Details of Disease

General Information of Disease (ID: DISFCQTG)

Disease Name Migraine disorder
Synonyms migraine disorder; migraine headache; migraine; migraine variant; migraine with or without aura
Definition A common, severe type of vascular headache often associated with increased sympathetic activity, resulting in nausea, vomiting, and light sensitivity.
Disease Hierarchy
DIS1GZDX: Neurovascular disorder
DISL7JK0: Hypnic headache
DIS6ZC3X: Brain disease
DISFCQTG: Migraine disorder
Disease Identifiers
MONDO ID
MONDO_0005277
MESH ID
D008881
UMLS CUI
C0149931
MedGen ID
57451
HPO ID
HP:0002076
SNOMED CT ID
37796009

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 11 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Acetaminophen DMUIE76 Approved Small molecular drug [1]
Aspirin DM672AH Approved Small molecular drug [2]
Caffeine DMKBJWP Approved Small molecular drug [3]
Dihydroergotamine DM5IKUF Approved Small molecular drug [4]
Ergotamine DMKR3C5 Approved Small molecular drug [5]
Lisuride DMCME17 Approved Small molecular drug [6]
Naproxen DMZ5RGV Approved Small molecular drug [7]
Naratriptan DMO50U2 Approved Small molecular drug [8]
Phenobarbital DMXZOCG Approved Small molecular drug [9]
Salicyclic acid DM2F8XZ Approved Small molecular drug [10]
Sumatriptan DMVYXR8 Approved Small molecular drug [11]
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⏷ Show the Full List of 11 Drug(s)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 64 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
AOC1 TTM3B5R Limited Genetic Variation [12]
ASIC1 TTRJYB6 Limited Biomarker [13]
AVP TTJ8EWH Limited Biomarker [14]
CA14 TTEYTKG Limited Genetic Variation [15]
CYSLTR1 TTGKOY9 Limited Altered Expression [16]
DCLK3 TTMYK4Z Limited Biomarker [17]
DRD5 TTS2PH3 Limited Genetic Variation [18]
F11 TTDM4ZU Limited Biomarker [19]
GABRQ TTXDUR9 Limited Genetic Variation [20]
GABRR2 TTQMXLS Limited Genetic Variation [21]
GABRR3 TT4N6D8 Limited Genetic Variation [21]
GUCY2D TTWNFC2 Limited Biomarker [22]
HCRT TTU5HJP Limited Biomarker [23]
HRH3 TT9JNIC Limited Genetic Variation [24]
HTR5A TTRUFDT Limited Genetic Variation [25]
LRP1 TTF2V7I Limited Genetic Variation [26]
MAPKAP1 TTWDKCL Limited Altered Expression [27]
RHAG TTVHFE8 Limited Genetic Variation [28]
SLCO1A2 TTUGD21 Limited Biomarker [29]
TPH1 TTZSJHV Limited Genetic Variation [30]
VIPR2 TT4O5P0 Limited Biomarker [31]
CES1 TTMF541 Disputed Biomarker [32]
ADCYAP1 TTW4LYC Strong Biomarker [33]
ADCYAP1R1 TT5OREU Strong Biomarker [34]
ASIC3 TTLGDIS Strong Biomarker [35]
BACE1 TTJUNZF Strong Genetic Variation [36]
CACNA1E TTYRP0M Strong Genetic Variation [37]
CALCRL TTY6O0Q Strong Biomarker [38]
CSNK1D TTH30UI Strong Altered Expression [39]
DAO TT7Y3EJ Strong Altered Expression [40]
F5 TT1O264 Strong Genetic Variation [41]
FSHR TTZFDBT Strong Genetic Variation [42]
GABRA3 TT37EDJ Strong Genetic Variation [43]
GABRG2 TT06RH5 Strong Genetic Variation [44]
