biomarker [90]
HNF4A TT2F3CD Limited Biomarker [91]
HTRA1 TT8POQR Limited Altered Expression [92]
IFNL1 TTM624L Limited Altered Expression [93]
IL11 TTGUYTR Limited Biomarker [94]
IL17A TTG0MT6 Limited Biomarker [95]
IL25 TTVMO5W Limited Biomarker [96]
ITGA2 TTSJ542 Limited Biomarker [97]
ITGAL TT48WR6 Limited Biomarker [98]
KITLG TTDJ51N Limited Biomarker [99]
LANCL1 TTZW8NS Limited Biomarker [100]
LGR4 TTY6C71 Limited Altered Expression [101]
LTB TTHQ6US Limited Biomarker [102]
LTB4R2 TTVJX54 Limited Biomarker [103]
MAP3K7 TTJQT60 Limited Biomarker [104]
MMP10 TTXLEG7 Limited Biomarker [105]
MOG TTQAFX5 Limited Biomarker [106]
MUC17 TTVO0JU Limited Biomarker [107]
NAMPT TTD1WIG Limited Biomarker [108]
NOD1 TTYSRXM Limited Genetic Variation [109]
NOD2 TTYPUHA Limited Altered Expression [110]
ORAI1 TTE76YK Limited Biomarker [111]
OSCAR TT71Q5Y Limited Biomarker [112]
PAH TTGSVH2 Limited Biomarker [113]
PF4 TTSG7Q5 Limited Altered Expression [114]
PPM1A TTLA7IX Limited Altered Expression [115]
PRKCH TTONI0R Limited Altered Expression [116]
PTH1R TTFPD47 Limited Genetic Variation [67]
RHBDF2 TTH1ZOP Limited Biomarker [117]
SIRPA TTBRJS9 Limited Biomarker [118]
SIRT6 TTUXYWF Limited Biomarker [119]
SOST TTYRO4F Limited Altered Expression [120]
SPP1 TT8ME6I Limited Biomarker [121]
SRR TTZFUY6 Limited Genetic Variation [122]
STAB2 TTM3DAY Limited Genetic Variation [123]
SUCNR1 TT4FX9Y Limited Biomarker [124]
SYVN1 TT8XKYM Limited Biomarker [125]
TCF3 TTULOD8 Limited Genetic Variation [126]
TIE1 TTT4236 Limited Biomarker [127]
TLR5 TTCXP8J Limited Biomarker [128]
TNFAIP3 TT5W0IO Limited Genetic Variation [129]
TNFRSF11A TT3K9S2 Limited Biomarker [130]
TNFRSF14 TTWGTC1 Limited Biomarker [131]
TNFRSF25 TTDV6BQ Limited Biomarker [132]
TNFRSF4 TTL31H0 Limited Biomarker [133]
TNFSF13 TTOI1RM Limited Biomarker [134]
TRB TT84HCW Limited Biomarker [135]
TRBC1 TT1DHW2 Limited Biomarker [135]
TYRO3 TTIEMFN Limited Biomarker [136]
WAS TTE8T73 Limited Biomarker [137]
ACR TTAHE2N Disputed Biomarker [138]
ARG1 TT7ZQEV Disputed Biomarker [139]
ARRB1 TTMVD4A Disputed Altered Expression [140]
ARRB2 TT8SO2I Disputed Biomarker [140]
CD27 TTDO1MV Disputed Genetic Variation [141]
CPB1 TT4UJX5 Disputed Biomarker [142]
CRLF2 TTRMZ0N Disputed Biomarker [143]
ENPP2 TTSCIM2 Disputed Biomarker [144]
EREG TTYSB89 Disputed Altered Expression [145]
F2RL2 TTVSEBF Disputed Altered Expression [146]
IL21R TTZO9B0 Disputed Biomarker [147]
PTPRJ TTWMKXP Disputed Altered Expression [148]
SPHK2 TTCN0M9 Disputed Biomarker [149]
ST3GAL5 TTVF2BJ Disputed Genetic Variation [150]
TLR8 TT8CWFK Disputed Altered Expression [151]
TRPA1 TTELV3W Disputed Biomarker [152]
TRPV2 TTBECWA Disputed Biomarker [153]
ADAMTS4 TTYG6BU moderate Biomarker [154]
BMP6 TT07RIB moderate Altered Expression [155]
CLEC12A TT70N8V moderate Biomarker [156]
HLA-B TTGS10J moderate Biomarker [157]
HSPD1 TT9HL5R moderate Biomarker [158]
TNFRSF1A TTG043C moderate Biomarker [159]
ACKR1 TTKY2NS Strong Biomarker [160]
ADORA1 TTK25J1 Strong Biomarker [161]
AIMP2 TTXWHGF Strong Biomarker [162]
ALOX15 TTN9T81 Strong Altered Expression [163]
ALOX5 TTSJ6Q4 Strong Altered Expression [164]
ANGPT1 TTWNQ1T Strong Genetic Variation [165]
ANK1 TTKFPMH Strong Biomarker [166]
AOC3 TT7HC21 Strong Biomarker [167]
BTK TTGM6VW Strong Biomarker [168]
BTLA TTER58P Strong Biomarker [169]
C5 TTKANGO Strong Biomarker [160]
C5AR1 TTHXFA1 Strong Biomarker [160]
CCL3 TT8I4WB Strong Biomarker [170]
CCN1 TTPK79J Strong Altered Expression [171]
CCR6 TTFDB30 Strong Altered Expression [172]
CD160 TTOFEAS Strong Biomarker [169]
CD209 TTBXIM9 Strong Biomarker [173]
CD248 TTYJWT7 Strong Altered Expression [174]
CD28 TTQ13FT Strong Biomarker [175]
CD300A TTI2YFK Strong Biomarker [176]
CD69 TTPQE9F Strong Genetic Variation [177]
CD83 TTT9MRQ Strong Biomarker [178]
CDA TTQ12RK Strong Biomarker [179]
CFB TTA0P7K Strong Biomarker [180]
CNR2 TTMSFAW Strong Biomarker [181]
CNTN1 TTPR8FK Strong Biomarker [180]
CRK TTFEUYR Strong Biomarker [162]
CRP TTWRN6M Strong Biomarker [182]
CSF1 TT0IQER Strong Biomarker [183]
CSF3R TTC70AJ Strong Biomarker [184]
CTLA4 TTI2S1D Strong Biomarker [175]
CTSK TTDZN01 Strong Biomarker [185]
CTSS TTUMQVO Strong Altered Expression [186]
CXCL10 TTQOVYA Strong Biomarker [187]
CXCR2 TT30C9G Strong Biomarker [160]
CXCR6 TT2BVUA Strong Biomarker [75]
