Details of Disease

General Information of Disease (ID: DISF3BXT)

• Disease Name: Herpetic keratitis
• Synonyms: HSV keratitis; Simplexvirus caused keratitis; Simplexvirus keratitis; herpetic keratitis; dendritic keratitis
• Disease Class: 1F00: Herpes simplex infection
• Definition: A superficial, epithelial Herpesvirus hominis infection of the cornea, characterized by the presence of small vesicles which may break down and coalesce to form dendritic ulcers (keratitis, dendritic). (Dictionary of Visual Science, 3d ed)
• Disease Hierarchy:
  DISN2KPA: Corneal infection
  DIS7K18Z: Herpes simplex virus infection
  DIS7YY4P: Viral eye infection
  DISEM33Q: Infectious disease
  DISF3BXT: Herpetic keratitis
• ICD Code:
  ICD-11: ICD-11: 1F00.10
  ICD-10: ICD-10: H19.1
  Expand ICD-11: '1F00.10
  Expand ICD-10: 'H19.1
• Disease Identifiers:
  MONDO ID: MONDO_0015288
  MESH ID: D016849
  UMLS CUI: C0019357
  MedGen ID: 5534
  SNOMED CT ID: 186542001

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Trifluridine	DMG2YBD	Approved	Small molecular drug	[1]
Vidarabine	DM0N85H	Approved	Small molecular drug	[2]

This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
AC-8	DMA2MCK	Investigative	NA	[3]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ACKR1	TTKY2NS	Limited	Biomarker	[4]
LAG3	TTNVXAW	Limited	Biomarker	[5]

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC7A2	DTWY9RT	Strong	Altered Expression	[6]

References

• [1] Trifluridine FDA Label
• [2] Vidarabine FDA Label
• [3] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [4] DNA vaccine expressing herpes simplex virus 1 glycoprotein C and D protects mice against herpes simplex keratitis.Int J Ophthalmol. 2017 Nov 18;10(11):1633-1639. doi: 10.18240/ijo.2017.11.01. eCollection 2017.
• [5] Blockade of PD-1 and LAG-3 Immune Checkpoints Combined with Vaccination Restores the Function of Antiviral Tissue-Resident CD8(+) T(RM) Cells and Reduces Ocular Herpes Simplex Infection and Disease in HLA Transgenic Rabbits.J Virol. 2019 Aug 28;93(18):e00827-19. doi: 10.1128/JVI.00827-19. Print 2019 Sep 15.
• [6] Detection and regulation of cationic amino acid transporters in healthy and diseased ocular surface.Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1112-21. doi: 10.1167/iovs.08-2368. Epub 2008 Nov 7.