GNAO1 TTAXD8Z Strong Genetic Variation [45]
GRIN2B TTN9D8E Strong Biomarker [46]
HCRTR1 TT60Q8D Strong Genetic Variation [47]
HLA-DQB2 TTL7VOU Strong Genetic Variation [45]
HTR1D TT6MSOK Strong Biomarker [48]
HTR1F TT0MI3F Strong Biomarker [49]
HTR7 TTO9X1H Strong Altered Expression [50]
IAPP TTHN8EM Strong Biomarker [51]
KCNK18 TTHT87J Strong Biomarker [52]
KCNN3 TT9JH25 Strong Biomarker [53]
MGLL TTZ963I Strong Biomarker [54]
MMP17 TTVSZKN Strong Genetic Variation [55]
NMUR2 TT2L6C5 Strong Genetic Variation [56]
NRP1 TTIPJCB Strong Genetic Variation [57]
P2RX7 TT473XN Strong Altered Expression [58]
PGR TTUV8G9 Strong Genetic Variation [59]
PRKG1 TT7IZSA Strong Genetic Variation [60]
S100A12 TTQ4ESF Strong Biomarker [61]
SCN1A TTANOZH Strong Genetic Variation [62]
TPH2 TT3KLDP Strong Genetic Variation [63]
TRPA1 TTELV3W Strong Biomarker [64]
TRPV1 TTMI6F5 Strong Biomarker [65]
TRPV3 TT946IA Strong Genetic Variation [66]
TYRP1 TTFRV98 Strong Altered Expression [67]
UTS2 TTERU0T Strong Genetic Variation [68]
VIP TTGTWLF Strong Biomarker [69]
YAP1 TT8UN2D Strong Genetic Variation [70]
MTDH TTH6SA5 Definitive Biomarker [71]
OPA1 TTTU49Q Definitive Biomarker [72]
SLC1A3 TT8WRDA Definitive Biomarker [73]
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⏷ Show the Full List of 64 DTT(s)
This Disease Is Related to 4 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC24A3 DTO18LP Limited Genetic Variation [74]
SLC4A4 DTWDEIL Limited Altered Expression [75]
KCNK2 DTENHUP Strong Biomarker [76]
SLC20A2 DTFD4VB Strong Genetic Variation [77]
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This Disease Is Related to 1 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
FAAH DEUM1EX Strong Biomarker [78]
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This Disease Is Related to 71 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ACSL5 OT3L9XO3 Limited Genetic Variation [79]
ADARB1 OTGKSZEV Limited Genetic Variation [80]
AK3 OTM59ZGG Limited Biomarker [81]
ANKK1 OT0OM1O0 Limited Genetic Variation [82]
BAZ1B OTD5KR2J Limited Genetic Variation [74]
CARF OTWE0T6Q Limited Genetic Variation [74]
CFDP1 OTXY7J96 Limited Genetic Variation [74]
CLTA OTLHOXMQ Limited Biomarker [22]
EFHC1 OTS9IBNE Limited Biomarker [28]
ESD OTUSIBPS Limited Genetic Variation [83]
FMR1 OTWEV0T5 Limited Genetic Variation [84]
INPP5A OT9CMGMS Limited Genetic Variation [74]
KCNK5 OT68V64E Limited Genetic Variation [74]
MOCOS OT0TL3Q5 Limited Biomarker [85]
PLCE1 OTJISZOX Limited Genetic Variation [74]
PTCRA OTQTO5QZ Limited Biomarker [19]
RNASE2 OT8Z4FNE Limited Genetic Variation [86]
RNF213 OT4OVE9O Limited Genetic Variation [74]
RPTOR OT4TQZ9F Limited Altered Expression [27]
SMCP OTXKY794 Limited Biomarker [85]
STATH OTQHBHM9 Limited Genetic Variation [87]
TNPO1 OT7W2CM8 Limited Altered Expression [27]
TRAF3IP2 OTLLZERL Limited Biomarker [88]
ADRM1 OTOU4EY6 Disputed Biomarker [89]