CYBB TT5T8MR Strong Biomarker [188]
DKK1 TTE3RAC Strong Biomarker [189]
DNAJB1 TTPXAWS Strong Biomarker [158]
ELANE TTPLTSQ Strong Altered Expression [190]
ESRRB TTKF0XS Strong Altered Expression [191]
FAP TTGPQ0F Strong Altered Expression [192]
FCER1G TTDGEC0 Strong Biomarker [193]
FCGR3A TTIFOC0 Strong Genetic Variation [194]
FGG TTR31L7 Strong Biomarker [180]
FOSL2 TT689IR Strong Altered Expression [195]
GPI TT19JIZ Strong Biomarker [196]
GPR101 TTUKZVG Strong Biomarker [197]
GRK3 TT5A4DX Strong Biomarker [198]
GRN TT0LWE3 Strong Biomarker [199]
HLA-DQA1 TTU2I3J Strong Biomarker [72]
HP TTLC8E1 Strong Biomarker [200]
HRH4 TTXJ178 Strong Biomarker [201]
HSD11B1 TTN7BL9 Strong Altered Expression [202]
IL17D TTC5LTG Strong Biomarker [203]
IL1RN TT6GSR3 Strong Biomarker [204]
IL20 TTNZMY2 Strong Biomarker [205]
IL21 TT9QEJ6 Strong Biomarker [206]
IL22 TTLDX4N Strong Altered Expression [172]
IL23A TTC1GLB Strong Biomarker [207]
IL32 TTD4G7L Strong Biomarker [208]
IL9 TT0JTFD Strong Biomarker [209]
ILDR2 TT0R2QD Strong Biomarker [210]
IRAK1 TTXAJWN Strong Genetic Variation [211]
ITGAE TTH0Z37 Strong Biomarker [212]
ITGAM TTB69FJ Strong Genetic Variation [213]
ITGB2 TTIJWR7 Strong Biomarker [214]
KLKB1 TTN0PCX Strong Biomarker [215]
LGALS1 TTO3NYT Strong Biomarker [216]
LIF TTGZ5WN Strong Biomarker [217]
LIFR TTID542 Strong Biomarker [218]
LTB4R TTN53ZF Strong Biomarker [219]
MAP3K5 TTOQCD8 Strong Biomarker [220]
MAZ TT059DA Strong Biomarker [221]
MMP1 TTMX39J Strong Altered Expression [222]
MMP13 TTHY57M Strong Altered Expression [223]
MMP14 TTJ4QE7 Strong Biomarker [224]
MMP17 TTVSZKN Strong Biomarker [225]
MMP2 TTLM12X Strong Altered Expression [226]
NCF1 TTZ4JC3 Strong Biomarker [227]
NLRP3 TT4EN8X Strong Altered Expression [228]
NR1I2 TT7LCTF Strong Altered Expression [146]
NR4A2 TT9HKN3 Strong Altered Expression [229]
OSM TTIVXSE Strong Altered Expression [230]
PADI4 TTQHAXM Strong Biomarker [231]
PDCD1 TTNBFWK Strong Biomarker [232]
PLA2G1B TT9V5JH Strong Biomarker [233]
PLA2G2A TTO8QRU Strong Biomarker [234]
PLA2G4A TTT1JVS Strong Biomarker [235]
PLD1 TT3T17P Strong Biomarker [236]
PPP3CA TTA4LDE Strong Biomarker [237]
PRDX5 TTLPJWH Strong Biomarker [238]
PRG4 TTSKF4V Strong Biomarker [239]
PROC TTZUXYS Strong Biomarker [240]
PTGES TTYLQ8V Strong Altered Expression [241]
PTGS1 TT8NGED Strong Altered Expression [242]
REL TT1ZCTH Strong Genetic Variation [243]
RIPK2 TTCQ2E5 Strong Biomarker [244]
S100A8 TT4AF6N Strong Biomarker [245]
S1PR1 TT9JZCK Strong Biomarker [246]
S1PR3 TTDYP7I Strong Altered Expression [247]
SAA1 TTY0DN9 Strong Genetic Variation [248]
SERPINA1 TTA7UJC Strong Biomarker [249]
SLC22A2 TT0XOJN Strong Altered Expression [250]
SPHK1 TTOHFIY Strong Biomarker [149]
SRGN TTCHB06 Strong Biomarker [251]
TBK1 TTMP03S Strong Biomarker [252]
TEK TT9VGXW Strong Biomarker [253]
THBD TTAPV67 Strong Biomarker [254]
TLR3 TTD24Y0 Strong Biomarker [255]
TLR4 TTISGCA Strong Biomarker [256]
TLR7 TTRJ1K4 Strong Biomarker [257]
TNFRSF11B TT2CJ75 Strong Altered Expression [131]
TNFRSF1B TT63WSF Strong Genetic Variation [258]
TNFSF11 TT9E8HR Strong Biomarker [259]
TNFSF13B TTWMIDN Strong Biomarker [260]
TNFSF15 TTEST6I Strong Biomarker [261]
TRAF6 TTCDR6M Strong Biomarker [262]
TREM1 TTHZQP0 Strong Biomarker [263]
TRPV1 TTMI6F5 Strong Biomarker [264]
TSLP TTHMW3T Strong Altered Expression [265]
TSPO TTPTXIN Strong Biomarker [266]
VIP TTGTWLF Strong Altered Expression [267]
VIPR2 TT4O5P0 Strong Altered Expression [268]
ZAP70 TTUMHT8 Strong Genetic Variation [110]
ACLY TT0Z6Y2 Definitive Genetic Variation [269]
CDC25B TTR0SWN Definitive Biomarker [270]
F2RL1 TTQR74A Definitive Biomarker [190]
GDF5 TT37XV9 Definitive Genetic Variation [271]
GJA8 TTJ7ATH Definitive Biomarker [272]
ICOSLG TTB9Z8R Definitive Biomarker [273]
IDO2 TTALN9W Definitive Biomarker [274]
IL19 TT87RWS Definitive Biomarker [205]
IL1R2 TT51DEV Definitive Posttranslational Modification [275]
LAIR1 TTSI7A8 Definitive Biomarker [276]
MC4R TTD0CIQ Definitive Altered Expression [277]
MCHR1 TTX4RTB Definitive Biomarker [278]
MSTN TTM8I2X Definitive Altered Expression [279]
P2RX3 TT2THBD Definitive Altered Expression [280]
PGF TT48I1Y Definitive Biomarker [281]
PLTP TTZF6SN Definitive Biomarker [282]
SCN10A TT90XZ8 Definitive Biomarker [283]
SEMA4D TT5UT28 Definitive Biomarker [284]
