Details of Disease | DrugMAP

General Information of Disease (ID: DISF6XLX)

Disease Name	Anterior horn disorder
Synonyms	ventral horn of spinal cord disease or disorder; ventral horn of spinal cord disease; disorder of ventral horn of spinal cord; disease or disorder of ventral horn of spinal cord; disease of ventral horn of spinal cord
Definition	Anterior horn disease is one of a number of medical disorders affecting the anterior horn of the spinal cord. Anterior horn diseases include spinal muscular atrophy, poliomyelitis and amyotrophic lateral sclerosis.\|TODO - check this. DO places as a subtype of SMA, but we invert this. Consider merging into MND
Disease Hierarchy	DISWD40R: Disease DISXV8FG: Myelopathy DISF6XLX: Anterior horn disorder
Disease Identifiers	MONDO ID MONDO_0003182 MESH ID D016472 UMLS CUI C0154681 MedGen ID 102314 HPO ID HP:0006802 SNOMED CT ID 85672005

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
PNPLA6	TTWAQU2	Limited	Biomarker	[1]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
PRDX3	OTLB2WEU	Strong	Biomarker	[2]
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References

1	Motor neuron disease due to neuropathy target esterase mutation: enzyme analysis of fibroblasts from human subjects yields insights into pathogenesis.Toxicol Lett. 2010 Nov 10;199(1):1-5. doi: 10.1016/j.toxlet.2010.06.020. Epub 2010 Sep 17.
2	Impairment of mitochondrial anti-oxidant defence in SOD1-related motor neuron injury and amelioration by ebselen. Brain. 2006 Jul;129(Pt 7):1693-709. doi: 10.1093/brain/awl118. Epub 2006 May 15.