AMELX OTIN26MM Disputed Biomarker [90]
IMPACT OTQ923OB Disputed Biomarker [91]
KCNK10 OT93GC7V Disputed Biomarker [92]
MMD OTB5I4OC Disputed Biomarker [93]
OLAH OTZVRM40 Disputed Genetic Variation [49]
OPN1MW OTPJ7LX4 Disputed Biomarker [94]
OR2AG1 OTEITRP4 Disputed Biomarker [95]
PNOC OTJEAADN Disputed Altered Expression [96]
ASTN2 OTF0W2FJ Strong Biomarker [97]
CHMP1B OTP715L8 Strong Genetic Variation [98]
CLVS1 OTQH008A Strong Genetic Variation [60]
CNNM2 OTZHO8WU Strong Genetic Variation [60]
COL4A1 OTL6D1YE Strong Biomarker [99]
CSAD OT3I2G0A Strong Biomarker [100]
DCLRE1C OTW3KB1I Strong Genetic Variation [60]
DUSP2 OTH54FMR Strong Biomarker [34]
FBN2 OT3KYJQL Strong Genetic Variation [60]
HAUS1 OTBML7XD Strong Genetic Variation [60]
HEPH OTZ2F15Z Strong Biomarker [101]
HJURP OTWMV16B Strong Genetic Variation [70]
HPSE2 OTGEPP8V Strong Genetic Variation [70]
KLF6 OTQY9S7F Strong Biomarker [34]
LEPROTL1 OTJ7VJTX Strong Genetic Variation [60]
MARCHF4 OTK43VNA Strong Genetic Variation [55]
MEIS1 OTH9DKAD Strong Genetic Variation [102]
MFN1 OTCBXQZF Strong Biomarker [103]
MPPED2 OT7XLMJ6 Strong Genetic Variation [70]
MRPL37 OTVD0REO Strong Genetic Variation [60]
MTHFD1 OTMKHVWC Strong Genetic Variation [104]
MZB1 OT071TET Strong Biomarker [34]
NEDD4L OT1B19RU Strong Genetic Variation [60]
OPN4 OT1LZ7TS Strong Biomarker [105]
PANX1 OTXPEDOK Strong Biomarker [106]
PHACTR1 OTAMPX9V Strong Genetic Variation [107]
PSMG1 OTZ5I6UM Strong Biomarker [34]
PTX3 OTPXHRKU Strong Altered Expression [108]
RABGAP1L OT7QO47I Strong Genetic Variation [60]
SPAST OTIF3AJI Strong Genetic Variation [109]
SPRTN OT01D5CE Strong Biomarker [110]
SPTAN1 OT6VY3A3 Strong Biomarker [111]
STX1A OTSBUZB4 Strong Biomarker [112]
SUV39H2 OTU0F4LL Strong Genetic Variation [60]
TBPL1 OT4I143E Strong Altered Expression [67]
TREX1 OTQG7K12 Strong Genetic Variation [113]
TSPAN33 OTH6C0WU Strong Genetic Variation [114]
COX2 OTTMVBJJ Definitive Genetic Variation [115]
POLG OTDUCT04 Definitive Genetic Variation [116]
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⏷ Show the Full List of 71 DOT(s)

References

1 Acetaminophen FDA Label
2 Aspirin FDA Label
3 Caffeine FDA Label
4 Dihydroergotamine FDA Label
5 Ergotamine FDA Label
6 Is the 5-HT(7) receptor involved in the pathogenesis and prophylactic treatment of migraine?. Eur J Pharmacol. 2002 Mar 29;439(1-3):1-11.
7 Naproxen FDA Label
8 Naratriptan FDA Label
9 Phenobarbital FDA Label
10 A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
11 Sumatriptan FDA Label
12 Diamine oxidasers10156191 and rs2052129 variants are associated with the risk for migraine.Headache. 2015 Feb;55(2):276-86. doi: 10.1111/head.12493. Epub 2015 Jan 22.
13 Effects of systemic inhibitors of acid-sensing ion channels 1 (ASIC1) against acute and chronic mechanical allodynia in a rodent model of migraine.Br J Pharmacol. 2018 Nov;175(21):4154-4166. doi: 10.1111/bph.14462. Epub 2018 Sep 22.