SLC40A1 TT6Y1PG Definitive Biomarker [285]
TRPC5 TT32NQ1 Definitive Biomarker [286]
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⏷ Show the Full List of 244 DTT(s)
This Disease Is Related to 5 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC11A1 DT650XW Limited Biomarker [287]
SLC22A4 DT2EG60 Limited Altered Expression [288]
SLC52A1 DT7NOKR Strong Biomarker [289]
SLC5A12 DTM301H Strong Biomarker [290]
SLC25A16 DTNU9EW Definitive Altered Expression [291]
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This Disease Is Related to 6 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
EGLN3 DEMQTKH Limited Biomarker [83]
ACP5 DESITDW Strong Biomarker [292]
DCXR DE3FEV8 Strong Biomarker [293]
FAAH DEUM1EX Strong Genetic Variation [294]
SPR DEJVDAT Strong Biomarker [295]
AOC2 DE8DP90 Definitive Biomarker [167]
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⏷ Show the Full List of 6 DME(s)
This Disease Is Related to 250 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
A2M OTFTX90K Limited Biomarker [296]
ADAMTS3 OT2U6VF5 Limited Biomarker [154]
ADGRE2 OTUYJVYG Limited Biomarker [297]
ADGRE5 OTTSB84Q Limited Biomarker [297]
AMELX OTIN26MM Limited Biomarker [298]
ARHGEF5 OTUVGFT9 Limited Biomarker [299]
ARMH1 OTTJC0D6 Limited Biomarker [100]
ASAH1 OT1DNGXL Limited Genetic Variation [300]
BTG3 OT9ANHVT Limited Genetic Variation [301]
C1QTNF6 OT57EPQC Limited Biomarker [302]
C5AR2 OTP1Q82J Limited Biomarker [303]
C6 OTCKR304 Limited Biomarker [304]
CBLIF OTNE20WU Limited Biomarker [305]
CCL7 OTDIS99H Limited Altered Expression [306]
CCL8 OTCTWYN8 Limited Biomarker [307]
CDC42EP1 OTT525WA Limited Biomarker [308]
CLEC2A OTHED3LS Limited Altered Expression [309]
CLEC5A OT19WV30 Limited Biomarker [310]
CNTRL OTQI3VBA Limited Biomarker [308]
COPA OTZ1DTXU Limited Genetic Variation [311]
COX5A OTP0961M Limited Biomarker [312]
CPOX OTIAY121 Limited Biomarker [312]
CXCL6 OTFTCQ4O Limited Biomarker [313]
EBNA1BP2 OTBRVMZH Limited Biomarker [100]
ENAM OTK8PU0T Limited Biomarker [298]
GOLGA4 OTCMEHNJ Limited Biomarker [313]
GPATCH2 OT09TY4W Limited Altered Expression [314]
GPSM3 OT2MO458 Limited Genetic Variation [315]
GZMA OT43R33L Limited Biomarker [316]
H2AC18 OTCE5JC7 Limited Biomarker [317]
H2AC20 OTEIVLM1 Limited Biomarker [317]
HCLS1 OTX7WGYN Limited Genetic Variation [126]
HGD OTTKLQOO Limited Biomarker [318]
HLA-C OTV38BUJ Limited Genetic Variation [319]
HLA-DRB3 OT5PM9N7 Limited Biomarker [320]
HLA-DRB4 OTNXIHQU Limited Biomarker [321]
HSPA14 OTZCA5LK Limited Biomarker [158]
IL17C OTKXIVNQ Limited Biomarker [322]
IL17RA OTVVI8ER Limited Biomarker [323]
IL3 OT0CQ35N Limited Biomarker [324]
IRF5 OT8SIIAP Limited Biomarker [325]
IVNS1ABP OTYHL4I7 Limited Biomarker [326]
KLF2 OTIP1UFX Limited Biomarker [327]
KRIT1 OT58AP1I Limited Biomarker [328]
KRTAP5-9 OTJ9E3R7 Limited Biomarker [329]
LGALS9 OT7MF91K Limited Biomarker [330]
LYPD8 OT5B9NNM Limited Biomarker [331]
MACIR OTPSW8Y8 Limited Altered Expression [332]
MASP1 OTWWCNZP Limited Biomarker [333]
MEFV OTRJ6S6K Limited Genetic Variation [334]
MOK OTQK7M9V Limited Biomarker [335]
MPP1 OTA2ENZQ Limited Genetic Variation [126]
MSC OTBRPZL5 Limited Biomarker [336]
MUC3A OTI4XUDY Limited Altered Expression [107]
NDEL1 OTAGFML5 Limited Biomarker [337]
NIF3L1 OT4MP90J Limited Biomarker [90]
NR2C2 OTDZWVOJ Limited Biomarker [104]
OR2AG1 OTEITRP4 Limited Biomarker [338]
PADI2 OTT40K94 Limited Biomarker [339]
PDCD5 OT6T2DDL Limited Biomarker [340]
PHC1 OT1JMX8U Limited Biomarker [83]
PIK3R3 OTXGJ8N1 Limited Genetic Variation [126]
PLA2G10 OTRZ2L5A Limited Biomarker [234]
POLG2 OTDBMZJB Limited Genetic Variation [126]
PROS1 OTXQWNOI Limited Biomarker [341]
PSMD12 OTWICA51 Limited Genetic Variation [126]
PSMD7 OT7PZZ4K Limited Biomarker [100]
RABEPK OTCZSREH Limited Biomarker [100]
RAG2 OTG9UYTW Limited Biomarker [342]
RARRES2 OT1BJE8K Limited Biomarker [343]
RETN OTW5Z1NH Limited Altered Expression [344]
RNPC3 OTW5MKC1 Limited Genetic Variation [301]
SAA2 OTYAVJWG Limited Altered Expression [345]
SERPINA4 OTBK0GG7 Limited Genetic Variation [346]
SIGLEC7 OTNDLURR Limited Genetic Variation [126]
SLURP1 OT89YD2E Limited Biomarker [116]
STAT4 OTAK3VFR Limited Genetic Variation [347]
STEAP4 OTFTLAEZ Limited Biomarker [348]
TAGAP OTHJNNO2 Limited Altered Expression [349]
