Details of Disease

General Information of Disease (ID: DISC5STS)

Disease Name	Herpes simplex labialis
Synonyms	fever blisters; blister, fever; Sore, cold; Sores, cold; herpes simplex labialis; labial Herpes simplex; Herpes simplex, labial; fever blister; blisters, fever; herpes labialis; cold sores; cold sore
Disease Class	1F00: Herpes simplex infection
Definition	A lesion caused by type 1 or type 2 herpes simplex virus, typically involving the oralfacial region.
Disease Hierarchy	DISV6DMU: Lip disorder DIS8MTAV: Disease arising from reactivation of latent virus DIS7K18Z: Herpes simplex virus infection DISC5STS: Herpes simplex labialis
ICD Code	ICD-11 ICD-11: 1F00.01 ICD-10 ICD-10: B00.8 Expand ICD-11 '1F00.01 Expand ICD-10 'B00.8
Disease Identifiers	MONDO ID MONDO_0043653 MESH ID D006560 UMLS CUI C0019345 MedGen ID 5533 SNOMED CT ID 1475003

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 3 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Aciclovir	DMYLOVR	Approved	Small molecular drug	[1]
Penciclovir	DMOUMDV	Approved	Small molecular drug	[2]
Valaciclovir	DMHKS94	Approved	Small molecular drug	[1]
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This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
BTL-TML-001	DMY5IX4	Phase 2	NA	[3]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ACKR1	TTKY2NS	moderate	Biomarker	[4]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
C21orf91	OTERV7NW	moderate	Genetic Variation	[5]
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References

1	Interventions for prevention of herpes simplex labialis (cold sores on the lips). Cochrane Database Syst Rev. 2015 Aug 7;2015(8):CD010095.
2	Penciclovir FDA Label
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Monoclonal Antibodies, Derived from Humans Vaccinated with the RV144 HIV Vaccine Containing the HVEM Binding Domain of Herpes Simplex Virus (HSV) Glycoprotein D, Neutralize HSV Infection, Mediate Antibody-Dependent Cellular Cytotoxicity, and Protect Mice from Ocular Challenge with HSV-1.J Virol. 2017 Sep 12;91(19):e00411-17. doi: 10.1128/JVI.00411-17. Print 2017 Oct 1.
5	C21orf91 genotypes correlate with herpes simplex labialis (cold sore) frequency: description of a cold sore susceptibility gene.J Infect Dis. 2011 Dec 1;204(11):1654-62. doi: 10.1093/infdis/jir633.