Details of Disease

Disease Name

Fungal keratitis

Disease Hierarchy

DISN2KPA: Corneal infection

DIS0X16C: Fungal infection of eye

DISEM33Q: Infectious disease

DISA0XP5: Fungal keratitis

Disease Identifiers

MONDO ID

MONDO_0033821

UMLS CUI

C1262117

MedGen ID

687913

Orphanet ID

519930

SNOMED CT ID

314558005

General Information of Disease (ID: DISA0XP5)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Natamycin	DMFEHXD	Approved	Small molecular drug	[1]
------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CD209	TTBXIM9	Strong	Genetic Variation	[2]
------------------------------------------------------------------------------------

This Disease Is Related to 3 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CLEC4E	OT7P8ICY	Strong	Altered Expression	[3]
CLEC7A	OTRTBH27	Strong	Biomarker	[4]
HEYL	OTN7BH79	Strong	Biomarker	[5]
------------------------------------------------------------------------------------

References

1	Natamycin FDA Label
2	Association of Dectin-1 and DC-SIGN gene single nucleotide polymorphisms with fungal keratitis in the northern Han Chinese population.Mol Vis. 2015 Apr 10;21:391-402. eCollection 2015.
3	The role of Mincle in innate immune to fungal keratitis.J Infect Dev Ctries. 2017 Jan 30;11(1):89-97. doi: 10.3855/jidc.7570.
4	Fusarium solani Activates Dectin-1 in Experimentally Induced Keratomycosis.Curr Med Sci. 2018 Feb;38(1):153-159. doi: 10.1007/s11596-018-1859-4. Epub 2018 Mar 15.
5	Cellular morphological changes detected by laser scanning in vivo confocal microscopy associated with clinical outcome in fungal keratitis.Sci Rep. 2019 Jun 6;9(1):8334. doi: 10.1038/s41598-019-44833-9.