14 Intranasal Vasopressin Relieves Orthopedic Pain AfterSurgery.Pain Manag Nurs. 2019 Apr;20(2):126-132. doi: 10.1016/j.pmn.2018.06.001. Epub 2018 Aug 3.
15 Specific matrix metalloproteinase 9 (MMP-9) haplotype affect the circulating MMP-9 levels in women with migraine.J Neuroimmunol. 2012 Nov 15;252(1-2):89-94. doi: 10.1016/j.jneuroim.2012.07.016. Epub 2012 Aug 17.
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22 A genome-wide linkage scan provides evidence for both new and previously reported loci influencing common migraine.Am J Med Genet B Neuropsychiatr Genet. 2008 Oct 5;147B(7):1186-95. doi: 10.1002/ajmg.b.30749.
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24 A280V polymorphism in the histamine H3 receptor as a risk factor for migraine.Arch Med Res. 2011 Jan;42(1):44-7. doi: 10.1016/j.arcmed.2011.01.009.
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27 Increased Serum CD14 Level Is Associated with Depletion of TNF- in Monocytes in Migraine Patients during Interictal Period.Int J Mol Sci. 2017 Feb 13;18(2):398. doi: 10.3390/ijms18020398.
28 Exclusion of the juvenile myoclonic epilepsy gene EFHC1 as the cause of migraine on chromosome 6, but association to two rare polymorphisms in MEP1A and RHAG.Neurosci Lett. 2006 Mar 27;396(2):137-42. doi: 10.1016/j.neulet.2005.11.039. Epub 2005 Dec 27.
29 Hydrophilic anti-migraine triptans are substrates for OATP1A2, a transporter expressed at human blood-brain barrier.Xenobiotica. 2012 Sep;42(9):880-90. doi: 10.3109/00498254.2012.675455. Epub 2012 Apr 18.
30 The A218C polymorphism of tryptophan hydroxylase gene and migraine.J Clin Neurosci. 2007 Mar;14(3):249-51. doi: 10.1016/j.jocn.2006.04.018. Epub 2006 Dec 27.
31 Pharmacological characterization of VIP and PACAP receptors in the human meningeal and coronary artery.Cephalalgia. 2011 Jan;31(2):181-9. doi: 10.1177/0333102410375624. Epub 2010 Jul 5.
32 Enhancing migraine self-efficacy and reducing disability through a self-management program.J Am Assoc Nurse Pract. 2019 Nov 13;33(1):20-28. doi: 10.1097/JXX.0000000000000323.
33 PACAP27 induces migraine-like attacks in migraine patients.Cephalalgia. 2020 Jan;40(1):57-67. doi: 10.1177/0333102419864507. Epub 2019 Jul 12.
34 Dynamic changes in CGRP, PACAP, and PACAP receptors in the trigeminovascular system of a novel repetitive electrical stimulation rat model: Relevant to migraine.Mol Pain. 2019 Jan-Dec;15:1744806918820452. doi: 10.1177/1744806918820452.
35 Inhibition of Nerve Growth Factor Signaling Alleviates Repeated Dural Stimulation-induced Hyperalgesia in Rats.Neuroscience. 2019 Feb 1;398:252-262. doi: 10.1016/j.neuroscience.2018.12.006. Epub 2018 Dec 14.
36 Genetic determinants of cardiovascular events among women with migraine: a genome-wide association study.PLoS One. 2011;6(7):e22106. doi: 10.1371/journal.pone.0022106. Epub 2011 Jul 14.
37 Possible Involvement of the CACNA1E Gene in Migraine: A Search for Single Nucleotide Polymorphism in Different Clinical Phenotypes.Headache. 2017 Jul;57(7):1136-1144. doi: 10.1111/head.13107. Epub 2017 Jun 1.
38 Distribution of CGRP and CGRP receptor components in the rat brain.Cephalalgia. 2019 Mar;39(3):342-353. doi: 10.1177/0333102417728873. Epub 2017 Aug 31.