TAP2 OTWSYFI7 Limited Genetic Variation [350]
TBCA OTCCWMGK Limited Biomarker [351]
TIA1 OTGPN3P8 Limited Biomarker [352]
TIMELESS OTD8DCBJ Limited Biomarker [299]
TIMP4 OT8A68SW Limited Biomarker [353]
TNFAIP6 OT1SLUZH Limited Biomarker [354]
TNP1 OTKQH7E5 Limited Biomarker [355]
TRIM21 OTA4UJCF Limited Biomarker [356]
TSC22D3 OT03UM03 Limited Altered Expression [357]
C1QTNF3 OTOJMWW0 Disputed Biomarker [358]
CABIN1 OT4G5CIK Disputed Altered Expression [359]
CCL28 OTY6XNQ7 Disputed Altered Expression [360]
CCR10 OT7ZWSSD Disputed Altered Expression [360]
CLEC4E OT7P8ICY Disputed Biomarker [361]
FBXO32 OTUE978R Disputed Altered Expression [362]
FUT1 OTODG57A Disputed Biomarker [363]
HPX OT14T7Q1 Disputed Biomarker [180]
MAP2K3 OTI2OREX Disputed Biomarker [364]
MAP2K6 OTK13JKC Disputed Biomarker [364]
MEPE OTXJRUW0 Disputed Biomarker [365]
NCF2 OTAUW7L2 Disputed Genetic Variation [366]
NFKBIL1 OTYFTPS0 Disputed Biomarker [367]
PARD3 OTH5BPLO Disputed Altered Expression [146]
PRDX6 OTS8KC8A Disputed Biomarker [368]
PTX3 OTPXHRKU Disputed Biomarker [369]
SEMA4A OT8901H3 Disputed Biomarker [370]
SH2D3C OTAGXO0N Disputed Biomarker [371]
SMG1 OTTS3SXE Disputed Biomarker [144]
TRAF1 OTTLM5RU Disputed Biomarker [329]
FCN1 OTK6ZHXH moderate Biomarker [372]
NLRC4 OTAIA3NA moderate Altered Expression [373]
NPNT OTFZAO1G moderate Biomarker [374]
PTPN22 OTDCNTC3 moderate Genetic Variation [375]
RASGRP2 OTABVLVQ moderate Biomarker [376]
A1BG OTFVUGNQ Strong Biomarker [180]
AATF OT1QOKLD Strong Genetic Variation [377]
ACAD8 OT3JI5GB Strong Biomarker [378]
ACAN OTUOCW8K Strong Biomarker [379]
ADAMTS12 OTG7HEA2 Strong Biomarker [380]
ADAMTS7 OTVKZ1DV Strong Biomarker [381]
AHSA1 OTC7AFHT Strong Biomarker [162]
ANKH OTCN25R5 Strong Genetic Variation [382]
ART1 OT7FBG5W Strong Biomarker [383]
ASF1A OT4S44GP Strong Biomarker [384]
BCKDHA OT0LHOZB Strong Biomarker [256]
BLNK OTSSPF6F Strong Biomarker [385]
C7 OTZ27VJN Strong Biomarker [386]
CADM3 OTSGOMWB Strong Biomarker [180]
CAPG OTJ86KI6 Strong Genetic Variation [387]
CCN6 OTRFHQ2Z Strong Genetic Variation [388]
CDCP1 OTD7RRWK Strong Biomarker [389]
CHI3L2 OT26R3HQ Strong Biomarker [390]
CHP1 OTHTXN1A Strong Biomarker [391]
CIITA OTRJNZFO Strong Altered Expression [392]
COL2A1 OT5E59C8 Strong Biomarker [393]
COMP OTS2FPMI Strong Altered Expression [394]
CTHRC1 OTV88X2G Strong Biomarker [395]
DCTN3 OTQOSUES Strong Biomarker [391]
DMP1 OTBWBWW7 Strong Biomarker [189]
DYNC1H1 OTD1KRKO Strong Biomarker [391]
ELMO1 OTY2ORXK Strong Biomarker [396]
ENO1 OTB1KWJS Strong Biomarker [397]
ERAL1 OTSH78HD Strong Biomarker [398]
FLT3LG OTU0YGC4 Strong Biomarker [399]
FRZB OTTO3DPY Strong Genetic Variation [400]
FSTL1 OT6KEZUD Strong Altered Expression [401]
GADD45GIP1 OT4IZ4TP Strong Altered Expression [402]
GDF11 OTOSNMND Strong Biomarker [403]
GFER OTVK43OK Strong Biomarker [404]
GRAP2 OTS5NIZ3 Strong Biomarker [162]
HAS1 OTJIAG1W Strong Altered Expression [405]
HFE OTDD93KB Strong Genetic Variation [406]
HOXC6 OTBCRAZV Strong Biomarker [407]
HYAL2 OTTVINXW Strong Biomarker [405]
IL10RA OTOX3D1D Strong Genetic Variation [408]
IL17B OTS86H50 Strong Biomarker [205]
IL27 OTIS3OF8 Strong Biomarker [203]
IL34 OTZ15VVK Strong Altered Expression [409]
IRGM OTKD3O5Z Strong Genetic Variation [410]
ISG20 OTCWRJJW Strong Biomarker [411]
JAM3 OTX0F9QL Strong Biomarker [412]
KHSRP OTDHZARB Strong Biomarker [413]
KLRC2 OTT4N86S Strong Biomarker [414]
LACC1 OT4SBHI8 Strong Biomarker [415]
LRBA OTOUZN9G Strong Biomarker [416]
MLKL OTDSLC81 Strong Biomarker [417]
MRAP OTLBWM7X Strong Genetic Variation [418]
MTX1 OTLSDNZO Strong Biomarker [419]
MYDGF OT9HRPL6 Strong Biomarker [203]
NCOA5 OTOGWTWB Strong Biomarker [384]
NCR3 OT20M764 Strong Biomarker [420]
NFAT5 OTKIE59S Strong Biomarker [421]
NFATC1 OT4TMERS Strong Altered Expression [422]
NFIL3 OTQH9HM3 Strong Genetic Variation [423]
NRGN OTVGE10W Strong Genetic Variation [424]
PADI6 OTS42I3K Strong Altered Expression [425]
PHB2 OTCAX3AW Strong Biomarker [391]
PIGQ OTOD93DQ Strong Biomarker [426]
PIP OTH719AH Strong Genetic Variation [387]
PLEKHO1 OTMVUQ9W Strong Genetic Variation [427]
POLDIP2 OT8SZSJ6 Strong Biomarker [162]
POU2AF1 OTOO6WHL Strong Biomarker [428]
PPP1R1A OTGTAGCV Strong Biomarker [429]
PROCR OTRHED17 Strong Biomarker [240]
PSORS1C1 OT9HK436 Strong Genetic Variation [430]
