Details of Disease

General Information of Disease (ID: DIS9EABZ)

Disease Name	Smallpox
Synonyms	variola virus infection; smallpox virus infection; variola virus VAR infection; Variola; Variola virus caused disease or disorder; Variola virus infectious disease; ordinary smallpox; Variola virus disease or disorder
Disease Class	1E70: Smallpox
Definition	A condition that is caused by infection with Variola, and that is characterized by small, raised bumps.
Disease Hierarchy	DISDI77C: Primary viral infectious disease DISEM33Q: Infectious disease DIS9EABZ: Smallpox
ICD Code	ICD-11 ICD-11: 1E70 ICD-10 ICD-10: B03 Expand ICD-11 '1E70 Expand ICD-10 'B03
Disease Identifiers	MONDO ID MONDO_0004651 MESH ID D012899 UMLS CUI C0037354 MedGen ID 20785 SNOMED CT ID 67924001

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Imvamune smallpox vaccine	DMEJRZF	Approved	NA	[1]
Tecovirimat	DMW5ML9	Approved	NA	[2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
CYB5R3	DE4A3BL	Strong	Genetic Variation	[3]
DTYMK	DEOTVYU	Strong	Biomarker	[4]
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This Disease Is Related to 5 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
BLZF1	OT5QD8FG	Strong	Genetic Variation	[5]
DCAF7	OT3W5DYL	Strong	Biomarker	[6]
HDGFL2	OTWX2GHS	Strong	Genetic Variation	[7]
MKRN3	OTAFO4YR	Strong	Biomarker	[8]
SH3BP4	OTVIRKW7	Strong	Biomarker	[9]
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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Tecovirimat, a p37 envelope protein inhibitor for the treatment of smallpox infection.IDrugs. 2010 Mar;13(3):181-91. Review
3	Four-gene-combination DNA vaccine protects mice against a lethal vaccinia virus challenge and elicits appropriate antibody responses in nonhuman primates.Virology. 2003 Feb 1;306(1):181-95. doi: 10.1016/s0042-6822(02)00038-7.
4	Design of inhibitors of thymidylate kinase from Variola virus as new selective drugs against smallpox: part II.J Biomol Struct Dyn. 2019 Oct;37(17):4569-4579. doi: 10.1080/07391102.2018.1554510. Epub 2019 Jan 2.
5	Inhibition of type III interferon activity by orthopoxvirus immunomodulatory proteins.J Interferon Cytokine Res. 2010 Mar;30(3):123-34. doi: 10.1089/jir.2009.0049.
6	Controlling orthopoxvirus infections--200 years after Jenner's revolutionary immunization.Arch Immunol Ther Exp (Warsz). 1996;44(5-6):373-8.
7	Protection against lethal vaccinia virus challenge in HLA-A2 transgenic mice by immunization with a single CD8+ T-cell peptide epitope of vaccinia and variola viruses.J Virol. 2004 Jul;78(13):7052-60. doi: 10.1128/JVI.78.13.7052-7060.2004.
8	A novel imprinted gene, encoding a RING zinc-finger protein, and overlapping antisense transcript in the Prader-Willi syndrome critical region.Hum Mol Genet. 1999 May;8(5):783-93. doi: 10.1093/hmg/8.5.783.
9	MC159 of Molluscum Contagiosum Virus Suppresses Autophagy by Recruiting Cellular SH3BP4 via an SH3 Domain-Mediated Interaction.J Virol. 2019 May 1;93(10):e01613-18. doi: 10.1128/JVI.01613-18. Print 2019 May 15.