39 Casein kinase i mutations in familial migraine and advanced sleep phase.Sci Transl Med. 2013 May 1;5(183):183ra56, 1-11. doi: 10.1126/scitranslmed.3005784.
40 Diamine oxidase (DAO) supplement reduces headache in episodic migraine patients with DAO deficiency: A randomized double-blind trial.Clin Nutr. 2019 Feb;38(1):152-158. doi: 10.1016/j.clnu.2018.01.013. Epub 2018 Feb 15.
41 Hypercoagulability and Migraine.Headache. 2018 Jan;58(1):173-183. doi: 10.1111/head.13044. Epub 2017 Feb 9.
42 Multilocus analyses reveal involvement of the ESR1, ESR2, and FSHR genes in migraine.Headache. 2008 Nov-Dec;48(10):1438-50. doi: 10.1111/j.1526-4610.2008.01294.x.
43 Interaction between -aminobutyric acid A receptor genes: new evidence in migraine susceptibility.PLoS One. 2013 Sep 5;8(9):e74087. doi: 10.1371/journal.pone.0074087. eCollection 2013.
44 Investigation of the role of the GABRG2 gene variant in migraine.J Neurol Sci. 2012 Jul 15;318(1-2):112-4. doi: 10.1016/j.jns.2012.03.014. Epub 2012 May 7.
45 Prevalence of HLA DQB1*0602 allele in patients with migraine.Arq Neuropsiquiatr. 2007 Dec;65(4B):1123-5. doi: 10.1590/s0004-282x2007000700005.
46 Role of glutamate and its receptors in migraine with reference to amitriptyline and transcranial magnetic stimulation therapy.Brain Res. 2018 Oct 1;1696:31-37. doi: 10.1016/j.brainres.2018.05.046. Epub 2018 May 31.
47 Orexin/hypocretin receptor gene (HCRTR1) variation is associated with aggressive behaviour.Neuropharmacology. 2019 Sep 15;156:107527. doi: 10.1016/j.neuropharm.2019.02.009. Epub 2019 Feb 10.
48 The Role of 5-Hydroxytryptamine in the Pathophysiology of Migraine and its Relevance to the Design of Novel Treatments.Mini Rev Med Chem. 2017;17(11):928-938. doi: 10.2174/1389557516666160728121050.
49 Phase 3 randomized, placebo-controlled, double-blind study of lasmiditan for acute treatment of migraine.Brain. 2019 Jul 1;142(7):1894-1904. doi: 10.1093/brain/awz134.
50 Liver 5-HT7 receptors: A novel regulator target of fibrosis and inflammation-induced chronic liver injury in vivo and in vitro.Int Immunopharmacol. 2017 Feb;43:227-235. doi: 10.1016/j.intimp.2016.12.023. Epub 2016 Dec 30.
51 CGRP and its receptors.Headache. 2017 Apr;57(4):625-636. doi: 10.1111/head.13064. Epub 2017 Feb 24.
52 Chemically Modified Derivatives of the Activator Compound Cloxyquin Exert Inhibitory Effect on TRESK (K(2P)18.1) Background Potassium Channel.Mol Pharmacol. 2019 Jun;95(6):652-660. doi: 10.1124/mol.118.115626. Epub 2019 Apr 12.
53 Variants in the human potassium channel gene (KCNN3) are associated with migraine in a high risk genetic isolate.J Headache Pain. 2011 Dec;12(6):603-8. doi: 10.1007/s10194-011-0392-7. Epub 2011 Oct 22.
54 Inhibition of monoacylglycerol lipase: Another signalling pathway for potential therapeutic targets in migraine?.Cephalalgia. 2018 May;38(6):1138-1147. doi: 10.1177/0333102417727537. Epub 2017 Aug 17.
55 Genome-wide association analysis identifies susceptibility loci for migraine without aura.Nat Genet. 2012 Jun 10;44(7):777-82. doi: 10.1038/ng.2307.
