Details of Disease

General Information of Disease (ID: DISXV8FG)

• Disease Name: Myelopathy
• Synonyms: myelopathy; spinal cord disorder; spinal cord disease or disorder; spinal cord disease; disorder of spinal cord; disease or disorder of spinal cord; disease of the spinal cord; disease of spinal cord
• Disease Class: 8B42: Myelopathy
• Definition: A disease involving the spinal cord.
• Disease Hierarchy:
  DISWD40R: Disease
  DISEP2HK: Central and peripheral nervous disease
  DISXV8FG: Myelopathy
• ICD Code: ICD-11: ICD-11: 8B42
• Disease Identifiers:
  MONDO ID: MONDO_0002545
  MESH ID: D013118
  UMLS CUI: C0037928
  MedGen ID: 11550
  HPO ID: HP:0002196
  SNOMED CT ID: 48522003

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
dequalinium	DMXM19W	Clinical trial	Small molecular drug	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 10 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ADA	TTLP57V	Strong	Biomarker	[2]
APP	TTE4KHA	Strong	Biomarker	[3]
CNTN2	TT2Z1WB	Strong	Altered Expression	[4]
IL18RAP	TTZUJVE	Strong	Genetic Variation	[5]
MBP	TT2RY5P	Strong	Biomarker	[6]
MTHFR	TTQWOU1	Strong	Genetic Variation	[7]
PTPN13	TT405FP	Strong	Altered Expression	[8]
RNPEP	TTD74YX	Strong	Biomarker	[9]
SERPINH1	TTPSWQG	Strong	Biomarker	[10]
SLC25A4	TTU5A6Q	Strong	Biomarker	[11]

This Disease Is Related to 2 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
ABCD1	DTKM9DZ	Strong	Biomarker	[12]
SLC25A6	DTLMGFJ	Strong	Biomarker	[11]

This Disease Is Related to 8 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ATF7IP	OTU6ZA7F	Strong	Biomarker	[13]
BTD	OTJYTQ69	Strong	Biomarker	[14]
DPYSL5	OT6F9T6F	Strong	Biomarker	[15]
NRSN1	OT1KKXC8	Strong	Biomarker	[16]
RAB4A	OT7BL9WW	Strong	Biomarker	[17]
TMED2	OTBLO7RW	Strong	Biomarker	[16]
TMTC1	OTZ7NW96	Strong	Biomarker	[18]
AMN	OTS1TJXG	Definitive	Genetic Variation	[19]

References

• [1] Pharmacological characterisation of the human small conductance calcium-activated potassium channel hSK3 reveals sensitivity to tricyclic antidepressants and antipsychotic phenothiazines. Neuropharmacology. 2001 May;40(6):772-83.
• [2] The activity of adenosine deaminase and the level of nitric oxide in spinal cord of methotrexate administered rats: protective effect of caffeic acid phenethyl ester.Toxicology. 2006 Feb 1;218(2-3):125-33. doi: 10.1016/j.tox.2005.10.014. Epub 2005 Dec 2.
• [3] Methotrexate-related nonnecrotizing multifocal axonopathy detected by beta-amyloid precursor protein immunohistochemistry.Arch Pathol Lab Med. 2002 Jan;126(1):79-81. doi: 10.5858/2002-126-0079-MRNMAD.
• [4] Human T-lymphotropic virus type I-associated myelopathy and tax gene expression in CD4+ T lymphocytes.Ann Neurol. 1996 Jul;40(1):84-90. doi: 10.1002/ana.410400114.
• [5] Role of APOE and IL18RAP gene polymorphisms in cervical spondylotic myelopathy in Indian population.J Clin Neurosci. 2019 Aug;66:83-86. doi: 10.1016/j.jocn.2019.05.017. Epub 2019 May 21.
• [6] Critical role for PAR1 in kallikrein 6-mediated oligodendrogliopathy.Glia. 2013 Sep;61(9):1456-70. doi: 10.1002/glia.22534. Epub 2013 Jul 8.
• [7] Reversible nitrous oxide myelopathy and a polymorphism in the gene encoding 5,10-methylenetetrahydrofolate reductase.Br J Anaesth. 2006 Feb;96(2):222-5. doi: 10.1093/bja/aei300. Epub 2005 Dec 16.
• [8] Expression of FAP-1 (Fas-associated phosphatase) and resistance to Fas-mediated apoptosis in T cell lines derived from human T cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis patients.AIDS Res Hum Retroviruses. 1998 Feb 10;14(3):261-7. doi: 10.1089/aid.1998.14.261.
• [9] Utility of the central motor conduction time recorded from the abductor pollicis brevis and the abductor digiti minimi muscles in patients with C6-7 myelopathy.J Spinal Cord Med. 2018 Mar;41(2):182-191. doi: 10.1080/10790268.2017.1322673. Epub 2017 May 17.
• [10] Establishment and characterization of an HTLV-I cell line from a Taiwanese patient with HTLV-I-associated myelopathy.J Neurol Sci. 1993 Dec 1;120(1):46-53. doi: 10.1016/0022-510x(93)90023-r.
• [11] Two-level cervical corpectomy-long-term follow-up reveals the high rate of material failure in patients, who received an anterior approach only.Neurosurg Rev. 2019 Jun;42(2):511-518. doi: 10.1007/s10143-018-0993-6. Epub 2018 Jun 18.
• [12] Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy.Hum Mol Genet. 2008 Jun 15;17(12):1762-73. doi: 10.1093/hmg/ddn085. Epub 2008 Mar 14.
• [13] Low genetic diversity of the Human T-cell Lymphotropic Virus (HTLV-1) in an endemic area of the Brazilian Amazon basin.PLoS One. 2018 Mar 20;13(3):e0194184. doi: 10.1371/journal.pone.0194184. eCollection 2018.
• [14] Profound biotinidase deficiency in a child with predominantly spinal cord disease.J Child Neurol. 2008 Sep;23(9):1043-8. doi: 10.1177/0883073808318062. Epub 2008 Jul 21.
• [15] Autoimmune myelopathy associated with collapsin response-mediator protein-5 immunoglobulin G.Ann Neurol. 2008 Apr;63(4):531-4. doi: 10.1002/ana.21324.
• [16] Linear antigenic regions of the structural proteins of human T-cell lymphotropic virus type I detected by enzyme-linked immunosorbent assays using synthetic peptides as antigens.J Clin Microbiol. 1992 Feb;30(2):287-90. doi: 10.1128/jcm.30.2.287-290.1992.
• [17] Increased seroreactivity to human T cell lymphoma/leukemia virus-related endogenous sequence-1 Gag peptides in patients with human T cell lymphoma/leukemia virus myelopathy.AIDS Res Hum Retroviruses. 2015 Feb;31(2):242-9. doi: 10.1089/AID.2014.0171. Epub 2014 Nov 19.
• [18] Outcomes of Surgery for Thoracic Myelopathy Owing to Thoracic Ossification of The Ligamentum Flavum in a Nationwide Multicenter Prospectively Collected Study in 223 Patients: Is Instrumented Fusion Necessary?.Spine (Phila Pa 1976). 2020 Feb 1;45(3):E170-E178. doi: 10.1097/BRS.0000000000003208.
• [19] Enzymatic characterization of ELOVL1, a key enzyme in very long-chain fatty acid synthesis.Biochim Biophys Acta. 2015 Feb;1851(2):231-7. doi: 10.1016/j.bbalip.2014.12.005. Epub 2014 Dec 11.