Details of Disease

General Information of Disease (ID: DISN2KPA)

Disease Name Corneal infection
Synonyms infective keratitis; keratitis caused by infection; infection of cornea; corneal infection
Definition A viral or bacterial infectious process affecting the cornea. Symptoms include pain and redness in the eye, photophobia and eye watering.
Disease Hierarchy
DISMFOEI: Keratitis
DISCQV4J: Endophthalmitis
DISEM33Q: Infectious disease
DISN2KPA: Corneal infection
Disease Identifiers
MONDO ID
MONDO_0023865
UMLS CUI
C0729777
MedGen ID
152673
Orphanet ID
519278
SNOMED CT ID
312428002

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 1 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
CHIA TTJB1O0 Definitive Biomarker [1]
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This Disease Is Related to 2 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
SIGIRR OTNC3XFD moderate Biomarker [2]
MXRA7 OTVQLYIY Strong Altered Expression [3]
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References

1 Aspergillus fumigatus corneal infection is regulated by chitin synthases and by neutrophil-derived acidic mammalian chitinase.Eur J Immunol. 2019 Jun;49(6):918-927. doi: 10.1002/eji.201847851. Epub 2019 May 14.
2 SIGIRR promotes resistance against Pseudomonas aeruginosa keratitis by down-regulating type-1 immunity and IL-1R1 and TLR4 signaling.J Immunol. 2006 Jul 1;177(1):548-56. doi: 10.4049/jimmunol.177.1.548.
3 Public data mining plus domestic experimental study defined involvement of the old-yet-uncharacterized gene matrix-remodeling associated 7 (MXRA7) in physiopathology of the eye.Gene. 2017 Oct 20;632:43-49. doi: 10.1016/j.gene.2017.08.018. Epub 2017 Aug 26.