56 Common variants at 5q33.1 predispose to migraine in African-American children.J Med Genet. 2018 Dec;55(12):831-836. doi: 10.1136/jmedgenet-2018-105359. Epub 2018 Sep 28.
57 The NRP1 migraine risk variant shows evidence of association with menstrual migraine.J Headache Pain. 2018 Apr 18;19(1):31. doi: 10.1186/s10194-018-0857-z.
58 Activation of P2X7 Receptors in Peritoneal and Meningeal Mast Cells Detected by Uptake of Organic Dyes: Possible Purinergic Triggers of Neuroinflammation in Meninges.Front Cell Neurosci. 2019 Feb 13;13:45. doi: 10.3389/fncel.2019.00045. eCollection 2019.
59 Progesterone receptor gene (PROGINS) polymorphism correlates with late onset of migraine.DNA Cell Biol. 2015 Mar;34(3):208-12. doi: 10.1089/dna.2014.2534. Epub 2014 Dec 10.
60 Genome-wide meta-analysis identifies new susceptibility loci for migraine.Nat Genet. 2013 Aug;45(8):912-917. doi: 10.1038/ng.2676. Epub 2013 Jun 23.
61 Problematic presentation and use of efficacy measures in current trials of CGRP monoclonal antibodies for episodic migraine prevention: A mini-review.Cephalalgia. 2020 Jan;40(1):122-126. doi: 10.1177/0333102419877663. Epub 2019 Sep 23.
62 Gain of function of sporadic/familial hemiplegic migraine-causing SCN1A mutations: Use of an optimized cDNA.Cephalalgia. 2019 Apr;39(4):477-488. doi: 10.1177/0333102418788336. Epub 2018 Jul 9.
63 Genetic TPH2 variants and the susceptibility for migraine: association of a TPH2 haplotype with migraine without aura.J Neural Transm (Vienna). 2010 Nov;117(11):1253-60. doi: 10.1007/s00702-010-0468-6. Epub 2010 Aug 26.
64 ROS/TRPA1/CGRP signaling mediates cortical spreading depression.J Headache Pain. 2019 Mar 6;20(1):25. doi: 10.1186/s10194-019-0978-z.
65 Ghrelin attenuated hyperalgesia induced by chronic nitroglycerin: CGRP and TRPV1 as targets for migraine management.Cephalalgia. 2018 Oct;38(11):1716-1730. doi: 10.1177/0333102417748563. Epub 2017 Dec 13.
66 SNP variants within the vanilloid TRPV1 and TRPV3 receptor genes are associated with migraine in the Spanish population.Am J Med Genet B Neuropsychiatr Genet. 2012 Jan;159B(1):94-103. doi: 10.1002/ajmg.b.32007. Epub 2011 Dec 7.
67 TRP Channels as Potential Targets for Sex-Related Differences in Migraine Pain.Front Mol Biosci. 2018 Aug 14;5:73. doi: 10.3389/fmolb.2018.00073. eCollection 2018.
68 Lack of association between urotensin-II (UTS2) gene polymorphisms (Thr21Met and Ser89Asn) and migraine.Bosn J Basic Med Sci. 2017 Aug 20;17(3):268-273. doi: 10.17305/bjbms.2017.2138.
69 PACAP and migraine headache: immunomodulation of neural circuits in autonomic ganglia and brain parenchyma.J Headache Pain. 2018 Mar 13;19(1):23. doi: 10.1186/s10194-018-0850-6.
70 Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.Nat Genet. 2016 Aug;48(8):856-66. doi: 10.1038/ng.3598. Epub 2016 Jun 20.
71 Astrocyte elevated gene-1 induces autophagy in diabetic cardiomyopathy through upregulation of KLF4.J Cell Biochem. 2019 Jun;120(6):9709-9715. doi: 10.1002/jcb.28249. Epub 2018 Dec 5.
72 The effects of repeated nitroglycerin administrations in rats; modeling migraine-related endpoints and chronification.J Neurosci Methods. 2017 Jun 1;284:63-70. doi: 10.1016/j.jneumeth.2017.04.010. Epub 2017 Apr 23.
