Details of Disease | DrugMAP

General Information of Disease (ID: DISE73OD)

Disease Name	Hypotrichosis simplex of the scalp
Synonyms	hereditary hypotrichosis simplex of the scalp
Definition	Hypotrichosis simplex of the scalp (HSS) is characterized by diffuse progressive hair loss that is confined to the scalp.
Disease Hierarchy	DIS37HU4: Alopecia DISE73OD: Hypotrichosis simplex of the scalp

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CDSN	OTQW4HV6	Supportive	Autosomal dominant	[1]
KRT74	OT9MEIJ1	Supportive	Autosomal dominant	[2]
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References

1	Hypotrichosis simplex of the scalp is associated with nonsense mutations in CDSN encoding corneodesmosin. Nat Genet. 2003 Jun;34(2):151-3. doi: 10.1038/ng1163.
2	Novel mutations in the keratin-74 (KRT74) gene underlie autosomal dominant woolly hair/hypotrichosis in Pakistani families. Hum Genet. 2011 Apr;129(4):419-24. doi: 10.1007/s00439-010-0938-9. Epub 2010 Dec 28.