General Information of Disease (ID: DIS9JZ35)

Disease Name Chronic progressive multiple sclerosis
Definition
A form of multiple sclerosis characterized by a progressive deterioration in neurologic function which is in contrast to the more typical relapsing remitting form. If the clinical course is free of distinct remissions, it is referred to as primary progressive multiple sclerosis. When the progressive decline is punctuated by acute exacerbations, it is referred to as progressive relapsing multiple sclerosis. The term secondary progressive multiple sclerosis is used when relapsing remitting multiple sclerosis evolves into the chronic progressive form. (From Ann Neurol 1994;36 Suppl:S73-S79; Adams et al., Principles of Neurology, 6th ed, pp903-914)
Disease Hierarchy
DISB2WZI: Multiple sclerosis
DIS9JZ35: Chronic progressive multiple sclerosis
Disease Identifiers
MONDO ID
MONDO_0005284
MESH ID
D020528
UMLS CUI
C0393665
MedGen ID
140733
SNOMED CT ID
816984002

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 1 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
MX1 OT6X8G5T Definitive Altered Expression [1]
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References

1 MxA protein--an interferon beta biomarker in primary progressive multiple sclerosis patients.Eur J Neurol. 2008 Aug;15(8):822-6. doi: 10.1111/j.1468-1331.2008.02190.x. Epub 2008 Jun 28.