73 Impaired K(+) binding to glial glutamate transporter EAAT1 in migraine.Sci Rep. 2017 Oct 24;7(1):13913. doi: 10.1038/s41598-017-14176-4.
74 Detection and interpretation of shared genetic influences on 42 human traits.Nat Genet. 2016 Jul;48(7):709-17. doi: 10.1038/ng.3570. Epub 2016 May 16.
75 Defective membrane expression of the Na(+)-HCO(3)(-) cotransporter NBCe1 is associated with familial migraine.Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15963-8. doi: 10.1073/pnas.1008705107. Epub 2010 Aug 23.
76 A TREK to Translate Genetics to Mechanisms of Migraine.Neuron. 2019 Jan 16;101(2):193-195. doi: 10.1016/j.neuron.2018.12.034.
77 First report of a de novo mutation at SLC20A2 in a patient with brain calcification.J Mol Neurosci. 2014 Dec;54(4):748-51. doi: 10.1007/s12031-014-0357-9. Epub 2014 Jun 27.
78 FAAH inhibition as a preventive treatment for migraine: A pre-clinical study.Neurobiol Dis. 2020 Feb;134:104624. doi: 10.1016/j.nbd.2019.104624. Epub 2019 Oct 17.
79 A splice variant in the ACSL5 gene relates migraine with fatty acid activation in mitochondria.Eur J Hum Genet. 2016 Nov;24(11):1572-1577. doi: 10.1038/ejhg.2016.54. Epub 2016 May 18.
80 Case-control study of ADARB1 and ADARB2 gene variants in migraine.J Headache Pain. 2015;16:511. doi: 10.1186/s10194-015-0511-y. Epub 2015 Apr 3.
81 Thrombophilic gene mutations in children with migraine.Hematology. 2012 Mar;17(2):115-7. doi: 10.1179/102453312X13221316478010.
82 Identification of a novel ANKK1 and other dopaminergic (DRD2 and DBH) gene variants in migraine susceptibility.Neuromolecular Med. 2013 Mar;15(1):61-73. doi: 10.1007/s12017-012-8195-9. Epub 2012 Aug 9.
83 Genetic markers: association study in migraine.Cephalalgia. 1995 Jun;15(3):200-4. doi: 10.1046/j.1468-2982.1995.015003200.x.
84 Fragile X syndrome: An overview and update of the FMR1 gene.Clin Genet. 2018 Feb;93(2):197-205. doi: 10.1111/cge.13075. Epub 2017 Oct 1.
85 Patients' perspective on the burden of migraine in Europe: a cross-sectional analysis of survey data in France, Germany, Italy, Spain, and the United Kingdom.J Headache Pain. 2018 Sep 10;19(1):82. doi: 10.1186/s10194-018-0907-6.
86 Relation of candidate genes that encode for endothelial function to migraine and stroke: the Stroke Prevention in Young Women study.Stroke. 2009 Oct;40(10):e550-7. doi: 10.1161/STROKEAHA.109.557462. Epub 2009 Aug 6.
87 Association between migraine and a functional polymorphism at the dopamine beta-hydroxylase locus.Neurogenetics. 2009 Jul;10(3):199-208. doi: 10.1007/s10048-009-0176-2. Epub 2009 Feb 14.
88 Spotlight on cervical vagus nerve stimulation for the treatment of primary headache disorders: a review.J Pain Res. 2018 Aug 27;11:1613-1625. doi: 10.2147/JPR.S129202. eCollection 2018.
89 Bidirectional association between migraine and fibromyalgia: retrospective cohort analyses of two populations.BMJ Open. 2019 Apr 8;9(4):e026581. doi: 10.1136/bmjopen-2018-026581.
90 Erenumab (AMG 334), a monoclonal antagonist antibody against the canonical CGRP receptor, does not impair vasodilatory or contractile responses to other vasoactive agents in human isolated cranial arteries.Cephalalgia. 2019 Dec;39(14):1745-1752. doi: 10.1177/0333102419867282. Epub 2019 Jul 31.
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