Details of Disease

General Information of Disease (ID: DIS920N0)

• Disease Name: Bacterial endocarditis
• Synonyms: bacterial endocarditis; Bacteria endocarditis (disease); Bacteria caused endocarditis (disease); bacterial endocarditis (disease)
• Definition: Endocarditis that is caused by an infection with a bacterial agent.
• Disease Hierarchy:
  DIS88NSA: Infective endocarditis
  DIS5QJ9S: Bacterial infection
  DISEM33Q: Infectious disease
  DIS920N0: Bacterial endocarditis
• Disease Identifiers:
  MONDO ID: MONDO_0006669
  MESH ID: D004697
  UMLS CUI: C0014121
  MedGen ID: 41779
  HPO ID: HP:0006689
  SNOMED CT ID: 301183007

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Ampicillin	DMHWE7P	Approved	Small molecular drug	[1]
Vancomycin	DM3JFIH	Approved	NA	[2]

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Benzylpenicillin	DMS9503	Phase 3	Small molecular drug	[3]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
AQP9	TTQEI32	Strong	Biomarker	[4]
MTM1	TTY2TCU	Strong	Biomarker	[5]

This Disease Is Related to 8 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CNMD	OTHND8EL	moderate	Biomarker	[6]
ARSD	OTAHW9M8	Strong	Biomarker	[7]
CYP4V2	OTQKNK0D	Strong	Biomarker	[8]
ITGA2B	OT4Y17PY	Strong	Biomarker	[9]
MANEA	OTV7L8I6	Strong	Biomarker	[10]
MCF2L2	OTOGFMIH	Strong	Biomarker	[11]
NLRP6	OTEREN4W	Strong	Biomarker	[12]
MAVS	OTTQ0J64	Definitive	Biomarker	[13]

References

• [1] Ampicillin FDA Label
• [2] Vancomycin FDA Label
• [3] Optimisation of the prevention and treatment of bacterial endocarditis. Drugs Aging. 2001;18(6):415-24.
• [4] The gene expression analysis of blood reveals S100A11 and AQP9 as potential biomarkers of infective endocarditis.PLoS One. 2012;7(2):e31490. doi: 10.1371/journal.pone.0031490. Epub 2012 Feb 3.
• [5] Multilocus sequence typing analysis of Streptococcus mutans strains with the cnm gene encoding collagen-binding adhesin.J Med Microbiol. 2011 Nov;60(Pt 11):1677-1684. doi: 10.1099/jmm.0.033415-0. Epub 2011 Jun 16.
• [6] Chondromodulin-1 in health, osteoarthritis, cancer, and heart disease.Cell Mol Life Sci. 2019 Nov;76(22):4493-4502. doi: 10.1007/s00018-019-03225-y. Epub 2019 Jul 17.
• [7] Infective endocarditis after device closure of atrial septal defects: Case report and review of the literature.Catheter Cardiovasc Interv. 2017 Feb 1;89(2):324-334. doi: 10.1002/ccd.26784. Epub 2016 Sep 19.
• [8] Use of a human-like low-grade bacteremia model of experimental endocarditis to study the role of Staphylococcus aureus adhesins and platelet aggregation in early endocarditis.Infect Immun. 2013 Mar;81(3):697-703. doi: 10.1128/IAI.01030-12. Epub 2012 Dec 17.
• [9] Multiple sites on Streptococcus gordonii surface protein PadA bind to platelet GPIIbIIIa.Thromb Haemost. 2013 Dec;110(6):1278-1287. doi: 10.1160/TH13-07-0580. Epub 2013 Oct 17.
• [10] Clinical presentation, aetiology and outcome of infective endocarditis. Results of the ESC-EORP EURO-ENDO (European infective endocarditis) registry: a prospective cohort study.Eur Heart J. 2019 Oct 14;40(39):3222-3232. doi: 10.1093/eurheartj/ehz620.
• [11] Increasing incidence of IV-drug use associated endocarditis in southern West Virginia and potential economic impact.Clin Cardiol. 2019 Apr;42(4):432-437. doi: 10.1002/clc.23162. Epub 2019 Mar 14.
• [12] Incidence and factors associated with infective endocarditis in patients undergoing left-sided heart valve replacement.Eur Heart J. 2018 Jul 21;39(28):2668-2675. doi: 10.1093/eurheartj/ehy153.
• [13] Heterogeneous vancomycin-intermediate susceptibility in a community-associated methicillin-resistant Staphylococcus aureus epidemic clone, in a case of Infective Endocarditis in Argentina.Ann Clin Microbiol Antimicrob. 2011 Apr 28;10:15. doi: 10.1186/1476-0711-10-15.