RBM45 OTWTHD77 Strong Biomarker [431]
RDX OTNSYUN6 Strong Biomarker [432]
RELB OTU3QYEF Strong Posttranslational Modification [433]
RGS1 OTGXJYMG Strong Biomarker [434]
RHOBTB2 OT2DATFX Strong Biomarker [435]
RIPK3 OTL1D484 Strong Biomarker [417]
RNF19A OTKWCV80 Strong Biomarker [162]
SDC4 OTKUVUGZ Strong Biomarker [436]
SH3BP2 OT90JNBS Strong Genetic Variation [437]
SH3BP4 OTVIRKW7 Strong Biomarker [438]
SPAAR OTWXG2R8 Strong Biomarker [439]
SUMF2 OT37I8JL Strong Genetic Variation [440]
TBP OT6C0S52 Strong Biomarker [441]
TBX3 OTM64N7K Strong Genetic Variation [442]
TBX5 OT70PISV Strong Biomarker [443]
TM7SF2 OTILU5S7 Strong Genetic Variation [165]
TMEM147 OTMKZ4PV Strong Biomarker [444]
TMEM60 OTRJU667 Strong Biomarker [445]
TNIP1 OTRAOTEW Strong Genetic Variation [446]
TRIM3 OT704FQ0 Strong Altered Expression [447]
ABCF1 OT6Q079J Definitive Biomarker [448]
ACKR2 OTWYY14H Definitive Altered Expression [449]
ADI1 OT8IOD03 Definitive Biomarker [450]
AGBL3 OTVH64PO Definitive Biomarker [451]
ANP32B OT3SQMLU Definitive Biomarker [134]
BATF OT9VSD2D Definitive Altered Expression [452]
CARD8 OTXXZYWU Definitive Genetic Variation [453]
CCDC134 OT70OQQV Definitive Biomarker [454]
CCRL2 OT5PX0RX Definitive Biomarker [455]
CLEC7A OTRTBH27 Definitive Biomarker [456]
CMC1 OTCWYKPI Definitive Biomarker [457]
CNN2 OTH3CSXA Definitive Biomarker [458]
COMMD1 OT7WUD5R Definitive Genetic Variation [459]
CORT OTX3GUHB Definitive Biomarker [460]
CUL4B OT2QX4DO Definitive Biomarker [461]
CYTL1 OTLYUPUY Definitive Altered Expression [462]
DUSP7 OT6Z5AHP Definitive Biomarker [270]
DVL2 OTMNYNCM Definitive Altered Expression [463]
EFNB2 OT0DCUOM Definitive Biomarker [464]
EHD2 OTTX391J Definitive Biomarker [465]
EMD OTR8ZANE Definitive Biomarker [466]
FCRL4 OT3DVTRV Definitive Altered Expression [467]
FOXO4 OT90X9LN Definitive Biomarker [468]
GYS1 OTJZJRWK Definitive Biomarker [469]
HIP1 OT7AKCFQ Definitive Genetic Variation [470]
IK OTWSSXX0 Definitive Biomarker [471]
IL17RD OTKD9XST Definitive Altered Expression [472]
IL1F10 OTJAASGC Definitive Biomarker [473]
ITGBL1 OTJDHE17 Definitive Altered Expression [474]
LRG1 OTLD0KWA Definitive Biomarker [475]
LST1 OTUVG424 Definitive Altered Expression [319]
MARCO OT0NW2Q0 Definitive Biomarker [476]
PANX1 OTXPEDOK Definitive Biomarker [477]
PIR OT8ALXHU Definitive Genetic Variation [478]
PPBP OT1FHGQS Definitive Altered Expression [114]
PSTPIP2 OTG6F93V Definitive Biomarker [479]
RCAN3 OTTS3CQA Definitive Biomarker [480]
RPL23A OTPYLCCX Definitive Biomarker [481]
RTL1 OTOT33IM Definitive Biomarker [482]
S100A7 OTJFVJRF Definitive Altered Expression [483]
SETMAR OTE2MIMZ Definitive Biomarker [482]
SH2D3A OTVJBSRC Definitive Biomarker [484]
SIGLEC9 OTZC7SIM Definitive Biomarker [485]
SLN OTERIU75 Definitive Genetic Variation [486]
SPESP1 OTWXKKTJ Definitive Biomarker [487]
SPRR2A OT62ZU6B Definitive Biomarker [488]
------------------------------------------------------------------------------------
⏷ Show the Full List of 250 DOT(s)

References

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7 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 062527.
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28 RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase. J Pharmacol Exp Ther. 1999 Nov;291(2):680-7.
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60 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
61 PAC 10649 Pacific licensing offer, Worldwide excluding South Korea. R & D Focus Drug News. September 22, 2003.
62 Secretion of a TNFR:Fc fusion protein following pulmonary administration of pseudotyped adeno-associated virus vectors. J Virol. 2004 Nov;78(22):12355-65.
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64 Matrix-degrading protease ADAMTS-5 cleaves inter--inhibitor and releases active heavy chain 2 in synovial fluids from arthritic patients.J Biol Chem. 2019 Oct 18;294(42):15495-15504. doi: 10.1074/jbc.RA119.008844. Epub 2019 Sep 4.
65 Increased expression of arginase II in patients with different forms of arthritis. Implications of the regulation of nitric oxide.J Rheumatol. 2002 Nov;29(11):2261-5.
66 Dual role of acid-sensing ion channels 3 in rheumatoid arthritis: destruction or protection?.Immunopharmacol Immunotoxicol. 2018 Aug;40(4):273-277. doi: 10.1080/08923973.2018.1485156. Epub 2018 Jul 23.
