Details of Disease

Disease Name

Complex regional pain syndrome type 1

Algodystrophy; CRPS I; reflex sympathetic dystrophy syndrome; reflex sympathetic dystrophy; RND; complex regional pain syndrome type 1; reflex neurovascular dystrophy; RSDS; Complex regional pain syndrome I; CRPS1

Definition

Complex regional pain syndrome type 1 (CRPS1) is a form of complex regional pain syndrome in which the pain is disproportionate to any known inciting event and is characterized by continuous pain, allodynia, or hyperalgesia as well as edema, coloration (changes in skin blood flow), or abnormal sudomotor activity in the region of pain. Onset of CRPS1 symptoms may occur within a few days to a month after an injury or trauma to the affected limb.

Disease Hierarchy

DIS6SVEE: Syndromic disease

DIS625IE: Complex regional pain syndrome

DISEUIQP: Complex regional pain syndrome type 1

Disease Identifiers

MONDO ID

MONDO_0011441

MESH ID

D012019

UMLS CUI

C0034931

OMIM ID

604335

MedGen ID

11159

Orphanet ID

99995

SNOMED CT ID

734947007

General Information of Disease (ID: DISEUIQP)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Lenalidomide	DM6Q7U4	Approved	Small molecular drug	[1]
Thalidomide	DM70BU5	Approved	Small molecular drug	[2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
NR2E3	OTO3GBHQ	Strong	Biomarker	[3]
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References

1	Lenalidomide FDA Label
2	Thalidomide FDA Label
3	Evaluation Through Transcutaneous Tissue Oximetry (Near Infrared Spectroscopy) of Spinal Cord Stimulation in Patients With Complex Regional Pain Syndrome Type I.Neuromodulation. 2020 Jul;23(5):698-703. doi: 10.1111/ner.12931. Epub 2019 Feb 20.