Details of Disease

Disease Name

Neonatal abstinence syndrome

neonatal withdrawal; NAS; neonatal narcotic withdrawal syndrome; drug withdrawal syndrome in newborn

Definition

A constellation of neurobehavioral features observed in a neonate following antenatal exposure to drugs including opioids, benzodiazepines, and selective serotonin reuptake inhibitors.

Disease Hierarchy

DISTT24U: Substance withdrawal syndrome

DIS9OO80: Neonatal abstinence syndrome

Disease Identifiers

MONDO ID

MONDO_0005566

MESH ID

D009357

UMLS CUI

C0027609

MedGen ID

10207

SNOMED CT ID

414819007

General Information of Disease (ID: DIS9OO80)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Clonidine	DM6RZ9Q	Approved	Small molecular drug	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
OPRM1	TTKWM86	Limited	Genetic Variation	[2]
OPRK1	TTQW87Y	Strong	Biomarker	[3]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
PNOC	OTJEAADN	Strong	Genetic Variation	[4]
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References

1	Clonidine FDA Label
2	The genetics and epigenetics of Neonatal Abstinence Syndrome.Semin Fetal Neonatal Med. 2019 Apr;24(2):105-110. doi: 10.1016/j.siny.2019.01.002. Epub 2019 Jan 25.
3	Expression of kappa opioid receptors in developing rat brain - Implications for perinatal buprenorphine exposure.Reprod Toxicol. 2018 Jun;78:81-89. doi: 10.1016/j.reprotox.2018.04.006. Epub 2018 Apr 7.
4	Association of maternal and infant variants in PNOC and COMT genes with neonatal abstinence syndrome severity.Am J Addict. 2017 Jan;26(1):42-49. doi: 10.1111/ajad.12483. Epub 2016 Dec 16.