67 A cumulative effect involving malfunction of the PTH1R and ATP4A genes explains a familial gastric neuroendocrine tumor with hypothyroidism and arthritis.Gastric Cancer. 2017 Nov;20(6):998-1003. doi: 10.1007/s10120-017-0723-8. Epub 2017 May 4.
68 Role of microRNA-26a in cartilage injury and chondrocyte proliferation and apoptosis in rheumatoid arthritis rats by regulating expression of CTGF.J Cell Physiol. 2020 Feb;235(2):979-992. doi: 10.1002/jcp.29013. Epub 2019 Jul 2.
69 Chemokine signals are crucial for enhanced homing and differentiation of circulating osteoclast progenitor cells.Arthritis Res Ther. 2017 Jun 15;19(1):142. doi: 10.1186/s13075-017-1337-6.
70 The role of B cell CD22 expression in Staphylococcus aureus arthritis and sepsis.Microbes Infect. 2004 Apr;6(4):377-82. doi: 10.1016/j.micinf.2003.12.013.
71 A CD46 transgenic mouse model for studying the histopathology of arthritis caused by subcutaneous infection with Streptococcus dysgalactiae subspecies equisimilis.J Med Microbiol. 2011 Dec;60(Pt 12):1860-1868. doi: 10.1099/jmm.0.034108-0. Epub 2011 Aug 18.
72 CD74/DQA1 dimers predispose to the development of arthritis in humanized mice.Immunology. 2016 Feb;147(2):204-11. doi: 10.1111/imm.12551. Epub 2015 Dec 21.
73 Cadherin-11 as a regulator of valve myofibroblast mechanobiology.Am J Physiol Heart Circ Physiol. 2018 Dec 1;315(6):H1614-H1626. doi: 10.1152/ajpheart.00277.2018. Epub 2018 Oct 25.
74 Effect of bone marrow mesenchymal stem cells on healing of temporomandibular joints in rats with induced rheumatoid arthritis.Eur J Oral Sci. 2018 Aug;126(4):272-281. doi: 10.1111/eos.12533. Epub 2018 Jun 27.
75 Chemerin-activated functions of CMKLR1 are regulated by G protein-coupled receptor kinase 6 (GRK6) and -arrestin 2 in inflammatory macrophages.Mol Immunol. 2019 Feb;106:12-21. doi: 10.1016/j.molimm.2018.12.016. Epub 2018 Dec 18.
76 Involvement of autoimmunity against type II collagen in the development of arthritis in mice transgenic for the human T cell leukemia virus type I tax gene.Eur J Immunol. 1999 Jan;29(1):54-64. doi: 10.1002/(SICI)1521-4141(199901)29:01<54::AID-IMMU54>3.0.CO;2-M.
77 Mannan-Binding Lectin Attenuates Inflammatory Arthritis Through the Suppression of Osteoclastogenesis.Front Immunol. 2019 Jun 4;10:1239. doi: 10.3389/fimmu.2019.01239. eCollection 2019.
78 The human complement receptor type 2 (CR2)/CR1 fusion protein TT32, a novel targeted inhibitor of the classical and alternative pathway C3 convertases, prevents arthritis in active immunization and passive transfer mouse models.Mol Immunol. 2019 Jan;105:150-164. doi: 10.1016/j.molimm.2018.09.013. Epub 2018 Dec 1.
79 Liposomes encapsulated dimethyl curcumin regulates dipeptidyl peptidase I activity, gelatinase release and cell cycle of spleen lymphocytes in-vivo to attenuate collagen induced arthritis in rats.Int Immunopharmacol. 2018 Dec;65:511-521. doi: 10.1016/j.intimp.2018.10.039. Epub 2018 Nov 5.
80 The chemokine fragment CXCL9(74-103) diminishes neutrophil recruitment and joint inflammation in antigen-induced arthritis.J Leukoc Biol. 2018 Aug;104(2):413-422. doi: 10.1002/JLB.3MA1217-502R. Epub 2018 May 7.
81 Cysteinyl leukotriene receptor antagonism: a promising pharmacological strategy for lowering the severity of arthritis.Inflammopharmacology. 2019 Oct;27(5):923-931. doi: 10.1007/s10787-019-00618-0. Epub 2019 Jul 16.
82 Dihydroorotate dehydrogenase (DHODH) inhibitors affect ATP depletion, endogenous ROS and mediate S-phase arrest in breast cancer cells.Biochimie. 2017 Apr;135:154-163. doi: 10.1016/j.biochi.2017.02.003. Epub 2017 Feb 11.
83 Transduction of the cytoplasmic domain of CTLA-4 inhibits TcR-specific activation signals and prevents collagen-induced arthritis.Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19875-80. doi: 10.1073/pnas.0805198105. Epub 2008 Dec 9.
84 CD64-directed immunotoxin inhibits arthritis in a novel CD64 transgenic rat model.J Immunol. 2006 May 15;176(10):5833-8. doi: 10.4049/jimmunol.176.10.5833.
85 FcRIIa and FcRIIIb polymorphisms and associations with clinical manifestations in systemic lupus erythematosus patients.Autoimmunity. 2014 Nov;47(7):451-8. doi: 10.3109/08916934.2014.921809. Epub 2014 Jun 4.
86 Neonatal Fc receptor blockade by Fc engineering ameliorates arthritis in a murine model.J Immunol. 2011 Jul 15;187(2):1015-22. doi: 10.4049/jimmunol.1003780. Epub 2011 Jun 20.
87 Opposing regulation of interleukin-8 and NF-kappaB responses by lipoxin A4 and serum amyloid A via the common lipoxin A receptor.Int J Immunopathol Pharmacol. 2004 May-Aug;17(2):145-56. doi: 10.1177/039463200401700206.
88 Gadd45beta deficiency in rheumatoid arthritis: enhanced synovitis through JNK signaling.Arthritis Rheum. 2009 Nov;60(11):3229-40. doi: 10.1002/art.24887.
89 Tyro3/Axl/Mertk-deficient mice develop bone marrow edema which is an early pathological marker in rheumatoid arthritis.PLoS One. 2018 Oct 18;13(10):e0205902. doi: 10.1371/journal.pone.0205902. eCollection 2018.
90 Induction of inducible nitric oxide synthase, argininosuccinate synthase, and GTP cyclohydrolase I in arthritic joints of human tumor necrosis factor-alpha transgenic mice.J Rheumatol. 2003 Apr;30(4):652-9.
