Details of Disease

General Information of Disease (ID: DISAP666)

Disease Name	Genital herpes
Synonyms	herpes genitalis; herpes genitalia; venereal herpes; virus-genital herpes; genital herpes simplex
Disease Class	1F00: Herpes simplex infection
Definition	Herpes simplex infection of the genitals, most commonly caused by the herpes simplex-2 virus.
Disease Hierarchy	DIS8MTAV: Disease arising from reactivation of latent virus DIS7K18Z: Herpes simplex virus infection DISV767Z: Viral sexually transmitted disease DISAP666: Genital herpes
ICD Code	ICD-11 ICD-11: 1A94 ICD-10 ICD-10: A60, A60.9
Disease Identifiers	MONDO ID MONDO_0005770 MESH ID D006558 UMLS CUI C0019342 MedGen ID 42436 SNOMED CT ID 33839006

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Aciclovir	DMYLOVR	Approved	Small molecular drug	[1]
Valaciclovir	DMHKS94	Approved	Small molecular drug	[2]
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This Disease is Treated as An Indication in 3 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Simplirix	DMOORLD	Phase 3	NA	[3]
GSK3943104A	DM4FE8G	Phase 1	Vaccine	[4]
HSV2 DNA vaccine	DMO9O9F	Phase 1	NA	[5]
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This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
AG-702	DM5AYD3	Discontinued in Phase 1/2	NA	[6]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CTSA	TT5NILS	Strong	Biomarker	[7]
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This Disease Is Related to 3 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CTTNBP2	OT4CL1EW	Strong	Biomarker	[8]
CXCL17	OTRCEVIZ	Strong	Biomarker	[9]
GEN1	OT1XFQXF	Strong	Biomarker	[10]
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References

1	Genital herpes. BMJ Clin Evid. 2011 Apr 15;2011:1603.
2	Interventions for men and women with their first episode of genital herpes. Cochrane Database Syst Rev. 2016 Aug 30;2016(8):CD010684.
3	ClinicalTrials.gov (NCT00698568) Safety Evaluation of Herpes Simplex Candidate Vaccine (gD2t) With Adjuvant in HSV Seropositive / Seronegative Subjects. U.S. National Institutes of Health.
4	Clinical pipeline report, company report or official report of GlaxoSmithKline
5	ClinicalTrials.gov (NCT00274300) Safety Study of HSV2 DNA Vaccine to Treat Patients With Recurrent Genital Herpes Caused by HSV-2. U.S. National Institutes of Health.
6	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013746)
7	Mechanistic Studies of Viral Entry: An Overview of Dendrimer-Based Microbicides As Entry Inhibitors Against Both HIV and HSV-2 Overlapped Infections.Med Res Rev. 2017 Jan;37(1):149-179. doi: 10.1002/med.21405. Epub 2016 Aug 12.
8	Granzyme B Cleaves Multiple Herpes Simplex Virus 1 and Varicella-Zoster Virus (VZV) Gene Products, and VZV ORF4 Inhibits Natural Killer Cell Cytotoxicity.J Virol. 2019 Oct 29;93(22):e01140-19. doi: 10.1128/JVI.01140-19. Print 2019 Nov 15.
9	CXCL17 Chemokine-Dependent Mobilization of CXCR8(+)CD8(+) Effector Memory and Tissue-Resident Memory T Cells in the Vaginal Mucosa Is Associated with Protection against Genital Herpes.J Immunol. 2018 Apr 15;200(8):2915-2926. doi: 10.4049/jimmunol.1701474. Epub 2018 Mar 16.
10	Therapeutic Vaccine for Genital Herpes Simplex Virus-2 Infection: Findings From a Randomized Trial.J Infect Dis. 2017 Mar 15;215(6):856-864. doi: 10.1093/infdis/jix004.