91 Genomic characterization of remission in juvenile idiopathic arthritis.Arthritis Res Ther. 2013 Aug 30;15(4):R100. doi: 10.1186/ar4280.
92 Lipopolysaccharide increases the incidence of collagen-induced arthritis in mice through induction of protease HTRA-1 expression.Arthritis Rheum. 2013 Nov;65(11):2835-46. doi: 10.1002/art.38124.
93 Interferon-lambda1 induces peripheral blood mononuclear cell-derived chemokines secretion in patients with systemic lupus erythematosus: its correlation with disease activity.Arthritis Res Ther. 2011 Jun 16;13(3):R88. doi: 10.1186/ar3363.
94 IL-11 facilitates a novel connection between RA joint fibroblasts and endothelial cells.Angiogenesis. 2018 May;21(2):215-228. doi: 10.1007/s10456-017-9589-y. Epub 2018 Jan 11.
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103 Nonredundant roles for leukotriene B4 receptors BLT1 and BLT2 in inflammatory arthritis.J Immunol. 2010 Sep 1;185(5):3049-56. doi: 10.4049/jimmunol.1001031. Epub 2010 Jul 23.
104 Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice.Arthritis Res Ther. 2019 Dec 17;21(1):292. doi: 10.1186/s13075-019-2073-x.
105 Matrix metalloproteinase-10 is a target of T and B cell responses that correlate with synovial pathology in patients with antibiotic-refractory Lyme arthritis.J Autoimmun. 2016 May;69:24-37. doi: 10.1016/j.jaut.2016.02.005. Epub 2016 Feb 26.
106 Carbidopa, a drug in use for management of Parkinson disease inhibits T cell activation and autoimmunity.PLoS One. 2017 Sep 12;12(9):e0183484. doi: 10.1371/journal.pone.0183484. eCollection 2017.
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108 Nicotinamide phosphoribosyltransferase/visfatin expression by inflammatory monocytes mediates arthritis pathogenesis.Ann Rheum Dis. 2013 Oct;72(10):1717-24. doi: 10.1136/annrheumdis-2012-202403. Epub 2013 Jan 12.
109 Role of NOD1 polymorphism in susceptibility and clinical progression of rheumatoid arthritis.Rheumatology (Oxford). 2013 May;52(5):806-14. doi: 10.1093/rheumatology/kes404. Epub 2013 Jan 25.
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112 Induction of osteoclast-associated receptor, a key osteoclast costimulation molecule, in rheumatoid arthritis.Arthritis Rheum. 2008 Oct;58(10):3041-50. doi: 10.1002/art.23943.
113 Unique clinical and autoantibody profile of a large Asian Indian cohort of scleroderma-do South Asians have a more aggressive disease?.Clin Rheumatol. 2019 Nov;38(11):3179-3187. doi: 10.1007/s10067-019-04659-2. Epub 2019 Jul 15.
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133 Potential involvement of OX40 in the regulation of autoantibody sialylation in arthritis.Ann Rheum Dis. 2019 Nov;78(11):1488-1496. doi: 10.1136/annrheumdis-2019-215195. Epub 2019 Jul 12.
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137 Effects of Wiskott-Aldrich Syndrome Protein Deficiency on IL-10-Producing Regulatory B Cells in Humans and Mice.Scand J Immunol. 2015 Jun;81(6):483-93. doi: 10.1111/sji.12282.
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141 B-cell subsets in the joint compartments of seropositive and seronegative rheumatoid arthritis (RA) and No-RA arthritides express memory markers and ZAP70 and characterize the aggregate pattern irrespectively of the autoantibody status.Mol Med. 2011 Sep-Oct;17(9-10):901-9. doi: 10.2119/molmed.2011.00034. Epub 2011 May 13.
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144 Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis.J Exp Med. 2012 May 7;209(5):925-33. doi: 10.1084/jem.20112012. Epub 2012 Apr 9.
145 Temporal expression of growth factors triggered by epiregulin regulates inflammation development.J Immunol. 2015 Feb 1;194(3):1039-46. doi: 10.4049/jimmunol.1400562. Epub 2015 Jan 2.
146 Thrombin promotes matrix metalloproteinase-13 expression through the PKC c-Src/EGFR/PI3K/Akt/AP-1 signaling pathway in human chondrocytes.Mediators Inflamm. 2013;2013:326041. doi: 10.1155/2013/326041. Epub 2013 Dec 9.
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148 Differential expression of CD148 on leukocyte subsets in inflammatory arthritis.Arthritis Res Ther. 2013;15(5):R108. doi: 10.1186/ar4288.
149 Impairment of chemical hypoxia-induced sphingosine kinase-1 expression and activation in rheumatoid arthritis synovial fibroblasts: A signature of exhaustion?.Biochem Pharmacol. 2019 Jul;165:249-262. doi: 10.1016/j.bcp.2019.02.009. Epub 2019 Feb 10.
150 Ganglioside GM3 has an essential role in the pathogenesis and progression of rheumatoid arthritis.PLoS One. 2012;7(6):e40136. doi: 10.1371/journal.pone.0040136. Epub 2012 Jun 29.
151 RNA recognition by human TLR8 can lead to autoimmune inflammation.J Exp Med. 2013 Dec 16;210(13):2903-19. doi: 10.1084/jem.20131044. Epub 2013 Nov 25.
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154 ADAMTS-4 in central nervous system pathologies.J Neurosci Res. 2017 Sep;95(9):1703-1711. doi: 10.1002/jnr.24021. Epub 2017 Jan 13.
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157 Evaluation of ERAP1 gene single nucleotide polymorphisms in immunomodulation of pro-inflammatory and anti-inflammatory cytokines profile in ankylosing spondylitis.Immunol Lett. 2020 Jan;217:31-38. doi: 10.1016/j.imlet.2019.10.016. Epub 2019 Nov 9.
158 Targeting of tolerogenic dendritic cells to heat-shock proteins in inflammatory arthritis.J Transl Med. 2019 Nov 14;17(1):375. doi: 10.1186/s12967-019-2128-4.
159 Mesenchymal TNFR2 promotes the development of polyarthritis and comorbid heart valve stenosis.JCI Insight. 2018 Apr 5;3(7):e98864. doi: 10.1172/jci.insight.98864. eCollection 2018 Apr 5.
160 Atypical complement receptor C5aR2 transports C5a to initiate neutrophil adhesion and inflammation.Sci Immunol. 2019 May 10;4(35):eaav5951. doi: 10.1126/sciimmunol.aav5951.
161 Critical roles of TRPV2 channels, histamine H1 and adenosine A1 receptors in the initiation of acupoint signals for acupuncture analgesia.Sci Rep. 2018 Apr 25;8(1):6523. doi: 10.1038/s41598-018-24654-y.
162 Inhibition of spinal p38 MAPK prevents articular neutrophil infiltration in experimental arthritis via sympathetic activation.Fundam Clin Pharmacol. 2018 Apr;32(2):155-162. doi: 10.1111/fcp.12338. Epub 2017 Dec 22.
163 Enhancement of PLGF production by 15-(S)-HETE via PI3K-Akt, NF-B and COX-2 pathways in rheumatoid arthritis synovial fibroblast.Eur J Pharmacol. 2013 Aug 15;714(1-3):388-96. doi: 10.1016/j.ejphar.2013.07.010. Epub 2013 Jul 17.
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168 Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritis.Eur J Med Chem. 2018 Feb 10;145:96-112. doi: 10.1016/j.ejmech.2017.12.079. Epub 2017 Dec 28.
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179 Selective inhibition of the p38 MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals.J Exp Med. 2018 May 7;215(5):1315-1325. doi: 10.1084/jem.20172063. Epub 2018 Mar 16.
180 Mass spectrometry-based analysis of cerebrospinal fluid from arthritis patients-immune-related candidate proteins affected by TNF blocking treatment.Arthritis Res Ther. 2019 Feb 15;21(1):60. doi: 10.1186/s13075-019-1846-6.
181 -Caryophyllene Mitigates Collagen Antibody Induced Arthritis (CAIA) in Mice Through a Cross-Talk between CB2 and PPAR- Receptors.Biomolecules. 2019 Jul 31;9(8):326. doi: 10.3390/biom9080326.
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183 CSF-1 in Inflammatory and Arthritic Pain Development.J Immunol. 2018 Oct 1;201(7):2042-2053. doi: 10.4049/jimmunol.1800665. Epub 2018 Aug 17.
184 Therapeutic Targeting of the G-CSF Receptor Reduces Neutrophil Trafficking and Joint Inflammation in Antibody-Mediated Inflammatory Arthritis.J Immunol. 2016 Dec 1;197(11):4392-4402. doi: 10.4049/jimmunol.1600121. Epub 2016 Nov 2.
185 Design, synthesis and biological evaluation of inhibitors of cathepsin K on dedifferentiated chondrocytes.Bioorg Med Chem. 2019 Mar 15;27(6):1034-1042. doi: 10.1016/j.bmc.2019.02.003. Epub 2019 Feb 2.
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188 A novel NOX2 inhibitor attenuates human neutrophil oxidative stress and ameliorates inflammatory arthritis in mice.Redox Biol. 2019 Sep;26:101273. doi: 10.1016/j.redox.2019.101273. Epub 2019 Jul 10.
189 Osteogenic Dkk1 Mediates Glucocorticoid-Induced but Not Arthritis-Induced Bone Loss.J Bone Miner Res. 2019 Jul;34(7):1314-1323. doi: 10.1002/jbmr.3702. Epub 2019 Mar 7.
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476 Expression of host defense scavenger receptors in spondylarthropathy.Arthritis Rheum. 2001 Apr;44(4):931-9. doi: 10.1002/1529-0131(200104)44:4<931::AID-ANR150>3.0.CO;2-T.
477 Microglial pannexin-1 channel activation is a spinal determinant of joint pain.Sci Adv. 2018 Aug 8;4(8):eaas9846. doi: 10.1126/sciadv.aas9846. eCollection 2018 Aug.
478 Autoimmune arthritis induces paired immunoglobulin-like receptor B expression on CD4(+) Tcells from SKG mice.Eur J Immunol. 2017 Sep;47(9):1457-1467. doi: 10.1002/eji.201646747. Epub 2017 Jul 27.
479 PSTPIP2 attenuates joint damage and suppresses inflammation in adjuvant-induced arthritis.Eur J Pharmacol. 2019 Sep 15;859:172558. doi: 10.1016/j.ejphar.2019.172558. Epub 2019 Jul 17.
480 Regulator of Calcineurin 3 Ameliorates Autoimmune Arthritis by Suppressing Th17 Cell Differentiation.Am J Pathol. 2017 Sep;187(9):2034-2045. doi: 10.1016/j.ajpath.2017.05.008. Epub 2017 Jul 10.
481 Dysbiosis Contributes to Arthritis Development via Activation of Autoreactive T Cells in the Intestine.Arthritis Rheumatol. 2016 Nov;68(11):2646-2661. doi: 10.1002/art.39783.
482 Maresin 1 improves the Treg/Th17 imbalance in rheumatoid arthritis through miR-21.Ann Rheum Dis. 2018 Nov;77(11):1644-1652. doi: 10.1136/annrheumdis-2018-213511. Epub 2018 Jul 25.
483 Low vitamin D-modulated calcium-regulating proteins in psoriasis vulgaris plaques: S100A7 overexpression depends on joint involvement.Int J Mol Med. 2016 Oct;38(4):1083-92. doi: 10.3892/ijmm.2016.2718. Epub 2016 Aug 26.
484 Fingolimod treatment abrogates chikungunya virus-induced arthralgia.Sci Transl Med. 2017 Feb 1;9(375):eaal1333. doi: 10.1126/scitranslmed.aal1333.
485 Siglec-9 is upregulated in rheumatoid arthritis and suppresses collagen-induced arthritis through reciprocal regulation of Th17-/Treg-cell differentiation.Scand J Immunol. 2017 Jun;85(6):433-440. doi: 10.1111/sji.12543.
486 Preclinical Explorative Assessment of Celecoxib-Based Biocompatible Lipidic Nanocarriers for the Management of CFA-Induced Rheumatoid Arthritis in Wistar Rats.AAPS PharmSciTech. 2018 Oct;19(7):3187-3198. doi: 10.1208/s12249-018-1148-3. Epub 2018 Aug 24.
487 A pure polysaccharide from Ephedra sinica treating on arthritis and inhibiting cytokines expression.Int J Biol Macromol. 2016 May;86:177-88. doi: 10.1016/j.ijbiomac.2016.01.010. Epub 2016 Mar 17.
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